Name: | (2秒)-1 (2S)-1,3,4,5,6,7-六氢-1 7-hexahydro-1,1,5,5-四甲基-2h-2 5-tetramethyl-2H-2,4a-甲基萘 4a-methanonaphthalene |
CAS号 CAS Number: | 1135-66-6 | 3D/INCHI
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ECHA EINECS - REACH 预注册 Pre-Reg: | 214-494-2 |
贝尔斯坦数 Beilstein Number: | 2207559 |
MDL : | mfcd00042616 MFCD00042616 |
XlogP3-AA: | 5.00(est) 5.00 (est) |
分子量 Molecular Weight: | 204.35628000 |
式 Formula: | c15 h24 C15 H24 |
核磁共振预测器 NMR Predictor: | 预测(适用于Chrome或Firefox) Predict (works with chrome or firefox) |
efsa / jecfa评论 EFSA/JECFA Comments: |
不再受行业支持(dg sanco No longer supported by Industry (DG SANCO, 2012). |
类别 Category:fragrance agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
出现 Appearance: | 无色至浅黄澄清液体(est) colorless to pale yellow clear liquid (est) |
化验 Assay: | 异构体总和为95.00至100.00 95.00 to 100.00 sum of isomers
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食品化学品法典列表 Food Chemicals Codex Listed: | No |
比重 Specific Gravity: | 0.92600 to 0.93200 @ 25.00 °C.
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磅每加仑-(est)。 Pounds per Gallon - (est).: | 7.705 to 7.755
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折光率 Refractive Index: | 1.49500 to 1.50100 @ 20.00 °C.
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沸点 Boiling Point: | 255.00 to 257.00 °C. @ 760.00 mm 汞 Hg
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蒸汽压力 Vapor Pressure: | 0.014000 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
闪点 Flash Point: | 216.00 °F. tcc TCC ( 102.22 °C. )
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logp(o / w) logP (o/w): | 6.150(est) 6.150 (est) |
溶于 Soluble in: |
| alcohol | | 水 water, 0.1401 mg / l @ 25°c(est) 0.1401 mg/L @ 25 °C (est) |
不溶于 Insoluble in: |
| 水 water |
感官特性 Organoleptic Properties:
气味类型 Odor Type: woody |
气味强度 Odor Strength:介质 medium |
woody dusty amber incense |
气味描述 Odor Description:at 100.00 %. 木本尘土飞扬的琥珀香 woody dusty amber incense |
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安徽海北 Anhui Haibei |
异长叶烯 isoLongifolene
气味 For Odor: 松木 Pine woody |
外合成 ExtraSynthese |
仅供实验/研究使用。 For experimental / research use only. |
异longifolene(gc)≥98%(对映异构体总和) isoLongifolene (GC) ≥98% (sum of enantiomers)
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Foreverest Resources |
异长叶烯85% Isolongifolene 85%
气味 For Odor: characteristic 采用 Use: 异长叶烯具有木质和琥珀的香气 Isolongifolene has woody and amber incense odors, 已被广泛用作化妆品中的香料 has been widely used as fragrances in cosmetics, 调香师 perfumers, 太空喷雾 space sprays, 清洁剂 detergents, 除臭剂 deodorants, 面料 fabrics, 纤维 fibers, 和肥皂 and soap, 烟草 tobacco, 面霜 creams, 纸制品。此外 paper products. In addition, 异longifolene抑制酪氨酸酶,后者是植物和动物中黑素生物合成的多功能含铜酶 Isolongifolene inhibits tyrosinase that is multifunctional copper-containing enzyme for melanin biosynthesis in plants and animals, 也 also, 氢化异longifolene已被用作桥接核心,以制备雌激素受体的手性配体,可用于调节生育力 hydrogenated Isolongifolene has been used as a bridged core to prepare a chiral ligand for the estrogen receptor that could be useful in regulating fertility, 预防 preventing, 和治疗乳腺癌 and treating breast cancer, 并用于更年期激素替代。异长叶烯也用作天然杀虫剂和农药。 and for menopausal hormone replacement. Isolongifolene also used as a natural insecticide and pesticide. |
