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类别 Category:natural substances and extractives
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 出现 Appearance: | 白至黄粉末（est） white to yellow powder (est) |
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 熔点 Melting Point: | 146.00 to 148.00 °C. @ 760.00 mm 汞 Hg
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| 沸点 Boiling Point: | 414.00 to 415.00 °C. @ 760.00 mm 汞 Hg
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| 闪点 Flash Point: | 400.00 °F. tcc TCC ( 204.44 °C. )
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| logp（o / w） logP (o/w): | 1.523（est） 1.523 (est) |
| 溶于 Soluble in: |
| | alcohol | | | 水 water, 706.2 mg/L @ 25 ＆deg °C (est) | | | acetic acid | | | 水 water, 30°C（实验）时为47.6 mg / l 47.6 mg/L @ 30 °C (exp) |
| 不溶于 Insoluble in: |
| | 水 water |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
| BOC Sciences |
| 仅供实验/研究使用。 For experimental / research use only. |
| 甲氧沙林> 98％ Methoxsalen >98%
气味 Odor: characteristic 采用 Use: 甲氧沙林也称为黄嘌呤 Methoxsalen also called xanthotoxin, 以商品名草酸 oxsoralen销售 , 三角洲 Deltasoralen, 美拉替宁是用于治疗牛皮癣的药物 Meladinine is a drug used to treat psoriasis, 湿疹 eczema, 白癜风 vitiligo, 和一些皮肤淋巴瘤 and some cutaneous lymphomas |
| 库姆波 Coompo |
| 仅供实验/研究使用。 For experimental / research use only. |
| 植物中的花椒毒素≥96％ Xanthotoxin from Plants ≥96%
气味 Odor: characteristic 采用 Use: 肉豆蔻毒素与黄嘌呤毒素之间的协同作用 Synergism between myristicin and xanthotoxin, 天然存在的植物毒物。 a naturally cooccurring plant toxicant.
当添加到末龄幼虫的饮食中时 When added to the diet of final instar larvae, 黄嘌呤毒素可以诱导中肠微粒体中的细胞色素p450单加氧酶（p450）活性，从而使其解毒。诱导是剂量依赖性的 xanthotoxin can induce the cytochrome P450 monooxygenase (P450) activity in midgut microsomes by which it is detoxified. Induction is dose-dependent, 当以0.5或1.0％鲜重的花椒毒素进行局部处理时，将幼虫以香菜为食时，幼虫的数量增加7倍。尽管黄腐毒素在被紫外线光激活时会发挥许多毒性作用 increasing sevenfold when larvae feed on parsley treated topically with xanthotoxin at 0.5 or 1.0% fresh weight. Although xanthotoxin exerts much of its toxic effects when photoactivated by ultraviolet light, 在存在或不存在紫外线的情况下，诱导p450活性无差异。尽管黄嘌呤毒素代谢的p450活性诱导了4.7倍 induction of P450 activity did not differ in the presence or absence of ultraviolet light. Despite a 4.7-fold induction of xanthotoxin-metabolizing P450 activity, 在相同的微粒体样品中测得的总p450含量没有显着增加。这些数据表明，黑燕尾中肠中存在多种形式的p450，并且它们是由黄嘌呤毒素差异诱导的。 total P450 content measured in the same microsomal samples did not increase significantly. These data indicate that multiple forms of P450 exist in the black swallowtail midgut and that they are differentially induced by xanthotoxin.
欧前胡素 imperatorin和xanthotoxin保护动物免受最大的电击诱发的癫痫发作 , 而Bergapten和羟哌丁宁 oxypeucedanin , 尽管它们在化学和结构上与黄腐毒素和欧前胡素相似 despite their chemical and structural similarities to xanthotoxin and imperatorin, 在癫痫发作试验中未发挥抗惊厥活性。 exerted no anticonvulsant activity in this seizure test. |
| 外合成 ExtraSynthese |
| 仅供实验/研究使用。 For experimental / research use only. |
| 黄原毒素c）≥90％ Xanthotoxin (HPLC) ≥90%
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| Glentham Life Sciences |
| Xanthotoxin
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| 印度世界贸易 Indo World Trading |
| 甲氧沙林（Xanthotoxin）bp / usp Methoxsalen (Xanthotoxin) BP/USP
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| 圣克鲁斯生物技术 Santa Cruz Biotechnology |
| 仅供实验/研究使用。 For experimental / research use only. |
| 甲氧沙林≥99％ Methoxsalen ≥99%
|
| 西格玛·奥尔德里奇 Sigma-Aldrich |
| 仅供实验/研究使用。 For experimental / research use only. |
| Xanthotoxin
分析analytical standard |
| TCI AMERICA |
| 仅供实验/研究使用。 For experimental / research use only. |
| 黄花毒素> 98.0％（gc） Xanthotoxin >98.0%(GC)
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安全信息 Safety Information:
| 首选sds SDS : 视图 View |
| 欧洲信息 European information : |
| 最重要的危害 Most important hazard(s): | | xn-有害。 Xn - Harmful. |
R 22 - 有害 Harmful if 吞下 swallowed.
