6-shogaol
4 dec-3-3 4-decen-3-one, 1-（4-羟基-3-甲氧基苯基）- 1-(4-hydroxy-3-methoxyphenyl)-, （4e）- (4E)-

供应商赞助商 Supplier Sponsors

• 
  BOC Sciences

  最好的化学品供应商 Best of Chemicals Supplier
  研究化学品和生化试剂（包括抑制剂）的优质供应商 Quality supplier of research chemicals and biochemicals including inhibitors, 建筑模块 building blocks, gmp产品 GMP Products, 杂质和代谢物 impurities and metabolites, 兽医用api APIs for Veterinary, 天然化合物 Natural Compounds, adcs ADCs, 干细胞分子和手性化合物。 Stem Cell Molecule and chiral compounds.
  卡波普＆reg; ultrez 21聚合物是我们用途最广泛的个 护理聚合物。它是一种疏水改性的交联丙烯酸酯共聚物，旨在有效地增稠 BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, 同位素标记服务 Isotope Labeling Service, 手性合成与拆分 Chiral Synthesis and Resolution, 生物共轭 Bioconjugation, 聚乙二醇化服务 PEGylation services, 分析服务。 analytical services.
  boc sciences是bocsci inc。的品牌。我们利用我们在发展领域的广泛业务 BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, 制造业 manufacturing, 行销 marketing, 和分销，以帮助您根据不断变化的优质化学品需求制定最明智的决策。我们完整的cro服务套件涵盖了整个分子开发流程，包括用于目标识别的合同研究 and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, 建筑模块 building blocks, 化合物合成 compound synthesis, 生化和细胞分析 biochemical and cellular analysis, 临床前动物试验 preclinical animal tests, 和临床研究。 and clinical studies.
  电子邮件 Email:	行销 marketing
  我们的电子邮件 US Email:	行销 marketing
  电子邮件 Email:	销售量 Sales
  我们的电子邮件 US Email:	销售量 Sales
  语音 Voice: 1-631-504-6093
  传真 Fax: 1-631-614-7828
  我们的声音 US Voice: 1-631-504-6093
  我们传真 US Fax: 1-631-614-7828
  Europe	44-203-286-1088
  脸书 Facebook
  推特 Twitter
  领英 Linkedin
  博客 Blog
  下载这个软件！ Get the App!
  产品 Product(s):
  555-66-8 6-shogaol> 98％ 555-66-8 6-Shogaol >98%
  6-shogaol是姜的刺激性成分，化学结构类似于姜醇。它具有抗炎特性。据报道，除具有抑制脂氧合酶活性的作用外，它还具有解热和镇痛作用。 6-Shogaol is a pungent constituent of ginger similar in chemical structure to gingerol. It has anti-inflammatory properties. lt was reported to have antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity.

Name: （e）-1-（4-羟基-3-甲氧基苯基）dec-4-en-3-one (E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one CAS号 CAS Number: 555-66-8 3D/INCHI FDA UNII: 83DNB5FIRF nikkaji网站 Nikkaji Web: J6.474B 贝尔斯坦数 Beilstein Number: 2056098 MDL : mfcd01736094 MFCD01736094 XlogP3: 3.70（est） 3.70 (est) 分子量 Molecular Weight: 276.37588000 式 Formula: c17 h24 o3 C17 H24 O3 核磁共振预测器 NMR Predictor: 预测（适用于Chrome或Firefox） Predict (works with chrome or firefox) 类别 Category:natural substances and extractives   美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent : 谷歌学术 Google Scholar: 搜索 Search 谷歌书 Google Books: 搜索 Search 谷歌学术 Google Scholar: with word "volatile" 搜索 Search 谷歌学术 Google Scholar: with word "flavor" 搜索 Search 谷歌学术 Google Scholar: with word "odor" 搜索 Search 谷歌专利 Google Patents: 搜索 Search 美国专利 US Patents: 搜索 Search 欧盟专利 EU Patents: 搜索 Search pubchem专利 Pubchem Patents: 搜索 Search 已发布 PubMed: 搜索 Search NCBI: 搜索 Search   物理性质 Physical Properties: 出现 Appearance: 浅黄至黄透明油状液体（est） pale yellow to yellow clear oily liquid (est) 化验 Assay: 92.00至100.00 92.00 to 100.00 食品化学品法典列表 Food Chemicals Codex Listed: No 沸点 Boiling Point: 427.00 to 428.00 °C. @ 760.00 mm 汞 Hg 闪点 Flash Point: 302.00 °F. tcc TCC ( 150.00 °C. ) logp（o / w） logP (o/w): 3.789（est） 3.789 (est) 溶于 Soluble in:   水 water, 25°C下3.378 mg / l（est） 3.378 mg/L @ 25 °C (est) 不溶于 Insoluble in:   石蜡油 paraffin oil   感官特性 Organoleptic Properties: 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found).   化妆品信息 Cosmetic Information: 没找到 None found   供应商 Suppliers: BOC Sciences 仅供实验/研究使用。 For experimental / research use only. 6-shogaol> 98％ 6-Shogaol >98% 气味 Odor: characteristic 采用 Use: 6-shogaol是姜的刺激性成分，化学结构类似于姜醇。它具有抗炎特性。据报道，除具有抑制脂氧合酶活性的作用外，它还具有解热和镇痛作用。 