类别 Category:surfactant, viscosity controlling agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
出现 Appearance: | 无色至浅黄澄清液体(est) colorless to pale yellow clear liquid (est) |
化验 Assay: | 95.00至100.00 95.00 to 100.00
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食品化学品法典列表 Food Chemicals Codex Listed: | No |
沸点 Boiling Point: | 470.00 to 471.00 °C. @ 760.00 mm 汞 Hg (est)
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闪点 Flash Point: | 384.00 °F. tcc TCC ( 195.50 °C. ) (est)
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logp(o / w) logP (o/w): | 7.859(est) 7.859 (est) |
溶于 Soluble in: |
| 水 water, 0.000509 mg / l @ 25°C(est) 0.000509 mg/L @ 25 °C (est) |
感官特性 Organoleptic Properties:
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
BOC Sciences |
仅供实验/研究使用。 For experimental / research use only. |
Triheptanoin
气味 Odor: characteristic 采用 Use: triheptanoin是一种甘油三酸酯,用于治疗遗传性代谢疾病 Triheptanoin is a triglyceride that is used for the treatment of inherited metabolic diseases, 癫痫 epilepsy, 心室肥大和心肌葡萄糖氧化。 ventricular hypertrophy and myocardial glucose oxidation. |
安全信息 Safety Information:
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危害识别 Hazards identification |
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物质或混合物的分类 Classification of the substance or mixture |
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
没有找到。 None found. |
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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象形图 Pictogram | |
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危险说明 Hazard statement(s) |
没有找到。 None found. |
防范说明 Precautionary statement(s) |
没有找到。 None found. |
口服/肠胃外毒性 Oral/Parenteral Toxicity: |
静脉老鼠 intravenous-老鼠 mouse LD50 320 mg/kg BEHAVIORAL: 肌肉收缩或痉挛) MUSCLE CONTRACTION OR SPASTICITY)
肾 KIDNEY, 输尿管 URETER, 和膀胱 AND BLADDER: 尿量增加 URINE VOLUME INCREASED
肺 LUNGS, 胸部 THORAX, 或呼吸 OR RESPIRATION: 其他 OTHER CHANGES Acta 生理学的 Physiologica 斯堪的纳维亚 Scandinavica. 卷 Vol. 40, pg。 338 Pg. 338, 1957.
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皮肤毒性 Dermal Toxicity: |
未定 Not determined
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吸入毒性 Inhalation Toxicity: |
未定 Not determined
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使用安全信息 Safety in Use Information:
类别 Category: | surfactant, viscosity controlling agents |
推荐使用三庚酸使用水平 Recommendation for triheptanoin usage levels up to: | | 不用于香水。 not for fragrance use.
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推荐使用三庚酸风味剂的使用水平 Recommendation for triheptanoin flavor usage levels up to: |
| 不用于调味料。 not for flavor use.
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安全参考 Safety references:
参考资料 References:
| 2,庚酸3-二(庚酰氧基)丙酯 3-di(heptanoyloxy)propyl heptanoate |
NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
pubchem(cid) Pubchem (cid): | 69286 |
pubchem(sid) Pubchem (sid): | 135026892 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core 组件 components note
潜在用途 Potential Uses:
存在(自然 Occurrence (nature, food, 其他) other): note
| 自然界中找不到 not found in nature |
同义词 Synonyms:
1,3- | di(庚酰氧基 heptanoyloxy)propan-2-yl heptanoate | 2,3- | di(庚酰氧基 heptanoyloxy)propyl heptanoate | | 甘油三庚酸酯 glycerol trienanthate | | 甘油 glycerol 三庚酸酯 triheptanoate | | heptanoic acid, 1,2,3-propanetriyl ester | | heptanoic acid, 1,2,3-丙三酸酯(9ci) 3-propanetriyl ester (9CI) | | heptanoin, 三(6ci tri- (6CI,7ci 7CI,8CI) | | propane-1,2,3-triyl 三庚酸酯 triheptanoate | | propane-1,2,3-triyl trisheptanoate | 1,2,3- | propanetriyl 三庚酸酯 triheptanoate | | 十三嘌呤 trienanthine | | trienanthoin | 1,2,3- | trienanthoyl甘油 glycerol | | 三庚二酮 triheptanion | | 三庚酸 triheptanoic 橙花酯 glyceride | | 三庚素 triheptylin | | 蛋黄素 trioenanthin | | trioenanthoin |
