| 已发布 PubMed:小ber碱代谢产物可诱导低密度脂蛋白受体上调，从而在 肝癌细胞中发挥降脂作用。 Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells. |
| 已发布 PubMed: 小nt碱抗脂肪形成活性不是由wnt /β-连环蛋白 β-catenin途径介导的。 |
| 已发布 PubMed:改善 Improvement of 苄基异喹啉 benzyl异喹啉 isoquinoline 生物碱 alkaloid 生产率 productivity by by 过度表达 over表达 expression of 3'-hydroxy-N-methyl可可碱 coclaurine 4'-邻甲基转移酶 O-methyl传递 transferase in 转基因 transgenic 黄连 Coptis japonica plants. |
| 已发布 PubMed:加利福尼亚州厚壳草细胞血红素碱生物合成中细胞色素p450的分子克隆和表征。 Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells. |
| 已发布 PubMed:黄连cjabcb2的表征 Characterization of Coptis japonica CjABCB2, 参与生物碱转运的atp结合盒蛋白。 an ATP-binding cassette protein involved in alkaloid transport. |
| 已发布 PubMed:小ber碱对糖尿病小鼠细胞色素p450表达的调节作用。 Modulations of cytochrome P450 expression in diabetic mice by berberine. |
| 已发布 PubMed:基本的 -环- 转录因子和生物碱生物合成的调节。 Basic helix-loop-helix transcription factors and regulation of alkaloid biosynthesis. |
| 已发布 PubMed:黄连中独特的bhlh型转录因子调节异喹啉生物碱生物合成。 Isoquinoline alkaloid biosynthesis is regulated by a unique bHLH-type transcription factor in Coptis japonica. |
| 已发布 PubMed:降钙素合酶是发病相关的10 / bet v1蛋白家族的成员。 Norcoclaurine synthase is a member of the pathogenesis-related 10/Bet v1 protein family. |
| 已发布 PubMed:黄连中异喹啉生物碱合成中邻甲基转移酶的分子特征 Molecular characterization of O-methyltransferases involved in isoquinoline alkaloid biosynthesis in Coptis japonica. |
| 已发布 PubMed: 瞬时核糖核酸 RNA系统鉴定参与生物碱生物合成的调节蛋白基因。 |
| 已发布 PubMed:通过在加州大麦草中引入分支途径，实现苄基异喹啉生物碱生物合成的代谢多样化。 Metabolic diversification of benzylisoquinoline alkaloid biosynthesis through the introduction of a branch pathway in Eschscholzia californica. |
| 已发布 PubMed:季生物碱同时表征 Simultaneous characterization of quaternary alkaloids, 8-氧代小ber碱生物碱 8-oxoprotoberberine alkaloids, 液相色谱-混合离子阱飞行时间质谱法测定f骨中的甾族化合物和甾族化合物。 and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry. |
| 已发布 PubMed:在表达abc转运蛋白的长春花细胞中改善了阿马利辛和四氢精氨酸积累。 Improved accumulation of ajmalicine and tetrahydroalstonine in Catharanthus cells expressing an ABC transporter. |
| 已发布 PubMed:培养的黄连细胞分离抗除草剂的4-羟基苯基丙酮酸双加氧酶。 Isolation of herbicide-resistant 4-hydroxyphenylpyruvate dioxygenase from cultured Coptis japonica cells. |
| 已发布 PubMed:加利福尼亚州大肠埃希菌中细胞色素p450氧化酶和异喹啉生物碱cyp719a家族。 CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica. |
| 已发布 PubMed:黄连的半乳糖醇合成酶基因参与了小ber碱耐受性。 Galactinol synthase gene of Coptis japonica is involved in berberine tolerance. |
| 已发布 PubMed:cyp80g2的分子克隆与表征 Molecular cloning and characterization of CYP80G2, 细胞色素p450催化在木兰花素生物合成中分子内c-c苯酚偶联 a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, 来自培养的黄连细胞。 from cultured Coptis japonica cells. |
| 已发布 PubMed:crmdr1的分子克隆与表征 Molecular cloning and characterization of Crmdr1, 长春花的一种新的mdr型abc转运蛋白基因。 a novel MDR-type ABC transporter gene from Catharanthus roseus. |
| 已发布 PubMed:四氢小ber碱顺式-正甲基转移酶的分子克隆与表征 Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, 一种与罂粟生物碱生物合成有关的酶。 an enzyme involved in alkaloid biosynthesis in opium poppy. |
