| Name: | (2s (2S,3s 3S,4s 4S,5r 5R,6r）-6-[（2秒 6R)-6-[(2S,3r 3R,5s 5S,6r）-3-乙酰氨基-2-[（2s 6R)-3-acetamido-2-[(2S,3s 3S,4r 4R,5r 5R,6r）-6-[（2r 6R)-6-[(2R,3r 3R,5s 5S,6r）-3-乙酰氨基2 6R)-3-acetamido-2,5-二羟基-6-（羟甲基）恶烷-4-基]氧基-2-羧基-4 5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-二氢 5-dihydr |
| CAS号 CAS Number: | 9004-61-9 |  3D/INCHI
|
| 其他 Other: | 165324-65-2 |
| echa ECha HA einecs EINECS - REACH 预注册 Pre-Reg: | 232-678-0 |
| FDA UNII: | S270N0TRQY |
| MDL : | mfcd00131348 MFCD00131348 |
| XlogP3-AA: | -7.40（est） -7.40 (est) |
| 分子量 Molecular Weight: | 776.65428000 |
| 式 Formula: | c28 h44 n2 o23 C28 H44 N2 O23 |
| 核磁共振预测器 NMR Predictor: | 预测（适用于Chrome或Firefox） Predict (works with chrome or firefox) |
类别 Category:nutrient adjuncts, dietary supplements, nutrient agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
|
| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 沸点 Boiling Point: | 1274.00 to 1275.00 °C. @ 760.00 mm 汞 Hg (est)
|
| 闪点 Flash Point: | 1336.00 °F. tcc TCC ( 724.50 °C. ) (est)
|
| logp（o / w） logP (o/w): | -6.623（est） -6.623 (est) |
| 溶于 Soluble in: |
| | 水 water, 8.271e + 005 mg / l @ 25°c（est） 8.271e+005 mg/L @ 25 °C (est) |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
| BOC Sciences |
| 仅供实验/研究使用。 For experimental / research use only. |
| 透明质酸 Hyaluronic Acid USP
|
| ECSA Chemicals |
| 透明质酸 Hyaluronic Acid USP
|
| 公司简介 Company Profile |
| 乔治·乌赫公司 George Uhe Company |
| 透明质酸 Hyaluronic Acid USP
|
| 奇华顿 Givaudan |
| Cristalhyal® range
气味 Odor: characteristic 采用 Use: Cristalhyal® range is a 年级 grade of 高 high 分子 molecular 重量 weight 透明质酸 Hyaluronic Acid USP 粉 powder (兆瓦 MW: 1-1,发酵获得4 mda） 4 MDa) obtained by fermentation, 使用可再生资源。 using renewable resources. |
| 奇华顿 Givaudan |
| Hyalusphere® pf PF or xp XP
气味 Odor: characteristic 采用 Use: Hyalusphere® is a 高 high 分子 molecular 重量 weight 透明质酸 Hyaluronic Acid USP (ha HA) 封装的 encapsulated 进入 into our 独家 exclusive 获得专利 patented 技术 technology, 球晶与贸易;。 Spherulite™. |
| 奇华顿 Givaudan |
| novhyal＆trade;生物技术 NovHyal™ Biotech G
气味 Odor: characteristic 采用 Use: 最新一代的透明质酸 The lastest generation of Hyaluronic Acid: 无针公顷 the � needle-free � HA, 充当补充肌肤的补充剂。比视黄醇更有效。 acting as a pro-filler to replump the skin. More efficient than retinol. |
| 奇华顿 Givaudan |
| 原始透明质3k PrimalHyal 3K
气味 Odor: characteristic 采用 Use: primalhyal 3k是一种具有丰富生物相容性的透明质酸混合物，能够渗透到皮肤中，从内部恢复活力。 PrimalHyal 3K is a rich biocompatible Hyaluronic Acid blend able to penetrate into the skin to rejuvenate it from within. |
| 奇华顿 Givaudan |
| 原始卫生与贸易; 300 PrimalHyal™ 300
气味 Odor: characteristic 采用 Use: 透明质酸粉末的中等分子量（mw Medium molecular weight of hyaluronic acid powder (MW: 100-300 kda）通过生物技术制造过程获得。 100-300 KDa) obtained by biotechnology manufacturing process. |
| 奇华顿 Givaudan |
| 原始卫生与贸易; 50 PrimalHyal™ 50
气味 Odor: characteristic 采用 Use: 原始卫生与贸易;是低分子量透明质酸（mw PrimalHyal™ is a patented grade of low molecular weight Hyaluronic Acid (MW: 20-50 kda） 20-50 KDa), 通过发酵获得。 obtained by fermentation. |
| 奇华顿 Givaudan |
| 原始卫生与贸易;金 PrimalHyal™ Gold
气味 Odor: characteristic 采用 Use: 新一代透明质酸允许在油性和无水配方中使用，打破了以往的配方限制。 This new generation of Hyaluronic Acid breaks the previous limits of formulation by allowing its use in oily and anhydrous formulas. |
| 奇华顿 Givaudan |
| 原始卫生与贸易;超填料 PrimalHyal™ Ultrafiller
气味 Odor: characteristic 采用 Use: r 11-高度易燃。r 34-引起灼伤。s 01/02-锁紧并放在儿童接触不到的地方。s 09-请将容器放在通风良好的地方。s 16-远离火源-禁止吸烟。s 24/25-避免与皮肤和眼睛接触。s 26-如果接触眼睛 PrimalHyal™ Ultrafiller is a unique and patent-pending hyaluronic acid (HA) derivative designed to offer a cosmetic alternative to the injectable fillers. It penetrates twice deeper into the skin than standard HA and is resistant to hyaluronidases thanks to its full acetylation, 延长皮肤寿命。 for a longer lifetime in the skin. |
| 奇华顿 Givaudan |
| 抵抗贸易 ResistHyal™
气味 Odor: characteristic 采用 Use: 抵抗贸易是新一代护发活性成分，含有优化比例的低分子量和高分子量透明质酸。 ResistHyal™ is a new generation of hair care active ingredient containing an optimised ratio of low and high molecular weight hyaluronic acids. |
| Jiangyin Healthway |
| 透明质酸低聚糖 Hyaluronic Acid Oligosaccharide
|
| 新功能食品成分 New functional food ingredients |
| Jiangyin Healthway |
| 透明质酸 Hyaluronic Acid USP
|
| 脂类化学品 Lipo Chemicals |
| 生物聚合物bha-10 Biopolymer BHA-10