福州远华 Fuzhou Farwell |
异长叶烯75%/ 80% Iso Longifolene 75%/80%
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Moellhausen |
异长叶烯 isoLongifolene
气味 For Odor: 软木香 soft woody, 有点尘土飞扬 slightly dusty |
Penta International |
异长叶烯 isoLongifolene
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轮回菲希特纳 Reincke & Fichtner |
异长叶烯 isoLongifolene
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圣克鲁斯生物技术 Santa Cruz Biotechnology |
仅供实验/研究使用。 For experimental / research use only. |
(-)-异长叶烯≥91% (-)-isoLongifolene ≥91%
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西格玛·奥尔德里奇 Sigma-Aldrich: 奥尔德里奇 Aldrich |
仅供实验/研究使用。 For experimental / research use only. |
(-)-异长叶烯≥98.0%(对映异构体总和 (-)-Isolongifolene ≥98.0% (sum of enantiomers, gc GC)
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安全信息 Safety Information:
首选SDS Preferred SDS: 视图 View |
欧洲信息 European information : |
最重要的危害 Most important hazard(s): | xi-刺激性 Xi - Irritant |
R 36/38 - 烦 的 Irritating to skin 皮 and 眼睛 eyes. S 02 - 保持 Keep out of the 达到 reach of 孩子们 children. S 24/25 - 避免 Avoid contact with skin 皮 and 眼睛 eyes. S 26 - In 案件 case of contact with 眼睛 eyes, 冲洗 rinse 立即 immediately with 充裕 plenty of 水 water and 寻求 seek 医疗 medical 忠告 advice. S 36 - 穿 我们 Wear 适当 suitable 保护性 protective 服装 clothing.
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危害识别 Hazards identification |
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物质或混合物的分类 Classification of the substance or mixture |
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
没有找到。 None found. |
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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象形图 Pictogram | |
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危险说明 Hazard statement(s) |
没有找到。 None found. |
防范说明 Precautionary statement(s) |
没有找到。 None found. |
口服/肠胃外毒性 Oral/Parenteral Toxicity: |
未定 Not determined
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皮肤毒性 Dermal Toxicity: |
未定 Not determined
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吸入毒性 Inhalation Toxicity: |
未定 Not determined
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使用安全信息 Safety in Use Information:
类别 Category: | fragrance agents |
IFRA IFRA 码 Code of 实践 Practice 通知 not Notification of the 49th 修正案 Amendment to the IFRA IFRA 码 Code of 实践 Practice |
推荐使用(-)-异长叶烯的使用水平 Recommendation for (-)-isolongifolene usage levels up to: | | 香料浓缩物中的4.000%。 4.0000 % in the fragrance concentrate.
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最大化源自调查的每日摄入量(msdi-eu) Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012(微克/ 均/天) 0.012 (μg/capita/day) |
修改后的理论增加的最大每日摄入量(mtamdi) Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 3500(微克/ /天) 3500 (μg/person/day) |
关注点 Threshold of Concern: | 1800(微克/ /天) 1800 (μg/person/day) |
结构类 Structure Class: | I |