R 43 - 可以 May 原因 cause 敏化 sensitisation by by skin 皮 contact.
S 01/02 - 保持 Keep 已锁定 locked up and out of the 达到 reach of 孩子们 children.
S 20/21 - 什么时候 When 使用 using do not eat, 喝 drink or 抽烟 smoke.
S 22 - do Do not 呼吸 breath dust.
S 24/25 - 避免 Avoid contact with skin 皮 and 眼睛 眼睛 eyes.
S 26 - In 案件 case of contact with 眼睛 眼睛 eyes, 冲洗 rinse 立即 immediately with 充裕 plenty of 水 water and 寻求 seek 医疗 medical 忠告 advice.
S 36/37/39 - 穿 我们 Wear 适当 suitable 服装 clothing, 手套和眼睛/面部防护。 gloves and eye/face protection.
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| 危害识别 Hazards identification |
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| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
口鼠 oral-rat LD50 791 mg/kg
行为的 BEHAVIORAL: 共济失调 ATAXIA
行为的 BEHAVIORAL: 运动活动的变化（特异性测定） CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
行为的 BEHAVIORAL: 抽搐 CONVULSIONS OR 影响 EFFECT ON 发作 SEIZURE THRESHOLD
Drug and Chemical Toxicology. 卷 Vol. 2, pg。 309 Pg. 309, 1979.
腹膜内大鼠 intraperitoneal-rat LD50 158 mg/kg
Drug and Chemical Toxicology. 卷 Vol. 2, pg。 309 Pg. 309, 1979.
老鼠 oral-老鼠 mouse LD50 423 mg/kg
行为的 BEHAVIORAL: 运动活动的变化（特异性测定） CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
行为的 BEHAVIORAL: 共济失调 ATAXIA
行为的 BEHAVIORAL: 抽搐 CONVULSIONS OR 影响 EFFECT ON 发作 SEIZURE THRESHOLD
Drug and Chemical Toxicology. 卷 Vol. 2, pg。 309 Pg. 309, 1979.
腹腔内小鼠 intraperitoneal-老鼠 mouse LD50 250 mg/kg
行为的 BEHAVIORAL: 共济失调 ATAXIA
行为的 BEHAVIORAL: 运动活动的变化（特异性测定） CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
行为的 BEHAVIORAL: 抽搐 CONVULSIONS OR 影响 EFFECT ON 发作 SEIZURE THRESHOLD
Drug and Chemical Toxicology. 卷 Vol. 2, pg。 309 Pg. 309, 1979.
几内亚口服 oral-guinea 猪 pig LD50 505 mg/kg
"补骨脂素 Psoralens in 化妆品 Cosmetics and 皮肤科 Dermatology, 国际研讨会论文集 Proceedings of the International Symposium, 巴黎 Paris, 1981," 卡恩 Cahn, j. J., 等。 et al., eds。 eds., 巴黎 Paris, 法国佩加蒙新闻社 Pergamon Press France, 1981卷-- 1981Vol. -, pg。 303 Pg. 303, 1981.
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| 皮肤毒性 Dermal Toxicity: |
皮下大鼠 sub皮肤的 cutaneous-rat LD50 1880 mg/kg
Drugs in 日本 Japan 卷 Vol. -, pg. 1372 Pg. 1372, 1995.
皮下老鼠 sub皮肤的 cutaneous-老鼠 mouse LD50 860 mg/kg
Drugs in 日本 Japan 卷 Vol. 6, pg。 837 Pg. 837, 1982.