6-Shogaol is a pungent constituent of ginger similar in chemical structure to gingerol. It has anti-inflammatory properties. lt was reported to have antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 道尔顿制药服务 Dalton Pharma Services 仅供实验/研究使用。 For experimental / research use only. 6-shogaol> 95％ 6-Shogaol >95% 外合成 ExtraSynthese 仅供实验/研究使用。 For experimental / research use only. 松果酚（hplc）≥90％ Shogaol (HPLC) ≥90% 圣克鲁斯生物技术 Santa Cruz Biotechnology 仅供实验/研究使用。 For experimental / research use only. [6] -shogaol [6]-Shogaol sds 西格玛·奥尔德里奇 Sigma-Aldrich 仅供实验/研究使用。 For experimental / research use only. [6] -shogaol [6]-Shogaol 分析analytical standard   安全信息 Safety Information: 首选sds SDS : 视图 View   危害识别 Hazards identification   物质或混合物的分类 Classification of the substance or mixture 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) 没有找到。 None found. ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements   象形图 Pictogram   危险说明 Hazard statement(s) 没有找到。 None found. 防范说明 Precautionary statement(s) 没有找到。 None found. 口服/肠胃外毒性 Oral/Parenteral Toxicity: 老鼠 口服 oral-老鼠 mouse LD50 687 mg/kg Journal of 药代动力学 药房 Pharmacobio-Dynamics. 卷 Vol. 7, pg。 836 Pg. 836, 1984. 腹腔内小鼠 intraperitoneal-老鼠 mouse LD50 109 mg/kg Journal of 药代动力学 药房 Pharmacobio-Dynamics. 卷 Vol. 7, pg。 836 Pg. 836, 1984. 静脉老鼠 intravenous-老鼠 mouse LD50 50900 ug ug/kg Journal of 药代动力学 药房 Pharmacobio-Dynamics. 卷 Vol. 7, pg。 836 Pg. 836, 1984. 皮肤毒性 Dermal Toxicity: 未定 Not determined 吸入毒性 Inhalation Toxicity: 未定 Not determined   使用安全信息 Safety in Use Information: 类别 Category: natural substances and extractives 推荐使用6-shogaol使用水平 Recommendation for 6-shogaol usage levels up to:   不用于香水。 not for fragrance use.   推荐使用6-樟脑酚的调味剂 Recommendation for 6-shogaol flavor usage levels up to:   不用于调味料。 not for flavor use.   安全参考 Safety references: Epi系统 EPI System: 视图 View 化学致癌研究信息系统 Chemical Carcinogenesis Research Information System:搜索 Search 癌症引文 Cancer Citations:搜索 Search 毒理学引文 Toxicology Citations:搜索 Search 环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search EPA ACToR:毒理学资料 Toxicology Data EPA物质注册服务（SRS） :注册表 Registry 实验室化学安全摘要 Laboratory Chemical Safety Summary :5281794 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data 德国wgk WGK Germany:3 （e）-1-（4-羟基-3-甲氧基苯基）dec-4-en-3-one (E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one chemidplus Chemidplus:0000555668   参考资料 References:   （e）-1-（4-羟基-3-甲氧基苯基）dec-4-en-3-one (E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one NIST化学网络书籍 NIST Chemistry WebBook: 搜索INCHI pubchem（cid） Pubchem (cid): 5281794 pubchem（sid） Pubchem (sid): 134976704   其他资料 Other Information: （iupac） (IUPAC): 元素的原子量2009 Atomic Weights of the Elements 2009 （iupac） (IUPAC): 元素的原子量2009（pdf） Atomic Weights of the Elements 2009 (pdf) 影片 Videos: 元素周期表 The Periodic Table of Videos RBC : 本网站使用的原子量 Atomic Weights use for this web site （iupac） (IUPAC): 元素周期表 Periodic Table of the Elements CHEBI: 视图 View CHEMBL: 视图 View KEGG (GenomeNet): C10494 hmdb（人类代谢组数据库） HMDB (The Human Metabolome Database): HMDB31463 食物 FooDB: FDB012388 典型的g.c. Typical G.C. vcf在线 VCF-Online: 食品中的挥发性有机化合物 VCF Volatile Compounds in Food 化学蜘蛛 ChemSpider: 视图 View 维基百科 Wikipedia: 视图 View rsc学习化学 RSC Learn Chemistry: 视图 View   潜在搅拌机 Potential Blenders and core components note 没找到 None found   潜在用途 Potential Uses: 没找到 None found   存在（自然 Occurrence (nature, food, 其他） other):note   姜油 ginger oil 搜索 Search Trop Picture   姜根茎 ginger rhizome 搜索 Search Trop Picture   姜根油 ginger rhizome oil 搜索 Search Trop Picture   姜根 ginger root 搜索 Search Trop Picture   姜根油 ginger rhizome oil 搜索 Search Trop Picture   姜根油二氧化碳提取物@ 12.22％ ginger root oil CO2 extract @ 12.22% Data gc GC 搜索 Search Trop Picture   姜根油二氧化碳提取物@ 0.31％ ginger root oil CO2 extract