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类别 Category:masking agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 熔点 Melting Point: | 107.00 °C. @ 760.00 mm 汞 Hg
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| 沸点 Boiling Point: | 304.50 °C. @ 760.00 mm 汞 Hg (est)
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| 蒸汽压力 Vapor Pressure: | 0.001000 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
| 闪点 Flash Point: | 237.00 °F. tcc TCC ( 113.80 °C. ) (est)
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| logp（o / w） logP (o/w): | 2.200 |
| 溶于 Soluble in: |
| | 水 water, 160 mg/L @ 30 ＆deg °C (经验值 exp) | | | 水 water, 253.8°C（最大）793.8 mg / l 793.8 mg/L @ 25 °C (est) |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
| 首选SDS Preferred SDS: 视图 View |
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| 危害识别 Hazards identification |
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| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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| 象形图 Pictogram | |
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| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
intra腹膜的 peritoneal-鸡 chicken ldlo LDLo 100 mg/kg
Proceedings of the 社会 Society for 实验性的 Experi心理 mental 生物学 Biology and 药物 中 Medicine. 卷 Vol. 43, pg。 125 Pg. 125, 1940.
腹腔内小鼠 intra腹膜的 peritoneal-mouse LD50 50 mg/kg
国民 National 技术 Technical Information 服务 Service. 卷 Vol. AD691-490
老鼠 口服 oral-mouse LD50 500 mg/kg
Proceedings of the 社会 Society for 实验性的 Experi心理 mental 生物学 Biology and 药物 中 Medicine. 卷 Vol. 43, pg。 125 Pg. 125, 1940.
口服兔子 口服 oral-rabbit ldlo LDLo 230 mg/kg
VASCULAR: 其他 OTHER CHANGES
Journal of 药理 Pharmacology and 实验性的 Experi心理 mental 疗法 Therapeutics. 卷 Vol. 75, pg。 111 Pg. 111, 1942.
腹膜内大鼠 intra腹膜的 peritoneal-rat LD50 75 mg/kg
Toxicology and 已应用 Applied 药理 Pharmacology. 卷 Vol. 18, pg。 185 Pg. 185, 1971.
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| 皮肤毒性 Dermal Toxicity: |
皮下老鼠 subcutaneous-mouse LD50 138 mg/kg
Journal of 药理 Pharmacology and 实验性的 Experi心理 mental 疗法 Therapeutics. 卷 Vol. 75, pg。 111 Pg. 111, 1942.
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| 吸入毒性 Inhalation Toxicity: |
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未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | | masking agents |
| 甲萘醌使用水平的推荐值 Recommendation for menadione usage levels up to: | | | 不用于香水。 not for fragrance use.
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| 甲萘醌风味使用水平的推荐值 Recommendation for menadione flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
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安全参考 Safety references:
欧洲食品安全局（efsa EFSA）参考 :
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科学的 Scientific 意见 Opinion on the 安全 safety and 功效 efficacy of 维生素k3 vitamin K3 (menadione sodium 亚硫酸氢盐 bisulphite and menadione 烟酰胺 nicotinamide 亚硫酸氢盐 bisulphite) as a 饲料 feed 添加剂 additive for all animal 种类 species
视图 View page or 视图 View pdf
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| Epi系统 EPI System: 视图 View |
| Clinicaltrials.gov ClinicalTrials.gov:search |
| 每日医学 Daily Med:search |
| nlm NLM有害物质数据库 :搜索 Search |
| 化学致癌研究信息系统 Chemical Carcinogenesis Research Information System:搜索 Search |
| 癌症引文 Cancer Citations:搜索 Search |
