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类别 Category:natural substances and extractives
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 熔点 Melting Point: | 3.00 to 4.00 °C. @ 760.00 mm 汞 Hg
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| 沸点 Boiling Point: | 112.00 to 115.00 °C. @ 20.00 mm 汞 Hg
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| 沸点 Boiling Point: | 96.00 to 97.00 °C. @ 8.00 mm 汞 Hg
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| 蒸汽压力 Vapor Pressure: | 1.783000 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
| 闪点 Flash Point: | 133.00 °F. tcc TCC ( 56.11 °C. )
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| logp（o / w） logP (o/w): | 2.244（est） 2.244 (est) |
| 溶于 Soluble in: |
| | alcohol | | | 水 water, 55.5 mg / l @ 25°c（est） 55.5 mg/L @ 25 °C (est) |
| 不溶于 Insoluble in: |
| | 水 water |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
| BOC Sciences |
| 仅供实验/研究使用。 For experimental / research use only. |
| Ascaridole
气味 Odor: characteristic 采用 Use: 一种有机过氧化物，其构成了剑兰油的60-80％。驱虫药。 An organic peroxide which constitutes 60-80% of oil of chenopodium. Anthelmintic. |
安全信息 Safety Information:
| |
| 危害识别 Hazards identification |
| |
| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
口鼠 oral-rat LD50 200 mg/kg
联邦 Federation Proceedings, 美国实验生物学学会联合会。卷7 Federation of American Societies for Experimental Biology. Vol. 7, pg。 252 Pg. 252, 1948.
老鼠 oral-mouse LD50 400 mg/kg
联邦 Federation Proceedings, 美国实验生物学学会联合会。卷7 Federation of American Societies for Experimental Biology. Vol. 7, pg。 252 Pg. 252, 1948.
口头狗 oral-dog ldlo LDLo 250 mg/kg
Journal of 药理 Pharmacology and 实验性的 Experimental 疗法 Therapeutics. 卷 Vol. 24, pg。 359 Pg. 359, 1925.
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| 皮肤毒性 Dermal Toxicity: |
|
未定 Not determined
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| 吸入毒性 Inhalation Toxicity: |
|
未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | natural substances and extractives |
| 推荐使用阿斯卡地尔的使用水平 Recommendation for ascaridol usage levels up to: | | | 不用于香水。 not for fragrance use.
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| |
| 推荐的阿斯卡地尔风味使用水平最高为 Recommendation for ascaridol flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
|
安全参考 Safety references:
参考资料 References:
| | 4-甲基-1-丙-2-基-7 4-methyl-1-propan-2-yl-7,8-二氧杂双环[2.2.2]辛-2-烯 8-dioxabicyclo[2.2.2]oct-2-ene |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| pubchem（cid） Pubchem (cid): | 10545 |
| pubchem（sid） Pubchem (sid): | 134978171 |
| 信息基 Pherobase: | 视图 View |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, food, 其他） other): note
同义词 Synonyms:
| | ascaridole | | 2,3- | dioxabicyclo(2.2.2)oct-5-ene, 1-isopropyl-4-methyl- | | 2,3- | dioxabicyclo(2.2.2)oct-5-ene, 1-methyl-4-(1-methylethyl)- | | 2,3- | dioxabicyclo[2.2.2]oct-5-ene, 1-isopropyl-4-methyl- | | 2,3- | dioxabicyclo[2.2.2]oct-5-ene, 1-methyl-4-(1-methylethyl)- | | 1,4-epi | dioxy-2-p-menthene | | 1,4-epi- | dioxy-2-p-menthene | | 1,4-epi- | dioxy-2-para-menthene | | 1,4-epi | dioxy-p-menth-2-ene | | 1,4-epi- | dioxy-p-menth-2-ene | | 