australia @ 0.31% Data gc GC 搜索 Search Trop Picture   天堂之谷 grains of paradise 搜索 Search Trop Picture   同义词 Synonyms: 4- decen-3-one, 1-（4-羟基-3-甲氧基苯基）- 1-(4-hydroxy-3-methoxyphenyl)-, （4e）- (4E)- (E)-1-(4- hydroxy-3-methoxy-phenyl)-dec-4-en-3-one (E)-1-(4- hydroxy-3-methoxy-phenyl)dec-4-en-3-one 1-(4- hydroxy-3-methoxyphenyl)-4 dec-3-3 4-decen-3-one （4e）- (4E)-1-(4- hydroxy-3-methoxyphenyl)dec-4-en-3-one (E)-1-(4- hydroxy-3-methoxyphenyl)dec-4-en-3-one (6)- shogaol (E)- shogaol [6]- shogaol   文章 Articles: 已发布 PubMed:对小细胞肺癌细胞系的细胞毒活性和从本杰库尔乙醇提取物中分离出的六种化合物的色谱指纹图谱。 Cytotoxic activity against small cell lung cancer cell line and chromatographic fingerprinting of six isolated compounds from the ethanolic extract of Benjakul. 已发布 PubMed:天堂谷物提取物的抗炎活性。 Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract. 已发布 PubMed:生姜酚类物质调节细胞色素p450代谢和跨肠上皮屏障运输。 Modulation of cytochrome P450 metabolism and transport across intestinal epithelial barrier by ginger biophenolics. 已发布 PubMed:生姜化合物[6] -shogaol及其半胱氨酸结合的代谢物（m2）在体内外均能激活结肠上皮细胞中的nrf2。 Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. 已发布 PubMed:姜（姜）对 膜的驱虫药。 Anthelmintic constituents from ginger (Zingiber officinale) against Hymenolepis nana. 已发布 PubMed:[6] -shogaol通过促进erk和pi3k / akt介导的mitf降解来抑制α-msh诱导的黑素生成。 [6]-Shogaol inhibits α-MSH-induced melanogenesis through the acceleration of ERK and PI3K/Akt-mediated MITF degradation. 已发布 PubMed:侧链结构变化对[6]-姜油酚相关化合物抗氧化能力的影响。 Influence of side chain structure changes on antioxidant potency of the [6]-gingerol related compounds. 已发布 PubMed:6-shogaol通过调节stat3和mapks信号通路发挥抗增殖和促凋亡作用。 6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways. 已发布 PubMed:6-shogaol, 姜中的主要成分 a major compound in ginger, 诱导芳烃受体介导的转录活性和基因表达。 induces aryl hydrocarbon receptor-mediated transcriptional activity and gene expression. 已发布 PubMed:6所 6-Shogaol, 姜的活性成分 an active constituent of ginger, 减轻痴呆动物模型中的橙花炎症和认知缺陷。 attenuates neuroinflammation and cognitive deficits in animal models of dementia. 已发布 PubMed:半胱氨酸结合的生姜成分代谢物 Cysteine-conjugated metabolites of ginger components, 肖加尔 shogaols, 通过氧化应激介导的p53途径诱导 结肠癌细胞凋亡。 induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells. 已发布 PubMed:姜中关键酚类化合物及其衍生物的合成及定额感知抑制活性 Synthesis and quorum sensing inhibitory activity of key phenolic compounds of ginger and their derivatives. 已发布 PubMed:生姜及其刺激性成分会非竞争性地抑制内脏传入橙花元上的血清素电流。 Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons. 已发布 PubMed:干姜中的6-松果酚通过抑制stat3和nf-κb信号传导，在体外和体内抑制前列腺癌细胞的生长。 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling. 已发布 PubMed:不同制备方法制备的生姜提取物的姜醇含量变化和色谱指纹图谱。 Variations in the contents of gingerols and chromatographic fingerprints of ginger root extracts prepared by different preparation methods. 已发布 PubMed:6-松果酚在叔丁基过氧化氢诱导的hepg2细胞凋亡中的作用 Role of 6-shogaol in tert -butyl hydroperoxide-induced apoptosis of HepG2 cells. 已发布 PubMed:回复 Reply to 注释 Comments on the article "[6] -shogaol [6]-Shogaol 诱发的 诱导 induced 钙 calcium 信号 signal in rat 胰岛素瘤 insulinoma 细胞 细胞 cells". 已发布 PubMed:注释 Comments on the article "[6] -shogaol [6]-Shogaol 诱发的 诱导 induced 钙 calcium 信号 signal in rat 胰岛素瘤 insulinoma 细胞 细胞 cells". 已发布 PubMed: hangas已 hashinto的多靶点作用对化疗诱导的口腔粘膜炎对 口腔角质形成细胞中可诱导的前列腺素e2产生的影响。 已发布 PubMed:[6] -shogaol及其半胱氨酸结合的代谢物m2通过p53途径诱导肺癌细胞凋亡。 Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2. 已发布 PubMed:生物活性生姜植物化学物质的肝肠循环与生姜提取物的肿瘤生长抑制活性增强有关。 Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract. 已发布 PubMed:吉西他滨的抗肿瘤活性可以通过6-shogaol调节tlr4 /nf-κb信号传导而在胰腺癌中得到增强。 Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signaling by 6-shogaol. 已发布 PubMed:[6] -shogaol通过激活大鼠胰岛素瘤ins-1e细胞中的trpv1通道来诱导ca²⁺信号。 [6]-shogaol induces Ca²⁺ signals by activating the TRPV1 channels in the rat insulinoma INS-1E cells. 已发布 PubMed:姜提取物抑制 低密度脂蛋白在体外的氧化。 Inhibition of human low-density lipoprotein oxidation in vitro by ginger extracts. 已发布 PubMed:tu-100对小鼠结肠炎2型模型的预防作用 Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: 可能增强肾上腺髓质素在肠上皮细胞中的作用。 Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells. 已发布 PubMed:[6] Shogaol通过直接调节akt1 / 2抑制非小细胞肺癌细胞的生长并诱导其凋亡。 [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2. 已发布 PubMed:6-shogaol通过半胱天冬酶介导的eif2α裂解过程诱导 白血病细胞凋亡。 6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α. 已发布 PubMed:6所 6-Shogaol 抑制 抑制 inhibits 软骨细胞 chondrocytes' 先天 innate 免疫的 immune 回应 响应 responses and 组织蛋白酶k cathepsin-K 活动 activity. 已发布 PubMed:姜的活性成分通过调节细胞骨架调节蛋白来增强β-激动剂诱导的气道平滑肌松弛。 Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. 已发布 PubMed:新型Shogaol类似物可抑制癌细胞的入侵和炎症 A novel shogaol analog suppresses cancer cell invasion and inflammation, 并通过调节nf-κb和nrf2-keap1信号通路显示出细胞保护作用。 and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways. 已发布 PubMed:6所 6-Shogaol, 姜的活性成分 an active constituent of ginger, 保护 protects 多巴胺能 dopaminergic 橙花元 neurons in Parkinson's 疾病 disease 楷模 models 通过 via 抗橙花炎症 anti-橙花炎症 neuro炎 inflammation. 已发布 PubMed:半胱氨酸结合的生姜成分[6] -shogaol的代谢物在癌细胞和小鼠中充当[6] -shogaol的载体。 Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice. 已发布 PubMed:6-shogaol通过过氧化物酶体增殖物激活受体γ（pparγ）的激活来抑制乳腺癌和结肠癌细胞的增殖。 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). 已发布 PubMed:[6] -shogaol通过调节hmc-1细胞中nf-κb和jnk磷酸化来抑制促炎细胞因子的产生。 [6]-Shogaol inhibits the production of proinflammatory cytokines via regulation of NF-κB and phosphorylation of JNK in HMC-1 cells. 已发布 PubMed:谷胱甘肽结合减弱了生姜中6-脱氢松果酚的生物活性。 Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger. 已发布 PubMed:代中毒的药代动力学分析 Population pharmacokinetic analysis of daikenchuto, 日本和美国的健康志愿者使用的传统日药。 a traditional Japanese medicine (Kampo) in Japanese and US health volunteers. 已发布 PubMed:6-shogaol通过抑制氧化的ldl诱发的lox-1信号转导来保护免受氧化的ldl诱导的内皮损伤。 6-Shogaol Protects against Oxidized LDL-Induced Endothelial Injruries by Inhibiting Oxidized LDL-Evoked LOX-1 Signaling. 已发布 PubMed:生姜及其刺激性成分会非竞争性地抑制 类重组和天然肠橙花元5-ht3受体的活化。 Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. 已发布 PubMed:使用基质固相分散萃取和uplc-ms / ms高效地制备样品并定量中草药成分。 Highly efficient sample preparation and quantification of constituents from traditional Chinese herbal medicines using matrix solid-phase dispersion extraction and UPLC-MS/MS. 已发布 PubMed:类收费受体（tlr）自由基循环在慢性炎症中的作用 Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: 针对tlr4途径的可能治疗方法。 possible treatments targeting the TLR4 pathway. 已发布 PubMed:一个来自芸苔属小菜的根的新的菲衍生物和两个二芳基庚烷。樟脑抑制癌细胞系的生长和ldl-氧化。 A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp. campestris inhibit the growth of cancer cell lines and LDL-oxidation. 已发布 PubMed:侵袭脚足病相关蛋白的阻断是6-shogaol和翼檀香烯减少乳腺癌细胞运动性和侵袭的新机制。 Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion. 已发布 PubMed:[6] Shogaol通过上调橙花营养因子来减轻过氧化氢处理的星形胶质细胞的橙花元凋亡。 [6]-shogaol attenuates neuronal apoptosis in hydrogen peroxide-treated astrocytes through the up-regulation of neurotrophic factors. 已发布 PubMed:生姜成分[6]-松果酚的代谢产物在癌细胞中仍具有生物活性，对正常细胞毒性低 Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: 化学合成和生物学评估。 chemical synthesis and biological evaluation. 已发布 PubMed:小鼠肝脏微粒体中生姜成分[6]-松果酚的代谢 Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, 狗 dog , 猴 monkey, 和 类。 and human. 已发布 PubMed: [6] -shogaol表征小鼠和 尿中生姜成分肖加尔 shogaols的硫醇共轭代谢产物以及癌细胞中谷胱甘肽水平的调节。 已发布 PubMed:天堂谷物提取物可激活棕色脂肪组织，并增加男性的全身能量消耗。 Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. 已发布 PubMed:上皮瞬时受体电位锚蛋白1（trpa1）依赖性肾上腺髓质素上调大鼠小肠的血流量。 Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine. 