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类别 Category:solvents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 出现 Appearance: | 无色透明液体（est） colorless clear liquid (est) |
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 比重 Specific Gravity: | 1.03704 to 1.04700 @ 25.00 °C.
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| 磅每加仑-（est）。 Pounds per Gallon - (est).: | 8.629 to 8.712
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| 折光率 Refractive Index: | 1.44300 @ 25.00 °C.
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| 熔点 Melting Point: | -20.00 °C. @ 760.00 mm 汞 Hg
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| 沸点 Boiling Point: | 170.00 °C. @ 1.00 mm 汞 Hg
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| 蒸汽压力 Vapor Pressure: | 1.000000毫米汞柱@ 170.00°c。 1.000000 mmHg @ 170.00 °C. |
| 蒸气密度 Vapor Density: | 12.4 ( 空气 Air = 1 ) |
| 闪点 Flash Point: | 285.00 °F. tcc TCC ( 140.56 °C. )
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| logp（o / w） logP (o/w): | 4.324（est） 4.324 (est) |
| 溶于 Soluble in: |
| | alcohol | | | 水 water, 27.37 mg / l @ 25°C（est） 27.37 mg/L @ 25 °C (est) |
| 不溶于 Insoluble in: |
| | 水 water |
| 稳定性 Stability: |
| | 不会支持树脂中的真菌生长 will not support fungous grouth in resins |
感官特性 Organoleptic Properties:
| 气味强度 Odor Strength:低 low |
| 实体性 Substantivity:400 400 Hour(s) |
| 气味描述 Odor Description:at 100.00 %. herbal plastic |
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
| BOC Sciences |
| 仅供实验/研究使用。 For experimental / research use only. |
| 柠檬酸三丁酯bp 233-234deg / 17mm Tributyl citrate BP 233-234deg/17mm
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| 共价化学 Covalent Chemical |
| 柠檬酸三丁酯 tributyl citrate
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| Emd 微孔 Millipore |
| 仅供实验/研究使用。 For experimental / research use only. |
| 柠檬酸三丁酯 tributyl citrate
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| 瑞士荣格本劳 Jungbunzlauer Suisse |
| CITROFOL® 双 BI
气味 Odor: bland 采用 Use: 柠檬酸酯已有40多年的历史，可用于各种应用中。原来 Citric acid esters have been available more than 40 years used in various applications. Initially, 他们发现在聚氯乙烯（pvc）和纤维素衍生物等聚合物中用作增塑剂。同时 they found utility as plasticiser in polymers such as polyvinyl chloride (PVC) and cellulose derivates. In the meantime, 随着更环保材料的趋势持续发展，它们的用途已发展为多种应用，需求也不断增长。 their usefulness has grown into multiple applications with a growing demand as the trends for more environmentally friendly materials continues.
柠檬酸盐为那些经过审查的产品提供了极好的替代品。它们在许多应用（例如化妆品）中具有相同的增塑剂性能，可替代邻苯二甲酸盐和己二酸酯 Citrates offer an excellent alternative for those products under scrutiny. They demonstrate equal plasticiser performance to replace phthalates and adipates in many applications such as cosmetics, 医药涂料 pharmaceutical coatings, 食品接触膜和塑料制品。由于它们的沸点高 food contact films and in plastic articles. Due to their high boiling point, 增塑剂几乎不挥发 plasticisers are hardly volatile, 从而 thus the 损失 losses from the 聚合物 聚合物 polymers are 微不足道 insignificant. 其 Their solvent 功率 power 确保 ensures 兼容性 compatibility with the resin. CITROFOL® 双 BI is one of 这些 these 增塑剂 plasticisers. |
| 西格玛·奥尔德里奇 Sigma-Aldrich: 奥尔德里奇 Aldrich |
| 仅供实验/研究使用。 For experimental / research use only. |
| 柠檬酸三丁酯≥97.0％ Tributyl Citrate ≥97.0%
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| TCI AMERICA |
| 仅供实验/研究使用。 For experimental / research use only. |
| 柠檬酸三丁酯> 98.0％（gc） Tributyl Citrate >98.0%(GC)
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安全信息 Safety Information:
| 首选SDS Preferred SDS: 视图 View |
| |
| 危害识别 Hazards identification |
| |
| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
腹腔内小鼠 intraperitoneal-mouse LD50 2900 mg/kg
VASCULAR: 其他变化 OTHER CHANGES
行为的 BEHAVIORAL: 嗜睡 SOMNOLENCE (一般 GENERAL 郁闷 DEPRESSED 活动 ACTIVITY)
日志 Journal of 制药业 Pharmaceutical Sciences. 卷 Vol. 53, pg。 774 Pg. 774, 1964.
