聚山梨酯85 polysorbate 85
补间85 TWEEN® 85

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9005-70-3补间85 9005-70-3 Tween 85

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产品 Product(s):
聚山梨酯85 polysorbate 85

CAS号 CAS Number:	9005-70-3
其他 Other:	111389-05-0
FDA UNII:	A7F3N56197
MDL :	mfcd01779641 MFCD01779641

类别 Category:emulsifiers, surfactants

美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :

谷歌学术 Google Scholar:	搜索 Search
谷歌书 Google Books:	搜索 Search
谷歌学术 Google Scholar: with word "volatile"	搜索 Search
谷歌学术 Google Scholar: with word "flavor"	搜索 Search
谷歌学术 Google Scholar: with word "odor"	搜索 Search
谷歌专利 Google Patents:	搜索 Search
美国专利 US Patents:	搜索 Search
欧盟专利 EU Patents:	搜索 Search
dg sante食品接触材料 DG SANTE Food Contact Materials:	聚乙二醇脱水山梨糖醇三油酸酯 polyethyleneglycol sorbitan trioleate
fda mainterm（iaufc） FDA Mainterm (IAUFC):	9005-70-3 ; POLYSORBATE 85

物理性质 Physical Properties:

化验 Assay:	95.00至100.00 95.00 to 100.00
食品化学品法典列表 Food Chemicals Codex Listed:	No
比重 Specific Gravity:	1.02800 @ 25.00 °C.
折光率 Refractive Index:	1.46800 @ 20.00 °C.
闪点 Flash Point:	> 230.00° tcc（> 110.00°c。） > 230.00 °F. TCC ( > 110.00 °C. )
溶于 Soluble in:
	水 water, 2.718e-019 mg / l @ 25°c（est） 2.718e-019 mg/L @ 25 °C (est)

感官特性 Organoleptic Properties:

来自其他的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found).

化妆品信息 Cosmetic Information:

CosIng:	化妆品数据 cosmetic data
化妆品用途 Cosmetic Uses:	乳化剂 emulsifying agents surfactants

供应商 Suppliers:

BOC Sciences

仅供实验/研究使用。 For experimental / research use only.

补间85 TWEEN® 85

化学导航-尼克尔 Chemical-navi - Nikkol

尼克尔至30v NIKKOL TO-30V

气味 Odor: characteristic

采用 Use: 可溶性油的乳化剂；水分散性油溶性植物来源 Emulsifier for soluble oils; water dispersible; oil soluble; plant-derived

共价化学 Covalent Chemical

聚山梨酯85 polysorbate 85

ECSA Chemicals

聚山梨酯85 polysorbate 85

公司简介 Company Profile

花王公司 Kao Corporation

流变 rheodol tw-o320v

气味 Odor: characteristic

采用 Use: 医药和化妆品乳化剂 Emulsifier for pharmaceuticals and cosmetics, 彩色材料的稳定剂 Stabilizer for color materials, 乳液聚合稳定剂 Stabilizer for emulsion polymerizations, 农药助剂乳化剂 Emulsifier for adjuvant of agrochemicals, 水性金属加工切削油用乳化剂 Emulsifier for water based metal process cutting oils, 表面涂层型抗静电剂。 Surface coating type antistatic agents.

隆萨集团 Lonza Group

伦斯特 lonzest＆trade; sto-20

莫希尼有机物 Mohini Organics

蒙巴特 monebat＆trade; -85

气味 Odor: characteristic

采用 Use: 蒙巴特 monebat＆trade; -85用作乳化剂 , 分散剂 dispersant, 增溶剂 solubilizer, 润滑剂 lubricant, 洗涤剂 detergent, 抗静电 antistat, 化妆品和药品的润湿剂。 wetting agent for cosmetics and pharmaceuticals.

西格玛·奥尔德里奇 Sigma-Aldrich: 西格玛 Sigma

仅供实验/研究使用。 For experimental / research use only.

TWEEN^® 85

sds sds

安全信息 Safety Information:

首选SDS Preferred SDS: 视图 View

危害识别 Hazards identification

物质或混合物的分类 Classification of the substance or mixture
根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
没有找到。 None found.
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements

象形图 Pictogram

危险说明 Hazard statement(s)
没有找到。 None found.
防范说明 Precautionary statement(s)
没有找到。 None found.
口服/肠胃外毒性 Oral/Parenteral Toxicity:
未定 Not determined
皮肤毒性 Dermal Toxicity:
未定 Not determined
吸入毒性 Inhalation Toxicity:
未定 Not determined

使用安全信息 Safety in Use Information:

类别 Category:		emulsifiers, surfactants
推荐的聚山梨酯85的使用水平直至 Recommendation for polysorbate 85 usage levels up to:
	不用于香水。 not for fragrance use.

