类别 Category:antioxidants
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
出现 Appearance: | 白粉末(est) white powder (est) |
化验 Assay: | 98.00至100.00 98.00 to 100.00
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食品化学品法典列表 Food Chemicals Codex Listed: | No |
熔点 Melting Point: | 68.00 °C. @ 760.00 mm 汞 Hg
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沸点 Boiling Point: | 334.00 °C. @ 760.00 mm 汞 Hg
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蒸汽压力 Vapor Pressure: | 0.000092 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
闪点 Flash Point: | 311.00 °F. tcc TCC ( 155.20 °C. ) (est)
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logp(o / w) logP (o/w): | 3.450 |
溶于 Soluble in: |
| acetone | | ether | | 水 water, 500毫克/升@ 18c(经验值 exp) |
感官特性 Organoleptic Properties:
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
首选SDS Preferred SDS: 视图 View |
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危害识别 Hazards identification |
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物质或混合物的分类 Classification of the substance or mixture |
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
没有找到。 None found. |
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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象形图 Pictogram | |
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危险说明 Hazard statement(s) |
没有找到。 None found. |
防范说明 Precautionary statement(s) |
没有找到。 None found. |
口服/肠胃外毒性 Oral/Parenteral Toxicity: |
口鼠 口服 oral-rat LD50 550 mg/kg Journal of 药理 Pharmacology and 实验性的 Experimental 疗法 Therapeutics. 卷 Vol. 53, pg。 198 Pg. 198, 1935.
老鼠 口服 oral-mouse LD50 1040 mg/kg Pharmazie. 卷 Vol. 30, pg。 147 Pg. 147, 1975.
腹腔内小鼠 intraperitoneal-mouse LD50 335 mg/kg Japanese 高海 Kokai 东京 Tokyo koho Koho 专利 专利 Patents. 卷 Vol. #90-292213
几内亚口服 口服 oral-guinea 猪 pig ldlo LDLo 400 mg/kg Proceedings of the 社会 Society for 实验性的 Experimental 生物学 Biology and 药物 中 Medicine. 卷 Vol. 28, pg。 609 Pg. 609, 1931.
未报告的鼠标 unreported-mouse ldlo LDLo 100 mg/kg Annals of Tropical 药物 中 Medicine and 寄生虫学 Parasitology. 卷 Vol. 32, pg。 177 Pg. 177, 1938.
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皮肤毒性 Dermal Toxicity: |
皮下老鼠 subcutaneous-mouse ldlo LDLo 750 mg/kg "Handbook of Toxicology," 4卷 4 vols., 费城 Philadelphia, w.b.桑德斯公司 W.B. Saunders Co., 1956-59卷。 5 1956-59Vol. 5, pg。 148 Pg. 148, 1959.
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吸入毒性 Inhalation Toxicity: |
未定 Not determined
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使用安全信息 Safety in Use Information:
类别 Category: | antioxidants |
推荐的4-己基间苯二酚的使用水平不超过 Recommendation for 4-hexyl resorcinol usage levels up to: | | 不用于香水。 not for fragrance use.
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推荐使用4-己基间苯二酚风味剂的使用水平 Recommendation for 4-hexyl resorcinol flavor usage levels up to: |
| 不用于调味料。 not for flavor use.