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| 皮肤毒性 Dermal Toxicity: |
|
未定 Not determined
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| 吸入毒性 Inhalation Toxicity: |
|
未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | solvents |
| 柠檬酸三丁酯的使用建议水平最高为 Recommendation for tributyl citrate usage levels up to: | | | 不用于香水。 not for fragrance use.
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| 柠檬酸三丁酯风味使用水平的建议值 Recommendation for tributyl citrate flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
|
安全参考 Safety references:
参考资料 References:
| | 三丁基-2-羟基丙烷-1 tributyl 2-hydroxypropane-1,2,3-三羧酸盐 3-tricarboxylate |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| pubchem（cid） Pubchem (cid): | 6507 |
| pubchem（sid） Pubchem (sid): | 134972807 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core 组件 components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, 餐饮 food, 其他） other): note
| | 自然界中找不到 not found in nature |
同义词 Synonyms:
| | citric acid 三正丁基 tri-N-butyl ester | | | citric acid, 三丁酯 tributyl ester | | | 雪铁龙 citroflex 4 | | | dibutyl 3-(丁氧羰基 butoxycarbonyl)-3-hydroxypentane-1,5-dioate | | 2- | hydroxy-1,2,3-propanetricarboxylate de tributyle | | 2- | hydroxy-1,2,3-丙三羧酸 3-propanetricarboxylic acid, 三丁酯 tributyl ester | | 1,2,3- | propanetricarboxylic acid, 2-羟基- 2-hydroxy-, 三丁酯 tributyl ester | | | 三正丁基 tri-N-butyl citrate | | | tributyl 2-羟基- 2-hydroxy-1,2,3-propanetricarboxylate | | | 三丁基-2-羟基丙烷-1 tributyl 2-hydroxypropane-1,2,3-三羧酸盐 3-tricarboxylate | | 1,2,3- | 三丁基-2-羟基丙烷-1 tributyl 2-hydroxypropane-1,2,3-三羧酸盐 3-tricarboxylate | | | 柠檬酸三丁酯 tributylcitrate |
文章 Articles:
| 已发布 PubMed:硅灰石-聚（2-丁基氰基丙烯酸正丁酯）复合材料的生物相容性。 Biocompatibility of wollastonite-poly(N-butyl-2-cyanoacrylate) composites. |
| 已发布 PubMed:电子自旋共振探测增塑聚丙交酯中的局部混合。 Local demixion in plasticized polylactide probed by electron spin resonance. |
| 已发布 PubMed:增塑剂对聚合物薄膜的侵蚀和机械性能的影响。 The effect of plasticizers on the erosion and mechanical properties of polymeric films. |
| 已发布 PubMed:气相色谱/质谱法确定的推进剂组分的聚焦超声提取的优化。 Optimization of focused ultrasonic extraction of propellant components determined by gas chromatography/mass spectrometry. |
| 已发布 PubMed:通过柠檬酸三丁酯的增塑改善了玉米蛋白膜的机械性能和耐水性。 Improved mechanical property and water resistance of zein films by plasticization with tributyl citrate. |
| 已发布 PubMed:[关于聚氯乙烯玩具中增塑剂的调查]。 [Survey of plasticizers in polyvinyl chloride toys]. |
| 已发布 PubMed:热熔挤出技术开发缓释亲脂硬脂酸钙微丸。 Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. |
| 已发布 PubMed:乙酰柠檬酸三丁酯 Acetyl tributyl citrate, 最广泛使用的邻苯二甲酸酯替代增塑剂 the most widely used phthalate substitute plasticizer, 通过类固醇和异种生物受体诱导细胞色素p450 3a。 induces cytochrome p450 3a through steroid and xenobiotic receptor. |
| 已发布 PubMed:苯二甲酸二酯的分析 Analysis of phthalic acid diesters, 单酯 monoester, 以及日本聚氯乙烯家用产品中的其他增塑剂。 and other plasticizers in polyvinyl chloride household products in Japan. |