推荐的聚山梨酯85调味剂的使用水平不超过 Recommendation for polysorbate 85 flavor usage levels up to:
	不用于调味料。 not for flavor use.

安全参考 Safety references:

Epi系统 EPI System: 视图 View

化学致癌研究信息系统 Chemical Carcinogenesis Research Information System:搜索 Search

EPA物质注册服务（tsca TSCA） :9005-70-3

EPA ACToR:毒理学资料 Toxicology Data

EPA物质注册服务（SRS） :注册表 Registry

国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data

德国wgk WGK Germany:1

chemidplus Chemidplus:0009005703

技术 RTECS:适用于CAS＃9005-70-3的wg2934500 WG2934500 for cas# 9005-70-3

参考资料 References:

加拿大国内分公司。清单 Canada Domestic Sub. List:	9005-70-3
pubchem（sid） Pubchem (sid):	135287157

其他资料 Other Information:

用于食品接触物质的fda间接添加剂 FDA Indirect Additives used in Food Contact Substances:	视图 View
hmdb（人类代谢组数据库） HMDB (The Human Metabolome Database):	搜索 Search
食物 FooDB:	FDB016184
出口关税代码 Export Tariff Code:	3402.13.2020

潜在搅拌机 Potential Blenders and 核心组件 core components note

没找到 None Found

潜在用途 Potential Uses:

	乳化剂 emulsifying agents
	surfactants

存在（自然 Occurrence (nature, food, 其他） other):note

自然界中找不到 not found in nature

同义词 Synonyms:

	糖精 glycosperse TO-20
	吸收 hetsorb TO-20
	脂质吸附 liposorb TO-20
	伦斯特 lonzest STO-20
	蒙巴特 monebat - 85
	尼克尔 nikkol TO-30V
	poe-20 sorbitan 三油酸酯 trioleate
	聚乙二醇脱水山梨糖醇三油酸酯 polyethyleneglycol sorbitan trioleate
	polyoxyethylene (20) sorbitan 三油酸酯 trioleate
	吸附 protasorb TO-20
	流变 rheodol TW-O320V
	毒素 toximul see-340
	补间85 TWEEN® 85

文章 Articles:

已发布 PubMed:不同表面活性剂的水包油乳液中纳米颗粒的行为研究 On the behaviour of nanoparticles in oil-in-water emulsions with different surfactants.

已发布 PubMed:优化的吐温85-聚乙烯亚胺偶联物可有效递送p65 shrna，以抑制肿瘤生长和淋巴转移。 Effective delivery of p65 shRNA by optimized Tween 85-polyethyleneimine conjugate for inhibition of tumor growth and lymphatic metastasis.

已发布 PubMed:聚山梨酯85的表征 Characterization of polysorbate 85, 非离子表面活性剂 a nonionic surfactant, 液相色谱与离子迁移分离与串联质谱联用。 by liquid chromatography vs. ion mobility separation coupled with tandem mass spectrometry.

已发布 PubMed:使用分散和消化测试对不含药物和含非诺贝特的脂质制剂进行体外评估可详细了解制剂在肠道中的命运。 In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine.

已发布 PubMed:通过使用可生物还原的基于pei / p65 shrna复合物的纳米颗粒阻断nf-κb信号通路来抑制乳腺癌的转移和生长。 The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles.

已发布 PubMed:新型w / o / w自乳化纳米乳的配方和细胞毒性评估。 Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions.

已发布 PubMed:增强（iv）-吐温85体系的化学发光及其分析应用 Enhanced chemiluminescence of cerium(IV)-Tween 85 system and the analytical application.

已发布 PubMed:无铜涂料中防污物质的共同作用。 Joint-action of antifouling substances in copper-free paints.

已发布 PubMed:新型甘草酸铵/脂质体输送系统的抗炎活性 Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: 和鼠模型。 human and murine models.

已发布 PubMed:食用纳米乳的低能形成 Low-energy formation of edible nanoemulsions: 影响乳液相转化产生的液滴尺寸的因素。 factors influencing droplet size produced by emulsion phase inversion.