| 已发布 PubMed:加利福尼亚州厚草生物中苯乙烯类生物合成的亚甲基二氧基桥形成酶的分子克隆和表征。 Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica. |
| 已发布 PubMed:黄连中降钙素合酶的功能分析。 Functional analysis of norcoclaurine synthase in Coptis japonica. |
| 已发布 PubMed:由于uvb（4-甲基亚苄基樟脑/甲氧基肉桂酸辛酯）和uva（二苯甲酮-3 /甲氧基二苯甲酰丁基甲烷）吸收剂敏化作用引起的光过敏性接触性皮炎。 Overexpression of Coptis japonica norcoclaurine 6-O-methyltransferase overcomes the rate-limiting step in Benzylisoquinoline alkaloid biosynthesis in cultured Eschscholzia californica. |
| 已发布 PubMed:Bowman-Birk蛋白酶抑制剂可赋予酵母重金属和多种药物耐受性。 Bowman-birk proteinase inhibitor confers heavy metal and multiple drug tolerance in yeast. |
| 已发布 PubMed:鉴定作为黄连中苄基异喹啉生物碱生物合成转录调节因子的蛋白质。 Identification of a WRKY protein as a transcriptional regulator of benzylisoquinoline alkaloid biosynthesis in Coptis japonica. |
| 已发布 PubMed:原小碱生物碱及其对p-gp的逆转活性表现为黄连木茎的根茎上的多药耐药性（mdr）。 Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino. |
| 已发布 PubMed:小ber碱对吗啡诱导的小鼠运动敏化和镇痛耐受性的抑制作用。 Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice. |
| 已发布 PubMed:黄连碱在血管平滑肌细胞中对细胞周期进程的双重阻断。 Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells. |
| 已发布 PubMed:黄连中内源生物碱小ber碱液泡运输的特征。 Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica. |
| 已发布 PubMed:黄连提取物可通过caspase3激活诱导snu-668 胃癌细胞凋亡。 Coptis japonica root extract induces apoptosis through caspase3 activation in SNU-668 human gastric cancer cells. |
| 已发布 PubMed: 黄连原生质体中双链核糖核酸 RNA介导的菜豆碱9-o-甲基转移酶表达的瞬时核糖核酸 RNA沉默。 |
| 已发布 PubMed: 重组可可碱 coclaurine n-甲基转移酶体内四氢异喹啉的生物转化。 |
| 已发布 PubMed:在草药中使用单克隆抗体对小ber碱及其相关化合物进行免疫定量分析。 Immunoquantitative analysis for berberine and its related compounds using monoclonal antibodies in herbal medicines. |
| 已发布 PubMed:(r (R,s）-网红7-o-甲基转移酶和（r S)-Reticuline 7-O-methyltransferase and (R,罂粟罂粟的s）-norclaclaurine 6-o-甲基转移酶-cdna的克隆和生物碱生物合成甲基罂粟的甲基转移酶的表征。 S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy. |
| 已发布 PubMed:韩国传统医学中使用的草药提取物的抗疟活性。 Antimalarial activity of herbal extracts used in traditional medicine in Korea. |
| 已发布 PubMed:罂粟生物碱生物合成相关基因转录本的发育和诱导型积累。 Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy. |
| 已发布 PubMed:黄连对吗啡诱导的小鼠条件性位置偏爱的影响 Effects of Coptis japonica on morphine-induced conditioned place preference in mice. |
| 已发布 PubMed:黃芩素的作用 Effects of baicalein, 小ber碱 berberine, 姜黄素和橙皮苷对气道杯状细胞中粘蛋白的释放。 curcumin and hesperidin on mucin release from airway goblet cells. |
| 已发布 PubMed:cyp719的分子克隆与表征 Molecular cloning and characterization of CYP719, 属于新型p450家族的亚甲二氧基桥形成酶 a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, 来自培养的黄连细胞。 from cultured Coptis japonica cells. |
| 已发布 PubMed:钒酸盐诱导的核苷酸捕获在植物细胞中检测abc蛋白的应用。 Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins. |
| 已发布 PubMed:cjmdr1的参与 Involvement of CjMDR1, 植物多药耐药型ATP结合盒蛋白 a plant multidrug-resistance-type ATP-binding cassette protein, 黄连中生物碱转运 in alkaloid transport in Coptis japonica. |
| 已发布 PubMed:黄连根异喹啉碱对大鼠晶状体醛糖还原酶的抑制作用。 Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids. |
| 已发布 PubMed:培养的黄连细胞中哥伦巴胺邻甲基转移酶的分子克隆 Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells. |
