尿酸 uric acid
1h-嘌呤-2 1H-purine-2,6,8（3h）-三酮 8(3H)-trione, 7,9-二氢-（9ci） 9-dihydro- (9CI)
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笔记 Notes: 氧化产物 an oxidation product, 通过黄嘌呤氧化酶 via xanthine oxidase, 氧嘌呤如黄嘌呤和次黄嘌呤。它是嘌呤分解代谢在 类和灵长类动物中的最终氧化产物 of oxypurines such as xanthine and hypoxanthine. it is the final oxidation product of purine catabolism in humans and primates, 而在大多数其他哺乳动物中，尿酸氧化酶将其进一步氧化为尿囊素。以磷酸盐形式存在于酵母和肉类产品中 whereas in most other mammals urate oxidase further oxidizes it to allantoin. Occurs as phosphate in yeast and meat products
例如 For example, 一些研究 员提出，高尿酸血症引起的氧化应激是代谢综合征的原因。另一方面 some researchers propose that hyperuricemia-induced oxidative stress is a cause of metabolic syndrome. On the other hand, 等离子体 plasma 尿酸 uric acid 等级 levels 相关 correlate with 长寿 longevity in 灵长类动物 primates and other mammals. 这个 This is 想必 presumably a function of 尿酸盐 urate's 抗氧化剂 antioxidant 属性 properties.; 尿酸 uric acid (or 尿酸盐 urate) is an organic compound of carbon, 氮 nitrogen, 氧和氢，分子式为c5h4n4o3。尿酸是一种杂环嘌呤衍生物，是嘌呤代谢的最终氧化产物。它是由黄嘌呤氧化酶产生的 oxygen and hydrogen with the formula C5H4N4O3.; Uric acid is a heterocyclic purine derivative that is the final oxidation product of purine metabolism. It is produced by the enzyme xanthine oxidase, which 氧化 oxidizes 氧嘌呤 oxy嘌呤 purines 这样 such as 黄嘌呤 xanthine 进入 into 尿酸 uric acid. In 最 most mammals, 类和高等灵长类动物除外 except humans and higher primates, the 酵素 enzyme 尿酸酶 uricase 进一步 further 氧化 oxidizes 尿酸 uric acid to 尿囊素 allantoin. 尿酸 uric acid is 也 also the end product of 氮 nitrogen 代谢 metabolism in 鸟类 birds and 爬虫类 reptiles. In 这样 such 种类 species, 正三甲基丙烷-1-氯化铵（r）-3-乙酰氧基-4-（三甲基铵）丁酸盐酸盐（r）-3-乙酰氧基-4-（三甲基铵）丁酸盐酸盐乙酰基-1-肉碱氯化物乙酰基-肉碱盐酸盐酸乙酰-1-肉碱盐酸盐-乙酰-1-肉碱盐酸盐（3r）-3-乙酰氧基-4-（三甲基氮杂基）丁酸;盐酸盐（2r）-2-（乙酰氧基）-3-羧基-n it is excreted in feces as a dry mass. Humans produce only small quantities of uric acid with excess accumulation leading to a type of arthritis known as gout. The loss of uricase in higher primates parallels the similar loss of the ability to synthesize ascorbic acid vitamin C. This may be because in higher primates uric acid partially replaces ascorbic acid.
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