| 毒理学引文 Toxicology Citations:搜索 Search |
| 环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search |
| EPA物质注册服务（tsca TSCA） :58-27-5 |
| EPA ACToR:毒理学资料 Toxicology Data |
| EPA物质注册服务（SRS） :注册表 Registry |
| 实验室化学安全摘要 Laboratory Chemical Safety Summary :4055 |
| 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data |
| 德国wgk WGK Germany:3 |
| 2-甲基萘-1 2-methylnaphthalene-1,4-二酮 4-dione |
| chemidplus Chemidplus:0000058275 |
| 技术 RTECS:CAS＃58-27-5的ql9100000 QL9100000 for cas# 58-27-5 |
参考资料 References:
| | 2-甲基萘-1 2-methylnaphthalene-1,4-二酮 4-dione |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| 加拿大国内分公司。清单 Canada Domestic Sub. List: | 58-27-5 |
| pubchem（cid） Pubchem (cid): | 4055 |
| pubchem（sid） Pubchem (sid): | 134971654 |
其他资料 Other Information:
| （iupac） (IUPAC): | 元素的原子量2009 Atomic Weights of the Elements 2009 |
| （iupac） (IUPAC): | 元素的原子量2009（pdf） Atomic Weights of the Elements 2009 (pdf) |
| 影片 Videos: | 元素周期表 The Periodic Table of Videos |
| RBC : | 本网站使用的原子量 Atomic Weights use for this web site |
| （iupac） (IUPAC): | 元素周期表 Periodic Table of the Elements |
| CHEBI: | 视图 View |
| CHEMBL: | 视图 View |
| 格尔姆代谢组数据库 Golm Metabolome Database: | 搜索 Search |
| KEGG (GenomeNet): | C05377 |
| hmdb（人类代谢组数据库） HMDB (The Human Metabolome Database): | HMDB01892 |
| 食物 FooDB: | FDB000953 |
| 出口关税代码 Export Tariff Code: | 2936.29.5050 |
| vcf在线 VCF-Online: | 食品中的挥发性有机化合物 VCF Volatile Compounds in Food |
| 化学蜘蛛 ChemSpider: | 视图 View |
| 维基百科 Wikipedia: | 视图 View |
| rsc学习化学 RSC Learn Chemistry: | 视图 View |
配方/制剂 Formulations/Preparations:
＆bull;甲萘醌 •menadione, nf（vit k3）...口服含有2片的片剂 nf (vit k3)...avail in oral admin in tablets containing 2, 5, 或10毫克 or 10 mg, ＆amp;作为油中甲萘醌的无菌溶液（通常为2 & as sterile soln of menadione in oil (usually 2, 10, 或25 毫克毫升 mgml）专为即时管理而设计。
＆bull;甲萘醌亚硫酸氢钠 •menadione sodium bisulfite, nf（催眠素 hykinone）...白结晶 , 吸湿粉。 ...水中的溶胶...以5毫克片剂和amp;在冲动 ampuls5-10 毫克毫升 mgml中。薄荷脑二磷酸钠注射液 , nf（卡帕地酮 nf (kappadione, 滑石 synkavite）... 冲动 ampuls ... 5 , 10, 或37.5 毫克毫升 mgml。薄荷脑二磷酸钠片 , nf ... 5毫克... nf...5 mg...
薄荷脑二磷酸钠注射液 •menadiol sodium diphosphate injection, nf（卡帕地酮 nf (kappadione, 滑石 synkavite） , 以含有5种药物的安非他命销售 is marketed in ampuls containing 5, 10, 或37.5 毫克毫升 mgml。薄荷脑二磷酸钠片 , nf, 含有5毫克盐，可口服。 contain 5 mg of salt for oral use.
具有商业意义的形式是甲萘醌亚硫酸氢钠和甲萘醌二甲基嘧啶醇。 •commercially significant forms are menadione sodium bisulfite and menadione dimethyl pyrimidinol.
＆bull;甲萘醌2 •menadione is available as a 2, 5, 和10毫克片剂，以及2和10毫克/毫升的注射剂（油中）。 and 10 mg tablet and as a 2 and 10 mgml injection (in oil).
甲萘醌的商标名称包括 •trade names for menadione include: 水族 aquakay, aquinone, Austrovit-k仓库 austrovit-k depot, 血气 hemodal, k-血栓基 k-thrombyl, 维生素 kavitamin, 卡尔戈纳 kaergona, 卡农 kanone, 贝尔kaom belgarum, 卡帕克桑 kappaxan, 卡帕新 kappaxin, 卡拉纳姆 karanum, 卡孔 karcon, 卡雷恩 kareon, 卡蒂夫 kativ-g, 维生素 kavitamin, 皮划艇 kayklot, 凯科特 kaykot, y醌 kayquinone, 基普卡 kipca, 基普卡油溶性 kipca-oil soluble, 乐透 klottone, Koaxin koaxin, Kolklot kolklot, menadion, 甲萘芬 menaphthon, 甲萘醌 menaphthone, 甲萘醌0 menaquinone 0, 米特农 mitenon, 米替农 mitenone, q mnq, 新齐玛 neo-zimema-k, 肌苷 panosine, Prokayvit prokayvit, 合成 synkay, 甲醌 thyloquinone, 维卡曼 vikaman, 维他命 vita-noxi k, 和维他韦 vitavel-k。