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| 吸入毒性 Inhalation Toxicity: |
|
未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | natural substances and extractives |
| 推荐使用黄腐毒素的水平 Recommendation for xanthotoxin usage levels up to: | | | 不用于香水。 not for fragrance use.
|
| |
| 推荐使用黄腐毒素的使用水平 Recommendation for xanthotoxin flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
|
安全参考 Safety references:
参考资料 References:
| | 9-甲氧基呋喃[3 9-methoxyfuro[3, 2-g] 铬 chromen-7-one |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| 加拿大国内分公司。清单 Canada Domestic Sub. List: | 298-81-7 |
| pubchem（cid） Pubchem (cid): | 4114 |
| pubchem（sid） Pubchem (sid): | 134974950 |
其他资料 Other Information:
| （iupac） (IUPAC): | 元素的原子量2009 Atomic Weights of the Elements 2009 |
| （iupac） (IUPAC): | 元素的原子量2009（pdf） Atomic Weights of the Elements 2009 (pdf) |
| 影片 Videos: | 元素周期表 The Periodic Table of Videos |
| RBC : | 本网站使用的原子量 Atomic Weights use for this web site |
| （iupac） (IUPAC): | 元素周期表 Periodic Table of the Elements |
| CHEBI: | 视图 View |
| CHEMBL: | 视图 View |
| KEGG (GenomeNet): | C01864 |
| hmdb（人类代谢组数据库） HMDB (The Human Metabolome Database): | HMDB14693 |
| 食物 FooDB: | FDB012474 |
| 出口关税代码 Export Tariff Code: | 2932.20.4500 |
| 雾度图 Haz-Map: | 视图 View |
| 典型的g.c. Typical G.C. |
| vcf在线 VCF-Online: | 食品中的挥发性有机化合物 VCF Volatile Compounds in Food |
| 化学蜘蛛 ChemSpider: | 视图 View |
| 维基百科 Wikipedia: | 视图 View |
| rsc学习化学 RSC Learn Chemistry: | 视图 View |
| efsa EFSA更新监测食品中呋喃水平的结果 : | 阅读报告 Read Report |
| efsa EFSA以前的报告 : 食品中呋喃水平监测的结果 Results on the monitoring of furan levels in food: | 阅读报告 Read Report |
| 欧洲反腐败委员会关于食品中呋喃的临时调查结果的efsa EFSA报告 : | 阅读报告 Read Report |
配方/制剂 Formulations/Preparations:
甲氧沙林为10毫克胶囊（草酸-超）。也可以使用1％的甲氧沙林（草酸 oxsoralen）外用乳液。
＆bull;胶囊 •capsules, 10毫克洗剂（由医生使用，不分配给患者） 10 mg. lotion (to be applied by a physician and not to be dispensed to patients), 1%.
＆bull;局部洗剂1％ •topical lotion 1%, 奥索拉林（与丙酮 oxsoralen (with acetone, 醇71％ alcohol 71%, 和丙二醇） and propylene glycol), 集成电路 icn
口服胶囊10毫克 •oral capsules 10 mg, 8拖把胶囊（含酒石黄） 8-mop capsules (with tartrazine), 集成电路 icn;胶囊 , 液体填充 liquid-filled, 奥索拉林-超 oxsoralen-ultra, 集成电路 icn
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潜在搅拌机 Potential Blenders and core 组件 components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, food, 其他） other): note
同义词 Synonyms:
| | 阿莫丁 ammodin | | | ammoidin | | 5- | 苯并 benzo呋喃 furanacrylic acid, 6-羟基-7-甲氧基 6-hydroxy-7-methoxy-, d-内酯 d-lactone | | | deltasoralen deltasoralen | | | dermox | | 7H- | furo(3,2-g）（1）苯并吡喃-7-一 2-g)(1)benzopyran-7-one, 9-methoxy- | | 7H- | furo[3, 2-g] [1] 苯并 benzopyran-7-one , 9-methoxy- | | 7- | 呋喃香豆素 furocoumarin | | | geroxalen | | 6- | hydroxy-7-methoxy-5-苯并 benzo呋喃 furanacrylic acid d-内酯 d-lactone | | | 褪黑素 meladinin | | | 美拉多生 meladoxen | | | meloxine | | 9- | metho xy-7H-furo(3,2-g)苯并 benzopyran-7-one | | | 甲氧嘧啶 methoxa-dome | | | 甲草胺 methoxalen | | | 甲氧西汀 methoxaten | | | methoxsalen | | | methoxsalen (xanthotoxin) bp BP/美国邮政 USP | | 8- | methoxy (呋喃 furano-3'.2':6.7-coumarin) | | 8- | methoxy-(呋喃 furano-3'.2':6.7-coumarin) | | 8- | methoxy-[呋喃 furano-3'.2':6.7-coumarin] | | 8- | methoxy-2',3',6,7-呋喃香豆素 7-furocoumarin | | 9- | methoxy-2H-furo[3,2-g]铬 chromen-2-one | | 9- | methoxy-7H-furo(3,2-g）（1）苯并吡喃-7-一 2-g)(1)benzopyran-7-one | | 9- | methoxy-7H-furo[3, 2-g] [1] 苯并 benzopyran-7-one | | 9- | methoxy-7H-furo[3, 2-g] 铬 chromen-7-one | | | methoxy-8-psoralen | | 8- | methoxy[呋喃 furano-3',2':6,7-coumarin] | | 8- | methoxy呋喃 furano-2,3,6,7-coumarin | | 9- | methoxy呋喃 furano[3,2-g]铬 chromen-2-one | | 8- | methoxy呋喃香豆素 呋喃 furanocoumarin | | 9- | methoxyfuro(3,2-g)铬 chromen-7-one | | 9- | methoxyfuro[3, 2-g] [1] 苯并 benzopyran-7-one | | 9- | methoxyfuro[3, 2-g] 铬 chromen-7-one | | 8- | methoxypsoralen | | 9- | methoxypsoralen | | 9-( | methyloxy)-7H-furo[3, 2-g] 铬 chromen-7-one | | O- | methylxanthotoxol | | 8- | 拖把 MOP | | | 草酸 oxoralen | | | 草酸 oxsoralen | | | 普罗拉莫 proralone-拖把 MOP | | | 补骨脂素 psoralen-拖把 MOP | | | 补骨脂 psoralon-拖把 MOP | | | 普瓦伦 puvalen | | | Puvamet puvamet | | | 超 ultra 拖把 MOP | | | 超扑 超 ultramop | | | 超扑 超 ultramop 洗剂 lotion | | | uvadex uvadex | | | 花色素毒素 zanthotoxin |
文章 Articles:
| 已发布 PubMed:来自不同农作系统的芹菜中的呋喃香豆素 Furanocoumarins in celeriac from different farming systems: 为期三年的研究。 a 3-year study. |
| 阶段 J-Stage:枫叶甲氧沙林对乙酰胆碱酯酶和三甲基锡诱导的学习和记忆障碍的影响 Effects of Methoxsalen from Poncirus trifoliata on Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment |
| 已发布 PubMed:呋喃香豆素会影响小鼠的肝细胞色素p450和肾脏有机离子转运蛋白。 Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice. |
| 已发布 PubMed:三叶草甲氧沙林对乙酰胆碱酯酶和三甲基锡诱导的学习和记忆障碍的影响。 Effects of methoxsalen from Poncirus trifoliata on acetylcholinesterase and trimethyltin-induced learning and memory impairment. |
| 已发布 PubMed:5-甲氧基补骨脂素在恒河猴中的经皮渗透。 Percutaneous penetration of 5-methoxypsoralen in rhesus monkeys. |
| 已发布 PubMed:[高效液相色谱法测定补骨脂素 [High-performance liquid chromatography for determination of psoralene, 希尔塔 hirta vahl中的佛手柑和芹菜素]。 |
| 已发布 PubMed:破坏长期的记忆，使白菜弯嘴的味觉习惯化 Dishabituating long-term memory for gustatory habituation in the cabbage looper, 毛滴虫 Trichoplusia ni. |
| 已发布 PubMed:克氏小球菌对佛手柑和黄腐毒素的生物转化。 Biotransformation of bergapten and xanthotoxin by Glomerella cingulata. |
| 已发布 PubMed:皮肤科植物学 Botanicals in dermatology: 循证审查。 an evidence-based review. |
| 已发布 PubMed:v79细胞中次黄嘌呤磷酸核糖基转移酶测定中呋喃香豆素和石灰蛋白的相对光致突变性。 Relative photomutagenicity of furocoumarins and limettin in the hypoxanthine phosphoribosyl transferase assay in V79 cells. |