| 已发布 PubMed:小ber碱转运到黄连细胞中的特征以及abc蛋白的参与。 Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein. |
| 已发布 PubMed:黄连培养细胞中可乐氨酸正甲基转移酶的分子克隆与表征 Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica. |
| 已发布 PubMed:黄连的药理研究（第2部分） Herbological studies of Coptidis rhizoma (Part 2): 黄连日本锦葵的古日语名称上。 on the old Japanese name of Coptis japonica makino. |
| 已发布 PubMed:来自黄连根茎的木脂素具有不同的抗炎作用。 Lignans from the rhizomes of Coptis japonica differentially act as anti-inflammatory principles. |
| 已发布 PubMed:一种新的黄连耐多药蛋白，优先在生物碱积累的根茎中表达。 A novel Coptis japonica multidrug-resistant protein preferentially expressed in the alkaloid-accumulating rhizome. |
| 已发布 PubMed:培养的黄连细胞中可乐碱n-甲基转移酶的纯化和鉴定。 Purification and characterization of coclaurine N-methyltransferase from cultured Coptis japonica cells. |
| 已发布 PubMed:植物生物碱生物合成的代谢工程。 Metabolic engineering of plant alkaloid biosynthesis. |
| 已发布 PubMed:黄连根茎中新木脂藤节苷的体外抗炎作用。 In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica. |
| 已发布 PubMed:虫草素 Cordycepin: 来自液体 liquid虫草的液体培养物针对梭菌的选择性生长抑制剂。 |
| 已发布 PubMed:黄连根中异喹啉类生物碱抗食性对豚鼠（鳞毛蕨） Antifeeding activity of isoquinoline alkaloids identified in Coptis japonica roots against Hyphantria cunea (Lepidoptera: arctiidae）和agelastica coerulea（鞘翅目） : galerucinae）。 Galerucinae). |
| 已发布 PubMed:s-腺苷-1-蛋氨酸分子表征 Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methyl可可碱 coclaurine 4'-邻甲基转移酶 O-methyl传递 transferase 涉及 involved in 异喹啉 isoquinoline 生物碱 alkaloid 生物合成 bio合成 synthesis in 黄连 Coptis japonica. |
| 已发布 PubMed:黄连木pro中小to碱抗光氧化活性在油中叶绿素敏感性光氧化中的作用。 Antiphotooxidative activity of protoberberines derived from Coptis japonica makino in the chlorophyll-sensitized photooxidation of oil. |
| 已发布 PubMed:黄连根异喹啉类生物碱对 肠道细菌的生长抑制作用 Growth-inhibiting effects of Coptis japonica root-derived isoquinoline alkaloids on human intestinal bacteria. |
| 已发布 PubMed:中草药对布鲁氏罗氏锥虫血流形式的体外抗胰锥作用。 Antitrypanosomal effects of traditional Chinese herbal medicines on bloodstream forms of Trypanosoma brucei rhodesiense in vitro. |
| 已发布 PubMed:黄连木茎中木酚素的抑制作用。脂多糖刺激的肿瘤中肿瘤坏死因子-α产生的解剖aw264.7细胞。 Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated RAW264.7 cells. |
| 已发布 PubMed:抑癌基因及其成分对 肝细胞hepg2细胞胆固醇酯合成的抑制作用 Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: 培养的hepg2细胞和acat体外测定的证据。 evidence from the cultured HepG2 cells and in vitro assay of ACAT. |
| 已发布 PubMed:黄连中小to碱生物碱对pc12细胞中儿茶酚胺生物合成的抑制作用 Inhibitory effects of protoberberine alkaloids from the roots of Coptis japonica on catecholamine biosynthesis in PC12 cells. |
| 已发布 PubMed:[关于用粗药物进行浴的研究。 ii。 [Study on baths with crude drug. II.: 黄连提取物作为皮肤渗透促进剂的作用] the effects of coptidis rhizoma extracts as skin permeation enhancer]. |
| 已发布 PubMed:腺苷-1-蛋氨酸分子克隆与表征 Molecular cloning and characterization of S-adenosyl-L-methionine: 黄连培养细胞中的苦瓜碱 scoulerine-9-o-甲基转移酶。 |
| 已发布 PubMed:腺苷-1-蛋氨酸纯化与表征 Purification and characterization of S-adenosyl-L-methionine: 培养的黄连细胞中的降钙素嘌呤6-邻甲基转移酶。 norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells. |