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潜在搅拌机 Potential Blenders and core 组件 components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, food, 其他） other): note
同义词 Synonyms:
| | 水族 aquakay | | | aquinone | | 1,4- | dhydro-1,4-dioxo-2-methylnaphthalene | | 1,4- | dihydro-1,4-dioxo-2-methylnaphthalene | | 1,4- | dihydro-2-甲基萘-1 2-methylnaphthalene-1,4-二酮 4-dione | | | 催眠素 hykinone | | | 幼虫 juva-K | | | 维生素 K-vitan | | | 卡尔戈纳 kaergona | | | 卡农 kanone | | | 卡帕克桑 kappaxan | | | 卡帕新 kappaxin | | | 卡孔 karcon | | | 卡雷恩 kareon | | | 卡蒂夫 kativ-G | | | 皮划艇 kayklot | | | 凯科特 kaykot | | | 甲萘醌 kaynone | | | y醌 kayquinone | | | Koaxin koaxin | | | Kolklot kolklot | | | menadion | | | 甲基萘 menaphthene | | | 甲萘醌 menaphtone | | | menaquinone O | | 2- | methyl-1,4-naphthalendione | | 2- | methyl-1,4-naphthochinone | | 2- | methyl-1,4-naphthodione | | 2- | methyl-1,4-naphthoquinone | | 2- | methylnaphthalene-1,4-二酮 4-dione | | 1,4- | naphthalenedione, 2-methyl- | | 1,4- | naphthoquinone, 2-methyl- | | | 肌苷 panosine | | | 合成 synkay | | | 维生素k3 vitamin K3 | | | vitamin-K3 |
文章 Articles:
| 已发布 PubMed:外部线粒体nadh依赖的氧化还原循环的还原酶 External mitochondrial NADH-dependent reductase of redox cyclers: vdac1或cyb5r3？ VDAC1 or Cyb5R3? |
| 已发布 PubMed:乳酸菌组的有氧和呼吸生长评估。 Assessment of Aerobic and Respiratory Growth in the Lactobacillus casei Group. |
| 已发布 PubMed: 基于抑制哺乳动物脱氧核糖核酸 DNA聚合酶活性的新型5-o-酰基羽扇豆蛋白的抗肿瘤作用。 |
| 已发布 PubMed:玫瑰红景天引起的寿命延长和与年龄相关的功能衰退延迟取决于饮食中大量营养素的平衡。 Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance. |
| 已发布 PubMed:维生素K代谢 Vitamin K metabolism: 当前的知识和未来的研究。 Current knowledge and future research. |
| 已发布 PubMed:植物乳杆菌c17的呼吸道培养中耐氧化应激的突变体的选择 Selection of mutants tolerant of oxidative stress from respiratory cultures of Lactobacillus plantarum C17. |
| 已发布 PubMed:液相色谱-二极管阵列-常压化学电离质谱法检测食品中维生素d和k的分散液-液微萃取 Dispersive liquid-liquid microextraction for the determination of vitamins D and K in foods by liquid chromatography with diode-array and atmospheric pressure chemical ionization-mass spectrometry detection. |
| 已发布 PubMed:富含菜籽油的饮食会改变体外甲萘醌和尼美舒利肝线粒体的毒性。 Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity. |
| 已发布 PubMed:α-茄碱和α-查茄碱诱导的协同细胞毒性。 Synergistic cytotoxicity induced by α-solanine and α-chaconine. |
| 已发布 PubMed:特定的饮食碳水化合物差异影响果蝇的寿命和繁殖力。 Specific dietary carbohydrates differentially influence the life span and fecundity of Drosophila melanogaster. |
| 已发布 PubMed:金黄熊果的小菌落变体（scvs）-一种细菌生存策略。 Small colony variants (SCVs) of Staphylococcus aureus--a bacterial survival strategy. |
| 已发布 PubMed: 李子 plumbagin和其他萘醌的抗突变和抗氧化性能。 |
| 已发布 PubMed:甲萘醌催化化学发光分析法进行食品安全快速评估的筛选试验。 Screening test for rapid food safety evaluation by menadione-catalysed chemiluminescent assay. |
| 已发布 PubMed:非核糖体肽合成酶介导柑橘类真菌病原体链格孢菌中铁载体的产生和毒力。 A nonribosomal peptide synthetase mediates siderophore production and virulence in the citrus fungal pathogen Alternaria alternata. |
| 已发布 PubMed:从氧化过程中的分离过程中分离出的马克斯克鲁维酵母酵母的呼吸能力。 Respiratory capacity of the Kluyveromyces marxianus yeast isolated from the mezcal process during oxidative stress. |
| 已发布 PubMed:skn7响应调节剂在抗逆性中的作用 Roles for SKN7 response regulator in stress resistance, 柑橘病原体交替链霉菌的致死性和毒力。 conidiation and virulence in the citrus pathogen Alternaria alternata. |
| 已发布 PubMed:维生素e降低了饲喂甲萘醌或叶醌的大鼠肝外甲萘醌4的浓度。 Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone. |