1,4-epi- | dioxy-para-menth-2-ene | | p- | menth-2-ene, 1,4-epidioxy- | | 2-para- | menthene-1,4-dioxide | | 4- | methyl-1-(propan-2-yl)-2,3-二氧杂双环[2.2.2]辛-5-烯 3-dioxabicyclo[2.2.2]oct-5-ene | | 4- | methyl-1-propan-2-yl-7,8-二氧杂双环[2.2.2]辛-2-烯 8-dioxabicyclo[2.2.2]oct-2-ene | | 1- | methyl-4-(1-methyl ethyl)-2,3-二氧杂双环（2.2.2）辛-5-烯 3-dioxabicyclo(2.2.2)oct-5-ene | | 1- | methyl-4-(1-methylethyl)-2,3-二氧杂双环（2.2.2）辛-5-烯 3-dioxabicyclo(2.2.2)oct-5-ene | | 1- | methyl-4-(1-methylethyl)-2,3-二氧杂双环[2.2.2]辛-5-烯 3-dioxabicyclo[2.2.2]oct-5-ene | | 1- | methyl-4-(propan-2-yl)-2,3-二氧杂双环[2.2.2]辛-5-烯 3-dioxabicyclo[2.2.2]oct-5-ene | | 1- | methyl-4-isopropyl-2-cyclohexene-1,4-dioxide | | 1,4- | peroxy-p-menth-2-ene | | 1-iso | propyl-4-methyl-2,3-二氧杂双环[2.2.2]辛-5-烯 3-dioxabicyclo[2.2.2]oct-5-ene | | 1,4- | proxido-2-p-menthene | | 1,4- | proxido-2-para-menthene |
文章 Articles:
| 已发布 PubMed:内过氧化物烟酰胺的活化调节其敏化能力。 Activation of the Endoperoxide Ascaridole Modulates Its Sensitizing Capacity. |
| 已发布 PubMed:scar啶酮的组合 Combinations of ascaridole, carvacrol, 和石蜡烯抗利什曼原虫。 and caryophyllene oxide against Leishmania. |
| 已发布 PubMed:作为茶树油增敏成分的烟灰素的最佳贴剂测试浓度。 The optimal patch test concentration for ascaridole as a sensitizing component of tea tree oil. |
| 已发布 PubMed:同时测定a啶 Simultaneous determination of ascaridole, 口服安布罗汉松的化学作用后，大鼠血浆中的对伞花精和α-萜品烯具有良好的杀伤力。由gc-ms。 p-cymene and α-terpinene in rat plasma after oral administration of Chenopodium ambrosioides L. by GC-MS. |
| 已发布 PubMed:创新型胃内scar啶酮漂浮片 Innovative intragastric ascaridole floating tablets: 发展 Development, 优化 optimization, 和体外-体内评估。 and in vitro-in vivo evaluation. |
| 已发布 PubMed:内过氧化物阿斯卡立醇在核苷酸切除修复缺陷型细胞中显示出强烈的细胞毒性差异。 The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells. |
| 已发布 PubMed:对螨油和茶树油的增敏作用。 Co-sensitization to ascaridole and tea tree oil. |
| 已发布 PubMed:Ascaridole, 茶树油的致敏成分 a sensitizing component of tea tree oil, 在两个系列的患者中分别以1％和5％的剂量测试了贴剂。 patch tested at 1% and 5% in two series of patients. |
| 已发布 PubMed:香芹酚的毒性作用 Toxic effects of carvacrol, 石竹烯氧化物 caryophyllene oxide, 线粒体上的安布藜的化学成分为香椿油。 and ascaridole from essential oil of Chenopodium ambrosioides on mitochondria. |
| 已发布 PubMed:茶树油品质和a啶的评估 Evaluation of tea tree oil quality and ascaridole: 通过手性和多心切割多维气相色谱系统结合质谱检测进行的深入研究。 a deep study by means of chiral and multi heart-cuts multidimensional gas chromatography system coupled to mass spectrometry detection. |
| 已发布 PubMed:巴豆和其组成成分a螨的叶子中精油的抗肿瘤活性。 Antitumor activity of the essential oil from the leaves of Croton regelianus and its component ascaridole. |
| 已发布 PubMed:che足虫属中的scar啶和相关过氧化物。 Ascaridole and related peroxides from the genus Chenopodium. |
| 已发布 PubMed:驱虫药草白粉病中杀螨醇的活性对抗敏感且具有多重耐药性的肿瘤细胞。 Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells. |
| 已发布 PubMed:scar啶的生物合成 Biosynthesis of ascaridole: 碘化物过氧化物酶催化的山bro藜果实可溶性提取物中单萜内过氧化物的合成。 iodide peroxidase-catalyzed synthesis of a monoterpene endoperoxide in soluble extracts of Chenopodium ambrosioides fruit. |
| 已发布 PubMed:无溴化奇诺氏假单胞菌的无scar啶酮输注物含有对哺乳动物平滑肌无毒的杀 剂。 Ascaridole-less infusions of Chenopodium ambrosioides contain a nematocide(s) that is(are) not toxic to mammalian smooth muscle. |
