2-糠酸 2 - Furoic Acid
呋喃甲酸 a-furancarboxylic acid

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    f0081 2-呋喃甲酸> 98.0%(gc)(t) F0081 2-Furancarboxylic Acid >98.0%(GC)(T)
Name:呋喃-2-羧酸 furan-2-carboxylic acid
CAS号 CAS Number: 88-14-2Picture of molecule3D/INCHI
ECHA EINECS - REACH 预注册 Pre-Reg:201-803-0
FDA UNII:P577F6494A
nikkaji网站 Nikkaji Web:J4.288I
贝尔斯坦数 Beilstein Number:0110149
MDL :mfcd00003238 MFCD00003238
代号 CoE Number:10098
XlogP3:0.50(est) 0.50 (est)
分子量 Molecular Weight:112.08448000
式 Formula:c5 h4 o3 C5 H4 O3
生物活性总结 BioActivity Summary:清单 listing
核磁共振预测器 NMR Predictor:预测(适用于Chrome或Firefox) Predict (works with chrome or firefox)
类别 Category:flavoring agents
 
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
谷歌学术 Google Scholar:搜索 Search
谷歌书 Google Books:搜索 Search
谷歌学术 Google Scholar: with word "volatile"搜索 Search
谷歌学术 Google Scholar: with word "flavor"搜索 Search
谷歌学术 Google Scholar: with word "odor"搜索 Search
调香师和调味师 Perfumer and Flavorist:搜索 Search
谷歌专利 Google Patents:搜索 Search
美国专利 US Patents:搜索 Search
欧盟专利 EU Patents:搜索 Search
pubchem专利 Pubchem Patents:搜索 Search
已发布 PubMed:搜索 Search
NCBI:搜索 Search
Flavis号码 FLAVIS Number:13.136(旧) 13.136 (Old)
dg sante食品调味料 DG SANTE Food Flavourings:13.136 2-糠酸 13.136 2-furoic acid
 
物理性质 Physical Properties:
化验 Assay: 95.00至100.00 95.00 to 100.00
食品化学品法典列表 Food Chemicals Codex Listed: No
熔点 Melting Point: 130.00 to 133.00 °C. @ 760.00 mm 汞 Hg
沸点 Boiling Point: 230.00 to 232.00 °C. @ 760.00 mm 汞 Hg
蒸汽压力 Vapor Pressure:0.033000 毫米汞柱 mm汞 Hg @ 25.00 °C. (est)
闪点 Flash Point: 201.00 °F. tcc TCC ( 93.89 °C. )
logp(o / w) logP (o/w): 0.640
溶于 Soluble in:
 alcohol
 水 water, 15100°C时为37100 mg / l(经验值 exp)
 
感官特性 Organoleptic Properties:
气味类型 Odor Type: odorless
气味描述 Odor Description:odorless
风味类型 Flavor Type: acidic
acidic caramellic earthy
口味描述 Taste Description: 酸性焦糖土 acidic caramellic earthy
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found).
 
化妆品信息 Cosmetic Information:
没找到 None found
 
供应商 Suppliers:
BOC Sciences
仅供实验/研究使用。 For experimental / research use only.
呋喃-2-羧酸> 98% Furan-2-carboxylic acid >98%
CJ Latta & Associates
糠酸 FUROIC ACID
纳加尔 Nagar 哈维利 Haveli香水和芳香剂
2-糠酸 2 - Furoic Acid
自然 Natural
气味 Odor: 酸性焦糖土 acidic caramellic earthy
纳加尔 Nagar 哈维利 Haveli香水和芳香剂
糠酸 FUROIC ACID
佩恩·凯姆 Penn A Kem
2-糠酸 2 - Furoic Acid
Penta International
2-糠酸 2 - Furoic Acid
圣克鲁斯生物技术 Santa Cruz Biotechnology
仅供实验/研究使用。 For experimental / research use only.
2-糠酸 2 - Furoic Acid
西格玛·奥尔德里奇 Sigma-Aldrich: 奥尔德里奇 Aldrich
仅供实验/研究使用。 For experimental / research use only.
2-糠酸98% 2-Furoic acid 98%
TCI AMERICA
仅供实验/研究使用。 For experimental / research use only.
2-呋喃羧酸> 98.0%(gc)(t) 2-Furancarboxylic Acid >98.0%(GC)(T)
 