已发布 PubMed:无label弹枪蛋白质组学和生物信息学分析揭示了6-松果酚处理的Hela 宫颈癌细胞的细胞毒性机制。 The Cytotoxicity Mechanism of 6-Shogaol-Treated HeLa Human Cervical Cancer Cells Revealed by Label-Free Shotgun Proteomics and Bioinformatics Analysis. 已发布 PubMed:毛细管液相色谱法同时测定生姜酚和生姜酚的含量及其在鉴别印度尼西亚三种生姜品种中的应用。 Simultaneous determination of gingerols and shogaol using capillary liquid chromatography and its application in discrimination of three ginger varieties from Indonesia. 已发布 PubMed:姜黄和乌头乌头配伍前后对四种姜酚含量的影响 [Effect of Zingiber offiicinale and Aconitum cainichaeli before and after compatibility on contents of four gingerols]. 已发布 PubMed:[6] Shogaol通过激活erk途径抑制b16小鼠黑素瘤细胞中的黑素生成。 [6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway. 已发布 PubMed:及其成分对气道平滑肌松弛和钙调节的影响 Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. 已发布 PubMed:高效液相色谱串联质谱法鉴定小鼠尿液中硫醇结合的[6]-樟脑醇的ii期代谢物。 Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry. 已发布 PubMed:1-dehydro- [6]-姜二酮的体外抗氧化和抗炎活性 In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-脱氢松果酚和六氢姜黄素。 6-dehydroshogaol and hexahydrocurcumin. 已发布 PubMed:姜根茎成分的抗血小板聚集和血管舒张作用。 Anti-platelet aggregation and vasorelaxing effects of the constituents of the rhizomes of Zingiber officinale. 已发布 PubMed:6-shogaol诱导 肝细胞癌细胞凋亡，并通过内质网应激在体内表现出抗肿瘤活性。 6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress. 已发布 PubMed:姜中富含6-shogaol的提取物上调细胞和小鼠的抗氧化防御系统。 6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice. 已发布 PubMed: 分子机制抑制6-shogaol和6-姜油醇 -姜醇 生姜 gingerol侵袭 类肝癌细胞。 已发布 PubMed:姜中富含6-樟脑酚的提取物的最佳提取条件的优化。 Optimization of Extraction Conditions for the 6-Shogaol-rich Extract from Ginger (Zingiber officinale Roscoe). 已发布 PubMed:姜黄（姜）在癌症化疗中作为止吐药 Zingiber officinale (ginger) as an anti-emetic in cancer chemotherapy: 回顾。 a review. 已发布 PubMed:l-天冬酰胺的质外性氧化参与绿藻类内生菌顶叶的控制。尼尔森（Nielsen）由红海藻球ndcrispus stackhouse设计。 Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae. 已发布 PubMed:6所 6-Shogaol, 姜制品 a ginger product, 调节橙花炎症 modulates neuroinflammation: 橙花保护的新方法离子。 a new approach to neuroprotection. 已发布 PubMed:松果酚对过氧化氢诱导的橙花元损伤后ht22细胞胆碱能信号的影响 Effects of [6]-shogaol on cholinergic signaling in HT22 cells following neuronal damage induced by hydrogen peroxide. 已发布 PubMed:姜中的苯丙酸酯及其对一氧化氮产生的抑制作用 Phenylpropanoid ester from Zingiber officinale and their inhibitory effects on the production of nitric oxide. 已发布 PubMed:［来自马利波兰的酚的酚和酰胺成分］。 [Phenolic and amide constituents from Lycianthes marlipoensis]. 已发布 PubMed:细胞毒性 Cytotoxic, 新鲜生姜中分离的酚类化合物的细胞保护和抗氧化作用。 cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. 已发布 PubMed:[6] -shogaol在小鼠和癌细胞中的代谢。 Metabolism of [6]-shogaol in mice and in cancer cells. 已发布 PubMed:[6] -shogaol对脂多糖诱导的鼠星形胶质细胞毒性的保护作用与脑源性橙花营养因子的产生有关。 Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor. 已发布 PubMed:[6]-松果酚的抗炎作用 Anti-inflammatory effects of [6]-shogaol: hdac抑制和hsp70诱导的潜在作用。 potential roles of HDAC inhibition and HSP70 induction. 已发布 PubMed:Daikenchuto的药代动力学 Pharmacokinetics of daikenchuto, 对健康的日本志愿者单次口服后的传统日本药（坎波 kampo）。 已发布 PubMed:生姜及其某些成分在 支气管上皮（beas-2b）细胞中的抗炎作用。 Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells. 已发布 PubMed:生姜的活性成分在 体中的药代动力学研究。 Examination of the pharmacokinetics of active ingredients of ginger in humans. 已发布 PubMed:松果酚在促凋亡浓度下诱导微管蛋白聚集相关的g（2）/ m阻滞和有丝分裂异常细胞死亡。 Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. 已发布 PubMed:膳食植物化学物质对癌症侵袭和转移的化学预防作用 Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: 酚酸 phenolic acids, 单酚 monophenol, 多酚 polyphenol, 及其衍生物。 and their derivatives. 已发布 PubMed:姜抑制邻苯二甲酸酯诱导的气道重塑。 Ginger suppresses phthalate ester-induced airway remodeling. 已发布 PubMed:生姜对阿司匹林诱发的大鼠胃溃疡的保护作用。 Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats. 