已发布 PubMed:生物降解角蛋白废物，并从淡紫色拟青霉产生清洁剂稳定的丝氨酸蛋白酶。 Biodegradation of a keratin waste and the concomitant production of detergent stable serine proteases from Paecilomyces lilacinus.

已发布 PubMed:/水-吐温85 / ipm微乳体系的结构和组成对5-氟尿嘧啶透皮递送的影响。 The influence of the structure and the composition of water/AOT-Tween 85/IPM microemulsion system on transdermal delivery of 5-fluorouracil.

已发布 PubMed:低分子量聚乙烯亚胺接枝吐温85可有效传递基因 Low molecular weight polyethylenimine-graft-Tween 85 for effective gene delivery: 合成和体外特性。 synthesis and in vitro characteristics.

已发布 PubMed:[用于透皮递送氟尿嘧啶的含nacl的油包水微乳液]。 [Water in oil microemulsions containing NaCl for transdermal delivery of fluorouracil].

已发布 PubMed:米曲霉全细胞在有机溶剂中乙酰化1-β-d-阿拉伯呋喃糖基胞嘧啶的新型生物催化方法。 A novel biocatalytic approach to acetylation of 1-β-D-arabinofuranosylcytosine by Aspergillus oryzae whole cell in organic solvents.

已发布 PubMed:[基于微乳的氟尿嘧啶透皮给药凝胶]。 [Microemulsion-based gel of fluorouracil for transdermal delivery].

已发布 PubMed:基于Immunor 308的自微乳化药物输送系统的配方和理化特性。 Formulation and physicochemical characterization of imwitor 308 based self microemulsifying drug delivery systems.

已发布 PubMed:高效抗胆碱酯酶植物油微乳的表征。 Characterization of potent anticholinesterase plant oil based microemulsion.

已发布 PubMed:盐酸格拉司琼经皮给药的纳米乳剂体系的制备及体外评价。 Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride.

已发布 PubMed:使用阴离子和阴离子/非离子反胶束提取单克隆抗体（igg1）。 Extraction of monoclonal antibodies (IgG1) using anionic and anionic/nonionic reverse micelles.

已发布 PubMed:通过et-aas超声辅助浆料采样直接快速测定固体植物材料中的痕量重金属。 Direct and rapid determination of ultratrace heavy metals in solid plant materials by ET-AAS ultrasonic-assisted slurry sampling.

已发布 PubMed:无溶剂系统中酶促甘油分解的单和二酰基甘油生产的优化。 Optimization of mono and diacylglycerols production from enzymatic glycerolysis in solvent-free systems.

已发布 PubMed:[用于透皮递送氟尿嘧啶的油包水微乳液]。 [Water in oil microemulsions for transdermal delivery of fluorouracil].

已发布 PubMed:盾叶薯蓣中杀菌皂苷的生物转化c。 H。哈茨木霉菌素对薯in皂甙元的影响。 Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum.

已发布 PubMed:纳米乳剂用于利福平静脉给药的潜力 Potential of nanoemulsions for intravenous delivery of rifampicin.

已发布 PubMed:双连续环孢菌素负载的水-乙酸/肉豆蔻酸85-肉豆蔻酸微乳液 Bicontinuous cyclosporin a loaded water-AOT/Tween 85-isopropylmyristate microemulsion: 体内的结构表征和皮肤药代动力学。 structural characterization and dermal pharmacokinetics in vivo.

已发布 PubMed:脂肪酶在疏水化氧化锆纳米粒子上的固定化 Immobilization of lipases on hydrophobilized zirconia nanoparticles: 高对映选择性和可重复使用的生物催化剂。 highly enantioselective and reusable biocatalysts.

已发布 PubMed:微乳系统用于美洛昔康透皮给药的研究。 Investigation of microemulsion system for transdermal delivery of meloxicam.

已发布 PubMed:赋形剂对尿素保湿效果的影响 Influence of excipients on moisturizing effect of urea.

已发布 PubMed:非离子表面活性剂稳定的大豆水包油乳液的化学行为 Behavior of soybean oil-in-water emulsion stabilized by nonionic surfactant.

已发布 PubMed:[吲哚-3-丁酸非保护性流体室温磷光和胶束稳定的室温磷光性能的比较]。 [Comparison of non-protected fluid room temperature phosphorescence and micellar-stabilized room temperature phosphorescence properties of indole-3-butyric acid].

