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类别 Category:cosmetic ingredient for skin conditioning
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 熔点 Melting Point: | 171.50 °C. @ 760.00 mm 汞 Hg
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| 沸点 Boiling Point: | 320.50 °C. @ 760.00 mm 汞 Hg (est)
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| 闪点 Flash Point: | 298.00 °F. tcc TCC ( 147.60 °C. ) (est)
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| logp（o / w） logP (o/w): | 3.090 |
| 溶于 Soluble in: |
| | 水 water, 1.00E+04 mg/L @ 20 ＆deg °C (经验值 exp) | | | 水 water, 522.2 mg / l @ 25°C（est） 522.2 mg/L @ 25 °C (est) |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
| 首选SDS Preferred SDS: 视图 View |
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| 危害识别 Hazards identification |
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| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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| 象形图 Pictogram | |
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| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
腹腔内小鼠 intraperitoneal-mouse ldlo LDLo 250 mg/kg
"摘要 Summary 桌子 Tables of 生物 Biological 测试 Tests," 国家研究委员会化学生物协调中心。卷7 National Research Council Chemical-Biological Coordination Center. Vol. 7, pg。 792 Pg. 792, 1955.
口鼠 口服 oral-rat LD50 250 mg/kg
药理 Pharmacology: 国际实验和临床药理学杂志。卷9 International Journal of Experimental and Clinical Pharmacology. Vol. 9, pg。 164 Pg. 164, 1973.
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| 皮肤毒性 Dermal Toxicity: |
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未定 Not determined
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| 吸入毒性 Inhalation Toxicity: |
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未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | cosmetic ingredient for skin conditioning |
| 推荐的5-氯水杨酸使用量不超过 Recommendation for 5-chlorosalicylic acid usage levels up to: | | | 不用于香水。 not for fragrance use.
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| 推荐的5-氯水杨酸风味剂的使用水平不超过 Recommendation for 5-chlorosalicylic acid flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
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安全参考 Safety references:
参考资料 References:
| | 5-氯-2-羟基苯甲酸 5-chloro-2-hydroxybenzoic acid |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| pubchem（cid） Pubchem (cid): | 9447 |
| pubchem（sid） Pubchem (sid): | 134975628 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core 组件 components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, 餐饮 food, 其他） other): note
| | 自然界中找不到 not found in nature |
同义词 Synonyms:
| | benzoic acid, 5-氯-2-羟基- 5-chloro-2-hydroxy- | | 5- | chloro salicylic acid | | 5- | chloro-2-hydroxybenzoic acid | | 5- | chloro-2-hydroxybenzoicacid | | 5- | chlorosalicyclic acid | | | chlorosalicylic acid | | 5- | chlorosalicylicacid | | 2- | hydroxy-5-chlorobenzoic acid | | | salicylic acid, 5-氯 5-chloro- |
文章 Articles:
| 已发布 PubMed:水杨酸及其某些衍生物作为粘胶纤维织物的抗菌剂。 Salicylic acid and some of its derivatives as antibacterial agents for viscose fabric. |
