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类别 Category:antimicrobial, skin conditioning
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 沸点 Boiling Point: | 389.00 to 390.00 °C. @ 760.00 mm 汞 Hg (est)
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| 闪点 Flash Point: | 342.00 °F. tcc TCC ( 172.00 °C. ) (est)
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| logp（o / w） logP (o/w): | 2.900 |
| 溶于 Soluble in: |
| | 水 water, 51.85 mg / l @ 25°c（est） 51.85 mg/L @ 25 °C (est) |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
| 首选SDS Preferred SDS: 视图 View |
| |
| 危害识别 Hazards identification |
| |
| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
口鼠 口服 oral-rat ld LD50 5576 mg/kg kg
行为的 BEHAVIORAL: 震颤 TREMOR
行为的 BEHAVIORAL: 改变的睡眠时间（包括矫正反射改变） ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
行为的 BEHAVIORAL: 共济失调 ATAXIA
日志 Journal of 传统的 Traditional 中文 Chinese 药物 Medicine 卷 Vol. 2, pg。 31 Pg. 31, 1982.
老鼠 口服 oral-mouse ld LD50 4228 mg/kg kg
行为的 BEHAVIORAL: 改变的睡眠时间（包括矫正反射改变） ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
行为的 BEHAVIORAL: 共济失调 ATAXIA
行为的 BEHAVIORAL: 震颤 TREMOR
日志 Journal of 传统的 Traditional 中文 Chinese 药物 Medicine 卷 Vol. 2, pg。 31 Pg. 31, 1982.
腹腔内小鼠 intraperitoneal-mouse ld LD50 1558 mg/kg kg
中文 Chinese 医疗 Medical 日志 Journal 卷 Vol. 92, pg。 811 Pg. 811, 1979.
肌内犬 intramuscular-dog ld LD > 800 mg/kg kg
行为的 BEHAVIORAL: 抽搐 CONVULSIONS OR 影响 EFFECT ON 发作 SEIZURE THRESHOld LD
日志 Journal of 传统的 Traditional 中文 Chinese 药物 Medicine 卷 Vol. 2, pg。 31 Pg. 31, 1982.
未报告的鼠标 unreported-mouse ld LD > 2000 mg/kg kg
Antimicrobial 代理商 Agents and 化学疗法 Chemo治疗 therapy. 卷 Vol. 37, pg. 1108 Pg. 1108, 1993.
肌内小鼠 intramuscular-mouse ld LD50 2800 mg/kg kg
中文 Chinese 医疗 Medical 日志 Journal 卷 Vol. 92, pg。 811 Pg. 811, 1979.
肌内大鼠 intramuscular-rat ld LD50 2571 mg/kg kg
行为的 BEHAVIORAL: 改变的睡眠时间（包括矫正反射改变） ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
行为的 BEHAVIORAL: 共济失调 ATAXIA
行为的 BEHAVIORAL: 震颤 TREMOR
日志 Journal of 传统的 Traditional 中文 Chinese 药物 Medicine 卷 Vol. 2, pg。 31 Pg. 31, 1982.
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| 皮肤毒性 Dermal Toxicity: |
|
未定 Not determined
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| 吸入毒性 Inhalation Toxicity: |
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未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | antimicrobial, skin conditioning |
| 推荐使用青蒿素的使用水平 Recommendation for artemisinin usage levels up to: | | | 不用于香水。 not for fragrance use.
