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类别 Category:cosmetic agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 出现 Appearance: | 无色透明粘稠液体（est） colorless clear viscous liquid (est) |
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 比重 Specific Gravity: | 1.00300 to 1.00500 @ 20.00 °C.
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| 磅每加仑-（est）。 Pounds per Gallon - (est).: | 8.356 to 8.372
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| 折光率 Refractive Index: | 1.43700 to 1.44000 @ 20.00 °C.
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| 熔点 Melting Point: | -50.00 °C. @ 760.00 mm 汞 Hg
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| 沸点 Boiling Point: | 195.00 to 196.90 °C. @ 760.00 mm 汞 Hg
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| 沸点 Boiling Point: | 190.00 to 191.00 °C. @ 760.00 mm 汞 Hg (est)
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| 蒸汽压力 Vapor Pressure: | 0.050100 毫米汞柱 mm汞 Hg @ 25.00 °C. |
| 蒸气密度 Vapor Density: | 3.1 ( 空气 Air = 1 ) |
| 闪点 Flash Point: | 200.00 °F. tcc TCC ( 93.33 °C. )
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| logp（o / w） logP (o/w): | -0.499（est） -0.499 (est) |
| 溶于 Soluble in: |
| | 水 water, 1.00e + 06 mg / l @ 25°C（实验） 1.00E+06 mg/L @ 25 °C (exp) |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
| 首选SDS Preferred SDS: 视图 View |
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| 危害识别 Hazards identification |
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| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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| 象形图 Pictogram | |
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| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
口鼠 oral-rat LD50 16000 mg/kg
"Prehled 恶作剧 Prumyslove 毒物学 Toxikologie; 有机酮 Organicke 懒汉 Latky," 马尔霍尔德 Marhold, j. J., 布拉格 Prague, 捷克斯洛伐克 Czechoslovakia, 香橙 Avicenum, 1986卷-- 1986Vol. -, pg。 207 Pg. 207, 1986.
腹腔内小鼠 intraperitoneal-mouse LD50 4192 mg/kg
毒理学 Toxicology and 已应用 Applied 药理 Pharmacology. 卷 Vol. 49, pg。 385 Pg. 385, 1979.
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| 皮肤毒性 Dermal Toxicity: |
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未定 Not determined
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| 吸入毒性 Inhalation Toxicity: |
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未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | cosmetic agents |
| 推荐1 Recommendation for 1,2-丁二醇的使用量高达 2-butane diol usage levels up to: | | | 不用于香水。 not for fragrance use.
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| 推荐1 Recommendation for 1,2-丁二醇的风味剂使用量最高可达 2-butane diol flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
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安全参考 Safety references:
参考资料 References:
| | 丁烷1 butane-1,2-二醇 2-diol |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| pubchem（cid） Pubchem (cid): | 11429 |
| pubchem（sid） Pubchem (sid): | 134978451 |
| 信息基 Pherobase: | 视图 View |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core 组件 components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, 餐饮 food, 其他） other): note
| | 自然界中找不到 not found in nature |
同义词 Synonyms:
| | 丁烷1 butane-1,2-二醇 2-diol | | ±-1,2- | butanediol | | 1,2- | butanediol | | 1,2- | butanediol, (±)- | | | butanediol, 1,2- | | 1,2- | butylene glycol | | alpha- | butylene glycol | | 1,2-( | dihydroxy)butane | | 1,2- | dihydroxybutane | | | 乙ethylethylene glycol |
文章 Articles:
| 已发布 PubMed:多余的混合焓 Excess Enthalpies of Mixing, 温度和组成对密度的影响 Effect of Temperature and Composition on the Density, {铵基离子液体+链烷二醇}二元体系的粘度和热力学性质 Viscosity and Thermodynamic Properties of Binary Systems of {Ammonium-Based Ionic Liquid + Alkanediol} |
