已发布 PubMed:诺丹宁对特应性皮炎样皮肤病变的治疗作用 Effect of nodakenin on atopic dermatitis-like skin lesions. |
已发布 PubMed: cur素 Decursin减弱了卡因酸诱导的小鼠癫痫发作。 |
已发布 PubMed:一种新的草药制剂(血红素)对链脲佐菌素诱导的糖尿病小鼠的免疫调节和抗糖尿病作用。 Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice. |
已发布 PubMed:当归的乙醇提取物通过抑制血管平滑肌细胞增殖来改善动脉粥样硬化。 An ethanolic extract of Angelica gigas improves atherosclerosis by inhibiting vascular smooth muscle cell proliferation. |
已发布 PubMed:草药提取物h003通过抑制stat3-il-6信号传导来抑制mda-mb-231乳腺癌细胞的肿瘤生长和转移。 Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling. |
已发布 PubMed:nc / nga小鼠的药代动力学/药效动力学/疾病进展模型的开发,用于开发新型抗特应性皮炎药物。 Development of a pharmacokinetic/pharmacodynamic/disease progression model in NC/Nga mice for development of novel anti-atopic dermatitis drugs. |
已发布 PubMed:草药(apr)对raw264.7细胞的抗炎和抗增殖作用。 Anti-inflammatory and anti-proliferative effect of herbal medicines (APR) in RAW264.7 cells. |
已发布 PubMed: cur素 Decursin通过抑制mcf-7 乳腺癌细胞中pkcα/ p38 /nf-κb依赖的mmp-9表达来防止tpa诱导的侵袭。 |
已发布 PubMed:从韩国的药用农作物中分离出的两种新的talalomyces种。 Two novel Talaromyces species isolated from medicinal crops in Korea. |
已发布 PubMed:通过调节th1 / 2细胞分化对草药的预防作用(血红素)对小鼠气道发炎的预防作用。 Preventative effect of an herbal preparation (HemoHIM) on development of airway inflammation in mice via modulation of Th1/2 cells differentiation. |
已发布 PubMed:新的草药配方 A New Herbal Formula, KSG-002 KSG-002, 通过靶向巨噬细胞中依赖nf-κb的tnfα产生来抑制乳腺癌的生长和转移。 Suppresses Breast Cancer Growth and Metastasis by Targeting NF- κ B-Dependent TNF α Production in Macrophages. |
已发布 PubMed: cur素 Decursin和阿霉素协同作用,通过 多发性骨髓瘤细胞中的stat3和/或mtor途径诱导凋亡。 |
已发布 PubMed: 从当归中分离出的cur素 Decursin通过nrf2介导的血红素加氧酶-1上调从淀粉样β蛋白诱导的橙花毒性中拯救pc12细胞 : mapk的潜在作用。 Potential Roles of MAPK. |
已发布 PubMed: cur素 Decursin通过抑制pin1活性和增强pin1 / p53关联,在mda-mb-231乳腺癌细胞中发挥抗癌活性。 |
已发布 PubMed:单倍剂量地精的药代动力学 Single oral dose pharmacokinetics of decursin, 地高辛诺尔 decursinol angelate, 和去氢醇在大鼠中。 and decursinol in rats. |
已发布 PubMed:(s)-(+)-递精蛋白衍生物 A (S)-(+)-decursin derivative, (s)-(+)-3-(3 (S)-(+)-3-(3,4-二羟基苯基)丙烯酸2 4-dihydroxy-phenyl)-acrylic acid 2,2-二甲基-8-氧代3 2-dimethyl-8-oxo-3,4-二氢-2h 4-dihydro-2H,8h-吡喃[3 8H-pyrano[3,2-g]-铬-3-基酯 2-g]-chromen-3-yl-ester, 减轻了nc / nga小鼠特应性皮炎样病变的发展。 attenuates the development of atopic dermatitis-like lesions in NC/Nga mice. |
已发布 PubMed:基于匹配质量指标的频谱匹配和投票相结合的新判别方法。 New discrimination method combining hit quality index based spectral matching and voting. |
已发布 PubMed: cur素 Decursin通过调节核因子-κb抑制uvb诱导的 皮肤成纤维细胞mmp表达。 |
已发布 PubMed:当归超细粉在 切除的大鼠中可正常化 激素水平并具有抗骨质疏松的特性 Ultrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: 粒径效应。 particle size effect. |
已发布 PubMed:cur素及其衍生物用于药物发现的生物药物表征。 Biopharmaceutical characterization of decursin and their derivatives for drug discovery. |
已发布 PubMed:inm-176的记忆改善作用 The memory ameliorating effects of INM-176, 当归乙醇提取物 an ethanolic extract of Angelica gigas, 抗东pol碱或aβ(1-42)诱导的小鼠认知功能障碍。 against scopolamine- or Aβ(1-42)-induced cognitive dysfunction in mice. |