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安全参考 Safety references:
参考资料 References:
| 4-己基苯-1 4-hexylbenzene-1,3-二醇 3-diol |
NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
加拿大国内分公司。清单 Canada Domestic Sub. List: | 136-77-6 |
pubchem(cid) Pubchem (cid): | 3610 |
pubchem(sid) Pubchem (sid): | 134973215 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core 组件 components note
潜在用途 Potential Uses:
存在(自然 Occurrence (nature, food, 其他) other): note
| 自然界中找不到 not found in nature |
同义词 Synonyms:
| benzenediol, 4-hexyl- | 1,3- | benzenediol, 4-hexyl- | | 己酮 caprokol | 1,3- | dihydroxy-4-hexyl benzene | | 凝胶过剩 gel过度 overmin | | hexyl resorcinol | 4- | hexyl-1,3-benzenediol | 4- | hexyl-1,3-二羟基苯 dihydroxybenzene | 4- | hexyl-benzene-1,3-二醇 3-diol | 4- | hexylbenzene-1,3-二醇 3-diol | 4- | hexylbenzol-1,3-二醇 3-diol | | hexylresorcin | 4- | hexylresorcine | 4- | hexylresorcinol | 4-N- | hexylresorcinol | p- | hexylresorcinol | | 蔗糖 sucrets | | 蠕虫原 worm-agen |
文章 Articles:
已发布 PubMed:丝素蛋白和4-己基间苯二酚掺入膜用于引导骨再生。 Silk fibroin and 4-hexylresorcinol incorporation membrane for guided bone regeneration. |
已发布 PubMed:4-己基间苯二酚通过抑制钙振荡发挥抗肿瘤作用,其抗肿瘤作用被钙通道阻滞剂抑制。 4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers. |
已发布 PubMed:在口腔粘膜黑素瘤异种移植模型中,顺铂和4-己基间苯二酚协同作用可减少转移并提高生存率 Cisplatin and 4-hexylresorcinol synergise to decrease metastasis and increase survival rate in an oral mucosal melanoma xenograft model: 初步研究。 a preliminary study. |
已发布 PubMed:4-正丁基间苯二酚 4-n-butylresorcinol, 一种高效酪氨酸酶抑制剂,用于局部色素沉着过度治疗。 a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation. |
已发布 PubMed:4-己基间苯二酚通过抑制e2f2刺激scc-9细胞分化 4-hexylresorcinol stimulates the differentiation of SCC-9 cells through the suppression of E2F2, e2f3和sp3表达以及sp1表达的促进。 E2F3 and Sp3 expression and the promotion of Sp1 expression. |
已发布 PubMed:简单循环伏安法(cv)和dpph测定法测定活性成分抗氧化能力的比较。 Comparison of the simple cyclic voltammetry (CV) and DPPH assays for the determination of antioxidant capacity of active principles. |
已发布 PubMed:4-己基间苯二酚抑制nf-κb磷酸化,并与kb细胞中的顺铂具有协同作用。 4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells. |
已发布 PubMed:用于牙科植入物的钛合金上的羟基磷灰石和4-己基间苯二酚涂层的气溶胶沉积。 Aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants. |
已发布 PubMed:太平洋牡蛎克氏丝藻中酚氧化酶的组织分布和特异性差异。 Differential tissue distribution and specificity of phenoloxidases from the Pacific oyster Crassostrea gigas. |
已发布 PubMed:franz扩散池中未搅拌的水界面层的测量。 A measurement of the unstirred aqueous boundary layer in a Franz diffusion cell. |
已发布 PubMed: 食用蘑菇(flammulina 天鹅绒 velutipes)提取物可抑制kuruma虾(marsupenaeus japonicus)黑素病。 |
已发布 PubMed:分子伴侣对球形红细菌溶菌酶和反应中心蛋白性质的影响 [Effect of chemical chaperones on properties of lysozyme and the reaction center protein from Rhodobacter sphaeroides]. |
已发布 PubMed:4-己基间苯二酚抑制转谷氨酰胺酶2的活性,并与kb细胞中的顺铂具有协同作用。 4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells. |
已发布 PubMed:太平洋牡蛎克氏丝酵母中漆酶活性的第一个证据。 First evidence of laccase activity in the Pacific oyster Crassostrea gigas. |
已发布 PubMed:蘑菇酪氨酸酶纯度导致ic(50)值的变化。 Variations in IC(50) values with purity of mushroom tyrosinase. |