气味 Odor: characteristic 采用 Use: 生物聚合物bha-10 Biopolymer BHA-10 is an association 复合物 complex between Polyquaternium-10 and 透明质酸 Hyaluronic Acid USP. The Polyquaternum-10 is 派生的 derived from 纤维素 细胞 cellulose, and 坚持 adheres 好 well to 蛋白质 蛋白 proteinacious 表面 表面 surfaces 这样 such as the skin and the 头发 hair. The 透明质酸 Hyaluronic Acid USP 发现 found in 生物聚合物bha-10 Biopolymer BHA-10 is 制造的 manufactured 通过 via a 微生物 microbial 发酵 fermentation 处理 process for a 绿 green and 自然 自然 naturally 派生的 derived product. |
| 脂类化学品 Lipo Chemicals |
| ha HA-24生物聚合物
气味 Odor: characteristic 采用 Use: 洋甘菊花油co2提取物洋甘菊courrantiana花油co2提取物洋甘菊recutita花花油co2提取物母菊chamomilla var。 recutita花油co2提取物母菊courrantiana花油co2提取物母菊recutita花油co2提取物 Biopolymer HA-24 is an association complex of Polyquaternium-24 and Hyaluronic Acid (Animal derived). This opalescent viscous liquid combines the moisturization properties of hyaluronic acid with the substantivity of a lauryl-substituted quaternized hydroxyethylcellulose, 产生可在多种皮肤护理应用中使用的透明质酸。 creating a substantive hyaluronic acid that can be utilized in a myriad of skin care applications. |
| 脂类化学品 Lipo Chemicals |
| 生物聚合物 Biopolymer SA-N
气味 Odor: characteristic 采用 Use: 生物聚合物sa-n是独特的三部分聚合物复合物，可物理抚平皱纹，使皮肤光滑 Biopolymer SA-N is a unique three-part polymer complex that physically lifts wrinkles to smooth the skin, 提供柔焦效果，以光学方式减少皱纹的出现 give a soft focus effect to optically reduce the appearance of wrinkles, 而 while 保湿 moisturizing the skin. 生物聚合物 Biopolymer SA-N is 包含 comprised of 透明质酸 Hyaluronic Acid USP, 血清蛋白和硫酸葡聚糖。 serum albumen and dextran sulfate. |
| 美宝工业 Maypro Industries |
| 透明质酸 Hyaluronic Acid USP
|
| 泛科学 Pangaea Sciences |
| 透明质酸 Hyaluronic Acid USP
|
| Penta International |
| 透明质酸 Hyaluronic Acid USP
|
| 普里诺娃 Prinova |
| 透明质酸 Hyaluronic Acid USP
|
| 野味 WILD Flavors |
| 透明质酸 Hyaluronic Acid USP
味道 Flavor: taste 透明质酸 Hyaluronic Acid USP (ha HA) 发生 occurs 自然 自然 naturally in the body. The 最高 高 highest 浓度 concentration is 发现 found in the 柔软的 soft 结缔 connective 组织 tissue. it It is 当下 present in 软骨 cartilage, 滑膜香柳叶菜液和皮肤组织。这对于保持滑液至关重要 synovial joint fluid and skin tissue. It is essential for preservation of synovial fluid, 维持骨骼和香柳叶菜。 ha还可以从内到外滋润皮肤。 which maintains bones and joints. HA also works to hydrate the skin from the inside out. |
安全信息 Safety Information:
| |
| 危害识别 Hazards identification |
| |
| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
|
未定 Not determined
|
| 皮肤毒性 Dermal Toxicity: |
|
未定 Not determined
|
| 吸入毒性 Inhalation Toxicity: |
|
未定 Not determined
|
使用安全信息 Safety in Use Information:
| 类别 Category: | | nutrient adjuncts, dietary supplements, nutrient agents |
| 透明质酸用量建议 Recommendation for hyaluronic acid usage levels up to: | | | 不用于香水。 not for fragrance use.
|
| |
| 透明质酸风味剂使用水平的推荐值 Recommendation for hyaluronic acid flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
|
安全参考 Safety references:
欧洲食品安全局（efsa EFSA）参考 :
|
科学的 Scientific 意见 Opinion on the 实证 substantiation of a health claim 有关 related to 透明质酸 Hyaluronic Acid USP and 保护 protection of the skin 反对 against 脱水 dehydration 根据 pursuant to Article 13(5) of 规 Regulation (EC) No 1924/2006
视图 View page or 视图 View pdf
|
| Epi系统 EPI System: 视图 View |
| Clinicaltrials.gov ClinicalTrials.gov:search |
| 每日医学 Daily Med:search |
| nlm NLM有害物质数据库 :搜索 Search |
| 辅助引文 AIDS Citations:搜索 Search |
| 癌症引文 Cancer Citations:搜索 Search |
| 毒理学引文 Toxicology Citations:搜索 Search |
| 环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search |
| 橙花发育和 毒性 NLM Developmental and Reproductive Toxicity:搜索 Search |
| EPA物质注册服务（tsca TSCA） :9004-61-9 |
| EPA ACToR:毒理学资料 Toxicology Data |
| EPA物质注册服务（SRS） :注册表 Registry |
| 实验室化学安全摘要 Laboratory Chemical Safety Summary :24759 |
| 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data |
| (2s (2S,3s 3S,4s 4S,5r 5R,6r）-6-[（2秒 6R)-6-[(2S,3r 3R,5s 5S,6r）-3-乙酰氨基-2-[（2s 6R)-3-acetamido-2-[(2S,3s 3S,4r 4R,5r 5R,6r）-6-[（2r 6R)-6-[(2R,3r 3R,5s 5S,6r）-3-乙酰氨基2 6R)-3-acetamido-2,5-二羟基-6-（羟甲基）恶烷-4-基]氧基-2-羧基-4 5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-二氢 5-dihydr |
| chemidplus Chemidplus:0009004619 |
参考资料 References:
| | (2s (2S,3s 3S,4s 4S,5r 5R,6r）-6-[（2秒 6R)-6-[(2S,3r 3R,5s 5S,6r）-3-乙酰氨基-2-[（2s 6R)-3-acetamido-2-[(2S,3s 3S,4r 4R,5r 5R,6r）-6-[（2r 6R)-6-[(2R,3r 3R,5s 5S,6r）-3-乙酰氨基2 6R)-3-acetamido-2,5-二羟基-6-（羟甲基）恶烷-4-基]氧基-2-羧基-4 5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-二氢 5-dihydr |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| 加拿大国内分公司。清单 Canada Domestic Sub. List: | 9004-61-9 |
| pubchem（cid） Pubchem (cid): | 24759 |
| pubchem（sid） Pubchem (sid): | 134989201 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and 核心 core components note