已发布 PubMed:姜成分对胃肠道的影响 Effects of ginger constituents on the gastrointestinal tract: 胆碱能m3和5-羟色胺能5-ht3和5-ht4受体的作用。 role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. 已发布 PubMed:闪式高速逆流色谱法制备姜醇和6-寿果酚的单体 Preparation of the monomers of gingerols and 6-shogaol by flash high speed counter-current chromatography. 已发布 PubMed:定量6- Quantitation of 6-, 高效液相色谱-电化学检测技术在 体血浆中的8-和10-姜油酚和6-shogaol。 8- and 10-Gingerols and 6-Shogaol in Human Plasma by High-Performance Liquid Chromatography with Electrochemical Detection. 已发布 PubMed:6所 6-Shogaol, 姜的活性成分 an active constituent of ginger, 通过阻断核因子-κb活化来降低基质金属蛋白酶9表达，从而抑制乳腺癌细胞的侵袭。 inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. 已发布 PubMed:口服日本传统药物后对 体血浆和尿液中吸收的化合物的分析 Profiling of the compounds absorbed in human plasma and urine after oral administration of a traditional Japanese (kampo) medicine, 大剑道。 daikenchuto. 已发布 PubMed:[6] -shogaol对 口腔癌细胞（oc2）的胞质Ca2 +水平和增殖的影响。 Effect of [6]-shogaol on cytosolic Ca2+ levels and proliferation in human oral cancer cells (OC2). 已发布 PubMed:黄姜（姜）化合物对临床广泛耐药的鲍曼不动杆菌具有四环素抗性修饰作用。 Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinical extensively drug-resistant Acinetobacter baumannii. 已发布 PubMed:反对单纯茴香的姜的幼虫成分（生姜）。 Larvicidal constituents of Zingiber officinale (ginger) against Anisakis simplex. 已发布 PubMed: 6-shogaol和6-姜油醇 -姜醇 生姜 gingerol的抗侵袭作用 , 姜中的两种活性成分 two active components in ginger, 在 类肝癌细胞上 on human hepatocarcinoma cells. 已发布 PubMed:姜根茎的化学成分 [Chemical constituents of rhizomes of Zingiber officinale]. 已发布 PubMed:6-shogaol在抑制12-o-十四烷酰佛波醇13-乙酸酯诱导的小鼠肿瘤生长方面比6-姜醇和姜黄素更有效。 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. 已发布 PubMed:[6] -shogaol的药代动力学 Pharmacokinetics of [6]-shogaol, 姜叶罗汉果的刺激性成分（第一部分）。 a pungent ingredient of Zingiber officinale Roscoe (Part I). 已发布 PubMed:红姜（姜黄变种）提取物的抗炎特性，并抑制其成分产生一氧化氮。 Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents. 已发布 PubMed:六松果酚抑制肿瘤坏死因子α的产生 Six-shogaol inhibits production of tumour necrosis factor alpha, 脂多糖刺激的原始264.7巨噬细胞中的明串球菌介素1β和一氧化氮。 interleukin-1 beta and nitric oxide from lipopolysaccharide-stimulated RAW 264.7 macrophages. 已发布 PubMed:姜对广州管圆 的杀幼虫活性。 Larvicidal activities of ginger (Zingiber officinale) against Angiostrongylus cantonensis. 已发布 PubMed:与姜醇相比，姜黄中的樟脑酚对 癌细胞的生长抑制作用增强，消炎力增强。 Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. 已发布 PubMed:[6]-姜油的比较抗氧化和抗炎作用 Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-姜油 [8]-gingerol, [10]-姜油和[6]​​-姜油。 [10]-gingerol and [6]-shogaol. 已发布 PubMed:6-shogaol抑制尿酸一钠晶体诱导的炎症-一项体内和体外研究。 6-Shogaol inhibits monosodium urate crystal-induced inflammation--an in vivo and in vitro study. 已发布 PubMed:高效液相色谱-串联质谱法测定和定量生姜膳食补充剂中的生姜醇及相关化合物。 Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry. 已发布 PubMed:6所 6-Shogaol, 饮食生姜的有效成分 an active constituent of dietary ginger, 通过抑制 非小细胞肺癌a549细胞中的akt / mtor途径诱导自噬。 induces autophagy by inhibiting the AKT/mTOR pathway in human non-small cell lung cancer A549 cells. 已发布 PubMed:四川和蜜瓜胡椒的化合物可活化 Compounds from Sichuan and Melegueta peppers activate, 共价和非共价 covalently and non-covalently, trpa1和trpv1通道。 TRPA1 and TRPV1 channels. 已发布 PubMed:tbk1靶向抑制6-shogaol的toll样受体的琐碎依赖信号通路 TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, 姜的活性成分。 an active component of ginger. 已发布 PubMed: 6-shogaol抑制收费 Toll样受体4的同型二聚化。 已发布 PubMed:气相色谱-质谱法分析姜油树脂中的挥发性和非挥发性成分 [Analysis of volatile and non-volatile compositions in ginger oleoresin by gas chromatography-mass spectrometry]. 已发布 PubMed:同时测定6-甘油 Simultaneous determination of 6-gingerol, 8-甘油 8-gingerol, 液相色谱-质谱法测定大鼠血浆中的10-姜油酚和6-寿果酚 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: 在药代动力学中的应用。 Application to pharmacokinetics. 已发布 PubMed:从姜中分离的化合物对巨噬细胞功能的调节。 