安全信息 Safety Information:
首选SDS Preferred SDS: 视图 View
欧洲信息 European information :
最重要的危害 Most important hazard(s):
xi-刺激性 Xi - Irritant
r 36/37/38-刺激眼睛 R 36/37/38 - Irritating to eyes, 呼吸系统 respiratory system, and skin 皮.
S 02 - 保持 Keep out of the 达到 reach of 孩子们 children.
S 24/25 - 避免 Avoid contact with skin 皮 and 眼睛 eyes.
S 26 - In 案件 case of contact with 眼睛 eyes, 冲洗 rinse 立即 immediately with 充裕 plenty of 水 water and 寻求 seek 医疗 medical 忠告 advice.
S 36 - 穿 我们 Wear 适当 suitable 保护性 protective 服装 clothing.
 
危害识别 Hazards identification
 
物质或混合物的分类 Classification of the substance or mixture
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
没有找到。 None found.
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements
 
象形图 Pictogram
 
危险说明 Hazard statement(s)
没有找到。 None found.
防范说明 Precautionary statement(s)
没有找到。 None found.
口服/肠胃外毒性 Oral/Parenteral Toxicity:
腹腔内小鼠 intraperitoneal-mouse LD50 100 mg/kg kg
Pharmaceutical 研究 Research. 卷 Vol. 2, pg。 233 Pg. 233, 1985.

皮肤毒性 Dermal Toxicity:
未定 Not determined
吸入毒性 Inhalation Toxicity:
未定 Not determined
 
使用安全信息 Safety in Use Information:
类别 Category:
flavoring agents
推荐的2-糠酸用量不超过 Recommendation for 2-furoic acid usage levels up to:
 不用于香水。 not for fragrance use.
 
最大化源自调查的每日摄入量(msdi-eu) Maximised Survey-derived Daily Intakes (MSDI-EU): 0.013(微克/ 均/天) 0.013 (μg/capita/day)
修改后的理论增加的最大每日摄入量(mtamdi) Modified Theoretical Added Maximum Daily Intake (mTAMDI): 1400(微克/ /天) 1400 (μg/person/day)
存在足够的诺埃尔 Adequate NOAEL exists: 是 Yes
关注点 Threshold of Concern:540(微克/ /天) 540 (μg/person/day)
结构类 Structure Class: II
 