潜在用途 Potential Uses:
| | 抗静电剂 antistatic agents |
| | 湿润剂 humectants |
存在（自然 Occurrence (nature, food, 其他） other): note
同义词 Synonyms:
| | biopolymer Bha HA-10 | | | biopolymer ha HA-24 | | | biopolymer sa-n SA-N | | | 透明质酸 Hyaluronic Acid USP 美国邮政 USP | | | Luronitluronit luronitluronit | | | 粘蛋白 mucoitin | | | 隔离层 sepra涂层 coat | | | Synvisc synvisc |
文章 Articles:
| 已发布 PubMed:透明质酸和磷脂的紫杉醇新型高分子胶束的合成与优化 Synthesis and optimization of a novel polymeric micelle based on hyaluronic acid and phospholipids for delivery of paclitaxel, 体外和体内评估。 in vitro and in-vivo evaluation. |
| 已发布 PubMed:水飞蓟素在ccl4处理的大鼠肝损伤的早期阶段抑制纤维化的进程。 Silymarin Inhibits the Progression of Fibrosis in the Early Stages of Liver Injury in CCl4-Treated Rats. |
| 已发布 PubMed:透明质酸有益作用。 Beneficial effects of hyaluronic Acid. |
| 已发布 PubMed:从海洋生物中分离和鉴定透明质酸。 Isolation and characterization of hyaluronic Acid from marine organisms. |
| 已发布 PubMed:药物诱导的离子胶凝技术靶向前列腺癌的顺二氯二氨基铂（ii）糖纳米颗粒 cis-Dichlorodiamminoplatinum (II) glyconanoparticles by drug-induced ionic gelation technique targeted to prostate cancer: 制备 Preparation, 优化和体外表征。 optimization and in vitro characterization. |
| 已发布 PubMed:金黄熊果透明质酸酶是一种由科迪调节的毒力因子。 Staphylococcus aureus Hyaluronidase Is a CodY-Regulated Virulence Factor. |
| 已发布 PubMed:血细胞转录组学作为香柳叶菜健康改善的潜在生物标志物的来源 Blood cells transcriptomics as source of potential biomarkers of articular health improvement: 摄入富含透明质酸公鸡梳子的效果。 effects of oral intake of a rooster combs extract rich in hyaluronic acid. |
| 已发布 PubMed:高产新型水ech透明质酸酶可加快特定透明质酸寡聚物的制备。 High-yield novel leech hyaluronidase to expedite the preparation of specific hyaluronan oligomers. |
| 已发布 PubMed:黃芩和阿拉伯树胶提取物的组合，可短期缓解与膝骨节螺藻相关的香柳叶菜不适。 A combination of Scutellaria baicalensis and Acacia catechu extracts for short-term symptomatic relief of joint discomfort associated with osteoarthritis of the knee. |
| 已发布 PubMed:中脸和口周体积恢复 Midface and perioral volume restoration: 美国和意大利之间的对话。 a conversation between the US and Italy. |
| 已发布 PubMed:壳聚糖基聚电解质复合物与天然多糖的药物开发新进展。 Recent development of chitosan-based polyelectrolyte complexes with natural polysaccharides for drug delivery. |
| 已发布 PubMed:2014年面部增容 Facial volume augmentation in 2014: 各种填料选项的概述。 overview of different filler options. |
| 已发布 PubMed:自体骨髓浓缩液 Autologous bone marrow concentrate: 软骨疾病的新型香柳叶菜内矫形器的综述和应用。 review and application of a novel intra-articular orthobiologic for cartilage disease. |
| 已发布 PubMed:皮肤科手术的现状。 Current status of surgery in dermatology. |
| 已发布 PubMed:透明质酸填充剂用于中脸容容不足 Volumizing hyaluronic acid filler for midface volume deficit: 一项关键的单盲随机对照研究的2年结果。 2-year results from a pivotal single-blind randomized controlled study. |
| 已发布 PubMed:透明质酸软组织填充物的生物物理特性及其与美学应用的相关性。 Biophysical characteristics of hyaluronic acid soft-tissue fillers and their relevance to aesthetic applications. |
| 已发布 PubMed: 酸碱度 pH值透明质酸腻子形成机理的研究 : 第二部分-理论分析。 part II--theoretical analysis. |
| 已发布 PubMed: 酸碱度 pH值透明质酸腻子形成机理的研究 : 第一部分实验测量。 part I. Experimental measurements. |
| 已发布 PubMed:最优化摇瓶培养基和马链球菌突变体nc2168生产透明质酸条件。 Optimization of flask culture medium and conditions for hyaluronic acid production by a Streptococcus equisimilis mutant nc2168. |
| 已发布 PubMed: 芋（colocasia esculenta esculenta l.shott）生长条件对酚类成分和生物学特性的影响 |
| 已发布 PubMed:可能适合制备三维皮肤替代品的支架的细胞毒性测试。 Cytotoxicity testing of scaffolds potentially suitable for the preparation of three-dimensional skin substitutes. |
| 已发布 PubMed:胶原蛋白水解物的摄入改善了无毛小鼠中uvb照射引起的表皮屏障功能的丧失和皮肤弹性。 Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice. |
| 已发布 PubMed:自由基解聚得到的透明质酸寡糖的在线分离和表征。 On-line separation and characterization of hyaluronan oligosaccharides derived from radical depolymerization. |
| 已发布 PubMed:低分子量透明质酸免疫刺激和抗血管生成活性。 Immunostimulatory and antiangiogenic activities of low molecular weight hyaluronic acid. |
| 已发布 PubMed:体外产生的猪胚胎的胚胎发育和性别比受能量底物和添加到培养基中的透明质酸影响。 Embryo development and sex ratio of in vitro-produced porcine embryos are affected by the energy substrate and hyaluronic acid added to the culture medium. |
| 已发布 PubMed:鸡肠和胰腺的蛋白水解活性 Proteolytic activity from chicken intestine and pancreas: 萃取 extraction, 鸡精分离透明质酸部分表征及应用。 partial characterization and application for hyaluronic acid separation from chicken comb. |
| 已发布 PubMed:12个月 A 12-month, 预期 prospective, 评估者对小凝胶透明质酸填充物在颞窝体积丢失的校正中的盲法研究。 evaluator-blinded study of small gel particle hyaluronic acid filler in the correction of temporal fossa volume loss. |