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根据委员会法规ec EC号的食品类别。 1565/2000(ec , 2000)在fge.06(efsa 2000) in FGE.06 (EFSA, 2002a). 根据 According to the 行业 Industry the "正常 normal" use is 定义的 de精细 fined as the 平均 average of 已报告 reported 用法 用法 usages and "最大 maximum use" is 定义的 de精细 fined as the 95th 百分位 percentile of 已报告 reported 用法 用法 usages (efsa EFSA, 2002i)。 2002i). |
注意 Note: 毫克/千克= 0.001 / 1000 = 0.000001 = 1/1000000 = 百万分之几 ppm |
| 平均 average 用法 usage mg/kg kg | 最大 maximum 用法 usage mg/kg kg |
乳制品 Dairy products, 不包括02.0(01.0)类产品 excluding products of category 02.0 (01.0): | 7.00000 | 35.00000 |
脂肪和油脂 Fats and oils, 和脂肪乳液(油包水型)(02.0) and fat emulsions (type water-in-oil) (02.0): | 5.00000 | 25.00000 |
食用冰 Edible ices, 包括果子露和果汁冰糕(03.0) including sherbet and sorbet (03.0): | 10.00000 | 50.00000 |
加工水果(04.1) Processed fruit (04.1): | 7.00000 | 35.00000 |
加工蔬菜(包括蘑菇和真菌) Processed vegetables (incl. mushrooms & fungi, 根与根块茎 roots & tubers, 豆类和豆类) pulses and legumes), 和坚果种子(04.2) and nuts & seeds (04.2): | - | - |
糖果(05.0) Confectionery (05.0): | 10.00000 | 50.00000 |
谷物和谷物产品 Cereals and cereal products, 含税面粉根和淀粉块茎 incl. flours & starches from roots & tubers, 脉冲和豆类 pulses & legumes, 不包括面包店(06.0) excluding bakery (06.0): | 5.00000 | 25.00000 |
烘焙用具(07.0) Bakery wares (07.0): | 10.00000 | 50.00000 |
肉和肉制品 Meat and meat products, 包括家禽和野味(08.0) including poultry and game (08.0): | 2.00000 | 10.00000 |
鱼和鱼制品 Fish and fish products, 包括软体动物 including molluscs, 甲壳类和棘皮类动物(麦克 MCE)(09.0) : | 2.00000 | 10.00000 |
鸡蛋和蛋制品(10.0) Eggs and egg products (10.0): | - | - |
甜味剂 Sweeteners, 包括蜂蜜(11.0) including honey (11.0): | - | - |
盐 Salts, 香料 spices, 汤类 soups, 酱料 sauces, 色拉 salads, 蛋白产品 protein products, 等(12.0) etc. (12.0): | 5.00000 | 25.00000 |
用于特定营养用途的食品(13.0) Foodstuffs intended for particular nutritional uses (13.0): | 10.00000 | 50.00000 |
不含醇 Non-alcoholic ("柔软的 soft") 饮料 beverages, 不包括乳制品(14.1) excl. dairy products (14.1): | 5.00000 | 25.00000 |
含醇的饮料 Alcoholic beverages, 含税无醇和低醇的对口(14.2) incl. alcohol-free and low-alcoholic counterparts (14.2): | 10.00000 | 50.00000 |
即食美味(15.0) Ready-to-eat savouries (15.0): | - | - |
复合食品(例如砂锅菜) Composite foods (e.g. casseroles, 肉馅饼 meat pies, 百果馅)-无法放在01.0-15.0(16.0)类别中的食物 mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 5.00000 | 25.00000 |
安全参考 Safety references:
欧洲食品安全法规(efsa) European Food Safety Athority(efsa):风味使用水平;亚急性 Flavor usage levels; Subacute, 亚慢性 Subchronic, 慢性和致癌性研究;发育/ 毒性研究;遗传毒性研究... Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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欧洲食品安全局(efsa EFSA)参考 :
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调味组评估25 Flavouring Group Evaluation 25, (fge.25)[1]-化学组31的脂族和芳族烃-食品添加剂专家组的科学意见 (FGE.25)[1] - Aliphatic and aromatic hydrocarbons from chemical group 31 - Scientific Opinion of the Panel on Food Additives, 调味料 Flavourings, 处理中 Processing 艾滋病 Aids and 材料 Materials in 联系 Contact with Food 视图 View page or 视图 View pdf
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糖蜜3-(5-双环[2.2.1]庚-2-烯基)-3-甲基环氧乙烷-2-羧酸甲酯3-双环(2.2.1)庚-5-烯-2-基-3-甲基环氧乙烷-2-羧甲基3-双环[2.2.1]庚-5-烯-2-基-3-甲基环氧乙烷-2-羧甲基3-甲基-3-(双环(2.2.1)庚-5-烯- 2-基)-2-环氧乙烷羧酸酯 Flavouring Group Evaluation 78 (FGE.78)[1] - Consideration of Aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25 - Scientific Opinion of the Panel on Food Additives,调味料 Flavourings, 处理中 Processing 艾滋病 Aids and 材料 Materials in 联系 Contact with Food (afc AFC) 视图 View page or 视图 View pdf