| 已发布 PubMed:三叶酸酯对乙酰胆碱酯酶的抑制作用和对三甲基锡诱导的学习和记忆障碍的减弱活性。 Inhibitory effect of Poncirus trifoliate on acetylcholinesterase and attenuating activity against trimethyltin-induced learning and memory impairment. |
| 已发布 PubMed:[葡萄柚汁和健康食品中呋喃香豆素的含量]。 [Contents of furanocoumarins in grapefruit juice and health foods]. |
| 已发布 PubMed:柑桔果皮提取物中的杀虫成分的分离与鉴定。 Isolation and identification of insecticidal components from Citrus aurantium fruit peel extract. |
| 已发布 PubMed:生物测定法对果酱中天然芳烃受体激动剂的鉴定。 Bioassay directed identification of natural aryl hydrocarbon-receptor agonists in marmalade. |
| 已发布 PubMed:食物衍生的8-甲氧基补骨脂素对小鼠cyp2a5和大鼠cyp2a3的不同抑制方式。 Different modes of inhibition of mouse Cyp2a5 and rat CYP2A3 by the food-derived 8-methoxypsoralen. |
| 已发布 PubMed:茴香成分对 肝细胞色素p450 3a4的抑制作用 Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): 基于机制的灭活剂的识别和表征。 identification and characterization of a mechanism-based inactivator. |
| 已发布 PubMed:使用阳光模拟器进行体内光化学皮肤微核试验 In vivo photochemical skin micronucleus test using a sunlight simulator: 检测无毛小鼠中的8-甲氧基补骨脂素和苯并[a] py。 detection of 8-methoxypsoralen and benzo[a]pyrene in hairless mice. |
| 已发布 PubMed:饮食中呋喃香豆素的摄入可以增强大剂量uva1治疗期间的红斑反应吗？ Can dietary furanocoumarin ingestion enhance the erythemal response during high-dose UVA1 therapy? |
| 已发布 PubMed:细胞色素p450介导的多毛乳头虫介导的花椒毒素的代谢。 Cytochrome P450-mediated metabolism of xanthotoxin by Papilio multicaudatus. |
| 已发布 PubMed:柑橘柠檬苦素的抗氧化活性 Antioxidant activity of citrus limonoids, 类黄酮 flavonoids, 和香豆素。 and coumarins. |
| 已发布 PubMed:天然呋喃香豆素作为大鼠肝细胞中细胞色素p450 1a1的诱导剂和抑制剂。 Natural furocoumarins as inducers and inhibitors of cytochrome P450 1A1 in rat hepatocytes. |
| 已发布 PubMed:当归中的邻苯二甲酸酯和呋喃香豆素类杀虫剂对果蝇具有杀虫作用。 Insecticidal effect of phthalides and furanocoumarins from Angelica acutiloba against Drosophila melanogaster. |
| 已发布 PubMed:芸香叶中的植物毒素。 Phytotoxins from the leaves of Ruta graveolens. |
| 已发布 PubMed:液相色谱法测定甲氧沙林原料药中的杂质 LC determination of impurities in methoxsalen drug substance: 大气压化学电离lc LC / ms MS和核磁共振 NMR分离和鉴定作为主要杂质的异海洛因。 |
| 已发布 PubMed:保存条件对呋喃香豆素水平的影响 Effects of storage conditions on furocoumarin levels in intact, 切碎的 chopped, 或均质的欧洲防风草。 or homogenized parsnips. |
| 已发布 PubMed:同时 Simultaneous 判定 determination of 呋喃 furano香豆素 coumarins in 输液 infusions and 汤剂 decoctions from "carapiá Carapiá" (dorstenia dorstenia 种类 species) by by 高性能的 高 high-performance 液体 liquid 色谱法 chromatography. |
| 已发布 PubMed:呋喃香豆素在芹菜和欧洲防风草中 Furanocoumarins in celery and parsnips: 方法和加拿大多年调查。 method and multiyear Canadian survey. |
| 已发布 PubMed:塞维利亚橙汁-非洛地平相互作用 Seville orange juice-felodipine interaction: 与稀柚子汁和呋喃香豆素的含量进行比较。 comparison with dilute grapefruit juice and involvement of furocoumarins. |