| 已发布 PubMed:内镜治疗小儿膀胱输尿管反流 Endoscopic treatment of vesicoureteral reflux in pediatric patients. |
| 已发布 PubMed:水分和干燥对天然透明质酸物理结构的影响。 Influence of water content and drying on the physical structure of native hyaluronan. |
| 已发布 PubMed:4-甲基点地梅酮在体外和体内抑制血管生成。 4-methylumbelliferone inhibits angiogenesis in vitro and in vivo. |
| 已发布 PubMed:生物可吸收的铁交联的透明质酸附着力预防溶液的相对稳定性。 Comparative stability of the bioresorbable ferric crosslinked hyaluronic acid adhesion prevention solutions. |
| 已发布 PubMed:注射式干细胞疗法结合再生药物进行乳头再生 Papilla regeneration by injectable stem cell therapy with regenerative medicine: 长期临床预后。 long-term clinical prognosis. |
| 已发布 PubMed:脂肪间质血管分数细胞移植后会形成什么组织？ What tissue is formed after graft of adipose-derived stromal vascular fraction cells? |
| 已发布 PubMed:用聚甲基丙烯酸甲酯增强的填料增强黄斑 Malar augmentation with a polymethylmethacrylate-enhanced filler: 一项为期12个月的开放标签试验研究的评估。 assessment of a 12-month open-label pilot study. |
| 已发布 PubMed:［使用不同配方的透明质酸钠膜评估术后粘连的评估］。 [Evaluation of postsurgical adhesion prevention using different formulated sodium hyaluronate membranes]. |
| 已发布 PubMed:硫酸软骨素 Chondroitin sulfate, 使用海洋废物源生产透明质酸和甲壳素/壳聚糖 hyaluronic acid and chitin/chitosan production using marine waste sources: 特点 characteristics, 应用和环保流程 applications and eco-friendly processes: 回顾。 a review. |
| 已发布 PubMed:一种基于纳米多孔膜的阻抗免疫传感器，用于无标记检测全脂牛奶中的致病菌。 A nanoporous membrane-based impedimetric immunosensor for label-free detection of pathogenic bacteria in whole milk. |
| 已发布 PubMed:透明质酸酶表达和生物膜参与金黄熊果uams-1及其萨拉 Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr和sara agr调节突变体。 agr and sarA agr regulatory mutants. |
| 已发布 PubMed:香柳叶菜内鲑鱼降钙素基纳米复合物可减少实验性炎症性节螺藻。 An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis. |
| 已发布 PubMed: 希兰 hylan - g-f 20表面修饰对滑膜外犬腱移植物滑行的影响。 |
| 已发布 PubMed:口服乙酰透明质酸可减少去 大鼠的骨转换。 Oral administration of hyaluronan reduces bone turnover in ovariectomized rats. |
| 已发布 PubMed:以hplc-dad-esi-msn为特征的叶绿素的提取物 Phlorotannin extracts from fucales characterized by HPLC-DAD-ESI-MSn: 透明质酸酶抑制能力和抗氧化性能的方法。 approaches to hyaluronidase inhibitory capacity and antioxidant properties. |
| 已发布 PubMed:胚芽头尾机车行为的定量分析 Quantitative analysis of locomotive behavior of human sperm head and tail. |
| 已发布 PubMed:注射式面部填充剂的当代评论。 Contemporary review of injectable facial fillers. |
| 已发布 PubMed:自体脂肪移植和可注射的皮肤填充剂用于 类免疫缺陷 相关的面部脂肪营养不良 Autologous fat grafting and injectable dermal fillers for human immunodeficiency virus-associated facial lipodystrophy: 安全性比较 a comparison of safety, 功效 efficacy, 和长期治疗结果。 and long-term treatment outcomes. |
| 已发布 PubMed:六 Six 脚步 steps to the "完善 perfect" lip. |
| 已发布 PubMed:最佳填料 The optimal filler: 乳化有机硅的即时和长期效果（1 immediate and long-term results with emulsified silicone (1,000厘oke）与交联的透明质酸。 000 centistokes) with cross-linked hyaluronic acid. |
| 已发布 PubMed:培养基优化了一种新型的具有优异保水活性的细菌细胞外多糖。 Culture medium optimization of a new bacterial extracellular polysaccharide with excellent moisture retention activity. |
| 已发布 PubMed:[关于透明质酸钠面部皮肤填充剂注册的想法]。 [Ideas about registration for sodium hyaluronate facial derma fillers]. |
| 已发布 PubMed: michelia alba提取物通过 皮肤成纤维细胞中的map激酶途径减弱uvb诱导的基质金属蛋白酶表达。 |
| 已发布 PubMed:基于细胞的糖胺聚糖微尺度分离，用于糖组学研究。 Cell-Based Microscale Isolation of Glycoaminoglycans for Glycomics Study. |
| 已发布 PubMed:氨基葡萄糖及其相关物质的生物活性。 Biological activities of glucosamine and its related substances. |
| 已发布 PubMed:[原发性膀胱输尿管反流的治疗选择 [Therapeutic options for primary vesicoureteral reflux: 内镜与开放式手术方法] endoscopic vs open surgical approach]. |
| 已发布 PubMed:自体脂肪组织衍生的干细胞在坏死性股骨头中诱导持久的骨样组织。 Autologous adipose tissue-derived stem cells induce persistent bone-like tissue in osteonecrotic femoral heads. |
| 已发布 PubMed:肽和胶原蛋白肽对正常 真皮成纤维细胞胶原蛋白合成的影响 Effects of soybean peptide and collagen peptide on collagen synthesis in normal human dermal fibroblasts. |
| 已发布 PubMed:下肢静脉溃疡。 Venous leg ulcers. |
| 已发布 PubMed:遗传毒性 Genotoxicity, 富含透明质酸钠的公鸡梳提取物在大鼠中的急性和亚慢性毒性研究。 acute and subchronic toxicity studies in rats of a rooster comb extract rich in sodium hyaluronate. |
| 已发布 PubMed:透明质酸微生物生产 Microbial production of hyaluronic acid: 当前状态 current state, 挑战 challenges, 和观点。 and perspectives. |
| 已发布 PubMed: 富含野生蓝莓（v。angustifolium）的饮食会改变自发性高血压大鼠的主动脉糖胺聚糖特性。 |
| 已发布 PubMed:低分子量透明质酸抗氧化活性。 Antioxidant acitivity of low molecular weight hyaluronic acid. |
| 已发布 PubMed:[macrolane（®） [Macrolane(®), 隆乳过早的迹象。专注于产品的最新知识]。 a too premature indication in breast augmentation. Focusing on current knowledge of the product]. |