文章 Articles:
已发布 PubMed:三月桂酸酯安全性评估的最终报告 Final report on the safety assessment of trilaurin, 三花生素 triarachidin, 山be素 tribehenin, 三环素 tricaprin, 甘油三辛 tricaprylin, trierucin, triheptanoin, 三庚基十一烷酸 triheptylundecanoin, 三异壬酸 triisononanoin, 三异帕米汀 triisopalmitin, triisostearin, 三油精 triricinolein, 曲霉素 trimyristin, 三辛酸 trioctanoin, 三油精 triricinolein, 雷帕米汀 tripalmitin, 三棕榈油精 tripalmitolein, 三油精 triricinolein, 三硬脂精 tristearin, triundecanoin, 甘油三乙酰基羟基硬脂酸酯 glyceryl triacetyl hydroxystearate, 三乙酰蓖麻油酸橙花酯 glyceryl triacetyl ricinoleate, 和硬脂酸橙花酯二乙酸酯。 and glyceryl stearate diacetate. |
已发布 PubMed:星形胶质细胞代谢的改变作为治疗癫痫的一种方法 Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: 三庚酸和乙酰基左旋肉碱。 Triheptanoin and Acetyl-L-Carnitine. |
已发布 PubMed:I型葡萄糖转运蛋白缺乏症(g1d)在25(1990-2015) Glucose Transporter Type I Deficiency (G1D) at 25 (1990-2015): 推定 Presumptions, Facts, 以及这种罕见疾病患者的生活。 and the Lives of Persons With This Rare Disease. |
已发布 PubMed:补充奇数或偶数中链脂肪酸超长链酰基辅酶A脱氢酶缺陷小鼠中的新脂肪酸生物合成和延伸。 De novo fatty acid biosynthesis and elongation in very long-chain acyl-CoA dehydrogenase-deficient mice supplemented with odd or even medium-chain fatty acids. |
已发布 PubMed:饲喂三庚酸为基础的生酮饮食的大鼠肝脏脂肪酸谱。 HEPATIC FATTY ACID PROFILE OF RATS FED A TRIHEPTANOIN-BASED KETOGENIC DIET. |
已发布 PubMed:三庚酸橙花酯减轻压力超负荷大鼠心室肥厚并改善心肌葡萄糖氧化。 Triheptanoin Alleviates Ventricular Hypertrophy and Improves Myocardial Glucose Oxidation in Rats With Pressure Overload. |
已发布 PubMed:过渡到三庚酸治疗前后长链脂肪酸氧化紊乱患者的长期主要临床结局-回顾性图表回顾。 Long-term major clinical outcomes in patients with long chain fatty acid oxidation disorders before and after transition to triheptanoin treatment-A retrospective chart review. |
已发布 PubMed:用抗血管紧张素三庚酸橙花酯饮食治疗后,可降低缺血性中风的严重程度并改善线粒体功能 Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin. |
已发布 PubMed:三庚酸改善亨廷顿病患者的脑能量代谢。 Triheptanoin improves brain energy metabolism in patients with Huntington disease. |
已发布 PubMed:再过三庚酸饮食可增强线粒体底物的使用,以重塑代谢组并延长寿命 Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, 运动功能 motor function, 和在mecp2-null小鼠中的社交能力。 and sociability in MeCP2-null mice. |
已发布 PubMed:三庚酸橙花酯用于I型葡萄糖转运蛋白缺乏症(g1d) Triheptanoin for glucose transporter type I deficiency (G1D): 类信息生成的调节 modulation of human ictogenesis, 脑代谢率 cerebral metabolic rate, 和补充食物的认知指数。 and cognitive indices by a food supplement. |
已发布 PubMed:生酮饮食对毛果芸香碱引起的大鼠癫痫持续状态的影响。 Effects of ketogenic diets on the occurrence of pilocarpine-induced status epilepticus of rats. |
已发布 PubMed:饮食三庚酸素可挽救少突胶质细胞损失 Dietary triheptanoin rescues oligodendrocyte loss, canavan疾病的nur7小鼠模型中的脱髓鞘和运动功能 dysmyelination and motor function in the nur7 mouse model of Canavan disease. |
已发布 PubMed:glut1缺乏症 GLUT1 deficiency syndrome: 更新。 an update. |
已发布 PubMed:三庚酸在小鼠匹罗卡品癫痫模型中可部分还原三羧酸循环中间体的水平。 Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy. |
已发布 PubMed:与不均匀的中链甘油三酸酯相比,海马葡萄糖代谢的改变。 Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides. |
已发布 PubMed:三庚酸不能成功治疗严重的丙酮酸羧化酶缺乏症。 Unsuccessful treatment of severe pyruvate carboxylase deficiency with triheptanoin. |
已发布 PubMed:三庚酸降低全身性癫痫的特定于综合征的小鼠模型中的癫痫发作敏感性。 Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy. |
已发布 PubMed:Triheptanoin 补品 补充 supplementation to 生酮的 ketogenic 饮食 diet 路边 curbs 认知的 cognitive 减损 impairment in APP/PS1 老鼠 mice 用过的 used as a 模型 model of 家族的 familial Alzheimer's 疾病 disease. |
已发布 PubMed:庚酸作为橙花燃料 Heptanoate as a neural fuel: 正常和葡萄糖转运蛋白i缺乏(g1d)脑中的能量和橙花递质前体。 energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain. |