| 已发布 PubMed:日粮中甲萘醌4的摄入量可能决定鸡的肝和胰腺甲萘醌4含量。 Dietary intake of menaquinone-4 may determine hepatic and pancreatic menaquinone-4 in chickens. |
| 已发布 PubMed:nadph氧化酶介导的过氧化氢（h（2）o（2））的产生和对柑橘的坏死性病原体交链孢菌的氧化应激的抵抗力。 The NADPH oxidase-mediated production of hydrogen peroxide (H(2)O(2)) and resistance to oxidative stress in the necrotrophic pathogen Alternaria alternata of citrus. |
| 已发布 PubMed:对酿酒酵母knu5377中甲萘醌诱导的氧化应激的适应性应激反应。 Adaptive stress response to menadione-induced oxidative stress in Saccharomyces cerevisiae KNU5377. |
| 已发布 PubMed:抗氧化剂抑制橙花毒素mptp的生物活化 Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, 氧化还原剂和单胺氧化酶抑制剂。 redox agents and monoamine oxidase inhibitors. |
| 已发布 PubMed:大鼠肝脏部分中双脱氧喹啉的代谢的体外生物转化和代谢酶的研究 In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, 鸡 chicken, 和猪。 and pigs. |
| 已发布 PubMed:红皮体操运动员的聚乙炔在体内和体外均具有保肝作用。 A polyacetylene from Gymnaster koraiensis exerts hepatoprotective effects in vivo and in vitro. |
| 已发布 PubMed:咖啡提取物和无细胞系统和 类结肠细胞系中选定成分的抗氧化功效。 Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines. |
| 已发布 PubMed:肝制剂中喹(+)-香柏酮类药物的代谢和氮氧化物的还原 The metabolism and N-oxide reduction of olaquindox in liver preparations of rats, 猪和鸡。 pigs and chicken. |
| 已发布 PubMed:活性氧在酿酒酵母中ty1逆转座诱导中的作用。 The role of reactive oxygen species in the induction of Ty1 retrotransposition in Saccharomyces cerevisiae. |
| 已发布 PubMed:槲皮素预处理或联合处理对大鼠原代混合橙花胶质细胞中甲萘醌毒性的影响。 The effect of pretreatment or combined treatment of quercetin on menadione toxicity in rat primary mixed glial cells in vitro. |
| 已发布 PubMed:食品和肠道乳酸菌植物乳杆菌wcfs1中具有选择性硝基还原特性的硝基还原酶的表征。 Characterization of a nitroreductase with selective nitroreduction properties in the food and intestinal lactic acid bacterium Lactobacillus plantarum WCFS1. |
| 已发布 PubMed:基于甲萘醌催化过氧化氢生产力的新型细胞毒性测试，用于食品安全性评估。 Novel cytotoxicity test based on menadione-catalyzed H2O2 productivity for food safety evaluation. |
| 已发布 PubMed:通过新型细胞毒性测试快速检测食品添加剂和污染物的细胞毒性 Rapid detection of cytotoxicity of food additives and contaminants by a novel cytotoxicity test, 甲萘醌催化的h（2）o（2）生产测定。 menadione-catalyzed H(2)O (2) production assay. |
| 已发布 PubMed:β-环糊精的荧光光谱研究 Spectrofluorimetric study of the beta-cyclodextrin:维生素k3复合物和维生素k3的测定。 vitamin K3 complex and determination of vitamin K3. |
| 已发布 PubMed:菊酯对维持 结肠癌细胞dna完整性的影响。 Impact of delphinidin on the maintenance of DNA integrity in human colon carcinoma cells. |
| 已发布 PubMed:生物活性营养素的异硫氰酸盐类共价抑制mekk1蛋白激酶。 The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase. |
| 已发布 PubMed:薄荷醇存在下甲萘醌亚硫酸氢钠的电化学发光行为研究。 Study on the electrochemiluminescent behavior of menadione sodium bisulfite in presence of luminol. |
| 已发布 PubMed:通过增加铜的周质表达来增强大肠杆菌的存活 Enhancing survival of Escherichia coli by increasing the periplasmic expression of Cu,来自酿酒酵母的zn超氧化物歧化酶。 Zn superoxide dismutase from Saccharomyces cerevisiae. |
| 已发布 PubMed:评估探针二氢骨钙素乙酰氧基甲基酯作为活性氧物种形成的指标，并与通过改良碱性洗脱技术测定的氧化dna碱修饰进行比较。 Evaluation of the probe dihydrocalcein acetoxymethylester as an indicator of reactive oxygen species formation and comparison with oxidative DNA base modification determined by modified alkaline elution technique. |
| 已发布 PubMed:铜的表达 Expression of Cu, 毕赤酵母中酿酒酵母的zn-超氧化物歧化酶基因及其对氧化应激的抗性 Zn-superoxide dismutase gene from Saccharomyces cerevisiae in Pichia pastoris and its resistance to oxidative stress. |