| 已发布 PubMed:输尿管反流治疗对尿路感染发生率的影响。 The impact of vesicoureteral reflux treatment on the incidence of urinary tract infection. |
| 已发布 PubMed:重组嗜热链球菌生产透明质酸。 Hyaluronic acid production by recombinant Streptococcus thermophilus. |
| 已发布 PubMed:颗石藻并伴颗石藻。 Pleuropulmonary paragonimiasis with intrathoracic mass. |
| 已发布 PubMed:离子交联的透明质酸 Ionically cross-linked hyaluronic acid: 湿润的 wetting, 润滑 lubrication, 改性的粘合屏障凝胶的粘弹性。 and viscoelasticity of a modified adhesion barrier gel. |
| 已发布 PubMed:0.18％透明质酸钠眼药水治疗干眼病的疗效证明 Demonstration of efficacy in the treatment of dry eye disease with 0.18% sodium hyaluronate ophthalmic solution (vismed, 雷耶纳 rejena）。 |
| 已发布 PubMed:炒作的影响 Effects of Pro-Hyp, 胶原蛋白水解物衍生肽 a collagen hydrolysate-derived peptide, 体外培养的滑膜细胞合成透明质酸和口服摄取骨胶原豚鼠模型中的胶原蛋白水解产物的研究 on hyaluronic acid synthesis using in vitro cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis. |
| 已发布 PubMed:什么 What's New in 填充物 Fillers in 2010? |
| 已发布 PubMed:啤酒花出口透明质酸抑制剂可防止骨节螺藻反应。 Inhibitors of hyaluronan export from hops prevent osteoarthritic reactions. |
| 已发布 PubMed:（85）sr在大鼠中解体的生物材料。 Biomaterials for the decorporation of (85)Sr in the rat. |
| 已发布 PubMed:果实（水果）对紫外线引起的 皮肤成纤维细胞光老化的作用 Effect of Emblica officinalis (fruit) against UVB-induced photo-aging in human skin fibroblasts. |
| 已发布 PubMed:ph对合成的影响 pH effect on the synthesis, 剪切性能 shear properties, 铁交联的透明质酸凝胶/粘附屏障的均质性和均一性。 and homogeneity of iron-crosslinked hyaluronic acid-based gel/adhesion barrier. |
| 已发布 PubMed:透明质酸共聚物（dx / ha）的内镜治疗初次v型膀胱输尿管反流。 Endoscopic treatment of primary grade V vesicoureteral reflux using hyaluronic acid copolymer (DX/HA). |
| 已发布 PubMed:拟南芥20cc的外生聚合物生产 Exobiopolymer production of Ophiocordyceps dipterigena BCC 2073: 优化 optimization, 生物反应器的生产和表征。 production in bioreactor and characterization. |
| 已发布 PubMed:皮肤科软组织增大术-2009更新。 Soft tissue augmentation in dermatology - 2009 update. |
| 已发布 PubMed:胶原衍生的二肽 Collagen-derived dipeptide, 脯氨酸羟脯氨酸 proline-hydroxyproline, 刺激培养的 类皮肤成纤维细胞中的细胞增殖和透明质酸合成。 stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. |
| 已发布 PubMed: 希兰 Hylan - g-f 20在症状性肱骨肱骨节螺藻中的疗效和安全性 : 预期的 a prospective, 试验研究。 pilot study. |
| 已发布 PubMed:高脂饮食可降低大鼠皮肤中I型原胶原和透明质酸水平。 High-fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin. |
| 已发布 PubMed:一组熊果物种精选菌株中透明质酸酶的基因型和表型评估。 Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species. |
| 已发布 PubMed:葛根及其水解产物对nhek细胞中透明质酸产生的刺激作用的Comparison of Puerariae Radix and its hydrolysate on stimulation of hyaluronic acid production in NHEK cells. |
| 已发布 PubMed:越桔提取物对培养的 角膜缘上皮细胞（hclec）的保护作用。 Protective effect of bilberry (Vaccinium myrtillus L.) extracts on cultured human corneal limbal epithelial cells (HCLEC). |
| 已发布 PubMed:填料革命 The filler revolution: 六年回顾展。 a six-year retrospective. |
| 已发布 PubMed:微创治疗美学区乳头状缺陷 Minimally invasive treatment for papillae deficiencies in the esthetic zone: 初步研究。 a pilot study. |
| 已发布 PubMed:artefill永久性注射剂，用于软组织扩张 ArteFill permanent injectable for soft tissue augmentation: ii。适应症和应用。 II. Indications and applications. |
| 已发布 PubMed:枯草芽孢杆菌纳豆发酵黄芪对 皮肤细胞透明质酸产生的刺激作用。 Stimulating effects of Bacillus subtilis natto-fermented Radix astragali on hyaluronic acid production in human skin cells. |
| 已发布 PubMed:注射剂 Injectable fillers: 美国的观点。 an American perspective. |
| 已发布 PubMed:透明质酸可治疗脚踝骨节螺藻。 Hyaluronic acid as a treatment for ankle osteoarthritis. |
| 已发布 PubMed:胶原蛋白真皮填充剂 Collagen-based dermal fillers: 过去 past, 当下 present, 未来。 future. |
| 已发布 PubMed:可注射面部填充剂的历史。 The history of injectable facial fillers. |
| 已发布 PubMed:测试其在有机和水性介质中的自由基清除能力时的高摩尔质量透明质酸行为 High-molar-mass hyaluronan behavior during testing its radical scavenging capacity in organic and aqueous media: 锰（ii）离子存在的影响。 effects of the presence of manganese(II) ions. |
| 已发布 PubMed:嗜热链球菌产生胞外多糖，包括透明质酸。 Streptococcus thermophilus produces exopolysaccharides including hyaluronic acid. |
| 已发布 PubMed:幼稚可注射凝胶 Juvéderm injectable gel: 多中心 a multicenter, 双盲 double-blind, 安全性和有效性的随机研究。 randomized study of safety and effectiveness. |
| 已发布 PubMed:吸收 Absorption, 大鼠和狗口服高分子量透明质酸摄取和组织亲和力。 uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs. |
| 已发布 PubMed:荧光团辅助碳水化合物电泳对酶促透明质酸定量和表征。 Quantification and characterization of enzymatically produced hyaluronan with fluorophore-assisted carbohydrate electrophoresis. |
| 已发布 PubMed:葡聚糖/透明质酸共聚物用于膀胱输尿管反流的治疗。 Dextranomer/hyaluronic acid copolymer for the treatment of vesicoureteral reflux. |
| 已发布 PubMed:活动而不是食物消耗导致骨节螺藻生物标志物发生变化。 Variation in osteoarthritis biomarkers from activity not food consumption. |