|
| |
| 推荐的青蒿素风味使用水平最高为 Recommendation for artemisinin flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
|
安全参考 Safety references:
参考资料 References:
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| pubchem（cid） Pubchem (cid): | 68827 |
| pubchem（sid） Pubchem (sid): | 135028424 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and 核心组件 core components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, 餐饮 food, 其他） other): note
同义词 Synonyms:
| | 青蒿素 artemisine | | | artemisinine | | | 青artemisininum | | | 黄花好素 huanghuahaosu | | (3R,5as 5aS,6r 6R,8as 8aS,9R,12s 12S,12aR)- | octahydro-3,6,9-三甲基-3 9-trimethyl-3,12-环氧-12h-吡喃（4 12-epoxy-12H-pyrano(4,3-j）-1 3-j)-1,2-benzodioxepin-10(3H)-one | | | 清 qing hau hau 秀 sau | | | 清 qinghaosu | | 1,5,9- | trimethyl-(1R,4s 4S,5r 5R,8s 8S,9R,12s 12S,13r）-11 13R)-11,14,15,16-tetraoxatetracyclo [10.3.1.04 16-tetraoxatetracyclo[10.3.1.04,13.08,13] hexadecan-10-one 13]hexadecan-10-one | | 1,5,9- | trimethyl-(1R,4s 4S,5r 5R,9R,12s 12S,13r）-11 13R)-11,14,15,16-tetraoxatetracyclo [10.3.1.04 16-tetraoxatetracyclo[10.3.1.04,13.08,13] hexadecan-10-one 13]hexadecan-10-one | | 1,5,9- | trimethyl-(1s (1S,4s 4S,5r 5R,8s 8S,9R,12s 12S,13s）-11 13S)-11,15,16-trioxatetracyclo [10.3.1.04 16-trioxatetracyclo[10.3.1.04,13.08,13] hexadecan-10-one 13]hexadecan-10-one | | (1R,4s 4S,5r 5R,8s 8S,9R,12s 12S,13r）-1 13R)-1,5,9- | trimethyl-11,14,15,16-tetraoxatetracyclo [10.3.1.04 16-tetraoxatetracyclo[10.3.1.04,13.08,13] hexadecan-10-one 13]hexadecan-10-one | | (1s (1S,4s 4S,5r 5R,8s 8S,9R,12s 12S,13r）-1 13R)-1,5,9- | trimethyl-11,14,15,16-tetraoxatetracyclo [10.3.1.04 16-tetraoxatetracyclo[10.3.1.04,13.08,13] hexadecan-10-one 13]hexadecan-10-one |
文章 Articles:
| 信息 Info:Artemisinin |
| 已发布 PubMed:在大肠杆菌中设计甲羟戊酸途径来生产类萜。 Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. |
| 已发布 PubMed:用于青蒿素合成的植物代谢工程。 Metabolic engineering of plants for artemisinin synthesis. |
| 已发布 PubMed:菊苣（菊苣）和艾草（蒿）的植物性次要类固醇和植物次生代谢产物对猪原代肝细胞中3β-羟基类固醇脱氢酶和磺基转移酶2a1基因表达的调控。 Regulation of 3β-hydroxysteroid dehydrogenase and sulphotransferase 2A1 gene expression in primary porcine hepatocytes by selected sex-steroids and plant secondary metabolites from chicory (Cichorium intybus L.) and wormwood (Artemisia sp.). |
| 已发布 PubMed:打气 Pumped up: 关于以青蒿素为靶标的p脂肪 fatp6的思考。 |
| 已发布 PubMed: 菊苣（菊苣）选择的次生植物代谢产物对猪原代肝细胞中细胞色素p450 姆纳 mRNA表达的调控 |
| 已发布 PubMed:青蒿素改变了癌细胞中的蛋白质相互作用网络 Artemisinin rewires the protein interaction network in cancer cells: 网络分析 network analysis, 途径鉴定 pathway identification, 和目标预测。 and target prediction. |
| 已发布 PubMed:高效液相色谱-串联质谱法快速，可靠地测定不同青蒿叶基食品中的青蒿素。 Fast and reliable artemisinin determination from different Artemisia annua leaves based alimentary products by high performance liquid chromatography-tandem mass spectrometry. |