已发布 PubMed:新型合成的α-硫辛酸-地松果酚杂合化合物在实验性短暂性脑缺血中的保护作用。 Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia. |
已发布 PubMed:当归中的cur素及其衍生物的理化性质和毒性。 Physicochemical characterization and toxicity of decursin and their derivatives from Angelica gigas. |
已发布 PubMed:韩国当归及其主要吡喃香豆素类化合物的抗癌和其他生物活性。 Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds. |
已发布 PubMed:cur素的首过代谢 First-pass metabolism of decursin, 当归的生物活性化合物 a bioactive compound of Angelica gigas, 在大鼠中。 in rats. |
已发布 PubMed: sa药汤对大鼠口服管理 administ鼠 ration药苷的食物和性别依赖性药代动力学。 |
已发布 PubMed:inm-176对脂多糖诱导的橙花元损伤的橙花保护作用。 Neuroprotective effects of INM-176 against lipopolysaccharide-induced neuronal injury. |
已发布 PubMed: cur素 Decursin通过抑制内皮祖细胞的分化和功能来抑制肿瘤早期发展中的血管生成。 |
已发布 PubMed: dart-tof-ms指纹图谱对形态相似的点地梅科草药进行化学计量学分类。 |
已发布 PubMed:定量测定海藻素 Quantitative determination of decursin, 地高辛诺尔 decursinol angelate, 液-液萃取和hplc提取小鼠血浆和肿瘤组织中的地松酚。 and decursinol in mouse plasma and tumor tissue using liquid-liquid extraction and HPLC. |
已发布 PubMed:cur素 Decursin, 从当归中分离出的活性化合物 an active compound isolated from Angelica gigas, 抑制脂肪堆积 inhibits fat accumulation, 减少高脂饮食喂养小鼠的脂肪细胞因子分泌并改善葡萄糖耐量。 reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet. |
已发布 PubMed:草药提取物(estrog-100)对预 The effect of herbal extract (EstroG-100) on pre-, 绝经前后妇女 peri- and post-menopausal women: 随机双盲 a randomized double-blind, 安慰剂对照研究。 placebo-controlled study. |
已发布 PubMed:具有增加的体内稳定性的合成的壁素类似物在体外和体内抑制雄激素受体信号传导。 A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo. |
已发布 PubMed:当归乙醇提取物在二硝基氟苯诱发的炎症模型中的抗过敏作用及其作用机理。 Anti-allergic effects and mechanisms of action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene-induced inflammation models. |
已发布 PubMed:使用1h nmr和uplc-ms分析,分析不同地理来源的当归的代谢产物。 Metabolite profiling of Angelica gigas from different geographical origins using 1H NMR and UPLC-MS analyses. |
已发布 PubMed:大鼠中当归中十氢萘酚的药代动力学特征。 Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats. |
已发布 PubMed:肉桂酸4-羟化酶基因的过表达增强了当归毛状根中癸内醇当归酸酯的生物合成。 Overexpression of cinnamate 4-hydroxylase gene enhances biosynthesis of decursinol angelate in Angelica gigas hairy roots. |
已发布 PubMed:韩国当归属多种精油对埃及伊蚊的免疫毒性活性。 Immunotoxicity activity from various essential oils of Angelica genus from South Korea against Aedes aegypti L. |
已发布 PubMed:当归干燥根中香豆素衍生物的体外抗血浆和细胞毒活性 Antiplasmodial and cytotoxic activity of coumarin derivatives from dried roots of Angelica gigas Nakai in vitro. |
已发布 PubMed:地精和地精醇对PC12细胞中淀粉样β蛋白诱导的氧化应激的保护作用 Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: nrf2和抗氧化酶的作用。 the role of Nrf2 and antioxidant enzymes. |
已发布 PubMed: 当归中的cur素 Decursin和cur素 Decursinol抑制鼠结肠癌的肺转移。 |
已发布 PubMed:通过连续分级当归中提取物增强嗜铬细胞瘤橙花细胞的生长。 Enhancement of pheochromocytoma nerve cell growth by consecutive fractionization of Angelica gigas Nakai extracts. |