| 已发布 PubMed:scar啶对恶性疟原虫体外发育的影响。 The effect of ascaridole on the in vitro development of Plasmodium falciparum. |
| 已发布 PubMed:am脚藜的挥发油及其主要成分 Essential oil from Chenopodium ambrosioides and main components: 对抗利什曼原虫的活动 activity against Leishmania, 它们的线粒体和其他微生物。 their mitochondria and other microorganisms. |
| 已发布 PubMed:苍白藜及其主要成分的精油对balb / c小鼠实验性皮肤利什曼病的抗衰老活性。 Antileishmanial activity of essential oil from Chenopodium ambrosioides and its main components against experimental cutaneous leishmaniasis in BALB/c mice. |
| 已发布 PubMed:scar啶对内耳的影响生物学和组织学研究耳蜗麦克风效应的定位。 On the effect of ascaridole on the inner ear electrobiological and histological studies on the localization of the cochlear microphone effect. |
| 已发布 PubMed:no脚油中的scar啶; scar啶的特征。 Ascaridole in oil of chenopodium; the characterization of ascaridole. |
| 已发布 PubMed:no藜油中的scar啶。 iv。 scar啶的合成。 Ascaridole in chenopodium oil. IV. The synthesis of ascaridole. |
| 已发布 PubMed:气相色谱-质谱法测定大鼠血浆中a啶的含量和药代动力学 Determination and pharmacokinetics of ascaridole in rat plasma by gas chromatography-mass spectrometry. |
| 已发布 PubMed:气相色谱法联用分析安息香假单胞菌精油 Combined analysis of the essential oil of Chenopodium ambrosioides by GC, gc-ms和13c-nmr光谱 GC-MS and 13C-NMR spectroscopy: scar啶的定量测定 quantitative determination of ascaridole, 热敏化合物。 a heat-sensitive compound. |
| 已发布 PubMed:安布罗尾螯虾减少实验性骨节螺藻的滑膜炎症和疼痛。 Chenopodium ambrosioides L. Reduces Synovial Inflammation and Pain in Experimental Osteoarthritis. |
| 已发布 PubMed:no藜油中的啶醇。 Ascaridol in oil of chenopodium. |
| 已发布 PubMed:进行阿斯卡地尔测定的研究；萜烯的碘化。 An investigation of the assay of ascaridol; the iodination of terpenes. |
| 已发布 PubMed:解离电子转移至scar啶和二氢a啶模型双环内过氧化物具有生物意义的动力学。 Kinetics of dissociative electron transfer to ascaridole and dihydroascaridole-model bicyclic endoperoxides of biological relevance. |
| 已发布 PubMed:化学成分 Chemical composition, 香茅和香茅藜精油的抑菌和杀虫活性。 antimicrobial and insecticidal activities of the essential oils of Conyza linifolia and Chenopodium ambrosioides. |
| 已发布 PubMed:超临界CO 2提取物和香精油顶叶的空中部分-化学成分和抗炎活性 Supercritical CO₂ extract and essential oil of aerial part of Ledum palustre L.--Chemical composition and anti-inflammatory activity. |
| 已发布 PubMed:Ascaridole as a 药理上 pharmacologically active 原理 principle of "佩科 Paico," 秘鲁药用植物。 a medicinal Peruvian plant. |
| 已发布 PubMed:mosyakin＆amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp; amp;格林尼治标准时间阿米巴肝脓肿仓鼠模型中的三叶草。 Amoebicidal Activity of Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants in an Amoebic Liver Abscess Hamster Model. |
| 已发布 PubMed:气相色谱法测定a啶醇含量 [Quantitative determination of ascaridol using gas-liquid chromatography]. |
| 已发布 PubMed:[用合成的Ascaridol制剂Ascarisin治疗a虫病]。 [Treatment of ascaridiasis with the synthetic ascaridol preparation ascarisin]. |
| 已发布 PubMed:[测定虎杖中油中的Ascaridol的方法]。 [Methods of determination of ascaridol in oil of Chenopodium]. |
| 已发布 PubMed:热和光对虎杖油中阿斯匹多醇含量的影响 Effect of heat and light on the ascaridol content in oil of chenopodium. |
| 已发布 PubMed:[关于α-萜品烯和amp的光氧化的研究。呋喃存在下的scar螨醇[2 [Research on the photo-oxidation of alpha-terpinene & ascaridol in the presence of furo [2,3-g]香豆素其他光动力药物]。 3-g] coumarin & other photodynamic drugs]. |
