climbazole
1-（4-氯苯氧基）-3 1-(4-clorophenoxy)-3,3-二甲基-1-（咪唑-1-基）-2-丁酮 3-dimethyl-1-(imidazole-1-yl)-2-butanone

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  38083-17-9攀苯唑> 98％ 38083-17-9 Climbazole >98%
  攀克唑是一种局部用抗真菌剂，通常用于治疗 的真马利筋、乳仔草、红乳草、细本乳仔草、千根草肤感染，如头皮屑和湿疹。康达唑已显示出对卵圆形糠ity孢子菌具有很高的体外和体内功效，似乎起着重要作用 Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role

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  ga1965攀克唑 GA1965 Climbazole

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  香气分子独特创新香精的化妆品成分 Symrise aroma molecules & cosmetic ingredients for unique and innovative fragrances, 香料和化妆品。 flavors and cosmetics.
  我们是全球公认的领先香精供应商 We are globally recognized as a leading provider of fragrances, 香水的香精和活性成分以及香气化学物质 flavors and active ingredients as well as aroma chemicals for the perfume, cosmetic, 制药业 pharmaceutical, 食品和饮料行业。 food and beverage industries. 我们结合了有关消费者的知识通过创造力和突破性技术不断变化的需求。在这样做 We combine our knowledge about consumers’ ever- changing needs with creativity and ground-breaking technologies. In doing so, 我们专注于为客户提供附加值的解决方案的开发。 we concentrate on the development of solutions that provide our customers with added value. 我们允许员工和股东分享我们公司的成功，从而确保持续的价值创造。 We ensure sustained value creation by allowing our employees and shareholders to share our Company’s success.
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  600306 Crinipan® AD 生活必需品 Life Essentials - 活跃分子 Actives
  Crinipan® AD is an 抗头皮屑 anti-dandruff dandruff agent. it It 行为 acts 特别 specifically 反对 against the 主要 main 原因 cause of dandruff dandruff, 糠马拉色菌。 the fungus malassezia furfur.

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  c2025攀登唑> 98.0％（hplc）（t） C2025 Climbazole >98.0%(HPLC)(T)

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  Vigon International, 公司 Inc.

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  507268 crinipan ad（climbazole） 507268 Crinipan AD (Climbazole)

