(e)-角鲨烯 (E)-squalene
trans-squalene

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    111-02-4(e 111-02-4 (E,E,E,e)角鲨烯> 98% E)-Squalene >98%
    角鲨烯是天然三萜,在胆固醇合成中起重要作用 Squalene is a natural triterpene that plays an important role in the synthesis of cholesterol, 类固醇激素 steroid hormones, 和 体中的维生素D。角鲨烯通常用作类固醇制备中的生化前体。 and vitamin D in the human body. Squalene is commonly used as a biochemical precursor in the preparation of steroids.
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    角鲨烷 SQUALANE, 鲨鱼 SHARK
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    19-48010角鲨烯(橄榄衍生) 19-48010 SQUALENE (OLIVE DERIVED)
    19-48015角鲨烯(鲨鱼衍生) 19-48015 SQUALENE (SHARK DERIVED)
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    h0097角鲨烯> 98.0%(gc) H0097 Squalene >98.0%(GC)
CAS号 CAS Number: 111-02-4Picture of molecule3D/INCHI
echa ECHA einecs EINECS - REACH 预注册 Pre-Reg:203-826-1
FDA UNII:7QWM220FJH
nikkaji网站 Nikkaji Web:J5.103I
贝尔斯坦数 Beilstein Number:1728919
MDL :mfcd00008912 MFCD00008912
XlogP3-AA:11.60(est) 11.60 (est)
分子量 Molecular Weight:410.72850000
式 Formula:c30 h50 C30 H50
生物活性总结 BioActivity Summary:清单 listing
核磁共振预测器 NMR Predictor:预测(适用于Chrome或Firefox) Predict (works with chrome or firefox)
类别 Category:cosmetic agents
 
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
谷歌学术 Google Scholar:搜索 Search
谷歌书 Google Books:搜索 Search
谷歌学术 Google Scholar: with word "volatile"搜索 Search
谷歌学术 Google Scholar: with word "flavor"搜索 Search
谷歌学术 Google Scholar: with word "odor"搜索 Search
谷歌专利 Google Patents:搜索 Search
美国专利 US Patents:搜索 Search
欧盟专利 EU Patents:搜索 Search
pubchem专利 Pubchem Patents:搜索 Search
已发布 PubMed:搜索 Search
NCBI:搜索 Search
 
物理性质 Physical Properties:
出现 Appearance:无色至浅黄澄清油状液体(est) colorless to pale yellow clear oily liquid (est)
化验 Assay: 98.00至100.00 98.00 to 100.00
食品化学品法典列表 Food Chemicals Codex Listed: No
比重 Specific Gravity:0.85500 to 0.85900 @ 20.00 °C.
磅每加仑-(est)。 Pounds per Gallon - (est).: 7.123 to 7.156
折光率 Refractive Index:1.49400 to 1.49700 @ 20.00 °C.
熔点 Melting Point: -75.00 °C. @ 760.00 mm 汞 Hg
沸点 Boiling Point: 429.00 to 430.00 °C. @ 760.00 mm 汞 Hg
沸点 Boiling Point: 285.00 °C. @ 25.00 mm 汞 Hg
闪点 Flash Point:> 230.00° tcc(> 110.00°c。) > 230.00 °F. TCC ( > 110.00 °C. )
logp(o / w) logP (o/w): 12.188(est) 12.188 (est)
保质期 Shelf Life: 如果正确存放,则为12.00个月或更长时间。 12.00 month(s) or longer if stored properly.
存储 Storage:在密封容器中冷藏。 refrigerate in tightly sealed containers.
溶于 Soluble in:
 alcohol
 水 water, 6.646e-010 mg / l @ 25°c(est) 6.646e-010 mg/L @ 25 °C (est)
不溶于 Insoluble in:
 水 water
 
感官特性 Organoleptic Properties:
气味描述 Odor Description:at 100.00 %. 花的 floral
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found).
 
