依替膦酸 etidronic acid
膦酸 phosphonic acid, (1-羟基亚乙基)双- (1-hydroxyethylidene)bis-

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    2809-21-4乙二膦酸> 98% 2809-21-4 Etidronic acid >98%
    依替膦酸(Didronel didronel)是一种 蛋白酪氨酸磷酸酶抑制剂,IC50值为0.2 nm。
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    h0587 1-羟基乙烷-1 H0587 1-Hydroxyethane-1,1-二膦酸(水中约60% 1-diphosphonic Acid (ca. 60% in Water, ca. 4.2摩尔/升) ca. 4.2mol/L)
CAS号 CAS Number: 2809-21-4Picture of molecule3D/INCHI
echa ECHA einecs Ein INECS - REACH 预注册 Pre-Reg:220-552-8
FDA UNII:M2F465ROXU
nikkaji网站 Nikkaji Web:J7.915D
贝尔斯坦数 Beilstein Number:1789291
MDL :mfcd00070585 MFCD00070585
XlogP3-AA:-3.70(est) -3.70 (est)
分子量 Molecular Weight:206.02768400
式 Formula:c2 h8 o7 p2 C2 H8 O7 P2
生物活性总结 BioActivity Summary:清单 listing
核磁共振预测器 NMR Predictor:预测(适用于Chrome或Firefox) Predict (works with chrome or firefox)
类别 Category:sequestrants
 
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食品添加剂 JECFA Food Additive: 1-羟亚乙基-1 1-Hydroxyethylidene-1,1-二膦酸 1-diphosphonic acid
fda mainterm(satf) FDA Mainterm (SATF):2809-21-4 ; 1-HYDROXYETHYLIDENE-1,1-二膦酸 1-diphosphonic acid
自由贸易区法规 FDA Regulation:
自由贸易区 FDA PART 173 -- 次要的 SECONDARY 直接 DIRECT FOOD 添加剂 ADDITIVES 允许的 PERMITTED in IN FOOD 对于 FOR 的 HUMAN CONSUMPTION
Subpart d特异的 D--浸膏 Specific 用法 Usage Additives
Sec. 173.310 锅炉 Boiler 水 water additives.


自由贸易区 FDA PART 173 -- 次要的 SECONDARY 直接 DIRECT FOOD 添加剂 ADDITIVES 允许的 PERMITTED in IN FOOD 对于 FOR 的 HUMAN CONSUMPTION
Subpart d特异的 D--浸膏 Specific 用法 Usage Additives
Sec. 173.315 Chemicals 用过的 used in 洗涤 washing or to 助攻 assist in the 剥皮 peeling of 水果 果 fruits and 蔬菜 vegetables.


自由贸易区 FDA PART 173 -- 次要的 SECONDARY 直接 DIRECT FOOD 添加剂 ADDITIVES 允许的 PERMITTED in IN FOOD 对于 FOR 的 HUMAN CONSUMPTION
Subpart d特异的 D--浸膏 Specific 用法 Usage Additives
Sec. 173.370 过氧酸 Peroxyacids.


自由贸易区 FDA PART 178 -- 间接 in IN直接 DIRECT FOOD 添加剂 ADDITIVES: 佐剂 ADJUVANTS, 生产助剂 PRODUCTION AIDS, and AND SANITIZERS
Subpart b--物质 B--Substances 被利用 Utilized To 控制 Control the 成长 Growth of Microorganisms
Sec. 178.1010 消毒 Sanitizing 解决方案 解 solutions.
 
物理性质 Physical Properties:
出现 Appearance:淡黄透明液体(est) pale yellow clear liquid (est)
食品化学品法典列表 Food Chemicals Codex Listed: No
比重 Specific Gravity:1.43000 to 1.47100 @ 20.00 °C.
磅每加仑-(est)。 Pounds per Gallon - (est).: 11.913至12.254 11.913 to 12.254
沸点 Boiling Point: 578.76 °C. @ 760.00 mm 汞 Hg (est)
闪点 Flash Point: 579.00 °F. tcc TCC ( 303.80 °C. ) (est)
logp(o / w) logP (o/w): -0.746(est) -0.746 (est)
溶于 Soluble in:
 水 water, 690000 mg / l @ 20°C(实验值) 690000 mg/L @ 20 °C (exp)
 
感官特性 Organoleptic Properties:
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found).
 