| 已发布 PubMed:抗氧化剂和其他营养物质不会干扰化学疗法或放射疗法，并且可以增加杀伤力并增加生存率 Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, 第2部分。 Part 2. |
| 已发布 PubMed:抗氧化剂和其他营养物质不会干扰化学疗法或放射疗法，并且可以增加杀伤力并增加生存率 Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, 第1部分。 part 1. |
| 已发布 PubMed:雌马酚 Equol: 外消旋化合物与纯化的s-对映异构体对生长的影响比较 a comparison of the effects of the racemic compound with that of the purified S-enantiomer on the growth, 侵入 invasion, 和乳腺癌和前列腺细胞的dna完整性。 and DNA integrity of breast and prostate cells in vitro. |
| 已发布 PubMed:甲萘醌催化的鲁米诺化学发光法快速检测活菌。 [Menadione-catalyzed luminol chemiluminescence assay for the rapid detection of viable bacteria]. |
| 已发布 PubMed: 结肠细胞系中酚苹果汁提取物的重构混合物对氧化性细胞损伤的调节作用 Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines. |
| 已发布 PubMed:nad（p）h的两个关键水平的体内相关性 In vivo relevance of two critical levels for NAD(P)H:醌氧化还原酶（nqo1）介导的针对亲电子试剂毒性的细胞保护作用在体外发现。 quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro. |
| 已发布 PubMed:禁忌烟中的皮中鉴定出的化合物对 肠道细菌的选择性生长抑制作用。 Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria. |
| 已发布 PubMed:甲萘醌催化的鲁米诺化学发光法可快速检测有氧条件下食品中的活菌。 Menadione-catalyzed luminol chemiluminescence assay for the rapid detection of viable bacteria in foods under aerobic conditions. |
| 已发布 PubMed:对弱酸对百日酵母的抑制作用的电化学评估。 Electrochemical evaluation of the inhibitory effects of weak acids on Zygosaccharomyces bailii. |
| 已发布 PubMed:甲萘醌亚硫酸氢钠的作用 Effect of menadione sodium bisulfite, 植物防御的诱因 an inducer of plant defenses, 致病过程中香蕉植物抗毒素积累动态的研究。 on the dynamic of banana phytoalexin accumulation during pathogenesis. |
| 已发布 PubMed:应激情况会在腐败酵母中诱导抗氰化物呼吸。 Stress situations induce cyanide-resistant respiration in spoilage yeasts. |
| 已发布 PubMed:用电化学丝网印刷的生物传感器阵列快速鉴定可行的大肠杆菌亚种。 Rapid identification of viable Escherichia coli subspecies with an electrochemical screen-printed biosensor array. |
| 已发布 PubMed:甲萘醌（维生素K3）的添加对植物油中脂质氧化和生育酚含量的影响 Effect of menadione (vitamin K3) addition on lipid oxidation and tocopherols content in plant oils. |
| 已发布 PubMed: 虹鳟（oncorhynchus 我的吻 mykiss）的百草枯和甲萘醌暴露-对肝和肾中戊糖-磷酸盐分流和硫胺素水平的影响研究。 |
| 已发布 PubMed: 黑升麻（cimicifuga racemosa l。）通过清除活性氧来防止甲萘醌引起的dna损伤 : 生物测定指导的有效成分的分离和表征。 bioassay-directed isolation and characterization of active principles. |
| 已发布 PubMed:γ-生育酚在预防中国仓鼠v79细胞中氧化剂诱导的姊妹染色单体交换方面不如α-生育酚有效。 Gamma-tocopherol is less effective than alpha-tocopherol in preventing oxidant-induced sister chromatid exchanges in Chinese hamster V79 cells. |
| 已发布 PubMed:枯草芽孢杆菌的耐甲萘醌突变体可有效生产甲萘醌（维生素k2）。 Efficient production of menaquinone (vitamin K2) by a menadione-resistant mutant of Bacillus subtilis. |
| 已发布 PubMed:甲萘醌（维生素K3）对植物油储存过程中生育酚的溶解和二聚以及三酰甘油的自氧化的影响 Influence of added menadione (vitamin K3) on dissolution and dimerization of tocopherols and autoxidation of triacylglycerols during storage of plant oils. |
| 已发布 PubMed:饮食中维生素K对生存的影响 Effects of dietary vitamin K on survival, growth, 鲍鱼的叶绿体醌（pk）和甲萘醌-4（mk-4）的含量和组织浓度 and tissue concentrations of phylloquinone (PK) and menaquinone-4 (MK-4) for juvenile abalone, haliotis铁饼汉内 hannai ino。 |
| 已发布 PubMed:类黄酮的保护机制 Mechanism of protection by the flavonoids, 槲皮素和芦丁 quercetin and rutin, 对抗叔丁基氢过氧化物和甲萘醌诱导的caco-2细胞中的dna单链断裂。 against tert-butylhydroperoxide- and menadione-induced DNA single strand breaks in Caco-2 cells. |
| 已发布 PubMed:醛氧化酶在猪体内3-甲基吲哚肝代谢中的作用 Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs. |
