| Name: | (2s (2S, 4as , 6a 6ar , 6a 6as , 6b 6br , 8a 8ar ,10s 10S,12岁 12aS,14br）-10-hydroxy-2 14bR)-10-hydroxy-2,4a 4a,6a 6a,6b 6b,9,9,12a-七甲基-13-氧代3 12a-heptamethyl-13-oxo-3,4,5,6,6a 6a,7,8,8a 8a,10,11,12,14b-十二烷基-1h-吡啶-2-羧酸 14b-dodecahydro-1H-picene-2-carboxylic acid |
| CAS号 CAS Number: | 471-53-4 |  3D/INCHI
|
| 其他 Other: | 107420-91-7 |
| echa ECHA einecs EINECS - REACH 预注册 Pre-Reg: | 207-444-6 |
| FDA UNII: | P540XA09DR |
| nikkaji网站 Nikkaji Web: | J5.943I |
| 贝尔斯坦数 Beilstein Number: | 2229654 |
| MDL : | mfcd00003706 MFCD00003706 |
| XlogP3-AA: | 6.40（est） 6.40 (est) |
| 分子量 Molecular Weight: | 470.69342000 |
| 式 Formula: | c30 h46 o4 C30 H46 O4 |
| 生物活性总结 BioActivity Summary: | 清单 listing |
| 核磁共振预测器 NMR Predictor: | 预测（适用于Chrome或Firefox） Predict (works with chrome or firefox) |
类别 Category:cosmetic ingredient for skin conditioning
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
|
| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 熔点 Melting Point: | 296.00 °C. @ 760.00 mm 汞 Hg
|
| 沸点 Boiling Point: | 588.34 °C. @ 760.00 mm 汞 Hg (est)
|
| 闪点 Flash Point: | 615.00 °F. tcc TCC ( 323.70 °C. ) (est)
|
| logp（o / w） logP (o/w): | 5.498（est） 5.498 (est) |
| 溶于 Soluble in: |
| | 水 water, 0.01138 mg / l @ 25°c（est） 0.01138 mg/L @ 25 °C (est) |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
| 首选SDS Preferred SDS: 视图 View |
| |
| 危害识别 Hazards identification |
| |
| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
腹腔内小鼠 intraperitoneal-老鼠 mouse LD50 308 mg/kg
Drugs in 日本 Japan 卷 Vol. -, pg。 319 Pg. 319, 1990.
静脉老鼠 intravenous-老鼠 mouse LD50 56 mg/kg
U.S. 军队 Army 军备 Armament 研究 Research & 发展 Development 命令 Command, 化学系统实验室 Chemical Systems Laboratory, 尼什交换化学品。卷NX＃02067 NIOSH Exchange Chemicals. Vol. NX#02067
|
| 皮肤毒性 Dermal Toxicity: |
皮下老鼠 subcutaneous-老鼠 mouse LD50 518 mg/kg
Gekkan 药师 Yakuji. 药品 Pharmaceuticals 每月一次 Monthly. 卷 Vol. 5, pg。 98 Pg. 98, 1963.
|
| 吸入毒性 Inhalation Toxicity: |
|
未定 Not determined
|
使用安全信息 Safety in Use Information:
| 类别 Category: | | cosmetic ingredient for skin conditioning |
| 推荐使用18-β-甘草次酸水平最高为 Recommendation for 18-beta-glycyrrhetinic acid usage levels up to: | | | 不用于香水。 not for fragrance use.