| 已发布 PubMed:lc-esi-ms-ms分析血清中的八种二醇。 Analysis of Eight Glycols in Serum Using LC-ESI-MS-MS. |
| 已发布 PubMed:比较低级邻位和末端链烷二醇在298.15 k的分子结构和氢键方面的超声弛豫研究。 A comparative ultrasonic relaxation study of lower vicinal and terminal alkanediols at 298.15 K in relation to their molecular structure and hydrogen bonding. |
| 已发布 PubMed:小麦秸秆在甲苯和乙醇中的加氢处理。 Hydrotreating of wheat straw in toluene and ethanol. |
| 已发布 PubMed:双丁二醇巯基酸（bis-bdma）作为丁二烯代谢活化为其最终致癌物质的泌尿生物标志物。 Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species. |
| 已发布 PubMed:液相中钴纳米棒各向异性形状的控制 Control of the anisotropic shape of cobalt nanorods in the liquid phase: 从实验到理论……然后再回来。 from experiment to theory… and back. |
| 已发布 PubMed:烃链长度的影响1 Effect of hydrocarbon chain length in 1,2-链烷二醇对甲硝唑经皮吸收的影响 2-alkanediols on percutaneous absorption of metronidazole: 致力于开发用于控制释放的通用载体。 toward development of a general vehicle for controlled release. |
| 已发布 PubMed:三种主要代谢产物1引起的dna损伤 DNA damage induced by three major metabolites of 1, 肝细胞102细胞中的3-丁二烯。 3-butadiene in human hepatocyte L02 cells. |
| 已发布 PubMed:有效转换为1 Efficient conversion of 1,使用氧化葡糖杆菌的整个细胞将2-丁二醇转化为（r）-2-羟基丁酸。 2-butanediol to (R)-2-hydroxybutyric acid using whole cells of Gluconobacter oxydans. |
| 已发布 PubMed:烷烃链长对皮肤刺激潜力的影响1 The influence of alkane chain length on the skin irritation potential of 1,2-链烷二醇。 2-alkanediols. |
| 已发布 PubMed:离子液体与多元醇的混溶性。 Miscibility of ionic liquids with polyhydric alcohols. |
| 已发布 PubMed:1代谢的定量研究 Quantitative investigation on the metabolism of 1,3-丁二烯及其氧化代谢产物存在于小鼠和大鼠的一次性肝脏灌注中。 3-butadiene and of its oxidized metabolites in once-through perfused livers of mice and rats. |
| 已发布 PubMed:异硬脂酸甘油/癸烷体系中多元醇对非离子表面活性剂反胶束结构的影响 Effect of polyol on the structure of nonionic surfactant reverse micelles in glycerol monoisostearate/decane systems. |
| 已发布 PubMed:多元醇对哦的反应性 Reactivity of poly-alcohols towards OH, 水溶液中加入NO3和SO4-。 NO3 and SO4- in aqueous solution. |
| 已发布 PubMed:通过线性红外光谱法区分邻二醇中弱分子内氢键的细微变化。 Differentiating subtle variation of weak intramolecular hydrogen bond in vicinal diols by linear infrared spectroscopy. |
| 已发布 PubMed:丁二烯和 类四种主要代谢物的基于生理的毒代动力学模型的开发 Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: 针对实验设计问题的全局敏感性分析。 global sensitivity analysis for experimental design issues. |
| 已发布 PubMed:3的重要性 The importance of 3,4-环氧-1 4-epoxy-1,3-丁烯-1中的2-丁二醇和羟甲基乙烯基酮 2-butanediol and hydroxymethylvinyl ketone in 3-butene-1,2-二醇相关的致突变性。 2-diol associated mutagenicity. |
| 已发布 PubMed:在四个内部转子系统1中逐步向单一异构状态进行构象冷却 Stepwise conformational cooling towards a single isomeric state in the four internal rotors system 1,2-butanediol. |
| 已发布 PubMed:β-乳球蛋白在醇和多元醇水溶液存在下的热稳定性。 Thermal stability of beta-lactoglobulin in the presence of aqueous solution of alcohols and polyols. |
| 已发布 PubMed:正己烷对1的处置和毒性的影响 Effect of n-hexane on the disposition and toxicity of the 1,3-丁二烯代谢物3-丁烯-1 3-butadiene metabolite 3-butene-1,2-二醇。 2-diol. |
| 已发布 PubMed:1的代谢 Metabolism of 1,3-丁二烯与单暴露小鼠和大鼠的毒理学相关代谢产物。 3-butadiene to toxicologically relevant metabolites in single-exposed mice and rats. |
| 已发布 PubMed:3的dna和血红蛋白加合物的定量 Quantification of DNA and hemoglobin adducts of 3,4-环氧-1 4-epoxy-1,暴露于3-丁烯-1的啮齿动物中的2-丁二醇 2-butanediol in rodents exposed to 3-butene-1,2-二醇。 2-diol. |
| 已发布 PubMed:暴露于1时小鼠和大鼠中双环氧化合物特异性环状n末端球蛋白加合物的分析 Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-丁二烯。 3-butadiene. |
| 已发布 PubMed:d。球形红球菌的半乳糖醇脱氢酶对脂肪族二醇的立体选择性氧化和羟基酮的还原d。 Stereoselective oxidation of aliphatic diols and reduction of hydroxy-ketones with galactitol dehydrogenase from Rhodobacter sphaeroides D. |