已发布 PubMed:当归中苯丙氨酸解氨酶和肉桂酸4-羟化酶的克隆与鉴定以及吡喃香豆素的生物合成 Cloning and characterization of phenylalanine ammonia-lyase and cinnamate 4-hydroxylase and pyranocoumarin biosynthesis in Angelica gigas. |
已发布 PubMed: cur素 Decursin通过增强 肾上皮细胞中的抗氧化酶来防止顺铂诱导的凋亡。 |
已发布 PubMed:一种改良的东方药物jangwonhwan制剂(lmk03)可以降低阿尔茨海默氏病tg-appswe / ps1de9小鼠模型大脑中的abeta(1-42)水平。 A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease. |
已发布 PubMed:一种改良的东方药物jangwonhwan制剂(lmk03)可以降低阿尔茨海默氏病tg-appswe / ps1de9小鼠模型大脑中的abeta(1-42)水平。 A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease. |
已发布 PubMed:女贞和当归的协同血管舒张作用和降压作用。 Synergistic vasorelaxant and antihypertensive effects of Ligusticum wallichii and Angelica gigas. |
已发布 PubMed:通过抑制pi3k来抑制地高辛醇安那酸酯阻止癌细胞的迁移和炎症活化 Decursinol angelate blocks transmigration and inflammatory activation of cancer cells through inhibition of PI3K, erk和nf-kappab激活。 ERK and NF-kappaB activation. |
已发布 PubMed:地精素通过凋亡抑制 膀胱和结肠癌细胞的生长 Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, g1期细胞周期停滞和细胞外信号调节激酶激活。 G1-phase cell cycle arrest and extracellular signal-regulated kinase activation. |
已发布 PubMed:当归的乙醇提取物通过抑制环氧合酶-前列腺素途径来抑制巴豆油诱发的炎症。 Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway. |
已发布 PubMed:分枝杆菌属植物对植物次生代谢产物cursin的生物转化。 pyr1001。 Biotransformation of plant secondary metabolite decursin by Mycobacterium sp. PYR1001. |
已发布 PubMed:吸收 Absorption, 分配 distribution, 代谢 metabolism, 当归中当归中的地精和地精醇的排泄物。 and excretion of decursin and decursinol angelate from Angelica gigas Nakai. |
已发布 PubMed:野菜对不同 类肿瘤细胞系的抗增殖活性 Antiproliferative activity of Korean wild vegetables on different human tumor cell lines. |
已发布 PubMed:评价用于东方医学的植物的光毒性潜力。 Evaluation of the phototoxic potential of plants used in oriental medicine. |
已发布 PubMed:当归乙醇提取物在角叉菜胶气袋炎症模型中的抗炎作用。 Anti-inflammatory effects of an ethanol extract of Angelica gigas in a Carrageenan-air pouch inflammation model. |
已发布 PubMed:去氢姜黄素的镇痛作用。 The analgesic effect of decursinol. |
已发布 PubMed:esp-102 ESP-102, 当归的联合提取物 a combined extract of Angelica gigas, 中国金龙和五味子 Saururus chinensis and Schizandra chinensis, 在大鼠皮层细胞的原代培养物中,它可防止谷氨酸诱导的毒性。 protects against glutamate-induced toxicity in primary cultures of rat cortical cells. |
已发布 PubMed: cur素 Decursin和cur素 Decursinol通过阻止细胞外信号调节激酶和c-jun n-末端激酶的激活来抑制vegf诱导的血管生成。 |
已发布 PubMed: cur素 Decursin和地高辛诺尔 decursinol angelate通过抑制vegfr-2信号通路抑制vegf诱导的血管生成。 |
已发布 PubMed:当归及其主要吡喃香豆素类递质的体内抗癌活性。 In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin. |
已发布 PubMed:从当归中提取的当归的抗糖尿病活性。 Antidiabetic activity of angelan isolated from Angelica gigas Nakai. |
已发布 PubMed:姜黄素和地姜辛醇对细胞色素p-450 1a1 / 2催化活性的体外抑制潜力 In vitro inhibitory potential of decursin and decursinol angelate on the catalytic activity of cytochrome P-450 1A1/2, 2天15 2D15, 和犬肝微粒体中的3a12亚型。 and 3A12 isoforms in canine hepatic microsomes. |
已发布 PubMed:化学蛋白质组学鉴定与去水松醇结合的蛋白质。 Identification of proteins binding to decursinol by chemical proteomics. |