化妆品信息 Cosmetic Information:
CosIng:化妆品数据 cosmetic data
化妆品用途 Cosmetic Uses: 螯合剂 chelating agents
 
供应商 Suppliers:
水生化学 AquaChemie
仅供实验/研究使用。 For experimental / research use only.
1-羟亚乙基-1 1-Hydroxyethylidene-1,1-二膦酸-HEPP 1-Diphosphonic acid - HEDP
BOC Sciences
仅供实验/研究使用。 For experimental / research use only.
依替膦酸> 98% Etidronic acid >98%
气味 Odor: characteristic
采用 Use: 依替膦酸(Didronel didronel)是一种 蛋白酪氨酸磷酸酶抑制剂,IC50值为0.2 nm。
Charkit Chemical
要求2010 DEQUEST 2010
连接化学品 Connect Chemicals
1-羟亚乙基-1 1-Hydroxyethylidene-1, 1-二膦酸(赫德 HEDP)
气味 Odor: characteristic
采用 Use: 1-羟亚乙基-1 1-Hydroxyethylidene-1,4'-羟基-乙芬芬-乙酰基-4-氨基苯酚-乙酰基-对-氨基苯酚4-(乙酰氨基)苯酚对-(乙酰氨基)苯酚对乙酰基氨基苯酚apapn-(4-羟基-苯基)-乙酰胺4'-羟基对乙酰苯胺基-羟基对乙酰苯胺-(4-羟基苯基)乙酰胺基-(4-羟基苯基)乙酰胺基-(对羟基苯基)乙酰胺基-(4-羟基苯基)乙酰胺基对乙酰氨基酚对乙酰氨基酚酚 1-diphosphonic acid (HEDP) is a cost effective scale inhibitor used in various industrial applications such as industrial water treatment and detergents. It further shows good stability in presence of chlorine as well as corrosion inhibition properties in presence of zinc and other phosphates. HEDP can be also used as chelating agent in the textile industry.
圣克鲁斯生物技术 Santa Cruz Biotechnology
仅供实验/研究使用。 For experimental / research use only.
依替膦酸≥90% Etidronic Acid ≥90%
湿婆化学药品和制药 Shiva Chemicals and Pharmaceuticals
赫德 HEDP
西格玛·奥尔德里奇 Sigma-Aldrich: 奥尔德里奇 Aldrich
仅供实验/研究使用。 For experimental / research use only.
依替膦酸60%水溶液 Etidronic Acid 60% aqueous solution
强力化学品 Strem Chemicals
仅供实验/研究使用。 For experimental / research use only.
1-羟亚乙基-1 1-Hydroxyethylidene-1,1-二膦酸 1-diphosphonic acid, 分钟95%Hepp min. 95% HEDP
TCI AMERICA
仅供实验/研究使用。 For experimental / research use only.
1-羟基乙烷-1 1-Hydroxyethane-1,1-二膦酸(水中约60% 1-diphosphonic Acid (ca. 60% in Water, ca. 4.2摩尔/升) ca. 4.2mol/L)
环球防腐化学公司 Universal Preserv-A-Chem Inc.
依替膦酸 etidronic acid
气味 Odor: characteristic
采用 Use: 是用于洗涤剂的双膦酸盐 Is a bisphosphonate used in detergents, 水处理 water treatment, 化妆品和药物治疗。依替膦酸(Didronel didronel-)是用于增强骨骼的双膦酸盐 , 治疗骨质疏松 treat osteoporosis, 并治疗佩吉特氏骨病。 and treat Paget's disease of bone.
zschimmer&施瓦兹 Zschimmer & Schwarz
酷他he-k 60 Cublen HE-K 60
 
安全信息 Safety Information:
首选SDS Preferred SDS: 视图 View
 
危害识别 Hazards identification
 
物质或混合物的分类 Classification of the substance or mixture
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
没有找到。 None found.
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements
 
象形图 Pictogram
 
危险说明 Hazard statement(s)
没有找到。 None found.
防范说明 Precautionary statement(s)
没有找到。 None found.
口服/肠胃外毒性 Oral/Parenteral Toxicity:
老鼠 口服 oral-mouse LD50 1800 mg/kg
Angewandte 化学 Chemie, 国际版英文。卷14 International Edition in English. Vol. 14, pg。 94 Pg. 94, 1975.