化妆品信息 Cosmetic Information:
CosIng:化妆品数据 cosmetic data
化妆品用途 Cosmetic Uses: 抗静电剂 antistatic agents
润肤剂 emollients
头发调理 hair conditioning
加脂剂 refatting agents
皮肤调理 skin conditioning
 
供应商 Suppliers:
BOC Sciences
仅供实验/研究使用。 For experimental / research use only.
(e (E,E,E,e)角鲨烯> 98% E)-Squalene >98%
气味 Odor: characteristic
采用 Use: 角鲨烯是天然三萜,在胆固醇合成中起重要作用 Squalene is a natural triterpene that plays an important role in the synthesis of cholesterol, 类固醇激素 steroid hormones, 和 体中的维生素D。角鲨烯通常用作类固醇制备中的生化前体。 and vitamin D in the human body. Squalene is commonly used as a biochemical precursor in the preparation of steroids.
Charkit Chemical
角鲨烷 SQUALANE, 鲨鱼 SHARK
库姆波 Coompo
仅供实验/研究使用。 For experimental / research use only.
Squalene from Plants ≥96%
气味 Odor: characteristic
采用 Use: 角鲨烯是胆固醇合成中的中间代谢产物。它通常与非常低密度的脂蛋白一起在血清中运输,并普遍分布在 体组织中 Squalene is an intermediate metabolite in the synthesis of cholesterol. It is transported in serum generally in association with very low density lipoproteins and is distributed ubiquitously in human tissues, 皮肤中浓度最高 with the greatest concentration in the skin, 而二水合物(caso4.2h2o)自然以石膏形式存在。无水形式自然以α-硬石膏形式存在。取决于二水合硫酸钙的煅烧方法 where it is one of the major components of skin surface lipids. Squalene is not very susceptible to peroxidation and appears to function in the skin as a quencher of singlet oxygen, 保护 protecting 的 human skin 表面 surface from lipid 过氧化 peroxidation 到期 due to 接触 exposure to 紫外线 UV and other 资料来源 sources of 电离 ionizing radiation. Squalene 可以 may 也 also act as a "下沉 sink" for 高度 highly 亲脂的 lipophilic 异生物素 xenobiotics. 以来 Since it is a 非极性 nonpolar 物质 substance, 它对非离子药物具有更高的亲和力。在 类中 it has a higher affinity for un-ionized drugs. In humans, 角鲨烯可能是增强某些降胆固醇药物作用的有用添加剂。目前,角鲨烯的主要治疗用途是作为多种癌症的辅助疗法。尽管是流行病学 squalene might be a useful addition to potentiate the effects of some cholesterol-lowering drugs. The primary therapeutic use of squalene currently is as an adjunctive therapy in a variety of cancers. Although epidemiological, 实验和动物证据表明其抗癌特性 experimental and animal evidence suggests anti-cancer properties, 迄今为止,尚未进行任何 体试验来验证这种营养素在癌症治疗方案中的作用。 to date no human trials have been conducted to verify the role this nutrient might have in cancer therapy regimens.
Emd 微孔 Millipore
仅供实验/研究使用。 For experimental / research use only.
Squalene
Glentham Life Sciences
Squalene
Penta International
角鲨烯(橄榄衍生) SQUALENE (OLIVE DERIVED)
Penta International
角鲨烯(鲨鱼衍生) SQUALENE (SHARK DERIVED)
圣克鲁斯生物技术 Santa Cruz Biotechnology
仅供实验/研究使用。 For experimental / research use only.
(e)-角鲨烯 (E)-squalene
西格玛·奥尔德里奇 Sigma-Aldrich: 西格玛 Sigma
仅供实验/研究使用。 For experimental / research use only.
角鲨烯≥98% Squalene ≥98%, 液体 liquid
TCI AMERICA
仅供实验/研究使用。 For experimental / research use only.
角鲨烯> 98.0%(gc) Squalene >98.0%(GC)
三产业 TRI-K Industries
clear鲨角鲨烷 MariClear Shark Squalane
气味 Odor: characteristic
采用 Use: 鲨鱼角鲨烷是鲨鱼的润肤剂 MariClear Shark Squalane is an emollient derived from shark, 有助于软化和舒缓皮肤。它也可以用于产品中,以纠正皮肤的干燥和结垢。 which helps to soften and soothe the skin. It may also be used in products to correct dryness and scaling of the skin.
三产业 TRI-K Industries
油橄榄色角鲨烷 OleaClear Olive Squalane
气味 Odor: characteristic
采用 Use: oleaclear橄榄角鲨烷是一种植物来源的角鲨烷,在面霜中可作为润肤剂使用 OleaClear Olive Squalane is a plant derived squalane that functions as an emollient for topical applications in creams, 洗剂 lotions, 软膏 ointments,口红 lipsticks, 和其他化妆品。 and other cosmetics.
欧洲的 Vevy Europe
PHYTOSQUAL
气味 Odor: characteristic
采用 Use: 油性成分,可替代矿物油。它既不是粉刺的,也不是昆虫的。润肤剂和润滑剂。 oily component used alternatively to mineral oil. It is not comedogenic nor achantotic. Emollient and lubricant.
 
