橙花酰胺酶抑制剂。正油酰基乙醇胺（noe或oea）是正酰基乙醇胺。 n-酰基乙醇胺（naes）构成一类天然存在于动植物膜中的脂质化合物，作为膜结合磷脂的成分 ceramidase inhibitor. N-Oleoylethanolamine (NOE or OEA) is a N-acylethanolamine. N-acylethanolamines (NAEs) constitute a class of lipid compounds naturally present in both animal and plant membranes as constituents of the membrane-bound phospholipid, 正酰基磷脂酰乙醇胺（项）。颈项由与常见的膜磷脂的氨基头部连接的第三脂肪酸部分组成 N-acylphosphatidylethanolamine (NAPE). NAPE is composed of a third fatty acid moiety linked to the amino head group of the commonly occurring membrane phospholipid, 磷脂酰乙醇胺。响应多种刺激，磷脂酶d型水解酶从nape中释放出naes。 nae的短暂释放和积累被归因于多种生物活性 phosphatidylethanolamine. NAEs are released from NAPE by phospholipase D-type hydrolases in response to a variety of stimuli. Transient NAE release and accumulation has been attributed a variety of biological activities, 包括橙花传递 including neurotransmission, 膜保护 membrane protection, 和动物的免疫调节正油酰乙醇胺是鞘脂信号通路的抑制剂 and immunomodulation in animals. N-oleoylethanolamine is an inhibitor of the sphingolipid signaling pathway, 通过 via 浸膏 specific 橙花酰胺酶 ceramidase 抑制 inhibition (橙花酰胺酶 ceramidase 转换 converts 橙花酰胺 ceramide to sphingosine). 正油酰乙醇胺 正油酰基 N-oleoylethanolamine 块 blocks the 效果 effects of tnf- TNF- and arachidonic acid on 细胞内 intra蜂窝状的 cellular Ca 浓度 concentration. (mid PMID: 12692337, 12056855, 12560208, 11997249）。正油酰基乙醇胺与内源性大麻素大麻酚有关。内源性大麻素通过大麻素受体（也被活性成分刺激）发出信号吨），但尽管在结构上相关 11997249). N-oleoyl ethanolamine is related to the endocannabinoid anandamide. Endocannabinoids signal through cannabinoid receptors (also stimulated by the active ingredient of cannabis) but although related in structure, 合成和降解为芳烷酰胺 synthesis and degradation to anandamide, p210-远离热源/火花/明火/热表面。 ＆mdash; p261-避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾.p272-不允许带污染的工作服离开工作场所。p280-戴防护手套/穿防护服/戴防护眼罩/戴面罩。p302 + p352-如果在皮肤上 NOE cannot be considered an endocannabinoid as it does not activate the cannabinoid receptors. Most of the reported responses to NOE can be attributed to activation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha). Administration of NOE inhibits body weight gain in rats. In adipocytes and hepatocytes, noe通过胰岛素受体抑制有丝分裂和代谢信号传导，并产生葡萄糖耐受不良。它也抑制胃排空 NOE inhibits mitogenic and metabolic signaling by the insulin receptor and produces glucose intolerance. It also inhibits gastric emptying, 哪一个 which 威力 might act 一起 together with the 感官 sensory 橙花元 neuronal 信号 信号 signals to 实现 achieve 饱腹感 satiety. noe NOE is 永久性 permanently 高架 elevated in 糖尿病 diabetic 肥胖的 obese 耐心 patients. noe NOE 也 also 减少 reduces 内脏 visceral and 发炎的 inflammatory 回应 响应 responses 通过 through a ppar-alpha激活 ppar-alpha PPAR-alpha-激活 activation 独立 independent 机制 mechanism (mid PMID: 17449181). noe NOE 已 has been been 显示 shown to be an 对抗者 antagonist of TRVP1 (the 短暂的 transient 受体 receptor 潜在 potential 香草 vanilloid type 1 受体 receptor). 总体 Overall, Noe通过控制食物摄入量对健康产生有益影响 NOE has beneficial effects on health by inducing food intake control, 脂质β-氧化 lipid beta-oxidation, 体重减轻和镇痛作用 body weight loss and analgesic effects (PMID: 18704536）。 [hmdb] 18704536). [HMDB]