| 已发布 PubMed:双氢青蒿素在斑马鱼的早期胚胎发育过程中促进血管生成。 Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish. |
| 已发布 PubMed:有毒的精油。第二部分 Toxic essential oils. Part II: chemical, 毒理学的 toxicological, 青蒿的药理和微生物学特征挥发物。 pharmacological and microbiological profiles of Artemisia annua L. volatiles. |
| 已发布 PubMed:蛋白复合物可指导恶性疟原虫中血红蛋白向血红蛋白的形成。 Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum. |
| 已发布 PubMed:氢青蒿素对佛波酯诱导的巨噬细胞环氧合酶-2表达的抑制作用。 Inhibitory effect of dihydroartemisinin against phorbol ester-induced cyclooxygenase-2 expression in macrophages. |
| 已发布 PubMed:蒿甲醚-荧光黄素在怀孕期间治疗疟疾的用途 Use of artemether-lumefantrine to treat malaria during pregnancy: 我们知道并且需要知道什么？ what do we know and need to know? |
| 已发布 PubMed:确定抗疟药对恶性疟原虫的作用时间。 Defining the timing of action of antimalarial drugs against Plasmodium falciparum. |
| 已发布 PubMed:青蒿完全成熟后的青蒿素产量和前体比率。植物承受外部压力。 Artemisinin production and precursor ratio in full grown Artemisia annua L. plants subjected to external stress. |
| 已发布 PubMed:在欧洲管理进口疟疾。 Management of imported malaria in Europe. |
| 已发布 PubMed:胁迫对青蒿生长过程中腺毛毛密度和大小的影响 Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, 抗疟疾青蒿素的来源。 the source of anti-malarial artemisinin. |
| 已发布 PubMed:尼日利亚三个州的专利药品销售商的抗疟疾政策和疟疾治疗实践意识。 Awareness of anti-malarial policy and malaria treatment practices of patent medicine vendors in three Nigerian states. |
| 已发布 PubMed:青蒿琥酯 Artemether-lumefantrine: 疟疾的一种选择。 an option for malaria. |
| 已发布 PubMed:吡咯烷-青蒿琥酯联合疗法治疗疟疾。 Pyronaridine-artesunate combination therapy for the treatment of malaria. |
| 已发布 PubMed:监测青蒿素 Monitoring of artemisinin, 双氢青蒿素 dihydroartemisinin, 和高效液相色谱-串联质谱（lc-ms / ms）在环境基质中的蒿甲醚。 and artemether in environmental matrices using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). |
| 已发布 PubMed:青蒿粗醇提物的体外杀菌作用 In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, 一个。苦艾酒 A. absinthium, 阿西米娜·三叶 Asimina triloba, 和紫锥菊 and Fumaria officinalis: 杀螨植物醇提取物。 trematocidal plant alcoholic extracts. |
| 已发布 PubMed:青蒿素降低了精神分裂症中针对麦醇溶蛋白的抗体水平。 Artemisinin reduces the level of antibodies to gliadin in schizophrenia. |
| 已发布 PubMed:青蒿米粥作为非洲疟疾儿童的急救药？ Millet-porridge with Artemisia annua as first aid for African children with malaria? |
| 已发布 PubMed:抗疟药青蒿琥酯在小鼠体细胞中的遗传毒性评估。 Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice. |
| 已发布 PubMed:青蒿提取物 Artemisia annua extracts, 青蒿素和1 artemisinin and 1,8-cineole, 防止大批水果出没 prevent fruit infestation by a major, 苹果的世界性害虫。 cosmopolitan pest of apples. |
| 已发布 PubMed:疟疾 Malaria: 严重 severe, 危及生命。 life-threatening. |
| 已发布 PubMed:食源性吸虫感染的诊断和治疗方面的最新信息。 Update on the diagnosis and treatment of food-borne trematode infections. |