| 已发布 PubMed:-l-乳酸植入物治疗鼻唇沟的评估 Evaluation of the poly-L-lactic acid implant for treatment of the nasolabial fold: 3年随访评估。 3-year follow-up evaluation. |
| 已发布 PubMed:透明质酸凝胶填充剂可管理面部衰老。 Hyaluronic acid gel fillers in the management of facial aging. |
| 已发布 PubMed:透明质酸皮肤填充剂的科学。 The science of hyaluronic acid dermal fillers. |
| 已发布 PubMed: 的透明质酸对乙酰氨基酚引起的急性肝毒性的影响。 Effect of gamma irradiated hyaluronic acid on acetaminophen induced acute hepatotoxicity. |
| 已发布 PubMed:下肢静脉溃疡。 Venous leg ulcers. |
| 已发布 PubMed:透明质酸在15摄氏度下储存3天后会延迟公猪胚芽获能。 Hyaluronic acid delays boar sperm capacitation after 3 days of storage at 15 degrees C. |
| 已发布 PubMed:透明质酸填充剂和A型肉毒杆菌毒素 Hyaluronic acid fillers and botulinum toxin type a: 他们的个 理由和联合使用可注射的面部复兴。 rationale for their individual and combined use for injectable facial rejuvenation. |
| 已发布 PubMed:非动物性透明质酸填充剂 Non-animal-based hyaluronic acid fillers: 科学和技术方面的考虑。 scientific and technical considerations. |
| 已发布 PubMed:透明质酸与透明质酸治疗膝盖骨节螺藻 Hylan versus hyaluronic acid for osteoarthritis of the knee: 系统的审查和荟萃分析。 a systematic review and meta-analysis. |
| 已发布 PubMed:野猪胚芽和前列腺素f2alpha。在冷却过程中向短期补充剂中添加前列腺素f2alpha后，公猪胚芽的质量。 Boar spermatozoa and prostaglandin F2alpha. Quality of boar sperm after the addition of prostaglandin F2alpha to the short-term extender over cooling time. |
| 已发布 PubMed:对非动物稳定的透明质酸注射液的持续性迟发型超敏反应。 Persistent delayed-type hypersensitivity reaction to injectable non-animal-stabilized hyaluronic acid. |
| 已发布 PubMed:农杆菌属重组重组乙酰透明质酸 Recombinant synthesis of hyaluronan by Agrobacterium sp. |
| 已发布 PubMed:随机的 A randomized, 评估者盲法比较透明质酸凝胶和禽源的希兰 hylan b plus凝胶对鼻唇沟的矫正效果。 |
| 已发布 PubMed:审查未经fda批准的填料。 Review of non-FDA-approved fillers. |
| 已发布 PubMed:羧甲基化的（1-3）-β-d-葡聚糖可保护脂质体免受紫外线诱导的脂质过氧化作用。 Carboxymethylated (1 --> 3)-beta-D-glucan protects liposomes against ultraviolet light-induced lipid peroxidation. |
| 已发布 PubMed:年轻女性的非血红素铁吸收不受纯化的硫酸化和未硫酸化的糖胺聚糖的影响。 Nonheme iron absorption in young women is not influenced by purified sulfated and unsulfated glycosaminoglycans. |
| 已发布 PubMed:透明质酸填充剂 Hyaluronic acid fillers: hylaform和captique。 Hylaform and Captique. |
| 已发布 PubMed:kukui坚果油可提供适量的润滑而不会留下油腻感。非常适合干裂的皮肤，可以防止疤痕。以10％-15％的稀释度使用。用于制皂 Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: 一项随机对照试验。 a randomized controlled trial. |
| 已发布 PubMed:在白内障手术中处理疑难病例的辅助设备 Adjunct devices for managing challenging cases in cataract surgery: 囊膜染色和眼科内窥镜手术设备。 capsular staining and ophthalmic viscosurgical devices. |
| 已发布 PubMed:伦理 Ethics, 法律问题 legal issues, 并同意使用填充物。 and consent for fillers. |
| 已发布 PubMed:水解鸡胸骨软骨制剂在大鼠中的急性和亚慢性口腔毒性研究。 Acute and subchronic oral toxicity studies in rats of a hydrolyzed chicken sternal cartilage preparation. |
| 已发布 PubMed:关于真皮填充剂注射的患者安全考虑。 Patient safety considerations regarding dermal filler injections. |
| 已发布 PubMed:可注射的软组织填充剂 Injectable soft-tissue fillers: 临床概述。 clinical overview. |
| 已发布 PubMed:海藻糖和透明质酸可协调稳定冻干胰腺激肽原酶。 Trehalose and hyaluronic acid coordinately stabilized freeze-dried pancreatic kininogenase. |
| 已发布 PubMed:葡聚糖/透明质酸共聚物时代膀胱输尿管反流管理的演变 The evolution of vesicoureteral reflux management in the era of dextranomer/hyaluronic acid copolymer: 儿科健康信息系统数据库研究。 a pediatric health information system database study. |
| 已发布 PubMed:皮肤填充剂 Dermal filler agents: 实用评论。 a practical review. |
| 已发布 PubMed:一crocrotaline暴露后，抗凝和一氧化氮合酶的抑制会影响肝脏缺氧。 Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure. |
| 已发布 PubMed:透明质酸填充剂。 Hyaluronic acid fillers. |
| 已发布 PubMed:软组织增强2006 Soft tissue augmentation 2006: 填料幻想。 filler fantasy. |
| 已发布 PubMed:对非动物稳定的透明质酸超敏反应。 Hypersensitivity reaction to nonanimal stabilized hyaluronic acid. |
| 已发布 PubMed:简单的抽吸技术，以解决与经尿道 /透明质酸共聚物经尿道注射相关的排尿障碍。 Simple aspiration technique to address voiding dysfunction associated with transurethral injection of dextranomer/hyaluronic acid copolymer. |
| 已发布 PubMed:乳清蛋白对d-半乳糖胺诱发的肝炎和肝纤维化的肝保护作用。 Hepatoprotective effects of whey protein on D-galactosamine-induced hepatitis and liver fibrosis in rats. |
| 已发布 PubMed:用于软组织增强的填充剂的数量和种类不断增加。 The number and variety of filling agents for soft tissue augmentation are continually increasing. |
| 已发布 PubMed:儿童中心内镜治疗输尿管反流的单中心经验。 Single center experience with endoscopic management of vesicoureteral reflux in children. |
| 已发布 PubMed:和苦姜黄对链脲佐菌素诱导的糖尿病大鼠不同组织糖胺聚糖成分的影响 Effect of bitter gourd and spent turmeric on constituents of glycosaminoglycans in different tissues in streptozotocin induced diabetic rats. |