Modulation of macrophage functions by compounds isolated from Zingiber officinale. 已发布 PubMed:α的特定反应 Specific reaction of alpha,β-不饱和羰基化合物，例如微管蛋白中带有巯基的6-松果酚，会导致微管损伤。 beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage. 已发布 PubMed:goshuyuto Goshuyuto, 偏头痛的传统日本药 a traditional Japanese medicine for migraine, 抑制豚鼠全血中的血小板聚集。 inhibits platelet aggregation in guinea-pig whole blood. 已发布 PubMed:鸡血小板提取物和高效液相色谱法分析姜黄的抗血小板凝集成分 Analysis of anti-platelet aggregation components of Rhizoma Zingiberis using chicken thrombocyte extract and high performance liquid chromatography. 已发布 PubMed:6-姜油醇的药代动力学 Pharmacokinetics of 6-gingerol, 8-甘油 8-gingerol, 10-姜油 10-gingerol, 健康 体中的6-shogaol和共轭代谢产物。 and 6-shogaol and conjugate metabolites in healthy human subjects. 已发布 PubMed:6-shogaol抑制了脂多糖诱导的鼠巨噬细胞inos和cox-2的表达。 6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. 已发布 PubMed:[rp-hplc指纹评估不同的姜汁作为加工材料]。 [RP-HPLC fingerprint evaluating different ginger juice as processing material]. 已发布 PubMed: 6-shogaol和6-姜油醇 -姜醇 生姜 gingerol , 姜的辛辣 the pungent of ginger, 抑制tnf-α alpha介导的脂联素表达通过3t3-1l脂肪细胞中的不同机制下调。 已发布 PubMed:熟过程中牙买加姜的油性树脂含量和刺激性生物活性成分的变化。 Changes in the contents of oleoresin and pungent bioactive principles of Jamaican ginger (Zingiber officinale Roscoe.) during maturation. 已发布 PubMed:姜干干根茎的细胞毒性成分。 Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe. 已发布 PubMed:6-shogaol通过产生ros诱导大肠癌细胞凋亡 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, 半胱天冬酶激活 caspase activation, 并添加153表达式。 and GADD 153 expression. 已发布 PubMed:姜抑制 癌细胞中的细胞生长并调节血管生成因子。 Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. 已发布 PubMed:液相色谱法测定6- Liquid chromatographic determination of 6-, 8-, 10-姜油 10-gingerol, 和生姜中的6-shogaol（生姜）和干燥的水提取物。 and 6-shogaol in ginger (Zingiber officinale) as the raw herb and dried aqueous extract. 已发布 PubMed:[6]-姜油和[6]​​-松果油在模拟胃液和肠液中的稳定性。 Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids. 已发布 PubMed:生姜成分通过独特的机制降低胃癌细胞的生存能力。 Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. 已发布 PubMed:6-甘油的高效液相色谱分析 High-performance liquid chromatographic analysis of 6-gingerol, 8-甘油 8-gingerol, 10-姜油 10-gingerol, 含姜膳食补充剂中的6-shogaol和6-shogaol and 6-shogaol in ginger-containing dietary supplements, 香料 spices, 茶 teas, 和饮料。 and beverages. 已发布 PubMed:6-shogaol（姜汁中的烷酮）通过氧化应激介导的胱天蛋白酶依赖性机制诱导 肝癌p53突变体mahlavu亚系凋亡。 6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism. 已发布 PubMed:蒸生姜的非刺激性成分[10]-松果酚-增加肾上腺素通过激活trpv1创建。 A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1. 已发布 PubMed:6所 6-Shogaol 减少 降低 reduced 慢性的 chronic 发炎的 inflammatory 响应 response in the 膝盖 knees of 老鼠 rats 处理过的 treated with 完成 complete Freund's 佐剂 adjuvant. 已发布 PubMed:6所 6-Shogaol, 天然产品 a natural product, 减少细胞死亡并恢复大鼠脊髓损伤中的运动功能 reduces cell death and restores motor function in rat spinal cord injury. 已发布 PubMed:种在生姜的促动力作用上的差异。 Species differences in the prokinetic effects of ginger. 已发布 PubMed:姜根膳食补充剂的浓度和标签变化。 Variation in concentration and labeling of ginger root dietary supplements. 已发布 PubMed:姜根茎提取物对炎性介质产生的影响。 The effect of extracts from ginger rhizome on inflammatory mediator production. 已发布 PubMed: 姜醇和肖加尔 shogaols对5-ht3受体的作用方式 : 结合研究 binding studies, 受体通道对阳离子的吸收和豚鼠回肠的收缩。 cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. 已发布 PubMed:姜水提取物及其酚类成分的心血管作用是通过多种途径介导的。 Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. 已发布 PubMed:从姜根茎上分离的芳基烷烃的5-ht3受体阻断活性。 5-HT3 receptor blocking activity of arylalkanes isolated from the rhizome of Zingiber officinale. 已发布 PubMed:商业加工的干姜（姜） Commercially processed dry ginger (Zingiber officinale): 组成及其对lps刺激的pge2产生的影响。 composition and effects on LPS-stimulated PGE2 production. 已发布 PubMed:分离和分离方法来分析sho-saiko-to（sst）东方医学的活性成分。 Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine. 已发布 PubMed:姜的成分，改善小肠运输的增强。 Component of Zingiber officinale that improves the enhancement of small intestinal transport. 已发布 PubMed:草药dai-kenchu-to及其有效成分之一[6] -shogaol可增加大鼠的肠道血流量。 The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats. 已发布 PubMed:姜醇和松果酚在水溶液中的稳定性。 The stability of gingerol and shogaol in aqueous solutions. 已发布 PubMed:姜的胃部原理。 iii。抗溃疡原则 Stomachic principles in ginger. III. An anti-ulcer principle, 6-姜磺酸 6-gingesulfonic acid, 和三种单酰基二乳糖基甘油 and three monoacyldigalactosylglycerols, 姜糖脂 gingerglycolipids A, B, 和c and C, 来自台湾的姜黄根茎。 from Zingiberis Rhizoma originating in Taiwan. 已发布 PubMed:（6）-松果酚对大鼠含p物质的初级传入的辣椒素样作用 Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: 其止痛作用的可能机制。 a possible mechanism of its analgesic action. 已发布 PubMed:【生姜中的stomachic原理。 ii。姜中低极性成分的辛辣和抗溃疡作用 [Stomachic principles in ginger. II. Pungent and anti-ulcer effects of low polar constituents isolated from ginger, 台湾栽培的金丝猴干的干根茎。新的二芳基庚烷的精华/精粹/精萃立体结构]。 the dried rhizoma of Zingiber officinale Roscoe cultivated in Taiwan. The absolute stereostructure of a new diarylheptanoid]. 已发布 PubMed:6-姜磺酸 6-gingesulfonic acid, 新的抗溃疡原则 a new anti-ulcer principle, 和姜糖脂 and gingerglycolipids A, B, 和c and C, 三种新的单酰基二乳糖基甘油 three new monoacyldigalactosylglycerols, 来自台湾的姜黄根茎。 from Zingiberis Rhizoma originating in Taiwan. 已发布 PubMed: [具有抑制酶活性的中药处方的研究。 v.hange-s已 hashin-to hange-s已 hashin-to的研究 , kanzo-s已 hashin-to kanzo-s已 hashin-to , shokyo-s已 hashin-to shokyo-s已 hashin-to与腺苷3 ',5'-cyclic 一磷酸 monophosphate 磷酸二酯酶 phosphodiesterase]. 已发布 PubMed:姜对5-羟色胺引起的体温过低和腹泻的影响。 [The effect of ginger on serotonin induced hypothermia and diarrhea]. 已发布 PubMed:生姜及其有效成分的胃肠蠕动增强作用。 Gastrointestinal motility enhancing effect of ginger and its active constituents. 已发布 PubMed:姜黄（中药）或[6]-松果酚和[6]-姜醇提取物对茴香木幼虫的体外致死作用。 Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro. 已发布 PubMed:与生姜提取物之间的逆转作用对小鼠肠系膜静脉中pgf2α诱导的收缩的作用。 Reversed effects between crude and processed ginger extracts on PGF2 alpha-induced contraction in mouse mesenteric veins. 已发布 PubMed:生姜衍生物的化学结构要求，以增强前列腺素f2α诱导的小鼠离体肠系膜静脉收缩。 Chemical structural requirement in gingerol derivatives for potentiation of prostaglandin F2 alpha-induced contraction in isolated mesenteric veins of mice. 已发布 PubMed:【生姜的药理研究。 v。（6）-松果酚和辣椒素的药理比较]。 [Pharmacological studies on ginger. V. Pharmacological comparison between (6)-shogaol and capsaicin]. 已发布 PubMed:生姜的药理研究。 ii。 （6）-松果酚在麻醉大鼠中的升压作用 Pharmacological studies on ginger. II. Pressor action of (6)-shogaol in anesthetized rats, 或后躯 or hindquarters, 大鼠的尾部和肠系膜血管床。 tail and mesenteric vascular beds of rats. 已发布 PubMed:【生姜的药理研究。 iv。 （6）-松果酚对花生四烯酸级联反应的影响 [Pharmacological studies on ginger. IV. Effect of (6)-shogaol on the arachidonic cascade]. 已发布 PubMed:生姜的药理研究。 iii。破坏对大鼠（6）-shogaol诱导的升压反应的影响。 Pharmacological studies on ginger. III. Effect of the spinal destruction on (6)-shogaol-induced pressor response in rats. 已发布 PubMed:生姜的药理研究。一世。刺激性成分的药理作用 Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, （6）-姜油醇和（6）-姜油醇。 (6)-gingerol and (6)-shogaol. 已发布 PubMed:诱变中[6]-姜油分子的活性部分。 The active part of the [6]-gingerol molecule in mutagenesis.

笔记 Notes: 从姜 from ginger, 姜黄;诱变性比姜油少。构成。天堂（淡黄）和姜（姜）[dfc] zingiber officinale; less mutagenic than gingerol. Constit. of grains of paradise (Amomum melegueta) and Zingiber officinale (ginger) [DFC] Shogaol, 也被称为（6）-shogaol also known as (6)-shogaol, 是姜的刺激性成分，化学结构与姜醇相似。像姜油酮 is a pungent constituent of ginger similar in chemical structure to gingerol. Like zingerone, 它是姜干或煮熟时产生的。构成。姜（姜）[dfc] it is produced when ginger is dried or cooked. Constit. of ginger (Zingiber officinale) [DFC]