| 已发布 PubMed:[口服黄连提取物后血浆中小ber碱浓度的比较研究 [Comparative studies on concentration of berberine in plasma after oral administration of coptidis rhizoma extract, 培养的细胞提取物 its cultured cells extract, 提取物与甘草提取物在大鼠中的联合使用] and combined use of these extracts and glycyrrhizae radix extract in rats]. |
| 已发布 PubMed:在黄连中的小ine碱生物合成中，降钙素尿苷途径是有效的。 The Norcoclaurine Pathway is Operative in Berberine Biosynthesis in Coptis japonica. |
| 已发布 PubMed: 植物细胞培养物中对外源小公差 tolerance碱耐受性的浸膏差异。 |
| 已发布 PubMed:1）苄基-二甲基十四烷基氯化铵n-苄基-正十四烷基二甲基氯化铵苄基（十四烷基）二甲基氯化铵苄基二甲基肉豆蔻基氯化铵苄基二甲基十四烷基氯化铵苄基十四烷基二甲基氯化铵 [Evaluation on equivalence of pharmacological properties between natural crude drugs and their cultured cells based on their components. Accelerative effect of lithospermi radix and inhibitory effect of coptidis rhizoma on proliferation of granulation tissue]. |
| 已发布 PubMed:通过反复选择获得的黄连高产和低产细胞系中细胞小ber碱含量的流式细胞仪分析。 Flow Cytometric Analysis of Cellular Berberine Contents in High- and Low-Producing Cell Lines of Coptis japonica Obtained by Repeated Selection. |
| 已发布 PubMed:隔离 Isolation, 序列 sequence, 培养的产生小ine碱黄连细胞中（s）-四氢小ber碱氧化酶的cdna的表达和细菌表达。 and bacterial expression of a cDNA for (S)-tetrahydroberberine oxidase from cultured berberine-producing Coptis japonica cells. |
| 已发布 PubMed:草药对花生四烯酸生物转化的影响 Effects of certain herbal medicines on the biotransformation of arachidonic acid: 一种使用血清的新药理测试方法。 a new pharmacological testing method using serum. |
| 已发布 PubMed:黄连细胞培养中小ber碱生物合成的替代性最终步骤。 Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures. |
| 已发布 PubMed:通过确定电子传输活性来估算植物细胞活力的新方法。 A new estimation method for plant cell viability by determining electron transport activity. |
| 已发布 PubMed:黄连和减水杨培养细胞中与生物碱产生相关的细胞学变化。 Cytological changes associated with alkaloid production in cultured cells of Coptis japonica and Thalictrum minus. |
| 已发布 PubMed:从培养的黄连细胞的单个原生质体获得的细胞系中染色体的不稳定性和生物碱含量。 Instability of chromosomes and alkaloid content in cell lines derived from single protoplasts of cultured Coptis japonica cells. |
| 已发布 PubMed:[Studies on 消炎 anti-inflammatory agents. ii II. 消炎 Anti-inflammatory 成分 constituents from 根茎 Rhizome of 黄连 Coptis japonica 牧野 Makino (author's 翻译 transl)]. |
| 已发布 PubMed:生物碱对家兔实验性角膜疱疹单纯性疱疹1型作用的影响 Effect of plant alkaloid against the action of herpes simplex type 1 in experimental corneal herpes in rabbits: 黄连makio水提取物对单纯疱疹的作用。 the effect of an aqueous extract of Coptis japonica Makino against herpes simplex. |
| 已发布 PubMed:研究了黄连makio叶的成分。一世。黄连苷i和ii的结构。 Studies on the components of the leaves of Coptis japonica Makino. I. The structures of coptiside I and II. |
| 已发布 PubMed:[黄连makio的培养实验。一世。强度对生长和产量的影响]。 [Cultivation experiments of Coptis japonica Makino. I. Effect of light intensity on the growth and yield]. |
| 已发布 PubMed:[关于通过薄层色谱法对原药中的成分进行定量分析的研究。一世。薄层色谱法定量分析黄连中小ber碱含量研究 [STUDIES ON THE QUANTITATIVE ANALYSIS OF CONSTITUENTS IN CRUDE DRUGS BY THIN-LAYER CHROMATOGRAPHY. I. STUDIES ON THE QUANTITATIVE ANALYSIS OF BERBERINE IN COPTIS JAPONICA MAKINO BY THIN-LAYER CHROMATOGRAPHY]. |