| 已发布 PubMed:葡聚糖/透明质酸用于膀胱输尿管反流 Dextranomer/hyaluronic acid for vesicoureteral reflux: 初始治疗失败后的成功率。 success rates after initial treatment failure. |
| 已发布 PubMed:食物摄入提高 体透明质酸循环水平的机制。 Mechanisms by which food intake elevates circulating levels of hyaluronan in humans. |
| 已发布 PubMed:2.5％透明质酸凝胶中3％的双氯芬酸用于治疗光化性角化病 Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: 对最近研究的荟萃分析。 a meta-analysis of the recent studies. |
| 已发布 PubMed:内镜治疗膀胱输尿管反流。 Endoscopic treatment of vesicoureteral reflux. |
| 已发布 PubMed:天然的透明质酸比交联的透明质酸产生的超敏反应少。 Native hyaluronan produces less hypersensitivity than cross-linked hyaluronan. |
| 已发布 PubMed:助焊剂会改变膀胱输尿管返流儿童的治疗方式吗？ Does deflux alter the paradigm for the management of children with vesicoureteral reflux? |
| 已发布 PubMed:非醇性脂肪性肝炎的机制。 Mechanisms of non-alcoholic steatohepatitis. |
| 已发布 PubMed: 使用雷公烷 Restylane增强软组织。 |
| 已发布 PubMed:纤维蛋白在脂多糖-雷尼替丁共同暴露中在特发性样肝损伤中的作用 Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. |
| 已发布 PubMed:膀胱输尿管反流 Vesicoureteral reflux: 手术方法。 surgical approaches. |
| 已发布 PubMed:科学遇见美丽 Science meets beauty: 用药改善外观。 using medicine to improve appearances. |
| 已发布 PubMed:猪the下脂肪垫的化学成分。 Chemical composition of the infrapatellar fat pad of swine. |
| 已发布 PubMed:香柳叶菜内透明质酸治疗膝骨节螺藻 Intra-articular hyaluronic acid in treatment of knee osteoarthritis: 荟萃分析。 a meta-analysis. |
| 已发布 PubMed:单芥子碱和细菌脂多糖共同暴露在协同肝毒性过程中内皮细胞损伤和凝血系统活化。 Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure. |
| 已发布 PubMed:[皮肤再生药]。 [Regenerative medicine for skin]. |
| 已发布 PubMed:香柳叶菜内透明质酸 Intra-articular hyaluronans: 对产品特定的安全配置文件的审查。 a review of product-specific safety profiles. |
| 已发布 PubMed:内毒素增强黄曲霉毒素b1肝毒性 Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: 内皮和凝血系统的参与。 involvement of endothelium and the coagulation system. |
| 已发布 PubMed:环境污染对p 组织中糖胺聚糖含量的影响。 The influence of environmental pollution on the amount of glycosoaminoglycans in the tissue of palatine tonsils. |
| 已发布 PubMed:tnfalpha和il-8调节 结肠癌细胞中cd44变异蛋白的表达和功能 TNFalpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells. |
| 已发布 PubMed:鸡蛋壳中的半乳糖胺聚糖成分。 Galactosaminoglycan composition in chicken eggshell. |
| 已发布 PubMed:透明质酸在流延下的流变学。 Rheology of hyaluronan solutions under extensional flow. |
| 已发布 PubMed:用于组织工程应用的可生物降解材料的简介。 An introduction to biodegradable materials for tissue engineering applications. |
| 已发布 PubMed:从鸡壳中提取糖胺聚糖。 Extraction of glycosaminoglycans from chicken eggshell. |
| 已发布 PubMed:当前的膀胱肿瘤检查 Current bladder tumor tests: 他们的预计效用是否满足临床需要？ does their projected utility fulfill clinical necessity? |
| 已发布 PubMed:透明质酸-吉兰糖混合物凝胶行为的流变学证据。 Rheological evidence of the gelation behavior of hyaluronan-gellan mixtures. |
| 已发布 PubMed:0.1 m乙酸钠从牛鼻软骨中提取糖胺聚糖肽。 Extraction of Glycosaminoglycan Peptide from Bovine Nasal Cartilage with 0.1 M Sodium Acetate. |
| 已发布 PubMed:注射剂治疗女性压力性尿失禁 Injectable agents in the treatment of stress urinary incontinence in women: 我们现在在哪？ where are we now? |
| 已发布 PubMed:概观 Overview: 软组织增大。 soft tissue augmentation. |
| 已发布 PubMed:粘液补充 Viscosupplementation: 膝骨节螺藻的治疗机制和临床潜力。 therapeutic mechanisms and clinical potential in osteoarthritis of the knee. |
| 已发布 PubMed:从 鹿的 中分离并鉴定蛋白聚糖。 Isolation and characterization of proteoglycans from growing antlers of wapiti (Cervus elaphus). |
| 已发布 PubMed:饮食对肝硬化患者血浆透明质酸影响 Effects of eating on plasma hyaluronan in patients with cirrhosis: 其作用机理及其对临床解释的影响。 its mechanism and influence on clinical interpretation. |
| 已发布 PubMed:吡非尼酮或曲安奈德治疗的无胸腺小鼠中瘢痕loid植入物的复性 Involution of keloid implants in athymic mice treated with pirfenidone or with triamcinolone. |
| 已发布 PubMed:血浆透明质酸浓度 Plasma hyaluronan concentration: 没有昼夜节律，但对 类的食物摄取影响很大。 no circadian rhythm but large effect of food intake in humans. |
| 已发布 PubMed:隔离 Isolation, （鹿）生长 中糖胺聚糖的特性和定位。 characterization and localization of glycosaminoglycans in growing antlers of wapiti (Cervus elaphus). |
| 已发布 PubMed:慢性肝病患者餐后血清透明质酸浓度 Post-prandial serum hyaluronan concentration in patients with chronic liver disease. |
| 已发布 PubMed:慢性肝病患者血清中透明质酸分子量 Molecular weight of hyaluronate in the serum of patients with chronic liver disease. |
| 已发布 PubMed:香柳叶菜内透明质酸注射液治疗膝盖骨节螺藻。 Intra-articular hyaluronan injections for treatment of osteoarthritis of the knee. |
| 已发布 PubMed:来自猪膝盖半月板不同区域的糖胺聚糖和蛋白聚糖。 Glycosaminoglycans and proteoglycans from different zones of the porcine knee meniscus. |