已发布 PubMed:当归对破骨细胞形成的抑制作用。 Inhibitory effects of Angelicae Gigantis Radix on osteoclast formation. |
已发布 PubMed:韩国沙拉植物地上部分甲醇提取物的抗氧化活性和细胞毒性。 Antioxidant activity and cytotoxicity of methanol extracts from aerial parts of Korean salad plants. |
已发布 PubMed:当归的橙花保护性香豆素 Neuroprotective coumarins from the root of Angelica gigas: 结构-活动关系。 structure-activity relationships. |
已发布 PubMed:通过高效液相色谱和当归种的比较微观形态研究,同时测定了当归和其他各种当归中的八种香豆素。 Simultaneous determination of eight coumarins in Angelica gigas and in various other Angelica species by high performance liquid chromatography and comparative micro-morphology study of Angelica species. |
已发布 PubMed:紫色和非紫色胡萝卜(胡萝卜)品种中基于花青素的花青素生物合成中涉及的结构基因的转录谱分析显示出不同的模式。 The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry. |
已发布 PubMed: cur素 Decursin和地高辛诺尔 decursinol angelate选择性抑制a虫的nadh-fuma鼠 rate还原酶。 |
已发布 PubMed:当归提取物对b16黑素瘤细胞黑素生成的影响。 Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells. |
已发布 PubMed: cur素 Decursin通过促进β-catenin的降解来抑制不依赖 类雄激素的pc3前列腺癌细胞的增殖。 |
已发布 PubMed:东方草药作为新型抗雄激素和前列腺癌化学预防剂的来源。 Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents. |
已发布 PubMed: cur素 Decursinol和cur素 Decursin保护原代培养的大鼠皮质细胞免受谷氨酸诱导的橙花毒性。 |
已发布 PubMed:机理:从当归中分离出地高辛醇的癸酸酯使细胞色素p450 2a6失活。 Mechanism-based inactivation of cytochrome P450 2A6 by decursinol angelate isolated from Angelica Gigas. |
已发布 PubMed:气相色谱/质谱-模式识别方法在韩国当归质量控制中的应用 Development of gas chromatographic/mass spectrometry-pattern recognition method for the quality control of Korean Angelica. |
已发布 PubMed:通过加速溶剂萃取来提取当归中次生挥发性代谢物的最佳条件。 Optimized conditions for the extraction of secondary volatile metabolites in Angelica roots by accelerated solvent extraction. |
已发布 PubMed: Nodakenin Nodakenin , 香豆素化合物 a coumarin compound, 改善东pol碱诱导的小鼠记忆破坏。 ameliorates scopolamine-induced memory disruption in mice. |
已发布 PubMed:地精和地精醇天使酸酯跨caco-2和mdr-mdck细胞单层转运 Transport of decursin and decursinol angelate across Caco-2 and MDR-MDCK cell monolayers: 肠和血脑屏障通透性的体外模型。 in vitro models for intestinal and blood-brain barrier permeability. |
已发布 PubMed:当归中挥发性有机化合物 Volatile organic compounds of Angelica gigas Nakai, 韩国药草。 Korean medicinal herb. |
已发布 PubMed:一类新型的吡喃香豆素抗雄激素受体信号传导化合物。 A novel class of pyranocoumarin anti-androgen receptor signaling compounds. |
已发布 PubMed:从当归中分离出的当归素通过toll样受体4诱导树突状细胞成熟。 Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4. |
已发布 PubMed:在有或没有促炎性uvr刺激的情况下epa摄入对皮肤中cox和lox介导类花生酸合成的影响-一项关于 体的随机对照研究的报告。 Identification of volatile components in Angelica species using supercritical-CO2 fluid extraction and solid phase microextraction coupled to gas chromatography-mass spectrometry. |
已发布 PubMed:无溶剂注射和加氢蒸馏,然后气相色谱-质谱分析法测定当归品种中的挥发性风味成分。 Determination of volatile flavor components in danggui cultivars by solvent free injection and hydrodistillation followed by gas chromatographic-mass spectrometric analysis. |