| 已发布 PubMed:甲硫咪唑对小鼠体内谷胱甘肽的代谢依赖性肝毒性。 Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione. |
| 已发布 PubMed:北美的光电穿刺经验。 The North American experience with photopheresis. |
| 已发布 PubMed:光活化的8-甲氧基补骨脂素治疗通过转化的淋巴细胞引起抗原依赖性肽依赖性增加。 Photoactivated 8-methoxypsoralen treatment causes a peptide-dependent increase in antigen display by transformed lymphocytes. |
| 已发布 PubMed:西维因可诱导cyp1a1基因在hepg2和hacat细胞中表达，但不是 肝ah受体的配体。 Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor. |
| 已发布 PubMed:抑制2-硝基芴的致突变性 Inhibition of the mutagenicity of 2-nitrofluorene, 黄酮类化合物对3-硝基荧蒽和1-硝基py的影响 3-nitrofluoranthene and 1-nitropyrene by flavonoids, 香豆素 coumarins, 醌和其他酚类化合物。 quinones and other phenolic compounds. |
| 已发布 PubMed:硅酞菁pc 4对血液进行光敏去污 Photosensitized decontamination of blood with the silicon phthalocyanine Pc 4: 没有激活 类免疫缺陷 启动子。 no activation of the human immunodeficiency virus promoter. |
| 已发布 PubMed:欧芹中抗菌素呋喃香豆素的分离与鉴定。 Isolation and identification of antimicrobial furocoumarins from parsley. |
| 已发布 PubMed:家蝇中成 特异性表达和诱导细胞色素p450lpr的表达。 Adult specific expression and induction of cytochrome P450lpr in house flies. |
| 已发布 PubMed:消耗谷胱甘肽的小鼠中苯乙烯诱导的肝毒性。 Styrene-induced hepatotoxicity in mice depleted of glutathione. |
| 已发布 PubMed:补骨脂素和紫外线治疗牛皮癣a。 8-甲氧基补骨脂素和5-甲氧基补骨脂素的双盲比较。 Treatment of psoriasis with psoralens and ultraviolet A. A double-blind comparison of 8-methoxypsoralen and 5-methoxypsoralen. |
| 已发布 PubMed:食物引起的5-甲氧基补骨脂素生物利用度增加。 Food-induced increase in bioavailability of 5-methoxypsoralen. |
| 已发布 PubMed:石灰中的光毒性香豆素。 Phototoxic coumarins in limes. |
| 已发布 PubMed:补骨脂素的光敏作用以及无毛小鼠的血浆和皮肤β-胡萝卜素浓度。 Psoralen photosensitization and plasma and cutaneous beta-carotene concentrations in hairless mice. |
| 已发布 PubMed:食物对8-甲氧基补骨脂素血清浓度和最小光毒性剂量的影响。 The influence of food on 8-methoxypsoralen serum concentration and minimal phototoxic dose. |
| 已发布 PubMed:补骨脂素加紫外线激活 类免疫缺陷 启动子的光谱效应。 Spectral effects in activation of the human immunodeficiency virus promoter by psoralens plus ultraviolet A treatment. |
| 已发布 PubMed:[（14）c] xanthotoxin（8-甲氧基补骨脂素）在产蛋鸡和哺乳山羊中的命运。 Fate of [(14)C]xanthotoxin (8-methoxypsoralen) in laying hens and a lactating goat. |
| 已发布 PubMed:豚鼠的光毒性测试。 Phototoxicity testing in guinea-pigs. |
| 已发布 PubMed:通过用丁硫氨酸亚砜亚胺处理的小鼠，在摄入谷胱甘肽后，与噻菌灵在结构上相关的噻唑的肾毒性。 Nephrotoxicity of thiazoles structurally related to thiabendazole in mice depleted of glutathione by treatment with buthionine sulfoximine. |
| 已发布 PubMed:饮食和 类光毒性呋喃香豆素的风险评估。 Dietary intake and risk assessment of phototoxic furocoumarins in humans. |
| 已发布 PubMed:用dl-丁硫氨酸磺胺嘧啶治疗丁香酚对小鼠丁香酚的肝毒性。 Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine. |
| 已发布 PubMed:[类维生素A对甲氧基-8-补骨脂素生物利用度的影响]。 [Influence of retinoids on the bioavailability of methoxy-8-psoralen]. |