皮肤毒性 Dermal Toxicity:
未定 Not determined
吸入毒性 Inhalation Toxicity:
未定 Not determined
 
使用安全信息 Safety in Use Information:
类别 Category: sequestrants
推荐使用依替膦酸使用水平 Recommendation for etidronic acid usage levels up to:
 不用于香水。 not for fragrance use.
 
推荐使用依替膦酸调味剂的最高使用量 Recommendation for etidronic acid flavor usage levels up to:
 不用于调味料。 not for flavor use.
 
安全参考 Safety references:
欧洲食品安全局(efsa EFSA)参考 :

科学的 Scientific 意见 Opinion on the 评价 evaluation of the safety and 功效 efficacy of 过氧乙酸 peroxyacetic acid 解决方案 解 solutions for 减少 reduction of 病原体 pathogens on 家禽 poultry 屠体 carcasses and meat
视图 View page or 视图 View pdf

Epi系统 EPI System: 视图 View
临床 Clinicaltrials.gov :search
nlm NLM有害物质数据库 :搜索 Search
癌症引文 Cancer Citations:搜索 Search
毒理学引文 Toxicology Citations:搜索 Search
环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search
橙花发育和 毒性 NLM Developmental and Reproductive Toxicity:搜索 Search
EPA物质注册服务(tsca TSCA) :2809-21-4
EPA ACToR:毒理学资料 Toxicology Data
EPA物质注册服务(SRS) :注册表 Registry
实验室化学安全摘要 Laboratory Chemical Safety Summary :3305
国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data
德国wgk WGK Germany:2
(1-羟基-1-膦酰基乙基)膦酸 (1-hydroxy-1-phosphonoethyl)phosphonic acid
chemidplus Chemidplus:0002809214
技术 RTECS:CAS#2809-21-4的sz8562100 SZ8562100 for cas# 2809-21-4
 
参考资料 References:
 (1-羟基-1-膦酰基乙基)膦酸 (1-hydroxy-1-phosphonoethyl)phosphonic acid
NIST化学网络书籍 NIST Chemistry WebBook: 搜索INCHI
加拿大国内分公司。清单 Canada Domestic Sub. List:2809-21-4
pubchem(cid) Pubchem (cid):3305
pubchem(sid) Pubchem (sid):134983248
 
其他资料 Other Information:
(iupac) (IUPAC):元素的原子量2009 Atomic Weights of the Elements 2009
(iupac) (IUPAC):元素的原子量2009(pdf) Atomic Weights of the Elements 2009 (pdf)
影片 Videos:元素周期表 The Periodic Table of Videos
RBC :本网站使用的原子量 Atomic Weights use for this web site
(iupac) (IUPAC):元素周期表 Periodic Table of the Elements
食品中添加的fda物质(以前为af) FDA Substances Added to Food (formerly EAFUS):视图 View
用于食品接触物质的fda间接添加剂 FDA Indirect Additives used in Food Contact Substances:视图 View
CHEBI:视图 View
CHEMBL:视图 View
KEGG (GenomeNet):C07736
hmdb(人类代谢组数据库) HMDB (The Human Metabolome Database):HMDB15210
食物 FooDB:FDB001018
出口关税代码 Export Tariff Code:2931.90.9041
fda食品添加剂状况清单 FDA Listing of Food Additive Status:视图 View
雾度图 Haz-Map:视图 View
家庭用品 Household Products:搜索 Search
化学蜘蛛 ChemSpider:视图 View
维基百科 Wikipedia:视图 View
rsc学习化学 RSC Learn Chemistry:视图 View
 