已发布 PubMed:天然抗褐变剂对鲜切富士苹果颜色和相关酶的影响,可替代使用抗坏血酸。 Effect of natural antibrowning agents on color and related enzymes in fresh-cut Fuji apples as an alternative to the use of ascorbic acid. |
已发布 PubMed:通过计算机模拟和体外方法鉴定食品添加剂中的异雌激素。 Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach. |
已发布 PubMed:焦磷酸和4-己基间苯二酚预处理对气调包装后冷藏白虾(南美白旱金莲/金莲花)品质的影响。 Effect of pyrophosphate and 4-hexylresorcinol pretreatment on quality of refrigerated white shrimp (Litopenaeus vannamei) kept under modified atmosphere packaging. |
已发布 PubMed:溶剂对4-己基间苯二酚光谱性质的影响。 Solvent effects on the spectroscopic properties of 4-hexylresorcinol. |
已发布 PubMed:抗坏血酸和4-己基间苯二酚防止褐变 Browning prevention by ascorbic acid and 4-hexylresorcinol: 在存在和不存在底物的情况下,对多酚氧化酶的不同作用机理。 different mechanisms of action on polyphenol oxidase in the presence and in the absence of substrates. |
已发布 PubMed:抗坏血酸和4-己基间苯二酚对梨ppo的影响和ppo催化的褐变反应。 Ascorbic acid and 4-hexylresorcinol effects on pear PPO and PPO catalyzed browning reaction. |
已发布 PubMed:氧白藜芦醇作为抗褐变剂,用于混浊的苹果汁和鲜切苹果。 Oxyresveratrol as an antibrowning agent for cloudy apple juices and fresh-cut apples. |
已发布 PubMed:利用实验设计方法从茄子中的葡萄糖和半胱氨酸多酚氧化酶半胱氨酸抑制剂制备美拉德反应产物。 Use of experimental design methodology to prepare Maillard reaction products from glucose and cysteine inhibitors of polyphenol oxidase from eggplant (Solanum melongena). |
已发布 PubMed:旱金莲/金莲花和螃蟹中4-己基间苯二酚残留的测定 [Determination of 4-hexylresorcinol residues in prawns and crabs]. |
已发布 PubMed:亚硫酸盐和4-己基间苯二酚在受控气氛下对深水粉红虾(旱金莲/金莲花)的微生物生长和黑素病预防的作用。 Role of sulfites and 4-hexylresorcinol in microbial growth and melanosis prevention of deepwater pink shrimp (Parapenaeus longirostris) using a controlled atmosphere. |
已发布 PubMed:白藜芦醇和4-己基间苯二酚对过氧化氢诱导的 淋巴细胞氧化性dna损伤的影响。 Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. |
已发布 PubMed:巴西橡胶树乳胶中的多酚氧化酶 Polyphenol oxidases from latex of Hevea brasiliensis: 纯化和表征。 purification and characterization. |
已发布 PubMed:使用抗褐变剂和气调包装保持鲜切芒果的质量。 Maintaining quality of fresh-cut mangoes using antibrowning agents and modified atmosphere packaging. |
已发布 PubMed:酚和十二烷基硫酸钠诱导 角质形成细胞和成纤维细胞中细胞因子的释放和细胞毒性。 Cytokine release and cytotoxicity in human keratinocytes and fibroblasts induced by phenols and sodium dodecyl sulfate. |
已发布 PubMed:茄多酚氧化酶的儿茶酚酶和甲酚酶活性的表征 Characterization of catecholase and cresolase activities of eggplant polyphenol oxidase. |
已发布 PubMed:液相色谱-荧光检测法测定虾中4-己基间苯二酚 Determination of 4-hexylresorcinol in shrimp by liquid chromatography with fluorescence detection. |
已发布 PubMed:ph的影响 Influence of pH, benzoic acid, glutathione, 埃达 EDTA, 4-hexylresorcinol, 和氯化钠对蘑菇多酚氧化酶的压力失活动力学。 and sodium chloride on the pressure inactivation kinetics of mushroom polyphenol oxidase. |
已发布 PubMed:黄酮槲皮素被多酚氧化酶氧化。 Oxidation of the flavonol quercetin by polyphenol oxidase. |
已发布 PubMed:使用天然产物及其衍生物延长鲜切苹果的储存寿命。 Extending storage life of fresh-cut apples using natural products and their derivatives. |
已发布 PubMed:多酚氧化酶氧化黄酮醇非瑟汀。 Oxidation of the flavonol fisetin by polyphenol oxidase. |