| 已发布 PubMed:防风草蠕虫对光毒性呋喃香豆素的防御作用 Defense of parsnip webworm against phototoxic furanocoumarins: 抗氧化酶的作用。 Role of antioxidant enzymes. |
| 已发布 PubMed:比格犬和小型猪中14c标记的8-甲氧基补骨脂素的排泄和组织分布。 Excretion and tissue distribution of 14C-labelled 8-methoxypsoralen in beagle dogs and miniature pigs. |
| 已发布 PubMed: 金霉素 gilvocarcin v加近紫外线 处理的 二倍体成纤维细胞对疱疹 成斑能力的抑制作用。 |
| 已发布 PubMed:噻苯达唑通过dl-丁硫氨酸亚砜亚胺治疗对谷胱甘肽耗竭的小鼠的肾毒性。 Nephrotoxicity of thiabendazole in mice depleted of glutathione by treatment with DL-buthionine sulphoximine. |
| 已发布 PubMed:食品中的天然农药和生物活性成分。 Natural pesticides and bioactive components in foods. |
| 已发布 PubMed:南方粘虫蛾幼虫中抗氧化酶水平对前氧化化感物质的响应 Antioxidant enzyme level response to prooxidant allelochemicals in larvae of the southern armyworm moth, 斜纹夜蛾。 Spodoptera eridania. |
| 已发布 PubMed:研究局部光毒性的预测性小鼠耳朵肿胀模型。 A predictive mouse ear-swelling model for investigating topical phototoxicity. |
| 已发布 PubMed:谷胱甘肽转移酶对三种鳞毛蕨物种的异硫氰酸酯化感物质的解毒作用。 Detoxification of isothiocyanate allelochemicals by glutathione transferase in three lepidopterous species. |
| 已发布 PubMed:豚鼠血清中8-甲氧基补骨脂素和5-甲氧基补骨脂素分布的动力学 Kinetics of 8-methoxypsoralen and 5-methoxypsoralen distribution in guinea pig serum, 表皮和眼晶状体。 epidermis and ocular lens. |
| 已发布 PubMed:甲氧沙林和其他补骨脂素的临床药代动力学。 Clinical pharmacokinetics of methoxsalen and other psoralens. |
| 已发布 PubMed:5-甲氧基补骨脂素。 5-Methoxypsoralen. |
| 已发布 PubMed:欧芹中香菜碱含量及其在引起皮肤光敏性中的意义。 The bergapten content of garden parsley and its significance in causing cutaneous photosensitization. |
| 已发布 PubMed:使用闭塞贴片评估豚鼠中化学物质的光敏特性。 Use of the occlusive patch to evaluate the photosensitive properties of chemicals in guinea-pigs. |
| 已发布 PubMed:用紫外线照射豚鼠皮肤的装置。 A device for irradiating guinea-pig skin with ultraviolet light. |
| 已发布 PubMed:定量评估无毛小鼠皮肤中的光毒性。 Quantitative assessment of phototoxicity in the skin of hairless mice. |
| 已发布 PubMed:芹菜菌核盘菌感染而引起的光毒性皮炎。 Phototoxic dermatitis caused by celery infected by Sclerotinia sclerotiorum. |
| 已发布 PubMed:牛皮癣和uv-a治疗牛皮癣的长期风险。 Long-term risks of psoralen and UV-A therapy for psoriasis. |
| 已发布 PubMed:健康芹菜中的线性呋喃香豆素（补骨脂素）的hplc分析。 HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). |
| 已发布 PubMed:5-甲氧基补骨脂素和近紫外光对大肠杆菌wp2缺乏修复菌株的遗传毒性。 Genotoxicity of 5-methoxypsoralen and near ultraviolet light in repair-deficient strains of Escherichia coli WP2. |
| 已发布 PubMed:对银屑病患者血清和吸水疱液中8-甲氧基补骨脂素动力学的影响 Influenced of food on the kinetics of 8-methoxypsoralen in serum and suction blister fluid in psoriatic patients. |
| 已发布 PubMed:制度的 Institutional 药剂师 pharmacists' 指南 guide to 遵守 complying with ppi PPI 规定 regulations. |
| 已发布 PubMed:食物对8-甲氧沙林动力学的影响。 Effect of food on kinetics of 8-methoxsalen. |