潜在搅拌机 Potential Blenders and core 组件 components note
没找到 None Found
 
潜在用途 Potential Uses:
 螯合剂 chelating agents
 
存在(自然 Occurrence (nature, food, 其他) other):note
 自然界中找不到 not found in nature
 
同义词 Synonyms:
 acetodi膦酸 phosphonic acid
 cublen cublen he-k HE-K 60
 Didronel didronel IV
oxyethylidenedi膦酸 phosphonic acid
(1-hydroxy-1-phosphono-ethyl)-膦酸 phosphonic acid
(1-hydroxy-1-phosphonoethyl)膦酸 phosphonic acid
(1-hydroxy-1,1-ethanediyl)bis(膦酸 phosphonic acid)
1-hydroxyethane-1,1-bis膦酸 phosphonic acid
1-hydroxyethane-1,1-二膦酸 1-diphosphonic acid
(1-hydroxyethane-1,1-diyl)bis(膦酸 phosphonic acid)
(1-hydroxyethane-1,1-diyl)di膦酸 phosphonic acid
1-hydroxyethane-1,1,-di膦酸 phosphonic acid
1-hydroxyethanedi膦酸 phosphonic acid
(1-hydroxyethylene)di膦酸 phosphonic acid
1-hydroxyethylidene-1,1-二膦酸 1-diphosphonic acid
1-hydroxyethylidene-1,1-diphosphonicacid
(1-hydroxyethylidene)bis(膦酸 phosphonic acid)
(1-hydroxyethylidene)bisphonic bisphonic acid
(1-hydroxyethylidene)bis膦酸 phosphonic acid
(1-hydroxyethylidene)双性的 diphoshonic acid
(hydroxyethylidene)di膦酸 phosphonic acid
(1-hydroxyethylidene)di膦酸 phosphonic acid
1-hydroxyethylidenedi膦酸 phosphonic acid
 膦酸 phosphonic acid, (1-羟基亚乙基)双- (1-hydroxyethylidene)bis-
 

文章 Articles:

已发布 PubMed:将重金属离子生物吸附到用1-羟基乙撑二膦酸官能化的农残荞麦壳上。 Biosorption of heavy metal ions onto agricultural residues buckwheat hulls functionalized with 1-hydroxylethylidenediphosphonic acid.
已发布 PubMed:静脉注射唑来膦酸 Intravenous zoledronic acid: 男性骨质疏松症的适应症有哪些? what are the indications for male osteoporosis?
已发布 PubMed:骨质疏松症治疗对死亡率的影响 Effect of osteoporosis treatment on mortality: 荟萃分析。 a meta-analysis.
已发布 PubMed:绝经后骨质疏松症每月一次与每天一次利塞膦酸盐的疗效Comparison of the effects of once-monthly versus once-daily risedronate in postmenopausal osteoporosis: 第二阶段 a phase II, 6个月 6-month, 多中心 multicenter, 随机的 randomized, 双盲 double-blind, 主动控制 active-controlled, 剂量范围研究。 dose-ranging study.
已发布 PubMed:绝经后骨质疏松症妇女早餐前服用利塞膦酸盐剂量与当天晚些时候服用剂量相比。 Risedronate dosing before breakfast compared with dosing later in the day in women with postmenopausal osteoporosis.
已发布 PubMed:利舍膦酸钠片与食品增稠剂的相容性。 Compatibility of risedronate sodium tablets with food thickeners.
已发布 PubMed:骨佩吉特病 Paget disease of bone: 治疗选择。 therapeutic options.
已发布 PubMed:含氮双膦酸盐可降低非椎骨骨折风险。 Nonvertebral fracture risk reduction with nitrogen-containing bisphosphonates.
已发布 PubMed:膦酸钠5 mg / d对绝经后期晚期骨质疏松女性骨矿物质密度和骨转换指标的影响 Effects of risedronate 5 mg/d on bone mineral density and bone turnover markers in late-postmenopausal women with osteopenia: 跨国公司 a multinational, 24个月 24-month, 随机的 randomized, 双盲 double-blind, 安慰剂对照 placebo-controlled, 平行组 parallel-group, iii期试验。 phase III trial.
已发布 PubMed:评估41钙作为评估骨代谢变化的新方法 Evaluation of 41calcium as a new approach to assess changes in bone metabolism: 膦酸盐干预对绝经后低骨量妇女的疗效。 effect of a bisphosphonate intervention in postmenopausal women with low bone mass.
已发布 PubMed:胃肠道给药部位对餐后吸收不良的药物的生物利用度的影响。 Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal.
已发布 PubMed:联合用药在双膦酸盐治疗骨质疏松症中的重要性 Importance of calcium co-medication in bisphosphonate therapy of osteoporosis: 一种改善正确摄入量和药物依从性的方法。 an approach to improving correct intake and drug adherence.
已发布 PubMed:制药业 Pharmaceutical care and 社区 community 药剂师 pharmacists' 理解 understanding of 双膦酸酯 bisphosphonate 加药 dosing information.
已发布 PubMed:利塞膦酸盐在日本志愿者中的临床试验 Clinical trial of risedronate in Japanese volunteers: 给药时间对吸收的影响的研究。 a study on the effects of timing of dosing on absorption.
已发布 PubMed:绝经后骨质疏松症的治疗方法 An approach to postmenopausal osteoporosis treatment: 案例研究评论。 a case study review.
已发布 PubMed:防治骨质疏松症。 Prevention and treatment of osteoporosis.
已发布 PubMed:绝经后妇女的骨密度随每周一次瑞斯膦酸钠而变化。 Bone density changes with once weekly risedronate in postmenopausal women.
已发布 PubMed:双膦酸盐治疗恶性高钙血症。 Treatment of hypercalcemia of malignancy with bisphosphonates.
已发布 PubMed:食物与药物的相互作用。 Food-drug interactions.
已发布 PubMed:利塞膦酸盐 Risedronate: 新的口服双膦酸盐。 a new oral bisphosphonate.
已发布 PubMed:骨质疏松症治疗中的性别差异 Gender differences in osteoporosis treatment: 临床研究综述。 a review of clinical research.
已发布 PubMed:周期性依替膦酸时机。 Timing of cyclical etidronate.
已发布 PubMed:防治骨质疏松症。 Prevention and treatment of osteoporosis.
已发布 PubMed:给药方案对利塞膦酸盐药代动力学的影响。 The effect of dosing regimen on the pharmacokinetics of risedronate.
已发布 PubMed:对大鼠给药14天后利塞膦酸盐对肝微粒体药物代谢酶活性的影响 Evaluation of the effects of risedronate on hepatic microsomal drug metabolizing enzyme activities following administration to rats for 14 days: 缺乏归纳反应。 lack of an induction response.
已发布 PubMed:利塞膦酸盐 Risedronate 已发布 released for 佩吉特 Paget's 疾病 disease.
已发布 PubMed:双膦酸盐 Bisphosphonates: 临床前方面以及在骨质疏松症中的用途。 preclinical aspects and use in osteoporosis.
已发布 PubMed:双膦酸盐的不利影响。比较评论。 Adverse effects of bisphosphonates. A comparative review.
已发布 PubMed:骨质疏松 Osteoporosis: 病理生理学 pathophysiology, 预防 prevention, 诊断 diagnosis, 和治疗。 and treatment.
已发布 PubMed:依替膦酸盐用于恶性肿瘤和骨质疏松症的高钙血症。 Etidronate for hypercalcemia of malignancy and osteoporosis.
已发布 PubMed:正常受试者口服二膦酸盐的吸收。 Absorption of oral diphosphonate in normal subjects.
 
笔记 Notes:
涂料的粘合剂和组分c部分-用作涂料组分的物质sec。 175.390锌-二氧化硅基质涂料.fda第73部分-免除认证的色料清单a--foodssec。 73.1食品用色料混合物中的稀释剂无需认证。 a diphosphonate which affects calcium metabolism. it inhibits ectopic calcification and slows down bone resorption and bone turnover. Food contaminant arising from its use as a boiler water additive for prepn. of steam used in food processing. Component of antimicrobial washes for poultry carcasses and fruit 皮肤和湿疹发痒。由于油太轻,它特别适合于滋养和保湿敏感的皮肤区域,例如眼睑和颈部。桃仁油也可用于卸妆。桃仁油的稳定性和轻盈的保湿质地使其成为制皂的重要成分。 Etidronic acid is a first generation (non-nitrogenous) bisphosphonate in the same family as clodronate and tiludronate. Etidronic acid affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the etidronic acid that is resorbed (from oral preparation) or infused (for intravenous drugs), 约有50%由肾脏排泄不变。其余的对骨组织有很高的亲和力 about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, 并迅速吸收到骨骼表面。在高钙血症的存在下,依替膦酸已显示出预防或延迟骨骼相关事件,减轻骨痛以及使钙水平正常化的作用。 and is rapidly absorbed onto the bone surface. Etidronic acid has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.
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