|
| |
| 推荐使用18-β-甘草次酸风味剂的使用水平 Recommendation for 18-beta-glycyrrhetinic acid flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
|
安全参考 Safety references:
| Epi系统 EPI System: 视图 View |
| Clinicaltrials.gov ClinicalTrials.gov:search |
| 化学致癌研究信息系统 Chemical Carcinogenesis Research Information System:搜索 Search |
| 辅助引文 AIDS Citations:搜索 Search |
| 癌症引文 Cancer Citations:搜索 Search |
| 毒理学引文 Toxicology Citations:搜索 Search |
| 环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search |
| EPA物质注册服务（tsca TSCA） :471-53-4 |
| EPA ACToR:毒理学资料 Toxicology Data |
| EPA物质注册服务（SRS） :注册表 Registry |
| 实验室化学安全摘要 Laboratory Chemical Safety Summary :10114 |
| 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data |
| 德国wgk WGK Germany:3 |
| (2s (2S, 4as , 6a 6ar , 6a 6as , 6b 6br , 8a 8ar ,10s 10S,12岁 12aS,14br）-10-hydroxy-2 14bR)-10-hydroxy-2,4a 4a,6a 6a,6b 6b,9,9,12a-七甲基-13-氧代3 12a-heptamethyl-13-oxo-3,4,5,6,6a 6a,7,8,8a 8a,10,11,12,14b-十二烷基-1h-吡啶-2-羧酸 14b-dodecahydro-1H-picene-2-carboxylic acid |
| chemidplus Chemidplus:0000471534 |
| 技术 RTECS:CAS＃471-53-4的rk0180000 RK0180000 for cas# 471-53-4 |
参考资料 References:
| | (2s (2S, 4as , 6a 6ar , 6a 6as , 6b 6br , 8a 8ar ,10s 10S,12岁 12aS,14br）-10-hydroxy-2 14bR)-10-hydroxy-2,4a 4a,6a 6a,6b 6b,9,9,12a-七甲基-13-氧代3 12a-heptamethyl-13-oxo-3,4,5,6,6a 6a,7,8,8a 8a,10,11,12,14b-十二烷基-1h-吡啶-2-羧酸 14b-dodecahydro-1H-picene-2-carboxylic acid |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| pubchem（cid） Pubchem (cid): | 10114 |
| pubchem（sid） Pubchem (sid): | 134975336 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, food, 其他） other): note
同义词 Synonyms:
| | 节肢arthrodont | | | 比奥松 biosone | | | BX-1 | | | 烯(+)-香柏酮 enoloxone | | | enoxolone | | | enoxolonum | | 18b- | glycyrrhetinic acid | | 18beta- | glycyrrhetinic acid | | | Hidermart hidermart | | (3b (3b,20b)-3- | hydroxy-11-oxoo靠 lean-12-en-29-oic acid | | 3b- | hydroxy-11-oxoo靠 lean-12-en-30-oic acid | | (2s (2S, 4as , 6a 6ar , 6a 6as , 6b 6br , 8a 8ar ,10s 10S,12岁 12aS,14bR)-10- | hydroxy-2,4a 4a,6a 6a,6b 6b,9,9,12a-七甲基-13-氧代3 12a-heptamethyl-13-oxo-3,4,5,6,6a 6a,7,8,8a 8a,10,11,12,14b-十二烷基-1h-吡啶-2-羧酸 14b-dodecahydro-1H-picene-2-carboxylic acid | | | rhetinic acid | | | 尿烯酸 uralenic acid |
文章 Articles:
| 已发布 PubMed:18β-甘草次酸可减轻Anandamide诱导的肥胖和高脂饮食诱导的肥胖。 18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity. |
| 已发布 PubMed:甘草次酸抑制了tnf-α诱导的肝细胞中nf-κb的活化。 Glycyrrhetinic Acid Suppressed NF-κB Activation in TNF-α-Induced Hepatocytes. |
| 已发布 PubMed:通过使用鼠原代脾细胞调节th1 / th2细胞因子分泌谱来测试27种选定的萜类化合物的抗炎作用。 Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes. |
| 已发布 PubMed:甘草水提取物在 呼吸道细胞系中对 呼吸道合胞 具有抗 活性。 Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. |
| 已发布 PubMed:小鼠肝脏微粒体中生姜成分[6]-松果酚的代谢 Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, 狗 dog , 猴 monkey, 和 类。 and human. |