已发布 PubMed:三庚酸在急性小鼠癫痫发作模型中的作用。 Triheptanoin in acute mouse seizure models. |
已发布 PubMed:沙棘胶树脂和三庚酸制剂对ccl-110皮肤成纤维细胞系的保护和修复作用。 Protective and restorative effects of a Commiphora mukul gum resin and triheptanoin preparation on the CCL-110 skin fibroblast cell line. |
已发布 PubMed:三庚酸橙花酯-具有奇数链脂肪酸中链甘油三酸酯 Triheptanoin--a medium chain triglyceride with odd chain fatty acids: 一种新的抗癫痫药抗惊厥药? a new anaplerotic anticonvulsant treatment? |
已发布 PubMed:临床实践中出现glut1缺乏症。 GLUT1 deficiency syndrome in clinical practice. |
已发布 PubMed:[通过二庚酸和三庚酸部分取代大豆油减轻ain-93饮食诱导的脂肪变性大鼠的肝脂肪酸谱]。 [Hepatic fatty acid profile of rats with AIN-93 diet-induced steatosis attenuated by the partial substitution of soybean oil by diheptanoin and triheptanoin]. |
已发布 PubMed:关于线粒体脂肪酸氧化紊乱的治疗的当前问题。 Current issues regarding treatment of mitochondrial fatty acid oxidation disorders. |
已发布 PubMed:肌肉脂质代谢异常 Disorders of muscle lipid metabolism: 诊断和治疗挑战。 diagnostic and therapeutic challenges. |
已发布 PubMed:三庚酸饮食对两种小鼠慢性癫痫发作模型的抗惊厥作用。 Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models. |
已发布 PubMed:成 聚葡聚糖体病(apbd) Adult Polyglucosan Body Disease (APBD): 无节食饮食疗法(三庚酸)和有缺陷的甲基化途径的证明。 Anaplerotic diet therapy (Triheptanoin) and demonstration of defective methylation pathways. |
已发布 PubMed:饮食上的 Dietary 骨质疏松 anaplerotic 治疗 therapy 改善 提高 improves 外围设备 peripheral 组织 tissue 能源 energy 代谢 metabolism in 耐心 patients with 亨廷顿 Huntington's 疾病 disease. |
已发布 PubMed:乙氧基化(平均摩尔比为2 mol)己胺c-2聚乙二醇(2)可可胺聚乙二醇(2)椰子胺聚氧乙烯(2)可可胺聚氧乙烯(2)椰子胺 Effect of dietary fats with odd or even numbers of carbon atoms on metabolic response and muscle damage with exercise in Quarter Horse-type horses with type 1 polysaccharide storage myopathy. |
已发布 PubMed:测定动物副产品中甘油三庚酸橙花酯(gth)的分析方法的验证 Validation of an analytical method for the determination of glyceroltriheptanoate (GTH) in processed animal by-products: 合作研究的结果。 results of a collaborative study. |
已发布 PubMed:正常大鼠中三萜酸肠胃外和肠内代谢。 ii。对脂肪分解的影响 Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. II. Effects on lipolysis, 葡萄糖产生 glucose production, 和肝酰基-Coa谱。 and liver acyl-CoA profile. |
已发布 PubMed:醋酸镁在高密度脂蛋白胆固醇测定中的应用 Use of glyceroltriheptanoate as marker for processed animal by-products: 开发和验证一种分析方法。 development and validation of an analytical method. |
已发布 PubMed:c4生酮之间的相互关系 Interrelations between C4 ketogenesis, c5生酮 C5 ketogenesis, 和灌注大鼠肝脏中的动脉粥样硬化。 and anaplerosis in the perfused rat liver. |
已发布 PubMed:次庚酸对马匹最大程度运动时肌肉代谢的影响。 Effect of triheptanoin on muscle metabolism during submaximal exercise in horses. |
已发布 PubMed:长期服用二庚酸和三treptanoin对大鼠脂肪变性的肝保护作用 [Hepatoprotective effect of diheptanoin and tritreptanoin chronic consumption against steatosis in rats]. |
已发布 PubMed:肉碱棕榈酰转移酶II缺乏症 Carnitine palmitoyltransferase II deficiency: 成功的过补饮食疗法。 successful anaplerotic diet therapy. |
已发布 PubMed:和长链甘油三酸酯生酮饮食短期和长期治疗对年轻大鼠皮质扩散抑制的影响。 Effects of short-term and long-term treatment with medium- and long-chain triglycerides ketogenic diet on cortical spreading depression in young rats. |
已发布 PubMed:遗传性代谢病的过节食疗法 Anaplerotic diet therapy in inherited metabolic disease: 治疗潜力。 therapeutic potential. |
已发布 PubMed:正常大鼠中三萜酸肠胃外和肠内代谢。 Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. |
已发布 PubMed:丙酮酸羧化酶缺乏症 Pyruvate carboxylase deficiency: 厌食饮食疗法的临床和生化反应。 clinical and biochemical response to anaplerotic diet therapy. |
已发布 PubMed:长瓣膜脂肪氧化失调症使用一种奇异的甘油三酸酯治疗心肌病和横纹肌溶解症。 Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. |
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