| 已发布 PubMed:电离 处理对包装-食品模拟物组合特定迁移特性的影响 Effect of ionising radiation treatment on the specific migration characteristics of packaging-food simulant combinations: 类型和剂量的影响。 effect of type and dose of radiation. |
| 已发布 PubMed:气相色谱/质谱法测定油性食品中邻苯二甲酸盐的研究进展 Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods. |
| 已发布 PubMed:疏水性聚丙交酯增塑剂的迁移和水解。 Migration and hydrolysis of hydrophobic polylactide plasticizer. |
| 已发布 PubMed:在捷克共和国使用的包装材料中出现可提取的油墨残留物。 Occurrence of extractable ink residuals in packaging materials used in the Czech Republic. |
| 已发布 PubMed:引导的具有生物可吸收屏障的组织再生iii十年会导致骨下缺损。 Guided tissue regeneration with bioabsorbable barriers III 10-year results in infrabony defects. |
| 已发布 PubMed:聚（丙烯酸乙酯）的胶粘剂基体的设计与表征 Design and characterization of an adhesive matrix based on a poly(ethyl acrylate, 甲基丙烯酸甲酯）。 methyl methacrylate). |
| 已发布 PubMed:聚乳酸/柠檬酸乙酰基三丁酯/炭黑作为导电聚合物复合材料的制备与表征。 Fabrication and characterization of poly(lactic acid)/acetyl tributyl citrate/carbon black as conductive polymer composites. |
| 已发布 PubMed:浊点萃取-微波辅助反萃取-气相色谱分离法测定水提取液中己二酸己二酯和乙酰基柠檬酸三丁酯 Determination of diethylhexyladipate and acetyltributylcitrate in aqueous extracts after cloud point extraction coupled with microwave assisted back extraction and gas chromatographic separation. |
| 已发布 PubMed:使用非邻苯二甲酸酯增塑剂的临时修复树脂。 Temporary restorative resins using non-phthalate ester plasticizers. |
| 已发布 PubMed: 分子生物标志物和对月冻中的环境压力的适应性（aurelia spp spp。）。 |
| 已发布 PubMed:聚乳酸薄膜的制备及Preparation and properties of plasticized poly(lactic acid) films. |
| 已发布 PubMed:从乙烯-乙酸乙烯酯基质中控制阿替洛尔的释放。 Controlled release of atenolol from the ethylene-vinyl acetate matrix. |
| 已发布 PubMed:[一些用于pvdc膜的添加剂的性激素活性检查]。 [Examination of sex-hormonal activity of some additives for PVDC film]. |
| 已发布 PubMed:通过透皮施用兔子中的乙烯-乙酸乙烯酯基质可增强阿替洛尔的生物利用度。 Enhanced bioavailability of atenolol by transdermal administration of the ethylene-vinyl acetate matrix in rabbits. |
| 已发布 PubMed:聚氯乙烯产品中软塑料玩具和增塑剂的材料标签。 [Material labeling of soft plastic toys and plasticizers in polyvinyl chloride products]. |
| 已发布 PubMed:根据日本对含有dehp的pvc手套的规定，在1周重复饮食样本中估计的增塑剂每日摄入量。 Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan. |
| 已发布 PubMed:[瓶装食品瓶盖密封中增塑剂的含量及其向食品中的迁移]。 [Contents of plasticizers in cap-sealing for bottled food and their migration into food]. |
| 已发布 PubMed:聚合松香 Polymerized rosin: 用于药物递送的新型成膜聚合物。 novel film forming polymer for drug delivery. |
| 已发布 PubMed:柠檬酸三乙酯安全性评估最终报告 Final report on the safety assessment of acetyl triethyl citrate, 乙酰柠檬酸三丁酯 Acetyl tributyl citrate, 乙酰柠檬酸三己酯 acetyl trihexyl citrate, 和乙酰柠檬酸三辛酯。 and acetyl trioctyl citrate. |
| 已发布 PubMed:新型无邻苯二甲酸酯组织调理剂的体外细胞相容性。 Cytocompatibility of new phthalate ester-free tissue conditioners in vitro. |
| 已发布 PubMed:二有机锡（iv）部分和2-吡嗪羧酸自组装 Self-adhesive thin films for topical delivery of 5-aminolevulinic acid. |