| 已发布 PubMed:红外吸收光谱分析药物和化学药品。一世。降钙素的定量分析 Analyses of drugs and chemicals by infrared absorption spectra. I. Quantitative analyses of santonin, thymol, 四氯乙烯 tetrachloroethylene, 混合药物中的阿斯卡立醇。 and ascaridol in mixed drugs. |
| 已发布 PubMed:[测定臭豆油中的Ascaridol。一世。超吸收光谱法测定] [Determination of ascaridol in oleum Chenopodii. I. Determination by ultrared absorption spectroscopy]. |
| 已发布 PubMed:scar虫研究。 ii。碘法和极谱法测定a啶的检验。 Ascaridole studies. II. An examination of the iodimetric and polarographic methods of determination of ascaridole. |
| 已发布 PubMed:scar虫研究。 iii。 a啶的纯化和表征。 Ascaridole studies. III. The purification and characterisation of ascaridole. |
| 已发布 PubMed:有关测定虎杖中油中的scar啶油含量的说明。 A note on the determination of ascaridole in oil of chenopodium. |
| 已发布 PubMed:蓖麻油中蓖麻油中和蓖麻油中蓖麻油中溶液中的scar啶含量的测定。 The determination of ascaridole in oil of chenopodium and in solution of oil of chenopodium in castor oil. |
| 已发布 PubMed:注释关于估计scar啶的微方法。 Note on a micromethod for the estimation of ascaridole. |
| 已发布 PubMed:[碘量法测定scar啶油和藜芦油]。 [Iodometric determination of ascaridole and Chenopodium oil]. |
| 已发布 PubMed:蓖麻油溶液中a啶的含量测定注意事项。 A note on the assay of ascaridole in castor oil solution. |
| 已发布 PubMed:刺脚藜（家庭）精油及其三种主要活性成分的评价 Evaluation of Essential Oil and its Three Main Active Ingredients of Chinese Chenopodium ambrosioides (Family: chenopodiaceae）对德国小att。 Chenopodiaceae) against Blattella germanica. |
| 已发布 PubMed:杜鹃种子精油的组成。 Composition of seed essential oils of Rhododendron tomentosum. |
| 已发布 PubMed:刺脚藜精油的组成及对玉米象鼻虫的杀虫活性 Composition of essential oil of Chinese Chenopodium ambrosioides and insecticidal activity against maize weevil, 玉米。 Sitophilus zeamais. |
| 已发布 PubMed:尼泊尔蒿种挥发性成分的生物活性。 Bioactivities of volatile components from Nepalese Artemisia species. |
| 已发布 PubMed:具有多种反应性的固定化有机光敏剂，适用于各种可见光应用。 Immobilized organic photosensitizers with versatile reactivity for various visible-light applications. |
| 已发布 PubMed:π-共轭多芯片作为高效且可重复使用的异质光敏剂。 π-Conjugated polyHIPEs as highly efficient and reusable heterogeneous photosensitizers. |
| 已发布 PubMed:主要活性类黄酮的hplc测定和砾石味失调（ama科）的挥发性成分的gc-ms分析。 HPLC determination of the major active flavonoids and GC-MS analysis of volatile components of Dysphania graveolens (Amaranthaceae). |
| 已发布 PubMed:贝宁的植物精油的化学组成和杀虫活性对冈比亚按蚊的影响。 Chemical composition and insecticidal activity of plant essential oils from Benin against Anopheles gambiae (Giles). |
| 已发布 PubMed:传统草药驱虫性白粉病的研究。 Studies on the traditional herbal anthelmintic Chenopodium ambrosioides L.: 民族药理学评估和临床现场试验。 ethnopharmacological evaluation and clinical field trials. |
| 已发布 PubMed:光敏的 Photoactive, 由孟加拉玫瑰接枝的聚苯乙烯制成的多孔蜂窝膜。 porous honeycomb films prepared from Rose Bengal-grafted polystyrene. |
| 已发布 PubMed:检测和鉴定在黄素单核苷酸和亚铁离子存在下，用可见光（436 nm）照射茶树（白千层）油产生的1-甲基乙基和甲基自由基。 Detection and identification of 1-methylethyl and methyl radicals generated by irradiating tea tree (Melaleuca alternifolia) oil with visible light (436 nm) in the presence of flavin mononucleotide and ferrous ion. |
| 已发布 PubMed:姜黄叶精油的组成和抑菌活性卡苏尔品种。 Composition and Antimicrobial Activity of the Essential Oil from Leaves of Curcuma longa L. Kasur Variety. |