Name: 1-（4-氯苯氧基）-1-咪唑-1-基-3 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-二甲基丁-2- 3-dimethylbutan-2-one CAS号 CAS Number: 38083-17-9 3D/INCHI echa ECHA einecs EINECS - REACH 预注册 Pre-Reg: 253-775-4 FDA UNII: 9N42CW7I54 nikkaji网站 Nikkaji Web: J19.421B 贝尔斯坦数 Beilstein Number: 0618020 MDL : mfcd00055505 MFCD00055505 XlogP3-AA: 3.70（est） 3.70 (est) 分子量 Molecular Weight: 292.76489000 式 Formula: c15 h17 cl n2 o2 C15 H17 Cl N2 O2 核磁共振预测器 NMR Predictor: 预测（适用于Chrome或Firefox） Predict (works with chrome or firefox) 类别 Category:antimicrobial preservatives   美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent : 谷歌学术 Google Scholar: 搜索 Search 谷歌书 Google Books: 搜索 Search 谷歌学术 Google Scholar: with word "volatile" 搜索 Search 谷歌学术 Google Scholar: with word "flavor" 搜索 Search 谷歌学术 Google Scholar: with word "odor" 搜索 Search 谷歌专利 Google Patents: 搜索 Search 美国专利 US Patents: 搜索 Search 欧盟专利 EU Patents: 搜索 Search pubchem专利 Pubchem Patents: 搜索 Search 已发布 PubMed: 搜索 Search NCBI: 搜索 Search   物理性质 Physical Properties: 出现 Appearance: 白结晶性粉末（est） white crystalline powder (est) 化验 Assay: 95.00至100.00 95.00 to 100.00 食品化学品法典列表 Food Chemicals Codex Listed: No 沸点 Boiling Point: 447.00 to 448.00 °C. @ 760.00 mm 汞 Hg (est) 闪点 Flash Point: 436.00 °F. tcc TCC ( 224.40 °C. ) (est) logp（o / w） logP (o/w): 3.486（est） 3.486 (est)   感官特性 Organoleptic Properties: 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found).   化妆品信息 Cosmetic Information: CosIng: 化妆品数据 cosmetic data 化妆品用途 Cosmetic Uses: 抗菌剂 antimicrobial agents preservatives   供应商 Suppliers: BOC Sciences 仅供实验/研究使用。 For experimental / research use only. 攀登唑> 98％ Climbazole >98% 气味 Odor: characteristic 采用 Use: 攀克唑是一种局部用抗真菌剂，通常用于治疗 的真马利筋、乳仔草、红乳草、细本乳仔草、千根草肤感染，如头皮屑和湿疹。康达唑已显示出对卵圆形糠ity孢子菌具有很高的体外和体内功效，似乎起着重要作用 Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role Glentham Life Sciences Climbazole 圣克鲁斯生物技术 Santa Cruz Biotechnology 仅供实验/研究使用。 For experimental / research use only. Climbazole sds 西格玛·奥尔德里奇 Sigma-Aldrich 仅供实验/研究使用。 For experimental / research use only. Climbazole PESTANAL®, 分析analytical standard Symrise Crinipan® AD 生活必需品 Life Essentials - 活跃分子 Actives 气味 Odor: characteristic 采用 Use: Crinipan® AD is an 抗头皮屑 anti-dandruff dandruff agent. it It 行为 acts 特别 specifically 反对 against the 主要 main 原因 cause of dandruff dandruff, 糠马拉色菌。 the fungus malassezia furfur. TCI AMERICA 仅供实验/研究使用。 For experimental / research use only. 攀登唑> 98.0％（hplc）（t） Climbazole >98.0%(HPLC)(T) Vigon International 克里尼潘广告（克霉唑） Crinipan AD (Climbazole)   安全信息 Safety Information: 首选sds SDS : 视图 View 欧洲信息 European information : 最重要的危害 Most important hazard(s): xn n-有害 Xn N - Harmful, 对环境有害。 Dangerous for the environment. r 52/53-对水生生物有害 R 52/53 - Harmful to qauatic organisms, 可以 may 原因 cause 长期 long-term 不利的 adverse 效果 effects in the 水 aquatic 环境 environment. S 22 - do Do not 呼吸 breath dust.   危害识别 Hazards identification   物质或混合物的分类 Classification of the substance or mixture 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) 没有找到。 None found. ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements   象形图 Pictogram   危险说明 Hazard statement(s) 没有找到。 None found. 防范说明 Precautionary statement(s) 没有找到。 None found. 口服/肠胃外毒性 Oral/Parenteral Toxicity: 口鼠 oral-rat LD50 400 mg/kg "Prehled 恶作剧 Prumyslove 毒物学 Toxikologie; 有机酮 Organicke 懒汉 Latky," 马尔霍尔德 Marhold, j. J., 布拉格 Prague, 捷克斯洛伐克 Czechoslovakia, 香橙 Avicenum, 1986卷-- 1986Vol. -, pg。 832 Pg. 832, 1986. 