已发布 PubMed:从当归中分离得到的果胶多糖可直接阻止细胞粘附并激活宿主免疫功能,从而抑制黑素瘤细胞的转移和生长。 Pectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functions. |
已发布 PubMed:当归含草药制剂的强抗雄激素和雄激素受体活性 Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: cur素作为一种新型活性化合物的鉴定,对预防和治疗前列腺癌具有重要意义。 identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. |
已发布 PubMed:当归中的精油抑制尼古丁致敏。 The essential oil from Angelica gigas NAKAI suppresses nicotine sensitization. |
已发布 PubMed: 新的消炎配方,含有Synurus Synurus deltoides deltoides提取物。 |
已发布 PubMed: cur素 Decursin和pdbu : 两个pkc激活剂分别在k562 红白血病细胞的巨核细胞分化中起作用。 two PKC activators distinctively acting in the megakaryocytic differentiation of K562 human erythroleukemia cells. |
已发布 PubMed: pkc PKC和罗斯 ROS参与抗白血病去壁素及其衍生物的细胞毒性机制及其在 k562红白血病和u937骨髓性白血病细胞中的构效关系。 |
已发布 PubMed:新型抗癌药 A novel anticancer agent, cur素 Decursin, 诱导 前列腺癌细胞中的g1阻滞和凋亡。 induces G1 arrest and apoptosis in human prostate carcinoma cells. |
已发布 PubMed:esp-102 ESP-102, 当归的标准化组合提取物 a standardized combined extract of Angelica gigas, 中国金龙和五味子 Saururus chinensis and Schizandra chinensis, 显着改善了东pol碱引起的小鼠记忆障碍。 significantly improved scopolamine-induced memory impairment in mice. |
已发布 PubMed:当归中四种新的橙花保护性二氢吡喃香豆素。 Four new neuroprotective dihydropyranocoumarins from Angelica gigas. |
已发布 PubMed: 高效液相色谱-液相色谱-质谱法测定当归及相关点地梅药用植物中plants本内酯的含量 |
已发布 PubMed:长期施用当归提取物或癸内醇的小鼠抗β-淀粉样肽诱导的记忆障碍的保护作用。 Protection against beta-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice. |
已发布 PubMed:当归地醇酚和当归中的去醇素的抗肿瘤活性。 Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. |
已发布 PubMed:当归中的当归粗提取物在各种疼痛模型中的抗伤害感受特性。 Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models. |
已发布 PubMed:当归的抗菌香豆素。 Antibacterial coumarins from Angelica gigas roots. |
已发布 PubMed:当归中的十足素降低了东pol碱在小鼠中引起的健忘症。 Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice. |
已发布 PubMed:实验证据和信号转导通路参与安吉兰在鼠巨噬细胞中激活nf-κb/ rel。 Experimental evidences and signal transduction pathways involved in the activation of NF-kappa B/Rel by angelan in murine macrophages. |
已发布 PubMed:从当归中分离出的香豆素抑制乙酰胆碱酯酶 Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: 结构-活动关系。 structure-activity relationships. |
已发布 PubMed:鼠巨噬细胞中安吉兰对丝裂原活化蛋白激酶途径的激活 Activation of mitogen-activated protein kinase pathways by angelan in murine macrophages. |
已发布 PubMed: 安吉兰 Angelan和lps对小鼠巨噬细胞的差异激活作用。 |
已发布 PubMed:当归中的聚乙炔及其对活化巨噬细胞中一氧化氮合成的抑制活性。 Polyacetylenes from angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages. |
已发布 PubMed:nf-kappab / rel在安吉兰刺激的巨噬细胞中的激活。 Activation of NF-kappaB/Rel in angelan-stimulated macrophages. |
已发布 PubMed:从当归中分离出的当归具有特征性的免疫刺激作用。 Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. |
已发布 PubMed:地高辛诺尔 decursinol angelate: 当归的一种细胞毒性和蛋白激酶c活化剂。 a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. |
已发布 PubMed:cur素 Decursin: 当归的一种细胞毒性剂和蛋白激酶c激活剂。 a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. |
已发布 PubMed:当归中的香豆素。 Coumarins from the root of Angelica gigas Nakai. |