| 已发布 PubMed:红景天根提取物的化学计量分布。联用气相色谱质谱技术。 Chemometric profile of root extracts of Rhodiola imbricata Edgew. with hyphenated gas chromatography mass spectrometric technique. |
| 已发布 PubMed:敏化试验 Sensitization assays: 单核细胞衍生的树突状细胞与单核细胞系（thp-1）。 monocyte-derived dendritic cells versus a monocytic cell line (THP-1). |
| 已发布 PubMed:巴豆巴豆的叶精油的杀幼虫和杀 活性。 Larvicidal and nematicidal activities of the leaf essential oil of Croton regelianus. |
| 已发布 PubMed:五种来自火鸡中的比目鱼collection的精油成分及其抗真菌和杀虫活性。 Essential oil composition of five collections of Achillea biebersteinii from central Turkey and their antifungal and insecticidal activity. |
| 已发布 PubMed:单萜的降解产物是茶树油中的敏化剂。 Degradation products of monoterpenes are the sensitizing agents in tea tree oil. |
| 已发布 PubMed:巴西che脚藜的精油的组成和抗真菌活性l。 Composition and antifungal activity of the essential oil of the Brazilian Chenopodium ambrosioides L. |
| 已发布 PubMed:比较化学 Comparative chemical, 臭头草的精油的细胞毒性和抗衰老特性。 cytotoxicity and antileishmanial properties of essential oils from Chenopodium ambrosioides. |
| 已发布 PubMed:智利大黄和德里米氏冬青精油的除草活性。 Herbicidal activity of Peumus boldus and Drimys winterii essential oils from Chile. |
| 已发布 PubMed:单溴化氢过氧化物，具有安息香小球虫的锥虫杀灭活性。 Monoterpene hydroperoxides with trypanocidal activity from Chenopodium ambrosioides. |
| 已发布 PubMed:臭脚藜的挥发油的挥发性成分和抗菌筛选l。在尼日利亚增长。 Volatile constituents and antibacterial screening of the essential oil of Chenopodium ambrosioides L. growing in Nigeria. |
| 已发布 PubMed: 狭特有种蒿（蒿 Artemisia 莫利尼耶里 molinieri）精油的季节性和物候变化及其生物学活性。 |
| 已发布 PubMed:艾菊的错误识别 Misidentification of tansy, 大叶艾菊 Tanacetum macrophyllum, 如西洋arrow草 as yarrow, 大花 Achillea grandifolia: 健康风险或益处？ a health risk or benefit? |
| 已发布 PubMed:[由重氮唑油引起的致命中毒 [Fatal poisoning caused by oil of epazote, 毛白屈菜 Chenopodium graveolens]. |
| 已发布 PubMed:萜烯和脂质-蛋白质分配理论可促进皮肤渗透。 Terpenes and the lipid-protein-partitioning theory of skin penetration enhancement. |
| 已发布 PubMed:香精油和生物碱含量的遗传变异研究。 Studies of Genetic Variation of Essential Oil and Alkaloid Content in Boldo (Peumus boldus). |
| 已发布 PubMed:生物合成过程中有利于前列腺素f形成的药物。 On agents favoring prostaglandin f formation during biosynthesis. |
| 已发布 PubMed:通过超临界二氧化碳中的单线态o2进行均相光化学氧化。 Homogeneous photochemical oxidation via singlet O2 in supercritical CO2. |
| 已发布 PubMed:对苯二酚和新萜类植物中的对苯二酚衍生物和单萜类化合物。 Hydroquinone derivatives and monoterpenoids from the Neotropical liverwort Plagiochila rutilans. |
| 已发布 PubMed:灭鼠疟疾的化学疗法。 xlviii。一些合成的活动1 The chemotherapy of rodent malaria. XLVIII. The activities of some synthetic 1,2,4-三恶烷对氯喹敏感和耐氯喹的寄生虫。第1部分 4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 1: 研究导致开发新型的顺式稠合环戊烯衍生物。 Studies leading to the development of novel cis-fused cyclopenteno derivatives. |
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具有驱虫特性的单萜内过氧化物。据说是主要的组成部分。的百日草（大胆 boldo）油
烟酰胺是一种天然有机化合物，被归类为双环单萜，具有不同欧的桥接过氧化物官能团。它是墨西哥茶油（dysphania 杀虫剂 ambrosioides）的主要成分 , 以前是chenopodium 杀虫剂 ambrosioides）。它是无色液体，可溶于大多数有机溶剂。像其他低分子量有机过氧化物 , 加热或用有机酸处理时不稳定，容易爆炸。 it is unstable and prone to explosion when heated or treated with organic acids.
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3D/INCHI