| 已发布 PubMed:甘草酸和18β-甘草次酸通过pi3k诱导的ap1恢复糖皮质激素抵抗 Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, cre和nfat激活。 CRE and NFAT activation. |
| 已发布 PubMed:甘草酸和18β-甘草次酸通过pi3kp110δ和p110γ抑制作用来抑制nf-κb，从而调节脂多糖诱导的炎症反应。 Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. |
| 已发布 PubMed:两种新型1的体外和体内药代动力学 In vitro and in vivo pharmacokinetics of two novel 1,大鼠18β-甘草次酸3环磷酸丙酯磷酸酯前药。 3-cyclic propanyl phosphate ester prodrugs of 18β-glycyrrhetic acid in rats. |
| 已发布 PubMed:甘草酸和18β-甘草次酸通过pi3k / akt / gsk3beta信号传导和糖皮质激素受体激活来抑制炎症。 Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation. |
| 已发布 PubMed:皂苷抑制 肾素活性。 Inhibition of human renin activity by saponins. |
| 已发布 PubMed:食用甘草精后测定甘草次酸含量，并将其用于死亡。 Determination of glycyrrhetic acid after consumption of liquorice and application to a fatality. |
| 已发布 PubMed:甘草 Licorice: 预防透析患者血钾过高的好方法吗？ a sweet alternative to prevent hyperkalemia in dialysis patients? |
| 已发布 PubMed:补充甘草次酸食物可降低慢性血液透析患者的血钾浓度。 Glycyrrhetinic acid food supplementation lowers serum potassium concentration in chronic hemodialysis patients. |
| 已发布 PubMed:甘草甜素和甘草显着影响甲氨蝶呤在大鼠体内的药代动力学。 Glycyrrhizin and licorice significantly affect the pharmacokinetics of methotrexate in rats. |
| 已发布 PubMed:甘草酸和18β-甘草次酸通过调节pi3k / akt途径对pc12细胞的橙花保护作用。 Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway. |
| 已发布 PubMed:甘草提取物对 细胞系生长特性的影响 Effect of the extracts from Glycyrrhiza uralensis Fisch on the growth characteristics of human cell lines: 抗肿瘤和免疫激活活性。 Anti-tumor and immune activation activities. |
| 已发布 PubMed:[由于甘草和甘草茶的消耗而引起的高血压]。 [Hypertension due to liquorice and liquorice tea consumption]. |
| 已发布 PubMed:对高脂饮食喂养的鼠疫大鼠的11β-羟类固醇脱氢酶抑制剂对体重和葡萄糖耐量的影响 Effects of 11beta-hydroxysteroid dehydrogenase inhibitor on body weight and glucose tolerance in Sprague-Dawley rats fed with a high-fat diet. |
| 已发布 PubMed:通过nf-kappab信号破坏阻断甘草异寡糖原蛋白对细胞因子诱导的内皮细胞粘附分子表达的影响。 Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. |
| 已发布 PubMed:使用hplc同时定量甘草中的类黄酮和三萜类化合物。 Simultaneous quantification of flavonoids and triterpenoids in licorice using HPLC. |
| 已发布 PubMed:同步hplc分析 Simultaneous HPLC analysis, 等度洗脱 with isocratic elution, 甘草根和糖食中的甘草甜素和甘草次酸含量。 of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products. |
| 已发布 PubMed:喜欢甘草精的老太太 The old lady who liked liquorice: 记忆力减退患者因长期中毒而引起的高血压。 hypertension due to chronic intoxication in a memory-impaired patient. |
| 已发布 PubMed:摄入甘草引起的严重低钾血症性麻痹和横纹肌溶解。 Severe hypokalaemic paralysis and rhabdomyolysis due to ingestion of liquorice. |
| 已发布 PubMed: 肥胖和瘦型扎克大鼠用甘草次酸处理对体重和肝11β-羟类固醇脱氢酶（11beta-hsd）1型姆纳 mrna对11beta-hsd抑制的反应不同。 |
| 已发布 PubMed:酱油提取物及其成分的功效 Effects of Sho-saiko-to extract and its components, 黃芩苷 Baicalin, 黃芩素 baicalein, 甘草甜素和甘草次酸 glycyrrhizin and glycyrrhetic acid, 水杨酰胺在四氯化碳中毒大鼠体内的药代动力学行为 on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats. |
| 已发布 PubMed:18β-甘草次酸-3-邻-β-d-葡糖醛酸抗过敏活性。 Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide. |