| 已发布 PubMed:光毒性和光致癌作用 Phototoxicity and photocarcinogenesis: 蒽和8-甲氧基补骨脂素在小鼠皮肤中的比较作用。 comparative effects of anthracene and 8-methoxypsoralen in the skin of mice. |
| 已发布 PubMed:光致癌作用的实验修饰。 ii。荧光增白剂和模拟太阳能紫外线。 Experimental modification of photocarcinogenesis. II. Fluorescent whitening agents and simulated solar UVR. |
| 已发布 PubMed:光致癌作用的实验修饰。 iii。模拟日光和荧光增白剂的暴露。 Experimental modification of photocarcinogenesis. III. Simulation of exposure to sunlight and fluorescent whitening agents. |
| 已发布 PubMed:菌核盘菌感染的芹菜中黄原毒素（8-甲氧基补骨脂素）和佛手柑（5-甲氧基补骨脂素）的分离和鉴定。 Isolation and identification of xanthotoxin (8-methoxypsoralen) and bergapten (5-methoxypsoralen) from celery infected with Sclerotinia sclerotiorum. |
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在几种植物中发现的天然呋喃香豆素化合物 a naturally occurring furocoumarin compound found in several species of plants, 包括补骨脂。它是一种光活性物质，在紫外线照射下会形成脱氧核糖核酸 dna加合物。芹菜中 , 尤其是外在的叶子 esp. the outer leaves, and other 共同 common 杂货店 grocery 蔬菜 vegetables. 牵连 Implicated in 光性皮炎 photo皮炎 dermatitis 其中 among 杂货店 grocery 工 workers. 异酚 Isol. from Aegle marmelos (bael bael)
甲氧沙林（以商品名草酸 oxsoralen出售）是用于治疗牛皮癣的药物 , 湿疹 eczema, 白癜风 vitiligo, 以及一些皮肤淋巴瘤与皮肤暴露在阳光下。甲氧沙林改变了皮肤细胞接受紫外线 的方式 and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, 据称正在清除疾病。剂量为10mg片剂 allegedly clearing up the disease. The dosage comes in 10mg tablets, 醛c 11十一醛c 11十一醛食品级醛c-11 fcc醛c-11十一醛c-11十一醛c-11十一醛fcc醛c-11十一醛天然醛c11十一醛十一碳烯醛十一醛1十一碳烷-十一碳二烯醛（醛c -11十一碳醛）十一碳醛α-十一碳烯十一碳烯醛n-十一碳烯醛十一碳烯醛十一碳烯醛 which are taken in the amount of 30mg 75 minutes before a PUVA light treatment. The substance is also present in bergamot oil which is used in many perfumes and aromatherapy oils.; Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, 固液萃取和亚硝基阴离子和十四烷基二甲基苄基铵阳离子形成的离子对预固溶后，通过原子吸收光谱法测定各种生物和环境样品中的痕量锰。 cellular RNA and protein synthesis are also suppressed.; Patients with high blood pressure or a history of liver problems are at risk for inflammation and irreparable damage to both liver and skin. The eyes must be protected from UVA radiation. Side effects include nausea, 头疼 headaches, 头晕 dizziness, 并在极少数情况下失眠。科隆香水诞生时 and in rare cases insomnia. When Eau de Cologne was made, 它成为一种流行的香水。它含有佛手柑油作为其成分之一。女士们在阳光照射皮肤的地方戴香水 it became a popular perfume. It contained bergamot oil as one of its components. Ladies wearing the perfume on places where the skin was radiated by the sun, 注意到他们的皮肤在那些斑点处变成褐色。这是由于佛手柑油中存在的甲氧沙林具有光毒性作用。除去甲氧沙林 noticed that their skin turned brownish at those spots. This is due to the phototoxic effects of methoxsalen present in the bergamot oil. The methoxsalen was removed, 含有佛手柑的大多数现代香水配方都被去甲氧沙林化。 and most modern formulations of perfumes containing bergamot are de-methoxsalenised.
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3D/INCHI