| 已发布 PubMed:吸入低浓度1的大鼠和小鼠组织中dna加合物形成的剂量反应 Dose responses for DNA adduct formation in tissues of rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-[（14）c]-丁二烯。 3-[(14)C]-butadiene. |
| 已发布 PubMed:自然发生的立体化学分配2 Stereochemical assignment of naturally occurring 2,3-环氧-2-甲基丁酸酯。 3-epoxy-2-methylbutanoate esters. |
| 已发布 PubMed:丁二烯衍生的n1-脱氧肌苷加合物和n6的致突变谱 Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,哺乳动物细胞中的n6-脱氧腺苷链内交联。 N6-deoxyadenosine intrastrand cross-links in mammalian cells. |
| 已发布 PubMed:气相色谱-质谱法测定生物样品中的乙二醇 Determination of glycols in biological specimens by gas chromatography-mass spectrometry. |
| 已发布 PubMed:使用dna和血红蛋白加合物改善丁二烯的风险评估。 Using DNA and hemoglobin adducts to improve the risk assessment of butadiene. |
| 已发布 PubMed:1的首过代谢 First-pass metabolism of 1,大鼠和小鼠一次灌流肝脏中的3-丁二烯。 3-butadiene in once-through perfused livers of rats and mice. |
| 已发布 PubMed:n-羟基邻苯二甲酰亚胺与co物种结合催化分子氧将醇有效氧化为羰基化合物 Efficient oxidation of alcohols to carbonyl compounds with molecular oxygen catalyzed by N-hydroxyphthalimide combined with a Co species |
| 已发布 PubMed:1的遗传和相关作用的综述 A review of the genetic and related effects of 1,啮齿动物和 类中的3-丁二烯。 3-butadiene in rodents and humans. |
| 已发布 PubMed:探索 Explorations of alkyl 多元醇 多元醇 polyols as "class I" organic 修饰语 modifiers to 调整 adjust 选择性 selectivity in 胶束 老鼠 micellar 电动的 electrokinetic capillary 色谱法 chromatography. |
| 已发布 PubMed:暴露于1的小鼠和大鼠中n-7鸟嘌呤加合物形成的分子计量学 Molecular dosimetry of N-7 guanine adduct formation in mice and rats exposed to 1,3-丁二烯。 3-butadiene. |
| 已发布 PubMed:脂族和脂环族二醇在培养的细胞和豚鼠皮肤中诱导黑素生成。 Aliphatic and alicyclic diols induce melanogenesis in cultured cells and guinea pig skin. |
| 已发布 PubMed:用4-乙氧基六氟丁酰氯从 血清中衍生化乙二醇的新方法，用于明确的气相色谱-化学电离质谱鉴定和定量。 A novel derivatization of ethylene glycol from human serum using 4-carbethoxyhexafluorobutyryl chloride for unambiguous gas chromatography-chemical ionization mass spectrometric identification and quantification. |
| 已发布 PubMed:通过填充柱或毛细管柱气相色谱法同时测定血清中的醇和乙二醇。 Simultaneous determination of alcohols and ethylene glycol in serum by packed- or capillary-column gas chromatography. |
| 已发布 PubMed:丁二烯及其环氧代谢物的致突变性 Mutagenicity of butadiene and its epoxide metabolites: 一世。诱变潜力为1 I. Mutagenic potential of 1,2-环氧丁烯 2-epoxybutene, 1,2,3,4-二环氧丁烷和3 4-diepoxybutane and 3,4-环氧-1 4-epoxy-1,培养的 淋巴母细胞中的2-丁二醇。 2-butanediol in cultured human lymphoblasts. |
| 已发布 PubMed:致突变性1 Mutagenicity of 1,从暴露的b6c3f1小鼠中分离出的 tk6细胞和脾t细胞中的3-丁二烯及其环氧代谢物。 3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F1 mice. |
| 已发布 PubMed:醇底物被大鼠肝微粒体氧化为甲醛的结构决定因素。 Structural determinants for alcohol substrates to be oxidized to formaldehyde by rat liver microsomes. |
| 已发布 PubMed:毛细管气相色谱法测定死后血液中的乙二醇 Determination of ethylene glycol in postmortem blood by capillary gas chromatography. |
| 已发布 PubMed:具有四个碳的线性多元醇的水溶液中玻璃的形成趋势和非晶态的稳定性。一世。二元体系水多元醇。 Glass-forming tendency and stability of the amorphous state in the aqueous solutions of linear polyalcohols with four carbons. I. Binary systems water-polyalcohol. |
| 已发布 PubMed:严格厌氧发酵降解聚乙二醇 Fermentative degradation of polyethylene glycol by a strictly anaerobic, 革兰氏阴性 gram-negative, 非孢子形成细菌 nonsporeforming bacterium, 威尼斯水杆菌十一月 Pelobacter venetianus sp. nov. |
| 已发布 PubMed:一种测定血液中乙二醇的改进方法。 An improved procedure for the determination of ethylene glycol in blood. |
| 已发布 PubMed:肝微粒体代谢1 Hepatic microsomal metabolism of 1,3-丁二烯。 3-butadiene. |
| 已发布 PubMed:【关于代谢和分布的1 [On metabolism and distribution of 1,2-丙二醇 2-propanediol, 1,2-丁二醇和1 2-butanediol and 1,2,兔体内的4-丁三醇]。 4-butanetriol in the rabbit]. |
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3D/INCHI