| 已发布 PubMed:青蒿琥酯静脉注射液用于治疗严重疟疾。 Intravenous artesunate for the treatment of severe malaria. |
| 已发布 PubMed:青蒿素对艾美尔球虫感染过程中卵囊壁形成和孢子形成的影响。 Effect of artemisinin on oocyst wall formation and sporulation during Eimeria tenella infection. |
| 已发布 PubMed:单剂量安全 Single-dose safety, 药代动力学 pharmacokinetics, 健康志愿者中复方萘醌磷酸酯片的制备和食品效果研究。 and food effects studies of compound naphthoquine phosphate tablets in healthy volunteers. |
| 已发布 PubMed:将中医药与现代药物发现技术相结合，以发现新药和功能食品。 Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods. |
| 已发布 PubMed:干燥影响青蒿素 Drying affects artemisinin, 二氢青蒿酸 dihydroartemisinic acid, 青蒿酸 artemisinic acid, 和青蒿的抗氧化能力。树叶。 and the antioxidant capacity of Artemisia annua L. leaves. |
| 已发布 PubMed:蒿甲醚/黄麻黄碱分散制剂 Dispersible formulation of artemether/lumefantrine: 专为婴幼儿开发。 specifically developed for infants and young children. |
| 已发布 PubMed:哌喹组合治疗疟疾的研究进展。 Progress in the development of piperaquine combinations for the treatment of malaria. |
| 已发布 PubMed:雅温得城市卫生机构中的卫生香基/香型 员从单一疗法到以青蒿素为基础的联合疗法治疗疟疾 Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, 中部省 central province, 喀麦隆。 Cameroon. |
| 已发布 PubMed:对老挝医药商店出售的劣质口服青蒿琥酯的比例进行的分层随机调查-对治疗失败和耐药性的影响。 A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR - implications for therapeutic failure and drug resistance. |
| 已发布 PubMed:青蒿素-二肽基乙烯基砜杂化分子 Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: 设计 design, 合成和初步sar的抗血浆活性和falcipain-2抑制作用。 synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition. |
| 已发布 PubMed:首个获准在美国使用的基于青蒿素的抗疟药组合市场。 First artemisinin-based antimalarial combination approved for U.S. market. |
| 已发布 PubMed:[怀孕和旅行]。 [Pregnancy and traveling]. |
| 已发布 PubMed:坦桑尼亚农村地区基于青蒿素的联合治疗的意愿和支付能力。 Willingness and ability to pay for artemisinin-based combination therapy in rural Tanzania. |
| 已发布 PubMed:蒿甲醚-氟美林汀与二氢青蒿素-哌喹治疗单纯性疟疾 Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: 一项指导乌干达政策的随机试验。 a randomized trial to guide policy in Uganda. |
| 已发布 PubMed:蒿甲醚+ lumantantrine Artemether + lumefantrine: 新药。阿托伐醌+异丙胍的替代品。 new drug. An alternative to atovaquone + proguanil. |
| 已发布 PubMed:南非和莫桑比克的疟疾家庭负担 Household burden of malaria in South Africa and Mozambique: 有灾难性的影响吗？ is there a catastrophic impact? |
| 已发布 PubMed:青蒿素和合成的三氧戊环在治疗蠕虫感染中。 Artemisinins and synthetic trioxolanes in the treatment of helminth infections. |
| 已发布 PubMed:[恶性疟疾的治疗]。 [The treatment of falciparum malaria]. |
| 已发布 PubMed:优化鲁美花碱口服生物利用度需要多少脂肪？ How much fat is necessary to optimize lumefantrine oral bioavailability? |
| 已发布 PubMed:青蒿素生产中的营养缺乏 Nutrient deficiency in the production of artemisinin, 二氢青蒿酸 dihydroartemisinic acid, 和青蒿酸中的青蒿。 and artemisinic acid in Artemisia annua L. |
| 已发布 PubMed:疟疾 Malaria: 简单 uncomplicated, 由恶性疟原虫引起。 caused by Plasmodium falciparum. |