| 已发布 PubMed:固化对所施加丙烯酸聚合物的粘合力和热机械性能的影响。 Influence of curing on the adhesive and thermomechanical properties of an applied acrylic polymer. |
| 已发布 PubMed:增塑剂的有机酯影响吸水率 Organic esters of plasticizers affecting the water absorption, 粘合性能 adhesive property, 丙烯酸丙烯酸酯薄膜的玻璃化转变温度和增塑剂的持久性。 glass transition temperature and plasticizer permanence of eudragit acrylic films. |
| 已发布 PubMed:带有生物可吸收屏障的引导性组织再生 Guided tissue regeneration with bioabsorbable barriers: 骨内缺损和ii级分叉。 intrabony defects and class II furcations. |
| 已发布 PubMed:增塑剂对酒石酸美托洛尔释放的影响颗粒涂有聚甲基丙烯酸酯薄膜。 The effects of plasticizers on the release of metoprolol tartrate from granules coated with a polymethacrylate film. |
| 已发布 PubMed:水基聚合物分散体中表面活性剂对丙烯酸薄膜热机械和粘合性能的影响 Influence of surfactants in aqueous-based polymeric dispersions on the thermomechanical and adhesive properties of acrylic films. |
| 已发布 PubMed:扩散控制的药物输送系统 Diffusion-controlled drug delivery systems: 计算所需的组成以达到所需的释放曲线。 calculation of the required composition to achieve desired release profiles. |
| 已发布 PubMed:用于固体剂型包衣的丙烯酸和纤维素聚合物薄膜的粘性。 Tackiness of acrylic and cellulosic polymer films used in the coating of solid dosage forms. |
| 已发布 PubMed:电子束辐照对食品级pvc和pvdc / pvc薄膜中doa和atbc增塑剂迁移的影响 Effect of high-dose electron beam irradiation on the migration of DOA and ATBC plasticizers from food-grade PVC and PVDC/PVC films, 分别 respectively, 放入橄榄油。 into olive oil. |
| 已发布 PubMed:扩散参数计算药物聚合物装置的尺寸 Calculation of the dimensions of drug-polymer devices based on diffusion parameters. |
| 已发布 PubMed:乙酰柠檬酸三丁酯和癸二酸二丁酯可抑制培养的哺乳动物细胞的生长。 Acetyl tributyl citrate and dibutyl sebacate inhibit the growth of cultured mammalian cells. |
| 已发布 PubMed:影响从涂有丙烯酸酯/甲基丙烯酸酯共聚物胶乳的渗透泵释放药物的机理的变量。 Variables that affect the mechanism of drug release from osmotic pumps coated with acrylate/methacrylate copolymer latexes. |
| 已发布 PubMed:乳胶涂料系统的加工注意事项 Processing considerations for an EC latex coating system: 固化时间和温度的影响。 influence of curing time and temperature. |
| 已发布 PubMed:从增塑薄膜迁移到食品。 3.邻苯二甲酸酯的迁移 Migration from plasticized films into foods. 3. Migration of phthalate, sebacate, 零售食品包装用薄膜中的柠檬酸酯和磷酸酯。 citrate and phosphate esters from films used for retail food packaging. |
| 已发布 PubMed:[使用软化剂控制包衣的肠胃外基质缓释片剂的药物释放]。 [Control of drug release from coated parenteral matrix-retard tablets using softening agents]. |
| 已发布 PubMed:从聚合物基质中体外释放治疗活性成分。 In vitro release of therapeutically active ingredients from polymer matrixes. |
| 已发布 PubMed:增塑剂的药理特性 Pharmacological properties of the plasticizer, 乙酰正柠檬酸三丁酯 acetyl N-tributyl citrate, 并从聚氯乙烯管中提取。 and its extraction from poly(vinyl chloride) tubing. |
| 已发布 PubMed:柠檬酸酯的毒理学 Toxicology of the citric acid esters: 柠檬酸三丁酯 tributyl citrate, 乙酰柠檬酸三丁酯 Acetyl tributyl citrate, 柠檬酸三乙酯 triethyl citrate, 和乙酰柠檬酸三乙酯。 and acetyl triethyl citrate. |
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3D/INCHI