| 已发布 PubMed:禁闭对质子转移光互变异构体光物理和动力学的影响 Effect of biological confinement on the photophysics and dynamics of a proton-transfer phototautomer: 探索与蛋白结合的药物的激发和发射波长依赖性光物理性质。 an exploration of excitation and emission wavelength-dependent photophysics of the protein-bound drug. |
| 已发布 PubMed:基于荧光的高通量筛选测定法，用于与ugt1a6的药物相互作用。 Fluorescence-based high-throughput screening assay for drug interactions with UGT1A6. |
| 已发布 PubMed:关于3的光物理 On the photophysics of 3,5,6-三氯水杨酸 6-Trichlorosalicylic acid: 光谱研究结合hartree-fock和密度泛函理论计算。 spectroscopic study combined with Hartree-Fock and Density Functional Theory calculations. |
| 已发布 PubMed:源自非甾体抗炎药的铋（iii）配合物及其对幽门螺杆菌的活性。 Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori. |
| 已发布 PubMed:破译5-氯水杨酸光物理 Deciphering the photophysics of 5-chlorosalicylic acid: 激发态分子内质子转移的证据。 evidence for excited-state intramolecular proton transfer. |
| 已发布 PubMed:水杨酸衍生物对 胞质碳酸酐酶同工酶i和ii的体外抑制。 In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. |
| 已发布 PubMed:水杨酸和结构相关化合物跨caco-2细胞单层膜和 造潘帕膜的转运评估。 Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes. |
| 已发布 PubMed:两个角双加氧酶有助于降解二苯并呋喃的红球菌sp。的代谢多功能性。菌株ha01。 Two angular dioxygenases contribute to the metabolic versatility of dibenzofuran-degrading Rhodococcus sp. strain HA01. |
| 已发布 PubMed:客体控制作用对β-环糊精聚合物的er行为。 Guest-controlling effects on ER behaviors of beta-cyclodextrin polymer. |
| 已发布 PubMed:离子交换纤维结构对模型水杨酸酯结合和释放的影响 Effect of ion-exchange fiber structure on the binding and release of model salicylates. |
| 已发布 PubMed:通过4-氯儿茶酚和马来酸乙酸酯在假单胞菌属物种中降解4-和5-氯水杨酸酯的新细菌途径。菌株mt1。 New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1. |
| 已发布 PubMed:两种具有角二加氧酶特性不同的细菌对氯化二苯并呋喃和二苯并-对-二恶英的降解作用。 Degradation of chlorinated dibenzofurans and dibenzo-p-dioxins by two types of bacteria having angular dioxygenases with different features. |
| 已发布 PubMed:二芳基烯烃的合成及生物活性 Synthesis and biological activity of new diarylalkenes. |
| 已发布 PubMed:联苯利用菌株jb1中2-氯二苯并-对-二恶英和2-氯二苯并呋喃的生物降解途径。 Biodegradation pathway of 2-chlorodibenzo-p-dioxin and 2-chlorodibenzofuran in the biphenyl-utilising strain JB1. |
| 已发布 PubMed: 表现出获得性抗性的感染和引诱黄瓜（黄瓜 Cucumis tiv sativus l。）下胚轴节中的防御反应。 |
| 已发布 PubMed: 用茉莉酸甲酯预处理欧芹（petroselinum crispum l。）悬浮培养物可增强活性氧的激发。 |
| 已发布 PubMed:e。中的结构活性研究曲霉毒素a（ota）及其类似物的大肠埃希菌菌株暗示了遗传毒性自由基和细胞毒性硫醇衍生物为反应性代谢产物。 Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites. |
| 已发布 PubMed: 欧芹（petroselinum crispum l。）悬浮细胞的条件调节可增加诱导物诱导的细胞壁酚类物质的掺入。 |
| 已发布 PubMed:鼠 歐洲海濱草中2-氯-4-硝基苯胺和5-氯水杨酸诱变活性 Mutagenic activity of 2-chloro-4-nitroaniline and 5-chlorosalicylic acid in Salmonella typhimurium: 烟酰胺的两种可能的代谢产物。 two possible metabolites of niclosamide. |
| 已发布 PubMed:曲霉毒素A及其结构相关化合物在大肠杆菌中的遗传毒性 Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: 研究他们的行动方式。 studies on their mode of action. |
| 已发布 PubMed:氯水杨酸酯的微生物代谢 Microbial metabolism of chlorosalicylates: 延长的继代培养对构建菌株的影响 effect of prolonged subcultivation on constructed strains. |
| 已发布 PubMed:氯水杨酸酯的微生物代谢 Microbial metabolism of chlorosalicylates: 通过自然遗传交换加速进化。 accelerated evolution by natural genetic exchange. |