根据委员会法规ec EC号的食品类别。 1565/2000(ec , 2000)在fge.06(efsa 2000) in FGE.06 (EFSA, 2002a). 根据 According to the Industry the "正常 normal" use is 定义的 de精细 fined as the 平均 average of 已报告 reported 用法 用法 usages and "最大 maximum use" is 定义的 de精细 fined as the 95th 百分位 percentile of 已报告 reported 用法 用法 usages (efsa EFSA, 2002i)。 2002i).
注意 Note: 毫克/千克= 0.001 / 1000 = 0.000001 = 1/1000000 = 百万分之几 ppm
 平均 average 用法 usage mg/kg kg最大 maximum 用法 usage mg/kg kg
乳制品 Dairy products, 不包括02.0(01.0)类产品 excluding products of category 02.0 (01.0): 3.0000015.00000
脂肪和油脂 Fats and oils, 和脂肪乳液(油包水型)(02.0) and fat emulsions (type water-in-oil) (02.0): 2.0000010.00000
食用冰 Edible ices, 包括果子露和果汁冰糕(03.0) including sherbet and sorbet (03.0): 3.0000015.00000
加工水果(04.1) Processed fruit (04.1): 2.0000010.00000
加工蔬菜(包括蘑菇和真菌) Processed vegetables (incl. mushrooms & fungi, 根与根块茎 roots & tubers, 豆类和豆类) pulses and legumes), 和坚果种子(04.2) and nuts & seeds (04.2): --
糖果(05.0) Confectionery (05.0): 5.0000025.00000
谷物和谷物产品 Cereals and cereal products, 含税面粉根和淀粉块茎 incl. flours & starches from roots & tubers, 脉冲和豆类 pulses & legumes, 不包括面包店(06.0) excluding bakery (06.0): 2.0000010.00000
烘焙用具(07.0) Bakery wares (07.0): --
肉和肉制品 Meat and meat products, 包括家禽和野味(08.0) including poultry and game (08.0): 1.000005.00000
鱼和鱼制品 Fish and fish products, 包括软体动物 including molluscs, 甲壳类和棘皮类动物(麦克 MCE)(09.0) : 1.000005.00000
鸡蛋和蛋制品(10.0) Eggs and egg products (10.0): --
甜味剂 Sweeteners, 包括蜂蜜(11.0) including honey (11.0): --
盐 Salts, 香料 spices, 汤类 soups, 酱料 sauces, 色拉 salads, 蛋白产品 protein products, 等(12.0) etc. (12.0): 2.0000010.00000
用于特定营养用途的食品(13.0) Foodstuffs intended for particular nutritional uses (13.0): 3.0000015.00000
不含醇 Non-alcoholic ("柔软的 soft") 饮料 beverages, 不包括乳制品(14.1) excl. dairy products (14.1): 2.0000010.00000
含醇的饮料 Alcoholic beverages, 含税无醇和低醇的对口(14.2) incl. alcohol-free and low-alcoholic counterparts (14.2): 5.0000025.00000
即食美味(15.0) Ready-to-eat savouries (15.0): 5.0000025.00000
复合食品(例如砂锅菜) Composite foods (e.g. casseroles, 肉馅饼 meat pies, 百果馅)-无法放在01.0-15.0(16.0)类别中的食物 mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 2.0000010.00000
 
安全参考 Safety references:
欧洲食品安全法规(efsa) European Food Safety Athority(efsa):风味使用水平;亚急性 Flavor usage levels; Subacute, 亚慢性 Subchronic, 慢性和致癌性研究;发育/ 毒性研究;遗传毒性研究... Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

欧洲食品安全局(efsa EFSA)参考 :

食品添加剂科学小组的意见 Opinion of the Scientific Panel on food additives, 调味料 flavourings, 处理中 processing 艾滋病 aids and 材料 materials in contact with food (afc AFC) 有关 related to 调味料 Flavouring 组 Group 评价 Evaluation 13 (ge FGE.13); 糠基 Furfuryl and furan 衍生品 derivatives with and 没有 without 额外 additional 侧链 侧 side-链 chain 取代基 substituents and 杂原子 heteroatoms from chemical group 14 (佣金 Commission 规 Regulation (ec EC) No 1565/2000 of 18
视图 View page or 视图 View pdf

调味组评估66(fge.66)[1] Flavouring Group Evaluation 66 (FGE.66)[1]:考虑 Con侧 sideration of furfuryl alcohol and 有关 related flavouring 物质 substances 已评估 evaluated by by Jec ECFA (55th 会议 meeting) 结构上 structurally 有关 related to 糠基 Furfuryl and furan 衍生品 derivatives with and 没有 without 额外 additional 侧 side 链 chain 取代基 substituents and 杂原子 heteroatoms 已评估 evaluated by by efsa EFSA in ge FGE.13 (2005)
视图 View page or 视图 View pdf