已发布 PubMed:4-己基间苯二酚作为虾黑素病抑制剂 4-Hexylresorcinol as inhibitor of shrimp melanosis: 功效和残留研究;在 体肠道体外模型(caco-2)中评估可能的毒性作用;初步安全评估。 efficacy and residues studies; evaluation of possible toxic effect in a human intestinal in vitro model (Caco-2); preliminary safety assessment. |
已发布 PubMed:蟹肉中4-己基间苯二酚的含量测定。 Determination of 4-hexylresorcinol in crab meat. |
已发布 PubMed:液相色谱法测定虾中加工助剂4-己基间苯二酚。 Liquid chromatographic determination of the processing aid 4-hexylresorcinol in shrimp. |
已发布 PubMed:通常被认为是对4-己基间苯二酚的安全(草)评估,可用于预防虾黑素病。 Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for prevention of melanosis in shrimp. |
已发布 PubMed:does Does 一切 每一个 everything "原因 cause" 癌症 cancer: an 另类 alternative 解释 interpretation of the "致癌作用 carcinogenesis" 生物测定 bioassay. |
已发布 PubMed:幼鼠白血病细胞移植模型的建立与验证 Development and validation of a cellular transplant model for leukemia in Fischer rats: 短期检测潜在的抗白血病化学物质。 a short-term assay for potential anti-leukemic chemicals. |
已发布 PubMed:4-己基间苯二酚抑制f344 / n大鼠和b6c3f1小鼠的某些自发性肿瘤。 Inhibition of some spontaneous tumors by 4-hexylresorcinol in F344/N rats and B6C3F1 mice. |
已发布 PubMed:f344 / n大鼠和b6c3f1小鼠中4-己基间苯二酚(CAS编号136-77-6)的ntp毒理学和致癌作用研究(管控研究)。 NTP Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CAS No. 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). |
已发布 PubMed: 杀螨剂和驱虫药在大肠杆菌波尔 pol a + / 波尔 pol a-中的遗传毒性。 |
已发布 PubMed:unifac基团贡献模型预测非理想多组分系统中的溶解度。 Prediction of solubility in nonideal multicomponent systems using the UNIFAC group contribution model. |
已发布 PubMed:鼠 歐洲海濱草微粒体测试系统中抗贫血药和驱虫药的致突变性。 Mutagenicity of antiamebic and anthelmintic drugs in the Salmonella typhimurium microsomal test system. |
已发布 PubMed:酚类化合物在己烷-乙酸乙酯中的溶解行为 Solubility behavior of phenolic compounds in hexane-ethyl acetate, 己酸肉豆蔻酸乙酯 hexane-ethyl myristate, 和己烷-新戊酸乙酯助溶剂体系。 and hexane-ethyl pivalate cosolvent systems. |
已发布 PubMed:4-己基间苯二酚与肉豆蔻酸乙酯的配合物形成对4-己基间苯二酚从凡士林碱中释放速率的影响。 Effect of complex formation between 4-hexylresorcinol and ethyl myristate on release rate of 4-hexylresorcinol from petrolatum base. |
已发布 PubMed:丙烯醛分析的4-己基间苯二酚程序的综述。 Review of the 4-hexylresorcinol procedure for acrolein analysis. |
已发布 PubMed:[通过与4-己基间苯二酚反应测定空气中的丙烯醛]。 [Determination of acrolein in the air by means of its reaction with 4-hexylresorcinol]. |
已发布 PubMed:酸解离常数在选择缓冲液中的使用,以实现二苯三酚的电泳分离 The use of acid dissociation constants in selecting buffers to effect the electrophoretic separation of bithionol, 芬替克 fenticlor, 六氯酚 hexachlorophene, 溴氯苯 bromchlorophene, 二氯苯 dichlorophene, 四氯酚和4-己基间苯二酚。 tetrachlorophene and 4-hexylresorcinol. |
已发布 PubMed:[实验性的 Experimental 抗癌药 anti癌症 cancer 学习 studies. II. on On the 抗肿瘤 anti-tumor 影响 effect of 6-(2'-hydroxy-3', 5'-dihalophenylazo)-4-hexylresorcinol and 有关 related compounds on 吉田 Yoshida 肉瘤 sarcoma and 埃里希 Ehrlich 腹水 ascites 癌 carcinoma in 体内 vivo]. |
已发布 PubMed:实验性的 Experimental 抗癌药 anti癌症 cancer 学习 studies. I. The 制备 preparation of 6-(2'-hydroxy-3', 5'-dibromophenylazo)-4-hexylresorcinol and 有关 related compounds, 简要介绍其抗癌活性。 with brief reference to their anticancer activity. |
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