| 已发布 PubMed:维生素和相关化合物对熟食中遗传毒性杂环胺的抗诱变作用和可能的作用机理。 Antimutagenic effects and possible mechanisms of action of vitamins and related compounds against genotoxic heterocyclic amines from cooked food. |
| 已发布 PubMed:uva1 触发两种不同的最终细胞凋亡途径。 UVA1 radiation triggers two different final apoptotic pathways. |
| 已发布 PubMed:蛋鸡不同年龄的骨骼结构和强度及饮食颗粒石灰石的影响 Bone structure and strength at different ages in laying hens and effects of dietary particulate limestone, 维生素K和抗坏血酸。 vitamin K and ascorbic acid. |
| 已发布 PubMed:过氧化氢导致啤酒酵母中g2的rad9依赖性细胞周期停滞，而甲萘醌则导致不依赖rad9功能的g1停滞。 Hydrogen peroxide causes RAD9-dependent cell cycle arrest in G2 in Saccharomyces cerevisiae whereas menadione causes G1 arrest independent of RAD9 function. |
| 已发布 PubMed:亚油酸氢过氧化物对酿酒酵母的毒性 Toxicity of linoleic acid hydroperoxide to Saccharomyces cerevisiae: 参与与呼吸有关的过程，以获得最大的敏感性和适应性反应。 involvement of a respiration-related process for maximal sensitivity and adaptive response. |
| 已发布 PubMed:永生化肝细胞作为毒性测试的体外模型系统 Immortalized hepatocytes as in vitro model systems for toxicity testing: 甲萘醌在永生细胞中的比较毒性 the comparative toxicity of menadione in immortalized cells, 肝细胞和htc肝癌细胞的原代培养。 primary cultures of hepatocytes and HTC hepatoma cells. |
| 已发布 PubMed:正常化剂（食品补充剂）对 血液中性粒细胞产生自由基的影响 Effects of bio-normalizer (a food supplementation) on free radical production by human blood neutrophils, 红细胞 erythrocytes, 和大鼠腹膜巨噬细胞。 and rat peritoneal macrophages. |
| 已发布 PubMed:视黄酸细胞毒性 Cytotoxicity of retinoic acid, 甲萘醌和黄曲霉毒素b（1）在大鼠肝切片中使用net好 well插入物作为新的培养系统。 |
| 已发布 PubMed:吡咯并喹啉醌特异的单克隆抗体的生产和应用。 Production and application of monoclonal antibodies specific to pyrroloquinoline quinone. |
| 已发布 PubMed:大鼠2-烷基和2-羟基萘醌的病理学 Pathology of 2-alkyl and 2-hydroxy naphthoquinone toxicity in rats. |
| 已发布 PubMed:分枝杆菌属物种减少和诱变硝基芳香族化合物。 Reduction and mutagenic activation of nitroaromatic compounds by a Mycobacterium sp. |
| 已发布 PubMed:蒽抗突变潜力的评估 Evaluation of the antimutagenic potential of anthracene: 体外和离体研究。 in vitro and ex vivo studies. |
| 已发布 PubMed:琼脂（5-羟基-1 Differential toxicity of juglone (5-hydroxy-1,4-萘醌）和与萘啶蛾相关的萘醌。 4-naphthoquinone) and related naphthoquinones to saturniid moths. |
| 已发布 PubMed:bht（丁基化羟基甲苯）对大鼠维生素K依赖性凝血的剂量依赖性作用。 The dose-dependent effect of BHT (butylated hydroxytoluene) on vitamin K-dependent blood coagulation in rats. |
| 已发布 PubMed:使用鼠肝细胞瘤细胞的食物提取物诱导抗癌酶醌还原酶。 Induction of the anti-carcinogenic enzyme quinone reductase by food extracts using murine hepatoma cells. |
| 已发布 PubMed:定量使用甲萘醌对少年海虾（旱金莲/金莲花）的维生素K需求量。 Quantifying the vitamin K requirement of juvenile marine shrimp (Penaeus monodon) with menadione. |
| 已发布 PubMed:氧化应激过程中碳酸酐酶iii上巯基的s-硫醇化和不可逆氧化 S-thiolation and irreversible oxidation of sulfhydryls on carbonic anhydrase III during oxidative stress: 一种研究完整细胞和组织中蛋白质修饰的方法。 a method for studying protein modification in intact cells and tissues. |
| 已发布 PubMed:硒缺乏会抑制氧化应激在大鼠肝细胞中碳酸酐酶iii的s-谷氨酰胺化。 Selenium deficiency suppresses the S-glutathiolation of carbonic anhydrase III in rat hepatocytes under oxidative stress. |
| 已发布 PubMed:和酚类结构对食用菌双孢蘑菇的致突变性的贡献。 Contribution of phenolic and quinonoid structures in the mutagenicity of the edible mushroom Agaricus bisporus. |
| 已发布 PubMed:产气荚膜梭菌的偶氮还原酶和硝基还原酶的比较。 Comparison of the azoreductase and nitroreductase from Clostridium perfringens. |