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调味组评估的科学见解25rev1 Scientific Opinion on Flavouring Group Evaluation 25Rev1: 脂族的 Aliphatic and aromatic hydrocarbons from chemical group 31 视图 View page or 视图 View pdf
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调味品组评价的科学见解78 Scientific Opinion on Flavouring Group Evaluation 78, 版本1(fge.78rev1) Revision 1 (FGE.78Rev1): 考虑 Consideration of 脂族的 aliphatic and 脂环族 alicyclic and aromatic hydrocarbons 已评估 evaluated by by Jec ECFA (63rd 会议 meeting) 结构上 structurally 有关 related to 脂族的 aliphatic and aromatic hydrocarbons 已评估 evaluated by by efsa EFSA in ge FGE.25Rev2 视图 View page or 视图 View pdf
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调味品组评价的科学见解25 Scientific Opinion on Flavouring Group Evaluation 25, 版本2(fge.25rev2) Revision 2 (FGE.25Rev2): 脂族的 Aliphatic and aromatic hydrocarbons from chemical group 31 视图 View page or 视图 View pdf
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调味品组评价的科学见解25 Scientific Opinion on Flavouring Group Evaluation 25, 版本3(fge.25rev3) Revision 3 (FGE.25Rev3): 脂族的 Aliphatic hydrocarbons from chemical group 31 视图 View page or 视图 View pdf
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Epi系统 EPI System: 视图 View |
EPA物质注册服务(tsca TSCA) :1135-66-6 |
EPA ACToR:毒理学资料 Toxicology Data |
EPA物质注册服务(SRS) :注册表 Registry |
实验室化学安全摘要 Laboratory Chemical Safety Summary :102562 |
国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:数据 Data |
明智的 WISER:联合国2319 UN 2319 |
德国wgk WGK Germany:3 |
(2秒)-1 (2S)-1,3,4,5,6,7-六氢-1 7-hexahydro-1,1,5,5-四甲基-2h-2 5-tetramethyl-2H-2,4a-甲基萘 4a-methanonaphthalene |
chemidplus Chemidplus:0001135666 |
参考资料 References:
| (2秒)-1 (2S)-1,3,4,5,6,7-六氢-1 7-hexahydro-1,1,5,5-四甲基-2h-2 5-tetramethyl-2H-2,4a-甲基萘 4a-methanonaphthalene |
NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
加拿大国内分公司。清单 Canada Domestic Sub. List: | 1135-66-6 |
pubchem(cid) Pubchem (cid): | 102562 |
pubchem(sid) Pubchem (sid): | 135058579 |
信息基 Pherobase: | 视图 View |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and 核心组件 core components note
潜在用途 Potential Uses:
存在(自然 Occurrence (nature, food, 其他) other): note
同义词 Synonyms:
1,3,4,5,6,7- | hexahydro-1,1,5,5-四甲基-2h-2 5-tetramethyl-2H-2,4-methanophthalene | (2s (2S,4ar)-1 4aR)-1,3,4,5,6,7- | hexahydro-1,1,5,5-四甲基-2h-2 5-tetramethyl-2H-2,4a-甲基萘 4a-methanonaphthalene | (2秒)-1 (2S)-1,3,4,5,6,7- | hexahydro-1,1,5,5-四甲基-2h-2 5-tetramethyl-2H-2,4a-甲基萘 4a-methanonaphthalene | | 六氢四甲基 hexahydrotetramethyl 甲烷萘 methanonaphthalene | (-)-iso | longifolene | 异 iso | longifolene | 2h-2 2H-2,4a- | 甲烷萘 methanonaphthalene, 1,3,4,5,6,7-六氢-1 7-hexahydro-1,1,5,5-四甲基- 5-tetramethyl- | 2h-2 2H-2,4a- | 甲烷萘 methanonaphthalene, 1,3,4,5,6,7-六氢-1 7-hexahydro-1,1,5,5-四甲基- 5-tetramethyl-, (2s (2S,4ar)- 4aR)- | 2,2,7,7- | tetramethyl tricyclo(6.2.1(1,8).0(1,6))十一碳烯 6))undec-5-ene |
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