| 已发布 PubMed:某些天然树脂的生物活性 Biological activity of some naturally occurring resins, 胶和颜料可抗体外ldl氧化。 gums and pigments against in vitro LDL oxidation. |
| 已发布 PubMed:真菌多糖类化合物抗肿瘤作用的免疫学研究 [Immunological study on the antitumor effects of fungus polysaccharides compounds]. |
| 已发布 PubMed:鲜根和干根中甘草甜素含量的有效方法 Efficient method for determining the glycyrrhizin content of fresh and dried roots, 和根提取物 and root extracts, 甘草种类。 of Glycyrrhiza species. |
| 已发布 PubMed:通过基于生理学的药代动力学模型评估了甘草酸药代动力学。 The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling. |
| 已发布 PubMed:酶水解甘草提取物甜味剂中主要成分的分离和鉴定。 Isolation and identification of main constituents in an enzymatically hydrolysed licorice extract sweetener. |
| 已发布 PubMed:一个基于生理生理学的药代动力学/药效学模型，用于通过甘草次酸抑制11-β-羟类固醇脱氢酶活性。 A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid. |
| 已发布 PubMed:甘草酸基于生理的药代动力学模型 Physiologically based pharmacokinetic modeling of glycyrrhizic acid, 进行系统前代谢和肝肠循环的化合物。 a compound subject to presystemic metabolism and enterohepatic cycling. |
| 已发布 PubMed:大鼠胃肠道内容物中甘草甜素代谢相关酶的定位 Localization of enzymes involved in metabolism of glycyrrhizin in contents of rat gastrointestinal tract. |
| 已发布 PubMed:甘草中的甘草酸-健康危害评估。 Glycyrrhizic acid in liquorice--evaluation of health hazard. |
| 已发布 PubMed:甘草次酸对鼠 歐洲海濱草致突变性的抑制及皮肤癌的致癌和促癌活性 Inhibition of mutagenicity in Salmonella typhimurium and skin tumor initiating and tumor promoting activities in SENCAR mice by glycyrrhetinic acid: 18个α-和18个β-立体异构体的比较。 comparison of 18 alpha- and 18 beta-stereoisomers. |
| 已发布 PubMed:某些英国甘草产品中甘草甜素的测定。 The determination of glycyrrhizin in selected UK liquorice products. |
| 已发布 PubMed:sprague-dawley大鼠中的甘草次酸铵的致畸性研究。 Teratogenicity study of ammonium glycyrrhizinate in the Sprague-Dawley rat. |
| 已发布 PubMed:[根据日本市场调查研究估计甘草次酸每日摄入量（i）]。 [Estimation of daily intake of glycyrrhizic acid according to the market basket studies in Japan (I)]. |
| 已发布 PubMed:[各种食品中的甘草甜素水平]。 [Glycyrrhizin levels in various food stuffs]. |
| 已发布 PubMed:氨化甘草甜素的致突变作用试验 Tests for mutagenic effects of ammoniated glycyrrhizin, 丁基化羟基甲苯 butylated hydroxytoluene, 和啮齿动物 细胞中的阿拉伯树胶。 and gum Arabic in rodent germ cells. |
| 已发布 PubMed:口服甘草次酸二钠致小鼠的致瘤性研究。 Tumorigenicity study of disodium glycyrrhizinate administered orally to mice. |
| 已发布 PubMed:卡贝索龙对消化性溃疡病患者胃内前列腺素（pg）e2释放的影响 Effects of carbenoxolone on gastric release of prostaglandin (PG)E2 in patients with peptic ulcer disease. |
| 已发布 PubMed:羧苄索龙对迷走橙花和五肽胃泌素刺激后消化性溃疡患者胃中前列腺素e2水平的影响 Effect of carbenoxolone on gastric prostaglandin E2 levels in patients with peptic ulcer disease following vagal and pentagastrin stimulation. |
| 已发布 PubMed:[STudies on the 可能性 喜欢 likelihood of growth of 链球菌 Streptococcus 粪便 faecium 以下 following 热的 thermal 治疗 treatment in 肉 meat 悬架 suspensions (author's 翻译 transl)]. |
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