已发布 PubMed: 表面活性剂hlb HLB和不同配方变量对聚-d性能的影响 ,纳曲酮的l-丙交酯微球通过双重乳液技术制备。 L-lactide microspheres of naltrexone prepared by double emulsion technique.

已发布 PubMed:同时测量电导率和粘度，以此作为通过相转化温度法跟踪乳液转化的技术。 Simultaneous conductivity and viscosity measurements as a technique to track emulsion inversion by the phase-inversion-temperature method.

已发布 PubMed:一锅合成co3o4纳米荜澄茄/山苍子体及其密闭和非密闭组织的层状表面活性剂上层结构的自生成。 Self-generation of tiered surfactant superstructures for one-pot synthesis of Co3O4 nanocubes and their close- and non-close-packed organizations.

已发布 PubMed:多粘菌素b增强了多种物种间iss介导的免疫反应。 Polymyxin B enhances ISS-mediated immune responses across multiple species.

已发布 PubMed:含有甲氧基肉桂酸辛酯的聚ε-己内酯纳米胶囊 Poly-epsilon-caprolactone nanocapsules containing octyl methoxycinnamate: 准备和表征。 preparation and characterization.

已发布 PubMed:表面活性剂疏水性对大肠杆菌o157脱离的影响 Influence of surfactant hydrophobicity on the detachment of Escherichia coli O157:h7从生菜。 H7 from lettuce.

已发布 PubMed:可乐宁微乳液配方 Microemulsion formulation of clonixic acid: 溶解度提高和疼痛减轻。 solubility enhancement and pain reduction.

已发布 PubMed:废水污泥为原料的表面活性剂对生物农药生产的影响 Effect of surface active agents on the production of biopesticides using wastewater sludge as a raw material.

已发布 PubMed:含有防晒剂的可生物降解的聚合物纳米胶囊 Biodegradable polymer nanocapsules containing a sunscreen agent: 制备和光保护。 preparation and photoprotection.

已发布 PubMed:混合胶束系统肌内滴定积雪草滴定液的新型剂型的开发。 Development of a novel dosage form for intramuscular injection of titrated extract of Centella asiatica in a mixed micellar system.

已发布 PubMed:剂含左旋多巴的明胶微球的制备及体外表征。 Preparation and in vitro characterization of gelatin microspheres containing Levodopa for nasal administration.

已发布 PubMed:使用溶解在油包水微乳液中的分枝杆菌生产手性环氧化物 Chiral epoxide production using mycobacterium solubilized in a water-in-oil microemulsion.

已发布 PubMed:非离子表面活性剂对caco-2细胞跨上皮通透性的影响 Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells.

已发布 PubMed:多杀性巴氏杆菌菌株的脂肪酶活性。 Lipase activity from strains of Pasteurella multocida.

已发布 PubMed:pbca纳米颗粒悬浮液的长期稳定性。 Long-term stability of PBCA nanoparticle suspensions.

已发布 PubMed:口服或直肠给药含有吲哚美辛的自乳化系统后，增强了吲哚美辛的吸收。 Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin to rats.

已发布 PubMed:明胶稳定的微乳液基有机凝胶 Gelatin-stabilised microemulsion-based organogels: 流变学及其在离子电渗透皮给药中的应用。 rheology and application in iontophoretic transdermal drug delivery.

已发布 PubMed:使用基于亲和力的反向胶束分离蛋白质 Protein separation using affinity-based reversed micelles

已发布 PubMed:纳米粒子技术可跨血脑屏障传递药物。 Nanoparticle technology for delivery of drugs across the blood-brain barrier.

已发布 PubMed:跨血脑屏障的口服达拉根负载纳米颗粒递送的功效。 Efficacy of oral dalargin-loaded nanoparticle delivery across the blood-brain barrier.

已发布 PubMed:预防由改进的油佐剂越橘接种水牛犊引起的出血性败血病。 Protection against haemorrhagic septicaemia induced by vaccination of buffalo calves with an improved oil adjuvant vaccine.

已发布 PubMed:给药载体对大鼠ccl4肝毒性和chcl3肾毒性的影响 Effect of dosing vehicle on the hepatotoxicity of CCl4 and nephrotoxicity of CHCl3 in rats.