| 已发布 PubMed:增加 公司 Increased 等级 水平 levels of 透明质酸 hyaluronan and 白蛋白 albumin 后 after 肠 intestinal 挑战 challenge in 成 adult 耐心 patients with cow's 牛奶 milk 不宽容 进入 intolerance. |
| 已发布 PubMed:细菌多糖在疾病和健康中。 1995年弗莱明演讲。 Bacterial polysaccharides in sickness and in health. The 1995 Fleming Lecture. |
| 已发布 PubMed:过敏和非过敏患者的肠道反应性 Intestinal reactivity in allergic and nonallergic patients: 一种确定粘膜反应复合物性的方法。 an approach to determine the complexity of the mucosal reaction. |
| 已发布 PubMed:空肠内元素饮食灌注对免疫球蛋白空肠分泌的影响 Effect of intrajejunal elemental diet perfusion on jejunal secretion of immunoglobulins, 白蛋白 albumin, 和透明质酸男 。 and hyaluronan in man. |
| 已发布 PubMed:［关于中草药和食品原味的抗氧化活性研究］。 [Antioxidative activity studies on the meaning of same original of herbal drug and food]. |
| 已发布 PubMed:锰病。生化和体视学研究，特别涉及磷酸盐的作用。 Manganese rickets. A biochemical and stereologic study with special reference to the effect of phosphate. |
| 已发布 PubMed:[橙花胶制剂的毒理卫生特性 [Toxicologic-hygienic characteristics of the preparation nerosin, 保护遭受风蚀的植物和土壤的试剂]。 an agent for protecting plants and soils subject to wind erosion]. |
| 已发布 PubMed:两栖动物消化道的研究 Studies on the alimentary canal of amphipods: talalchestia 马滕西 martensii（weber）（甲壳纲）头状粘液腺的组织化学 : ampampoda）。 Amphipoda). |
| 已发布 PubMed:围产期和围产期限制食物摄入对大鼠脑中硫酸化糖胺聚糖浓度的影响。 Effects of pre- and peri-natal restricted food intake on sulphated glycosaminoglycan concentrations in rat brain. |
| 已发布 PubMed:印度龙虾thenus Orientalis（lund）的研究 Studies on the Indian sand lobster Thenus orientalis (Lund): 皮层腺的粘多糖。 mucopolysaccharides of the tegumental glands. |
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一种天然的高粘度粘多糖，具有交替的β（1-3）葡糖醛酸苷和β（1-4）葡糖胺酸键。在脐带中发现 a natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. it is found in the umbilical cord, 在玻璃体和滑液中。早衰发现尿液水平高。透明质酸（公顷） in vitreous body and in synovial fluid. a high urinary level is found in progeria. Hyaluronic acid (HA), 是哺乳动物组织中含量最丰富的糖胺聚糖（gag）。它以高浓度存在于结缔组织中 is the most abundant glycosaminoglycan (GAG) in mammalian tissue. It is present in high concentrations in connective tissue, 如皮 such as skin, 玻璃体 vitreous humor, 软骨 cartilage, 和脐带 and umbilical cord, 但最大的单个储层是穿刺香柳叶菜的滑液（sf） but the largest single reservoir is the synovial fluid (SF) of the diarthrodial joints, 浓度达到0.5-4 mg / ml。透明质酸 where concentrations of 0.5-4 mg/mL are achieved. Hyaluronic acid, 是香柳叶菜科幻小说的主要流体动力学非蛋白质成分。其独特的粘弹性能赋予科幻 SF出色的减震和润滑能力 , （z）肉桂酸甲酯（2z）-3-苯基-2-丙烯酸甲酯（2z）-3-苯基丙烯酸甲酯（2z）-3-苯基丙-2-丙烯酸甲酯（z）-3-苯基丙-2 -烯酸肉桂酸甲酯（z）顺式肉桂酸甲酯（2z）-3-苯基-2-丙烯酸酸甲酯（z）-3-苯基-2-丙烯酸酸甲酯2-丙烯酸 while its enormous macromolecular size and hydrophilicity serve to retain fluid in the joint cavity during articulation. HA restricts the entry of large plasma proteins and cells into SF but facilitates solute exchange between the synovial capillaries and cartilage and other joint tissues. In addition, 可以在细胞周围形成细胞包被 HA can form a pericellular coat around cells, 与促炎介质相互作用 interact with proinflammatory mediators, 并与细胞受体结合 and bind to cell receptors, 例如簇决定簇（cd）44和透明质酸介导的运动（rhamm）受体 such as cluster determinant (CD)44 and receptor for hyaluronate-mediated motility (RHAMM), 它调节细胞增殖 where it modulates cell proliferation, 移民 migration, 丁基乙基乙醛丁基乙基乙醛乙基丁基乙醛2-乙基己醛α-乙基己醛2-乙基己醛2-乙基己醛2-乙基己醛乙基丁基乙醛2-乙基己醛a-乙基己醛2-乙基己醛乙基己醛2-乙基己醛2-乙基己醛2-乙基己基醛3-甲醛庚烷3-甲醛庚烷 and gene expression. All these physicochemical and biologic properties of HA have been shown to be molecular weight (MW) dependent. The diverse physicochemical properties of HA arise from its unique macromolecular structure. The HA is an exceptionally long (3-30 μm) and unbranched nonsulfated GAG composed of repeating disaccharide units of N-acetylglucosamine, 葡萄糖醛酸和葡萄糖醛酸通过它们各自的1-4个环位置糖基连接。葡萄糖醛酸基1和葡萄糖基3位的羟基氧用于进一步聚合ha二糖单元以形成链 and glucuronic acid glycosidically linked through their respective 1-4 ring positions. Hydroxyl group oxygens at the glucuronyl-1 and glucosamine 3-positions are used for further polymerization of the HA disaccharide units to form chains that, 从细胞质膜释放时 when released from the cell plasma membrane, 具有可变长度，因此具有多分散性。尽管ha主结构很简单 are of variable length and thus polydispersity. Despite the simplicity of the HA primary structure, 该线性聚电解质在溶液中采用复合物构象 this linear polyelectrolyte adopts complex conformations in solution, 使它具有多种生物学特性。在香柳叶菜腔内 which engender it with diverse biologic properties. Within the joint cavity, ha分子主要由b型滑膜细胞合成。 （pmid 12219318）[hmdb] HA molecules are predominately synthesized by the type B synovial cells. (PMID 12219318) [HMDB]
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