| 已发布 PubMed:美 酮的胃溃疡作用Comparative gastric ulcerogenic effects of meseclazone, 对大鼠急性和反复口服后，5-氯水杨酸和其他非甾体类抗炎药。 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats. |
| 已发布 PubMed:甲硫拉zone Meseclazone, 5-氯水杨酸和乙酰水杨酸。比较它们对体外和离体血小板聚集的作用。 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation. |
| 已发布 PubMed:美 酮的相对抗炎活性 Comparative antiphlogistic activity of meseclazone, 5-氯水杨酸 5-chlorosalicylic acid, 乙酰水杨酸 acetylsalicylic acid, 苯丁zone phenylbutazone, 吲哚美辛和氢化可的松在各种大鼠爪水肿模型中的作用。 indomethacin and hydrocortisone in various rat paw edema models. |
| 已发布 PubMed:[5-氯水杨酸4-氯苯胺的慢性毒性] [Chronic toxicity of 4-chloroanilide of 5-chlorosalicylic acid (Arylide)]. |
| 已发布 PubMed:急性和慢性炎症模型中肝微粒体酶系统的改变和非甾体类抗节螺藻药的致死作用。 Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation. |
| 已发布 PubMed:比较抗炎药 Comparative anti-inflammatory, analgesic, 和7-chloro-3的解热活性 and antipyretic activities of 7-chloro-3,3a-二氢-2-甲基-2h 3a-dihydro-2-methyl-2H,9h-isoxazolo-（3 9H-isoxazolo-(3,2-b）（1 2-b)(1,3）-大鼠的苯并恶嗪-9-一和5-氯水杨酸。 3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats. |
| 已发布 PubMed:吸收 Absorption, 分配 distribution, 和7-chloro-3的代谢 and metabolic fate of 7-chloro-3,3a-二氢-2-甲基-2h 3a-dihydro-2-methyl-2H,9h-isoxazolo-（3 9H-isoxazolo-(3,2-b）（1 2-b)(1,3）-大鼠体内的苯并恶嗪-9- 3)-benzoxazin-9-one in rats, 小狗 dogs, 和 类。 and humans. |
| 已发布 PubMed:链霉素在5-氯水杨酸4-氯苯胺存在下对耐酸杆菌的杀菌作用 [Bactericidal effect of streptomycin on acid-fast bacilli in the presence of 4-chloroanilid of 5-chlorosalicylic acid]. |
| 已发布 PubMed:[5-氯水杨酸4-氯苯胺的某些药理特性]。 [Some pharmacological properties of 4-chloroanilide of 5-chlorosalicylic acid]. |
| 已发布 PubMed:[5-氯水杨酸4-氯苯胺与血清蛋白和其他蛋白物质的结合。一世。蛋白物质与芳脂结合的定性方法] [Binding of 4-chloroanilide of 5-chlorosalicylic acid by blood serum proteins and other protein substances. I. Qualitative methods for determination of the binding of arylid by protein substances]. |
| 已发布 PubMed:复合物的结构研究。 iv。 1的晶体结构 Structural studies on complexes. IV. Crystal structure of a 1:1 5-氯水杨酸与茶碱复合。 1 5-chlorosalicylic acid and theophylline complex. |
| 已发布 PubMed:[5-氯水杨酸4-氯苯胺对动物的各种毒性] [Toxicity of 4-chloroanilid of 5-chlorosalicylic acid (arylid) for various species of laboratory animals]. |
| 已发布 PubMed:[5-氯水杨酸作用 [Effect of 5-chlorosalicylic acid, 4-氯苯胺对结核杆菌的作用]。 4-chloroanilide on tubercle bacilli]. |
| 已发布 PubMed:篇名[5-氯水杨酸4-氯苯胺对结核菌体外存活力的影响] [Effect of 4-chloroanilid of 5-chlorosalicylic acid on the viability of tubercle bacilli in vitro]. |
| 已发布 PubMed:5-氯水杨酸4-氯苯胺对豚鼠实验性肺结核的影响 [Effect of 4-chloroanilid of 5-chlorosalicylic acid on experimental tuberculosis in guinea pigs]. |
| 已发布 PubMed:[5-氯水杨酸4-氯苯胺对结核杆菌呼吸作用的影响]。 [Effect of the 4-chloroanilide of 5-chlorosalicylic acid on the respiration of tubercle bacilli]. |
| 已发布 PubMed:篇名[5-氯水杨酸4-氯苯胺对白鼠实验结核的影响] [Effect of 4-chloroanilide of 5-chlorosalicylic acid in experimental tuberculosis of white mice]. |
| 已发布 PubMed:篇名：5-氯水杨酸4-氯苯胺对结核分枝杆菌的体外影响 [EFFECT OF 4-CHLOROANILIDE OF 5-CHLOROSALICYLIC ACID ON MYCOBACTERIUM TUBERCULOSIS IN VITRO]. |
| 已发布 PubMed:[治疗 Treatment of 表皮赘生 epidermophytosis with the 2'-chloroanilide of 5-氯水杨酸 5-chlorosalicylic acid]. |
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3D/INCHI