| 已发布 PubMed:非洲的药物警戒和新的基本药物 Pharmacovigilance and new essential drugs in Africa: 赞比亚从自身的经验和其他经验中吸取了教训。 Zambia draws lessons from its own experiences and beyond. |
| 已发布 PubMed:合成三氧戊环rbx11160（oz277）的抗疟疾作用机理。 Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277). |
| 已发布 PubMed:pfmdr1与恶性疟原虫食物液泡溶质输入的遗传连锁。 Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. |
| 已发布 PubMed:模拟青蒿素的分解机理。 Modeling the decomposition mechanism of artemisinin. |
| 已发布 PubMed:口服青蒿素可预防和延缓7的发展 Oral artemisinin prevents and delays the development of 7,12-二甲基苯并[a]蒽（dmba）诱发的大鼠乳腺癌。 12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat. |
| 已发布 PubMed: 蒿中青蒿素的含量分析通过液晶显示器 LC-MS选择离子监测。 |
| 已发布 PubMed:恶性疟原虫纯化质膜和消化液的ATP酶活性 ATPase activity of purified plasma membranes and digestive vacuoles from Plasmodium falciparum. |
| 已发布 PubMed:以青蒿素为基础的联合疗法，用于单纯性疟疾。 Artemisinin-based combination therapies for uncomplicated malaria. |
| 已发布 PubMed:的视黄醇对恶性疟原虫体外影响的特征分析。 Characterization of the effect of retinol on Plasmodium falciparum in vitro. |
| 已发布 PubMed:青蒿素与血红蛋白的反应 Reaction of artemisinin with haemoglobin: 对抗疟活动的影响。 implications for antimalarial activity. |
| 已发布 PubMed:抗疟药喹啉和青蒿素抑制恶性疟原虫的胞吞作用。 Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum. |
| 已发布 PubMed:青蒿素靶向恶性疟原虫的浆膜。 Artemisinins target the SERCA of Plasmodium falciparum. |
| 已发布 PubMed:含青蒿素衍生物的药物治疗疟疾的安全性评估。 Safety evaluations of drugs containing artemisinin derivatives for the treatment of malaria. |
| 已发布 PubMed:机理的寄生虫靶向青蒿素衍生物设计 Mechanism-based design of parasite-targeted artemisinin derivatives: 新型二胺类似物的合成和抗疟活性。 synthesis and antimalarial activity of new diamine containing analogues. |
| 已发布 PubMed:蒿甲醚对大鼠听觉radial臂迷宫任务的影响 Effects of arteether on an auditory radial-arm maze task in rats. |
| 已发布 PubMed:口服青蒿素衍生物对小鼠的橙花毒性的研究。 Studies of the neurotoxicity of oral artemisinin derivatives in mice. |
| 已发布 PubMed: 25 mg / kg kg /天单次和多次剂量后，大鼠的香柳叶菜运动毒性动力学和药代动力学。 |
| 已发布 PubMed:抗寄生虫剂。 Antiparasitic agents. |
| 已发布 PubMed:恶性疟原虫翻译控制的肿瘤蛋白 The Plasmodium falciparum translationally controlled tumor protein: 亚细胞定位和钙结合。 subcellular localization and calcium binding. |
| 已发布 PubMed:甲氟喹与青蒿琥酯联合治疗急性恶性疟疾患儿的药代动力学。 Pharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malaria. |
| 已发布 PubMed:摄入量对健康越南受试者口服青蒿素药代动力学的影响。 Effect of food intake on pharmacokinetics of oral artemisinin in healthy Vietnamese subjects. |
| 已发布 PubMed:青蒿素增强血红素催化脂质膜的氧化。 Artemisinin enhances heme-catalysed oxidation of lipid membranes. |
| 已发布 PubMed:疟疾中的氧化应激；对预防和治疗的意义。 Oxidative stress in malaria; implications for prevention and therapy. |
| 已发布 PubMed:青蒿素在恶性疟原虫中的形态学影响。 Morphologic effects of artemisinin in Plasmodium falciparum. |
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3D/INCHI