安全信息 Safety Information:
首选SDS Preferred SDS: 视图 View
欧洲信息 European information :
最重要的危害 Most important hazard(s):
无-找不到。 None - None found.
S 02 - 保持 Keep out of the 达到 reach of 孩子们 children.
S 24/25 - 避免 Avoid contact with skin and 眼睛 eyes.
 
危害识别 Hazards identification
 
物质或混合物的分类 Classification of the substance or mixture
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
没有找到。 None found.
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements
 
象形图 Pictogram
 
危险说明 Hazard statement(s)
没有找到。 None found.
防范说明 Precautionary statement(s)
没有找到。 None found.
口服/肠胃外毒性 Oral/Parenteral Toxicity:
静脉老鼠 intravenous-mouse LD50 1800 mg/kg
Japanese 日志 Journal of Cancer 研究 Research. 卷 Vol. 76, pg. 1021 Pg. 1021, 1985.

老鼠 oral-mouse LD50 5000 mg/kg
Japanese 日志 Journal of Cancer 研究 Research. 卷 Vol. 76, pg. 1021 Pg. 1021, 1985.

皮肤毒性 Dermal Toxicity:
未定 Not determined
吸入毒性 Inhalation Toxicity:
未定 Not determined
 
使用安全信息 Safety in Use Information:
类别 Category:
cosmetic agents
推荐的(e)-角鲨烯用量不超过 Recommendation for (E)-squalene usage levels up to:
 不用于香水。 not for fragrance use.
 
推荐的(e)-角鲨烯调味剂的使用水平不超过 Recommendation for (E)-squalene flavor usage levels up to:
 不用于调味料。 not for flavor use.
 
安全参考 Safety references:
Epi系统 EPI System: 视图 View
Clinicaltrials.gov ClinicalTrials.gov:search
每日医学 Daily Med:search
辅助引文 AIDS Citations:搜索 Search
癌症引文 Cancer Citations:搜索 Search
毒理学引文 Toxicology Citations:搜索 Search
环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search
橙花发育和 毒性 NLM Developmental and Reproductive Toxicity:搜索 Search
EPA物质注册服务(tsca TSCA) :111-02-4
EPA ACToR:毒理学资料 Toxicology Data
EPA物质注册服务(SRS) :注册表 Registry
实验室化学安全摘要 Laboratory Chemical Safety Summary :638072
国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data
德国wgk WGK Germany:2
(6e (6E,10e 10E,14e 14E,18e)-2 18E)- 2,6,10,15,19,23-六甲基四cosa-2 23-hexamethyl tetracosa-2,6,10,14,18,22-己烯 22-hexaene
chemidplus Chemidplus:0000111024
epa / noaa客串 EPA/NOAA CAMEO:有害物质 hazardous materials
技术 RTECS:适用于CAS#111-02-4的xb6010000 XB6010000 for cas# 111-02-4
 
参考资料 References:
 (6e (6E,10e 10E,14e 14E,18e)-2 18E)- 2,6,10,15,19,23-六甲基四cosa-2 23-hexamethyl tetracosa-2,6,10,14,18,22-己烯 22-hexaene
NIST化学网络书籍 NIST Chemistry WebBook: 搜索INCHI
加拿大国内分公司。清单 Canada Domestic Sub. List:111-02-4
pubchem(cid) Pubchem (cid):638072
pubchem(sid) Pubchem (sid):134974713
 
其他资料 Other Information:
(iupac) (IUPAC):元素的原子量2009 Atomic Weights of the Elements 2009
(iupac) (IUPAC):元素的原子量2009(pdf) Atomic Weights of the Elements 2009 (pdf)
影片 Videos:元素周期表 The Periodic Table of Videos
RBC :本网站使用的原子量 Atomic Weights use for this web site
(iupac) (IUPAC):元素周期表 Periodic Table of the Elements
CHEBI:视图 View
CHEMBL:视图 View
格尔姆代谢组数据库 Golm Metabolome Database:搜索 Search
KEGG (GenomeNet):C00751
hmdb(人类代谢组数据库) HMDB (The Human Metabolome Database):HMDB00256
食物 FooDB:FDB015781
ymdb(酵母代谢组数据库) YMDB (Yeast Metabolome Database):YMDB00769
出口关税代码 Export Tariff Code:2901.29.5000
典型的g.c. Typical G.C.
vcf在线 VCF-Online:食品中的挥发性有机化合物 VCF Volatile Compounds in Food
化学蜘蛛 ChemSpider:视图 View
维基百科 Wikipedia:视图 View
rsc学习化学 RSC Learn Chemistry:视图 View
 