已发布 PubMed:离子去污剂的疏水性对大鼠肠道刷状边界膜囊泡膜脂流动性和二吡酰胺吸收的影响 Contribution of hydrophobicity of nonionic detergents to membrane lipid fluidity and disopyramide uptake by rat intestinal brush-border membrane vesicles.

已发布 PubMed:[过氧化氢酶在辛烷表面活性剂微乳液中的催化性能]。 [Catalytic properties of catalase in microemulsions of surface-active agents in octane].

已发布 PubMed:聚丙烯酰胺凝胶电泳变性后大鼠去唾液酸糖蛋白受体主要亚基的复性和配体印迹 Renaturation and ligand blotting of the major subunit of the rat asialoglycoprotein receptor after denaturing polyacrylamide gel electrophoresis.

已发布 PubMed:连续流两相微乳液反应器中农药的降解 Degradation of pesticides in a continuous-flow two-phase microemulsion reactor.

已发布 PubMed:吐温85非离子油包水微乳液中农药的生物降解 Biodegradation of pesticides in nonionic water-in-oil microemulsions of tween 85: 胶束结构与活性之间的关系。 Relationship between micelle structure and activity.

已发布 PubMed:反向胶束中蛋白质迁移的高压epr研究。 High pressure EPR studies of protein mobility in reversed micelles.

已发布 PubMed:表面活性剂诱导的蓝细菌中的氢产生。 Surfactant-Induced hydrogen production in cyanobacteria.

已发布 PubMed:可压缩流体微乳中蛋白质的溶解和活性。 Solubilization and activity of proteins in compressible-fluid based microemulsions.

已发布 PubMed:逆胶束中使用脂氧合酶的极谱法测量氧吸收。 Polarographic measurement of oxygen uptake using lipoxygenase in reverse micelles.

已发布 PubMed:2-n-辛基-4-异噻唑啉-3-one（skane m-8）的刺激性和致敏性 The irritancy and allergenicity of 2-n-octyl-4-isothiazolin-3-one (Skane M-8), 有关斑块测试浓度的建议。 with recommendations for patch test concentration.

已发布 PubMed:哺乳动物表皮中脂肪酶和鞘磷脂酶活性的细胞化学和生化定位。 Cytochemical and biochemical localization of lipase and sphingomyelinase activity in mammalian epidermis.

已发布 PubMed:通过反胶团将细菌细胞溶解在有机溶剂中。 Solubilization of bacterial cells in organic solvents via reverse micelles.

已发布 PubMed:[在母细胞增生症患者中，聚氧乙烯（20）脱水山梨糖醇三油酸酯（吐温85）对电子玫瑰红形成的影响（体外）]。 [Effect of polyoxyethylene (20) sorbitan trioleate (tween 85) on E-rosette formation (in vitro) in blastomatosis patients].

已发布 PubMed:表面和表面活性剂对热输出的触发作用 The triggering effect of surfaces and surfactants on heat output, 饥饿的海洋弧菌的耗氧量和尺寸减小。 oxygen consumption and size reduction of a starving marine Vibrio.

已发布 PubMed:[表面活性物质对微生物碳氢化合物氧化过程的复合物影响]。 [Complex effect of surface-active substances on the process of microbiological hydrocarbon oxidation].

已发布 PubMed:牛莫拉菌的水解酶。 Hydrolytic enzymes of Moraxella bovis.

已发布 PubMed:菜子（甘蓝型油菜）子叶的膜结合甘油三酸酯脂肪酶的性质 Properties of a membrane-bound triglyceride lipase of rapeseed (Brassica napus L.) cotyledons.

已发布 PubMed:研究2 Studies on 2', 3'-cyclic 安培 AMP 3'-phosphohydrolase in 兔子 rabbit skin 皮.

已发布 PubMed:体内监测聚山梨酯85对表皮渗透性影响的方法。 In vivo method for monitoring polysorbate 85 effect on epidermal permeability.

已发布 PubMed:聚山梨酯85对体皮肤的影响。 Effect of polysorbate 85 on human skin.

笔记 Notes:

乳化剂 emulsifying agents, 润湿剂 wetting agent, 分散剂 dispersant, 稳定剂 stabiliser, 增溶剂 solubilizer 硫酸钠是一种适度溶于水和酸钠源，用于与硫酸盐相容的用途。硫酸盐化合物是通过用金属代替一个或两个氢而形成的硫酸盐或酯。大多数金属硫酸盐化合物易溶于水，用于水处理等用途 Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids. (Wikipedia)

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