调味组评估的科学见解13rev1 Scientific Opinion on Flavouring Group Evaluation 13Rev1: 糠基 Furfuryl and furan 衍生品 derivatives with and 没有 without 额外 additional 侧链 侧 side-链 chain 取代基 substituents and 杂原子 heteroatoms from chemical group 14
视图 View page or 视图 View pdf

考虑 Con侧 sideration of 硫取代的 sulfur-substituted furan 衍生品 derivatives 用过的 used as flavouring agents 已评估 evaluated by by Jec ECFA (59th 会议 meeting) 结构上 structurally 有关 related to a 亚组 subgroup of 物质 substances 中 within the group of 呋喃基 �糠基 Furfuryl and furan 衍生品 derivatives with and 没有 without 额外 additional 侧链 侧 side-链 chain 取代基 substituents and 杂原子 heteroatoms from chemical group 14� 已评估 evaluated by by efsa EFSA in ge FGE.13Rev1 (2009)
视图 View page or 视图 View pdf

调味组评估67(fge.67) Flavouring Group Evaluation 67 (FGE.67): 考虑40种呋喃取代的脂肪烃 Consideration of 40 furan-substituted aliphatic hydrocarbons, 酒类 alcohols, 醛类 aldehydes, 酮类 ketones, 羧酸及相关酯 carboxylic acids and related esters, 硫化物 sulfides, jecfa在第六十五次会议上评估了二硫化物和醚(jecfa disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b),并在第69次会议上重新评估(jecfa 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c)
视图 View page or 视图 View pdf

调味品组评价的科学见解13 Scientific Opinion on Flavouring Group Evaluation 13, 版本2(fge.13rev2) Revision 2 (FGE.13Rev2): 糠基 Furfuryl and furan 衍生品 derivatives with and 没有 without 额外 additional 侧链 侧 side-链 chain 取代基 substituents and 杂原子 heteroatoms from chemical group 14
视图 View page or 视图 View pdf

调味品组评价的科学意见67 Scientific Opinion on Flavouring Group Evaluation 67, 版本1(fge.67rev.1) Revision 1 (FGE.67Rev.1): 考虑40种呋喃取代的脂肪烃 Consideration of 40 furan-substituted aliphatic hydrocarbons, 酒类 alcohols, 醛类 aldehydes, 酮类 ketones, 羧酸及相关酯 carboxylic acids and related esters, 硫化物 sulfides, jecfa在第六十五次会议上评估了二硫化物和醚(jecfa disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b),并在第69次会议上重新评估(jecfa 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c)
视图 View page or 视图 View pdf

Epi系统 EPI System: 视图 View
化学致癌研究信息系统 Chemical Carcinogenesis Research Information System:搜索 Search
癌症引文 Cancer Citations:搜索 Search
毒理学引文 Toxicology Citations:搜索 Search
环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search
EPA物质注册服务(tsca TSCA) :88-14-2
EPA ACToR:毒理学资料 Toxicology Data
EPA物质注册服务(SRS) :注册表 Registry
实验室化学安全摘要 Laboratory Chemical Safety Summary :6919
国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data
德国wgk WGK Germany:3
呋喃-2-羧酸 furan-2-carboxylic acid
chemidplus Chemidplus:0000088142
技术 RTECS:lv1763000适用于CAS#88-14-2 LV1763000 for cas# 88-14-2
 
参考资料 References:
 呋喃-2-羧酸 furan-2-carboxylic acid
NIST化学网络书籍 NIST Chemistry WebBook: 搜索INCHI
加拿大国内分公司。清单 Canada Domestic Sub. List:88-14-2
pubchem(cid) Pubchem (cid):6919
pubchem(sid) Pubchem (sid):134972020
 
