壬二酸 nonanedioic acid
1,7-庚二羧酸 7-heptanedicarboxylic acid
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类别 Category:indirect food additives: adhesives and components of coatings
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笔记 Notes: 发生在腐臭的脂肪中。分离。来自一些高等植物 Occurs in rancid fats. Isol. from a few higher plants
乙酸小苍兰3（或4）-（4-甲基戊烯-3-基）环己-3-烯-1-乙酸甲酯甲基戊烯基环己烯-1-乙酸甲酯3（或4）-（4-甲基-3-戊烯基）- 3-环己烯-1-基）乙酸甲酯3（或4）-（4-甲基-3-戊烯基）-3-环己烯-1-甲醇乙酸酯[（1s）-3-（4-甲基戊-3-烯基）- 1-环己-3-烯基]乙酸甲酯 Azelaic acid (AZA) is a naturally occurring saturated nine-carbon dicarboxylic acid (COOH (CH2)7-COOH). It possesses a variety of biological actions both in vitro and in vivo. Interest in the biological activity of AZA arose originally out of studies of skin surface lipids and the pathogenesis of hypochromia in pityriasis versicolor infection. Later, 邻甲氧基-2-巯基苯甲醚2-甲氧基苯硫基2-甲氧基硫代苯酚2-甲氧基苯硫基-甲氧基苯硫代邻甲氧基苯硫基2-甲氧基苯-1-硫基2-甲氧基苯硫基-甲氧基苯硫代邻甲氧基苯硫基2-甲氧基硫代酚基-甲氧基硫代苯酚-甲氧基硫代酚基-硫代愈创木酚 it was shown that Pityrosporum can oxidize unsaturated fatty acids to C8-C12 dicarboxylic acids that are cornpetitive inhibitors of tyrosinase in vitro. Azelaic acid was chosen for further investigation and development of a new topical drug for treating hyperpigmentary disorders for the following reasons: 它具有中等水平的抗酪氨酸酶活性 it possesses a middle-range of antityrosinase activity, 便宜 is inexpensive, and 更多 more 易溶 soluble to be 合并 incorporated 进入 into a base 奶油 cream than other dicarboxylic acids acids. 壬二酸 nonanedioic acid is 另一个 another 选项 option for the 局部的 topical 治疗 treatment of 轻度 mild to 中等 moderate 发炎的 inflammatory 粉刺 acne vulgaris. it It 优惠 提供 offers 效力 有效 effectiveness 类似 similar to that of other 代理商 agents 没有 without the 系统的 systemic 侧 side 效果 effects of 口服 oral 抗生素类 antibiotics or the 过敏的 allergic 敏化 sensitization of 局部的 topical benzoyl 过氧化物 peroxide and with 减 less 刺激 irritation than 抗坏血酸 tretinoin. 壬二酸 nonanedioic acid is 减 less 昂贵 经验值 expensive than 某些 certain other 处方 prescription 粉刺 acne 准备工作 preparations, 但它比非处方过氧化苯甲酰制剂贵得多。与其他药物联合使用时是否安全有效还未知。 （pmid but it is much more expensive than nonprescription benzoyl peroxide preparations. Whether it is safe and effective when used in combination with other agents is not known. (PMID: 7737781, 8961845）；壬二酸是小麦中天然存在的饱和二羧酸 8961845); Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, 黑麦 rye, and 大麦 barley. it It is a 自然 natural substance that is produced by by 马拉色菌病 Malassezia 糠醛 furfur (也 also k现在 nown as 糠疹 Pityrosporum 椭圆形 ovale), 一种生活在正常皮肤上的酵母。对多种皮肤状况有效 a yeast that lives on normal skin. It is effective against a number of skin conditions, 如轻度至中度 such as mild to moderate acne, 当以20％的乳霜配方局部使用时。它通过阻止引起 的皮肤细菌的生长而部分起作用 when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by by 保持 keeping skin 毛孔 pores 明确 clear. 壬二酸 nonanedioic acid's 抗菌剂 anti微生物 microbial action 可以 may be 归因于 attribut butable to 抑制 inhibition of 微生物 microbial 蜂窝状的 cellular 蛋白 protein 合成 synthesis.; 壬二酸 nonanedioic acid is a 饱和的 saturated dicarboxylic acid 发现 found 自然 自然 naturally in 小麦 wheat, 黑麦 rye, 和大麦。它是fur马拉色菌（malassezia 糠醛 furfur）（也称为椭圆形pityrosporum椭圆形）产生的天然物质 , 一种生活在正常皮肤上的酵母。对多种皮肤状况有效 a yeast that lives on normal skin. It is effective against a number of skin conditions, 如轻度至中度 such as mild to moderate acne, 当以20％的乳霜配方局部使用时。壬二酸可用作头发生长促进剂。[需要引证] when applied topically in a cream formulation of 20%. Azelaic acid may be useful as a hair growth stimulant.[citation needed]
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3D/INCHI