潜在搅拌机 Potential Blenders and core components note
没找到 None Found
 
潜在用途 Potential Uses:
 抗静电剂 antistatic agents
 润肤剂 emollients
 
存在(自然 Occurrence (nature, food, 其他) other):note
 棉籽油 cotton seed oil
搜索 Search Trop Picture
 茴香精华/精粹/精萃甜@ 0.20% fennel absolute sweet @ 0.20%
Data gc GC 搜索 Search Trop Picture
 艾蒿 mugwort
搜索 Search Trop Picture
 菜籽油 rape seed oil
搜索 Search Trop Picture
 丹参叶油@ 0.20% salvia lavandulifolia vahl. leaf oil @ 0.20%
Data gc GC 搜索 Search Trop Picture
 植物油 vegetable oil
搜索 Search Picture
 金缕梅叶油@ 0.09% witch hazel leaf oil @ 0.09%
Data gc GC 搜索 Search Trop Picture
 
同义词 Synonyms:
(6z (6Z,10e 10E,14e 14E,18e)-2 18E)- 2,6,10,15,19,23-hexamethyl tetracosa-2,6,10,14,18,22-己烯 22-hexaene
(全能 all-E)- 2,6,10,15,19,23-hexamethyl tetracosa-2,6,10,14,18,22-己烯 22-hexaene
(6e (6E,10e 10E,14e 14E,18e)-2 18E)- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-己烯 22-hexaene
 植物毒素 phytosqual (委婉的 Vevy)
(全能 all-E)-spinacene
mariclear shark squalane
oleaclear olive squalane
(e (E,E,E,E)-squalene
trans-squalene
 squalene (olive 派生的 derived)
 squalene from plants ≥96%
 squalene, olive
 