其他资料 Other Information:
(iupac) (IUPAC):元素的原子量2009 Atomic Weights of the Elements 2009
(iupac) (IUPAC):元素的原子量2009(pdf) Atomic Weights of the Elements 2009 (pdf)
影片 Videos:元素周期表 The Periodic Table of Videos
RBC :本网站使用的原子量 Atomic Weights use for this web site
(iupac) (IUPAC):元素周期表 Periodic Table of the Elements
CHEBI:视图 View
CHEMBL:视图 View
代谢组学数据库 Metabolomics Database:搜索 Search
嗯bbd UM BBD:搜索 Search
KEGG (GenomeNet):C01546
hmdb(人类代谢组数据库) HMDB (The Human Metabolome Database):HMDB00617
食物 FooDB:FDB000951
出口关税代码 Export Tariff Code:2932.19.5100
vcf在线 VCF-Online:食品中的挥发性有机化合物 VCF Volatile Compounds in Food
化学蜘蛛 ChemSpider:视图 View
efsa EFSA更新监测食品中呋喃水平的结果 :阅读报告 Read Report
efsa EFSA以前的报告 : 食品中呋喃水平监测的结果 Results on the monitoring of furan levels in food:阅读报告 Read Report
欧洲反腐败委员会关于食品中呋喃的临时调查结果的efsa EFSA报告 :阅读报告 Read Report
 
潜在搅拌机 Potential Blenders and core 组件 components note
气味 For Odor
用于调味 For Flavor
麦芽 malty
麦芽 malt distillates
FL
 
潜在用途 Potential Uses:
FLcoffee
FL番石榴 guava
FLpapaya
FLrum
FLvegetable
 
存在(自然 Occurrence (nature, food, 其他) other):note
  芦笋煮熟的芦笋-0.01 mg / kg kg
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  啤酒-最高0.8 mg / kg kg
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 咖啡-最高80毫克/千克 coffee - up to 80 mg/kg
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  番石榴果实-少于0.05 mg / kg kg
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  木瓜果实-少于0.05 mg / kg kg
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 朗姆酒-0.4毫克/千克 rum - 0.4 mg/kg
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 木橡木 wood oak wood
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同义词 Synonyms:
2-carboxyfuran
2-furan carboxylic acid
alpha-furan carboxylic acid
 呋喃-2-羧酸 furan-2-carboxylic acid
2-furancarboxylic acid
a-furancarboxylic acid
alpha-furancarboxylic acid
b-furancarboxylic acid
2-furanoic acid
a-furoic acid
alpha-furoic acid
2-furoicacid
 pyromucic acid
 
 
笔记 Notes:
分离。从菜豆的根(扁豆) Isol. from roots of Phaseolus vulgaris (kidney bean) 木犀科lipobutter橄榄lipovol o nikkol橄榄油olea europaea水果油橄榄黄油-超精制(tm)异黄酮橄榄gw(symrise)橄榄油可食用的纯橄榄油可食用的橄榄油b可分级的橄榄油nforganic橄榄油olifeel有机油橄榄油有机橄榄油精制-有机有机橄榄油西班牙橄榄油西班牙有机橄榄油 Furoic acid is a metabolite that appears in the urine of workers occupationally exposed to furfural and is marker of exposure to this compound. Furfural is a heterocyclic aldehyde that is commonly used as a solvent in industry. It is readily absorbed into the body via the lungs and has significant skin absorption. Furfural is an irritant of the eyes, 黏mucous membranes, 和皮肤,是中枢橙花系统抑制剂。糠醛是一种已确认的动物致癌物,与 类的相关性未知(已提出该物质可引起肝硬化)。一旦进入体内 and skin and is a central nervous system depressant. Furfural as a confirmed animal carcinogen with unknown relevance to humans (It has been suggested that is a substance that produces hepatic cirrhosis). Once in the body, 糠醛通过氧化迅速代谢为代谢产物糠酸 furfural is metabolized rapidly via oxidation to the metabolite furoic acid, 然后将其与甘氨酸结合,并以游离和结合形式在尿液中排泄。 (pmid which is then conjugated with glycine and excreted in the urine in both free and conjugated forms. (PMID: 3751566, 4630229, 12587683)
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