皮肤毒性 Dermal Toxicity: 皮鼠 skin 皮-rat LD50 > 5000 mg/kg Farmaco. 卷 Vol. 53, pg。 405 Pg. 405, 1998. 吸入毒性 Inhalation Toxicity: 未定 Not determined   使用安全信息 Safety in Use Information: 类别 Category: antimicrobial preservatives 推荐的攀登唑用量不超过 Recommendation for climbazole usage levels up to:   不用于香水。 not for fragrance use.   推荐的攀克唑风味剂使用水平最高为 Recommendation for climbazole flavor usage levels up to:   不用于调味料。 not for flavor use.   安全参考 Safety references: Epi系统 EPI System: 视图 View 化学致癌研究信息系统 Chemical Carcinogenesis Research Information System:搜索 Search EPA ACToR:毒理学资料 Toxicology Data EPA物质注册服务（SRS） :注册表 Registry 实验室化学安全摘要 Laboratory Chemical Safety Summary :37907 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data 明智的 WISER:联合国3077 UN 3077 德国wgk WGK Germany:3 1-（4-氯苯氧基）-1-咪唑-1-基-3 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-二甲基丁-2- 3-dimethylbutan-2-one chemidplus Chemidplus:0038083179 技术 RTECS:CAS708 38083-17-9的el7085000 EL7085000 for cas# 38083-17-9   参考资料 References:   1-（4-氯苯氧基）-1-咪唑-1-基-3 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-二甲基丁-2- 3-dimethylbutan-2-one NIST化学网络书籍 NIST Chemistry WebBook: 搜索INCHI pubchem（cid） Pubchem (cid): 37907 pubchem（sid） Pubchem (sid): 135001046   其他资料 Other Information: （iupac） (IUPAC): 元素的原子量2009 Atomic Weights of the Elements 2009 （iupac） (IUPAC): 元素的原子量2009（pdf） Atomic Weights of the Elements 2009 (pdf) 影片 Videos: 元素周期表 The Periodic Table of Videos RBC : 本网站使用的原子量 Atomic Weights use for this web site （iupac） (IUPAC): 元素周期表 Periodic Table of the Elements CHEBI: 视图 View CHEMBL: 视图 View hmdb（人类代谢组数据库） HMDB (The Human Metabolome Database): 搜索 Search 出口关税代码 Export Tariff Code: 2933.29.4300 化学蜘蛛 ChemSpider: 视图 View 维基百科 Wikipedia: 视图 View rsc学习化学 RSC Learn Chemistry: 视图 View   潜在搅拌机 Potential Blenders and core 组件 components note 没找到 None Found   潜在用途 Potential Uses:   preservatives   存在（自然 Occurrence (nature, 餐饮 food, 其他） other):note   自然界中找不到 not found in nature   同义词 Synonyms:   baypival baypival   baysan 2- butanone, 1-（4-氯苯氧基）-1-（1h-咪唑-1-基）-3 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl- 2- butanone, 1-（对氯苯氧基）-3 1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)- 1-(4- chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-二甲基-2-丁酮 3-dimethyl-2-butanone 1-(4- chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-二甲基丁-2- 3-dimethylbutan-2-one 1-(4- chlorophenoxy)-1-(1H-imidazolyl)-3,3-二甲基-2-丁酮 3-dimethyl-2-butanone 1-(4- chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl butanone 1-(4- chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone 1-(p- chlorophenoxy)-1-imidazol-1-yl-3,3-二甲基-2-丁酮 3-dimethyl-2-butanone 1-(4- chlorophenoxy)-1-imidazolyl-3,3-二甲基丁-2- 3-dimethylbutan-2-one 1-(p- chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone 1-(4- clorophenoxy)-3,3-二甲基-1-（咪唑-1-基）-2-丁酮 3-dimethyl-1-(imidazole-1-yl)-2-butanone   crinipan AD (Symrise)   文章 Articles: 已发布 PubMed:三氯生作为家用杀菌剂的替代品 Triclosan as a surrogate for household biocides: 对高度城市化地区水生环境中的杀生物剂的调查。 An investigation into biocides in aquatic environments of a highly urbanized region. 已发布 PubMed:同时测定姜黄中三种姜黄素的含量。液相色谱-串联质谱联用加压液体萃取。 Selective determination of antimycotic drugs in environmental water samples by mixed-mode solid-phase extraction and liquid chromatography quadrupole time-of-flight mass spectrometry. 已发布 PubMed:蔗糖酯稳定的固体脂质纳米颗粒和纳米结构脂质载体。 ii。咪唑类抗真菌药物负载的纳米颗粒分散液及其凝胶制剂的评价。 