| 已发布 PubMed:用来区分耐地非那非和易感挪威大鼠的血凝反应试验的发展 The development of a blood clotting response test for discriminating between difenacoum-resistant and susceptible Norway rats (Rattus norvegicus, 伯克。）。 Berk.). |
| 已发布 PubMed:从 体胃肠道分离的厌氧细菌减少硝基芳香化合物的含量。 Reduction of nitroaromatic compounds by anaerobic bacteria isolated from the human gastrointestinal tract. |
| 已发布 PubMed:贻贝中抗氧化剂和脂质过氧化对氧化损伤暴露的响应 Responses of antioxidants and lipid peroxidation in mussels to oxidative damage exposure. |
| 已发布 PubMed:枯草杆菌分泌的维生素K2结合因子。 A vitamin-K2-binding factor secreted from Bacillus subtilis. |
| 已发布 PubMed:维生素及其类似物终末分化的比较研究 Comparative investigation of vitamins and their analogues on terminal differentiation, 从前脂肪细胞到脂肪细胞 from preadipocytes to adipocytes, 3t3-l1细胞。 of 3T3-L1 cells. |
| 已发布 PubMed:婴儿配方食品中维生素A的上限 Upper limits of vitamin A in infant formulas, 关于维生素K的一些评论。 with some comments on vitamin K. |
| 已发布 PubMed:从禁食和进食的大鼠分离的肝细胞中甲萘醌代谢引起的能量状态改变。 Alterations in energy status by menadione metabolism in hepatocytes isolated from fasted and fed rats. |
| 已发布 PubMed:使用柱后锌还原剂的高效液相色谱荧光法测定合成动物饲料中的维生素k3（甲萘醌亚硫酸氢钠）。 Fluorimetric determination of vitamin K3 (menadione sodium bisulfite) in synthetic animal feed by high-performance liquid chromatography using a post-column zinc reducer. |
| 已发布 PubMed:维生素k3饲料添加剂预防甜三叶草疾病的评估 Evaluation of vitamin K3 feed additive for prevention of sweet clover disease. |
| 已发布 PubMed:新开发的无菌小鼠维生素K缺乏模型。 Newly developed model for vitamin K deficiency in germfree mice. |
| 已发布 PubMed:改变和模拟油菜籽鸡产蛋肝出血的实验系统。 Experimental systems which modify and simulate rapeseed-induced liver haemorrhages in in-lay hens. |
| 已发布 PubMed:甲萘醌诱导的进食和禁食大鼠肝细胞氧化应激 Menadione-induced oxidative stress in hepatocytes isolated from fed and fasted rats: Nadph再生途径的作用。 the role of NADPH-regenerating pathways. |
| 已发布 PubMed:饮食对大鼠肝脏和肠道dt-黄递酶活性的影响。 Dietary influences on rat hepatic and intestinal DT-diaphorase activity. |
| 已发布 PubMed:细胞毒性机制的体外研究。 In vitro studies of mechanisms of cytotoxicity. |
| 已发布 PubMed:直接气液色谱法测定饲料预混合物中的水溶性维生素k3。 Direct gas-liquid chromatographic determination of water-soluble vitamin K3 in feed premixes. |
| 已发布 PubMed:蛋氨酸和维生素k3对饲喂含辐照牛肉的定量饲料引起的出血的影响。 EFFECT OF METHIONINE AND VITAMIN K3 ON HEMORRHAGES INDUCED BY FEEDING A RATION CONTAINING IRRADIATED BEEF. |
| 已发布 PubMed:维生素k3和睾丸激素对受辐照牛肉喂养的大鼠出血性素质的影响 EFFECT OF VITAMIN K3 AND TESTOSTERONE ON HEMORRHAGIC DIATHESIS IN RATS FED IRRADIATED BEEF. |
| 已发布 PubMed:根据应力等级的不同，两个巨型念珠菌的转醛酶同工酶的表现方式也不同。 Two transaldolase isogenes from Moniliella megachiliensis behave in a different way depending on the stress class. |
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没有类异戊二烯侧链和生物活性的合成萘醌 a synthetic naphthoquinone without the isoprenoid side chain and biological activity, 但可以转化为活性维生素k2 but can be converted to active vitamin k2, menaquinone, 体内烷基化后。促血栓形成的维生素（合成的） after alkylation in vivo. Prothrombogenic vitamin (synthetic)