 
笔记 Notes:
在鱼肝油中发现 Found in fish liver oils, 酵母脂质和许多植物油 yeast lipids and many vegetable oils, 例如棕榈油 e.g. palm oil, 棉籽油 cotton seed oil, 菜籽油 rape seed oil A 自然 natural 生的 raw 材料 material 发现 found in 的 human sebum (5%) and in 鲨鱼肝 shark-肝 liver oil. An 不饱和 unsaturated 脂族的 aliphatic 烃 hydrocarbon (类胡萝卜素 carotenoid) with 六 six 不共轭的 unconjugated 双 double 债券 bonds. (Hawley's 浓缩的 Condensed Chemical 参考 Reference) 生物 Biological 资源 Source: 在鱼肝油中发现 Found in fish liver oils, 酵母脂质和许多植物油 yeast lipids and many vegetable oils, 例如棕榈油 e.g. palm oil, 棉籽油 cotton seed oil, 菜籽油 rape seed oil. 易挥发的 卷 Volatile 零件 component of scent 材料 material from saguinus Saguinus 俄狄浦斯 oedipus (棉质上衣 棉 cotton-top 猴 tamarin 猴 monkey) and saguinus Saguinus 镰刀菌 fuscicollis (鞍背 saddle-back 猴 tamarin 猴 monkey). 零件 Component of 成 adult 的 human sebum 原则上 principally 负责任的 responsible for the 定影 fixing of 指纹 fingerprints (化学碱 ChemNetBase) Squalene is a 自然 natural organic compound 本来 originally 获得 obtained for 商业的 commercial 目的 目的 purposes 主要 primarily from shark 肝 liver oil, 虽然也有植物来源 though there are botanical sources as well, 包括米糠 including rice bran, 小麦胚芽 wheat germ, 和橄榄。所有高级生物都产生角鲨烯 and olives. All higher organisms produce squalene, 包括 类。它是碳氢化合物和三萜。 -维基百科;角鲨烯是一种低密度化合物,通常储存在鲨鱼等软骨鱼类体内 including humans. It is a hydrocarbon and a triterpene. -- Wikipedia; Squalene is a low density compound often stored in the bodies of cartilaginous fish such as sharks, 缺乏游泳膀胱,因此必须通过脂肪和油类降低其身体密度。角鲨烯 which lack a swim bladder and must therefore reduce their body density with fats and oils. Squalene, 哪一个 which is 储存的 stored 主要是 mainly in the shark's 肝 liver, 肉豆蔻肉豆蔻水果油肉豆蔻eo肉豆蔻ess选择01肉豆蔻ess。油(用于香精)(robertet)肉豆蔻香精油肉豆蔻馏分eo较低的藏红花和me肉豆蔻indonesie eo肉豆蔻油肉豆蔻油e.i.肉豆蔻油印度东部肉豆蔻油el肉豆蔻油印度尼西亚肉豆蔻油印度尼西亚肉豆蔻油低黄樟油肉豆蔻油天然肉豆蔻油有机肉豆蔻油斯里兰卡有机肉豆蔻油 is lighter than water with a specific gravity of 0.855. Recently it has become a trend for sharks to be hunted to process their livers for the purpose of making squalene health capsules. Environmental and other concerns over shark hunting have motivated its extraction from vegetable sources instead.; Squalene is a low density compound often stored in the bodies of cartilaginous fishes such as sharks, 缺乏游泳膀胱,因此必须通过脂肪和油类降低其身体密度。角鲨烯 which lack a swim bladder and must therefore reduce their body density with fats and oils. Squalene, 哪一个 which is 储存的 stored 主要是 mainly in the shark's 肝 liver, is 打火机 lighter than 水 water with a 浸膏 specific 重力 gravity of 0.855. -- 维基百科 Wikipedia 用途 Uses: 杀菌剂。药品生产中的中间体 Bactericide. Intermediate in the manufacture of pharmaceuticals, 橡胶化学品和着色材料(化学物质的物理常数);角鲨烯是一种天然有机化合物,最初是从商业用途中主要从鲨鱼肝油中获得的 rubber chemicals and coloring materials (Physical Constants of Chemical Substances); Squalene is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, 虽然也使用植物来源(主要是植物油) though botanic sources (primarily vegetable oils) are used as well, 包括a菜种子 including amaranth seed, 米糠 rice bran, 小麦胚芽 wheat germ, 和橄榄。所有高级生物都产生角鲨烯 and olives. All higher organisms produce squalene, 包括 类。它是碳氢化合物和三萜。角鲨烯是胆固醇合成的天然和重要组成部分 including humans. It is a hydrocarbon and a triterpene. Squalene is a natural and vital part of the synthesis of cholesterol, 类固醇激素 steroid hormones, 体中的维生素D;角鲨烯是整个类固醇的生化前体。角鲨烯末端双键之一的氧化(通过角鲨烯单加氧酶)产生2 and vitamin D in the human body; Squalene is the biochemical precursor to the whole family of steroids. Oxidation (via squalene monooxygenase) of one of the terminal double bonds of squalene yields 2,3-氧化角鲨烯 3-squalene oxide, 经过酶催化的环化反应得到羊毛甾醇 which undergoes enzyme-catalyzed cyclization to afford lanosterol, 然后将其制成胆固醇和其他类固醇。角鲨烯是整个类固醇的生化前体。角鲨烯末端双键之一的氧化产生2 which is then elaborated into cholesterol and other steroids.; Squalene is the biochemical precursor to the whole family of steroids. Oxidation of one of the terminal double bonds of squalene yields 2,3-角鲨烯氧化物经过酶催化的环化反应生成羊毛甾醇 3-squalene oxide which undergoes enzyme-catalyzed cyclization to afford lanosterol, 然后将其制成胆固醇和其他类固醇。 -维基百科;越橘最初包含一种弱化或杀死的病原体。较新的越橘仅包含纯蛋白质或蛋白质片段 which is then elaborated into cholesterol and other steroids. -- Wikipedia; Vaccines originally contained a weakened or killed pathogen. Newer vaccines contain only pure proteins or protein fragments, 这使它们更安全。但是病原体的缺失部分是免疫反应的一部分。佐剂用来代替那些零件 which makes them safer. But the missing parts of the pathogen are part of the immune response. Adjuvants are used to replace those parts, 角鲨烯是这些佐剂之一。 and squalene is one of those adjuvants.
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