Sucrose ester stabilized solid lipid nanoparticles and nanostructured lipid carriers. II. Evaluation of the imidazole antifungal drug-loaded nanoparticle dispersions and their gel formulations. 已发布 PubMed:蛋白酶活性 Protease activity, 在 的毛囊中的定位和抑制。 localization and inhibition in the human hair follicle. 已发布 PubMed:克霉唑的生态毒性 Ecotoxicity of climbazole, 去头皮屑洗发水中所含的杀菌剂。 a fungicide contained in antidandruff shampoo. 已发布 PubMed:超高效液相色谱-串联质谱法测定从护发产品到 造皮肤和 头皮上的爬克唑的沉积量。 Ultra-high-performance liquid chromatography-tandem mass spectrometry measurement of climbazole deposition from hair care products onto artificial skin and human scalp. 已发布 PubMed:生物固体施用后，在生物固体改良过的土壤和植物中使用典型的唑类杀生物剂。 Typical azole biocides in biosolid-amended soils and plants following biosolid applications. 已发布 PubMed:去屑洗发水的治疗功效 Therapeutic efficacy of anti-dandruff shampoos: 一项基于增强型巯氧吡啶锌和吡啶硫酮锌/克仑唑的产品进行比较的随机临床试验。 a randomized clinical trial comparing products based on potentiated zinc pyrithione and zinc pyrithione/climbazole. 已发布 PubMed:三种唑类杀菌剂克霉唑的发生与消散 Occurrence and dissipation of three azole biocides climbazole, 生物固体改良土壤中的克霉唑和咪康唑。 clotrimazole and miconazole in biosolid-amended soils. 已发布 PubMed:超高效液相色谱-串联质谱法测定不同环境基质中的杀菌剂 Determination of biocides in different environmental matrices by use of ultra-high-performance liquid chromatography-tandem mass spectrometry. 已发布 PubMed:含有巯氧吡啶锌和克霉唑的去头屑洗发剂的功效和感官特性得到增强。 Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole. 已发布 PubMed:吡罗酮羟胺/克仑巴唑洗发水与巯氧吡啶锌洗发水在中度至重度头皮屑受试者中的疗效比较。 Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff. 已发布 PubMed:电喷雾电离和大气压化学电离用于杀生物剂多残留分析的Comparison of electrospray ionization and atmospheric pressure chemical ionization for multi-residue analysis of biocides, 液相色谱-串联质谱法测定水性基质和活性污泥中的紫外线过滤器和苯并噻唑。 UV-filters and benzothiazoles in aqueous matrices and activated sludge by liquid chromatography-tandem mass spectrometry. 已发布 PubMed:咪唑抗真菌性攀克唑的遗传毒性评价 Evaluation of the genotoxicity of the imidazole antifungal climbazole: 与其他唑类化合物的公开结果进行比较。 comparison to published results for other azole compounds. 已发布 PubMed:反相液相色谱法同时测定洗发水产品中的四种去头皮屑剂，包括章鱼硫醇。 Simultaneous determination of four anti-dandruff agents including octopirox in shampoo products by reversed-phase liquid chromatography. 已发布 PubMed:死海洗发水的流变学，其中含有去头屑克霉唑。 Rheology of Dead Sea shampoo containing the antidandruff climbazole. 已发布 PubMed:[去屑剂水杨酸测定 [Determination of antidangdruff agent salicylic acid, 巯氧吡啶锌 zinc pyrithione, 章鱼 octopirox, 高效液相色谱法测定洗发剂中的樟脑唑和酮康唑 climbazole and ketoconazole in shampoo by high performance liquid chromatography]. 已发布 PubMed:发束测试-一种测试去屑制剂抗真菌作用的新方法。 The hair strand test - a new method for testing antifungal effects of antidandruff preparations. 已发布 PubMed:康唑诱导和抑制细胞色素p450和药物代谢酶。 Induction and inhibition of cytochrome P450 and drug-metabolizing enzymes by climbazole. 已发布 PubMed:攀克唑是大鼠肝细胞色素p450的一种新型有效诱导剂。 Climbazole is a new potent inducer of rat hepatic cytochrome P450. 已发布 PubMed:脂溢性头皮湿疹的临床研究和耐受性 [Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]. 已发布 PubMed:[天然（磺胺吡咯胺和铀酸钠）和合成（克林巴唑和吡罗酮醇胺）去屑剂的热稳定性比较]。 [Comparison of the thermostability of natural (sulfoprolamine and sodium usnate) and synthetic (climbazole and piroctone olamine) antidandruff agents]. 已发布 PubMed:克霉唑的体外活性 In vitro activity of climbazole, 克霉唑和磺胺嘧啶银对疟原虫马拉色菌的分离株。 clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis. 已发布 PubMed:糠醛马拉色菌对唑类化合物的体外敏感性。 In vitro susceptibility of Malassezia furfur against azole compounds. 已发布 PubMed:糠马拉色菌的体外敏感性。 In vitro susceptibility of Malassezia furfur.

笔记 Notes: 没找到 None Found