没有类异戊二烯侧链和生物活性的合成萘醌 a synthetic naphthoquinone without the isoprenoid side chain and biological activity, 但可以转化为活性维生素k2 but can be converted to active vitamin k2, menaquinone, 体内烷基化后。 -pubchem;尽管它可以作为各种维生素K的前体 after alkylation in vivo. -- Pubchem; Despite the fact that it can serve as a precursor to various types of vitamin K, 1h-核磁共振波谱分析收获时间对番石榴叶片代谢的影响，并预测其清除自由基的活性 menadione is generally not used as a nutritional supplement. Large doses of menadione have been reported to cause adverse outcomes including hemolytic anemia due to G6PD deficiency, 新生儿脑或肝损伤 neonatal brain or liver damage, 或某些情况下新生儿死亡。此外 or neonatal death in some cases. Moreover, 甲萘醌补充剂由于其高毒性而被fda禁止。它有时被称为维生素K3 menadione supplements have been banned by the FDA because of their high toxicity.; It is sometimes called vitamin K3, 尽管萘醌的衍生物在3位没有侧链，但不能发挥k维生素的所有功能甲萘醌是k2的维生素前体，它利用肝脏中的烷基化作用产生甲萘醌（mk-n although derivatives of naphthoquinone without the sidechain in the 3-position cannot exert all the functions of the K vitamins. Menadione is a vitamin precursor of K2 which utilizes alkylation in the liver to yield menaquinones (MK-n, n=1-13; it It is 也 also known as "甲萘醌 menaphthone".; it It is 有时 some次 times called called 维生素k3 vitamin K3, 尽管萘醌衍生物在3位不带侧链不能发挥k维生素的所有功能甲萘醌是k2的维生素前体，它利用烷基化作用生成甲萘醌（mk-n although derivatives of naphthoquinone without the side chain in the 3-position cannot exert all the functions of the K vitamins. Menadione is a vitamin precursor of K2 which utilizes alkylation to yield menaquinones (MK-n, n = 1-13； k2维他命） n=1-13; K2 vitamers), 因此 and hence, 更好地归为维他命原。 k2维他命） is better classified as a provitamin.; K2 vitamers), 因此 and hence, 更好地归类为维生素原。 -维基百科;甲萘醌（维生素k3）是脂溶性维生素前体，可在肝脏中转化为甲萘醌。维生素k1和k2是维生素k的天然类型。前者 is better classified as a provitamin. -- Wikipedia; Menadione (Vitamin K3) is a fat-soluble vitamin precursor that is converted into menaquinone in the liver. Vitamin K1 and K2 are the naturally occurring types of vitamin K. The former, 也称为叶醌 which is also known as phylloquinone, 由植物合成，可以在菠菜等食物中找到 is synthesized by plants and can be found in such foods as spinach, 西兰花 broccoli, 生菜 lettuce, 和大豆。后者 and soybeans. The latter, 有时也称为甲萘醌 sometimes alternatively referred to as menaquinone, 它主要是由肠道前部和肠道中的细菌产生的。维生素k3 is primarily produced by bacteria in the anterior part of the gut and the intestines. Vitamin K3, 另一方面 on the other hand, 是维生素K的许多 造版本之一。也称为甲萘醌 is one of the many manmade versions of vitamin K. Also called menadione, 这种淡黄 this yellowish, 合成的晶体物质在动物体内转化为活性形式的k2维生素。维生素K缺乏症可能很危险 synthetic crystalline substance is converted into the active form of the K2 vitamin inside of the animal body. While a vitamin K deficiency can be dangerous, 特别是对于那些容易遭受广泛出血的婴儿 especially to infants that may easily suffer from extensive hemorrhaging, 过量可能同样有害。维生素K3剂量过大的新生儿可能患有kernerterus an overdose can be as equally detrimental. Newborns that are administered too great a dosage of vitamin K3 can suffer from kernicterus, 一种严重的脑损伤，可能导致运动减少 a form of severe brain damage that may produce decreased movement, 食欲不振 loss of appetite, 癫痫发作 seizures, 耳聋 deafness, 智力低下 mental retardation, 甚至死亡。这种情况与胆红素浓度异常高有关 and even death. This condition is associated with an abnormally high concentration of bilirubin, 色素 a bile pigment, 在脑组织中 in the tissues of the brain, 这可能是由于存在k3引起的。为此原因 which can be caused by the presence of K3. For this reason, 与以前相比，k3在医学上的使用较少。甲萘醌是一种多环芳族酮 K3 is less often utilized medically than it was in former times.; Menadione is a polycyclic aromatic ketone, 基于1 based on 1,4-naphthoquinone, 具有2-甲基取代基。 with a 2-methyl substituent.
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