| Name: | (3e (3E,7e）-3 7E)-3,7-二甲基-10-丙烷-2-亚烷基环癸3 7-dimethyl-10-propan-2-ylidenecyclodeca-3,7点1个 7-dien-1-one |
| CAS号 CAS Number: | 6902-91-6 |  3D/INCHI
|
| 贝尔斯坦数 Beilstein Number: | 2047453 |
| MDL : | mfcd00210050 MFCD00210050 |
| XlogP3-AA: | 3.50（est） 3.50 (est) |
| 分子量 Molecular Weight: | 218.33954000 |
| 式 Formula: | c15 h22 o C15 H22 O |
| 核磁共振预测器 NMR Predictor: | 预测（适用于Chrome或Firefox） Predict (works with chrome or firefox) |
类别 Category:natural substances and extractives
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
|
| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 沸点 Boiling Point: | 330.30 °C. @ 760.00 mm 汞 Hg (est)
|
| 闪点 Flash Point: | 299.00 °F. tcc TCC ( 148.40 °C. ) (est)
|
| logp（o / w） logP (o/w): | 4.760（est） 4.760 (est) |
| 溶于 Soluble in: |
| | 水 water, 0.8354 mg / l @ 25°C（est） 0.8354 mg/L @ 25 °C (est) |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
| BOC Sciences |
| 仅供实验/研究使用。 For experimental / research use only. |
| 杀菌素0.95 Germacrone 0.95
气味 Odor: 特性 characteristic 采用 Use: 从姜黄郁金根茎中分离出的菌丝酮。它具有抗肿瘤活性。 Germacrone isolated from the rhizoma of Curcuma wenyujin. It has anti-tumor activity.
抗菌;抗真菌药 antibacterial; antifungal; |
| 库姆波 Coompo |
| 仅供实验/研究使用。 For experimental / research use only. |
| Germacrone from 植物 Plants ≥98%
气味 Odor: 特性 characteristic 采用 Use: 杀菌剂治疗可显着抑制细胞增殖 Germacrone treatment significantly inhibited cell proliferation, 乳酸脱氢酶（ldh）释放增加 increased lactate dehydrogenase (LDH) release, 消毒剂b部分-用于控制微生物生长的物质。 178.1010消毒溶液.fda 182部分-一般公认安全的物质a-一般规定sec。 182.90种物质从纸和纸板产品迁移到食品中。 and induced mitochondrial membrane potential (??m) depolarization in both MCF-7 and MDA-MB-231 cells in a dose-dependent manner. Germacrone induced MDA-MB-231 and MCF-7 cell cycle arrest at the G0/G1 and G2/M phases respectively and induced MDA-MB-231 cell apoptosis. Furthermore, 杀菌剂治疗可显着增加线粒体的bok表达和细胞色素c释放，且不影响bcl-2 germacrone treatment significantly increased Bok expression and cytochrome c release from mitochondria without affecting Bcl-2, bcl-xl Bcl-xL, bax Bax, 和bim蛋白表达。此外 and Bim protein expressions. In addition, 杀菌剂诱导的半胱天冬酶 caspase-3 , 7, 9, 立即用大量水冲洗并寻求医疗建议。s 36/39-穿着合适的衣服并保护眼睛/面部。s 60-该材料及其容器必须作为危险废物处置。s 61-避免释放到环境中。请参阅特殊说明/安全数据表。 PARP cleavage. We concluded that germacrone inhibited the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. These results might provide some molecular basis for the anti-tumor activity of Rhizoma curcuma.
可以通过调节与g2 / m细胞周期和细胞凋亡相关的蛋白的表达来控制 器 器可能是一种新的有效的肝癌化学预防药物 Germacrone might be a new potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, p53和氧化损伤可能在胚芽酮抑制 肝癌细胞生长中起重要作用。 and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone. |
| 西格玛·奥尔德里奇 Sigma-Aldrich |
| 仅供实验/研究使用。 For experimental / research use only. |
| 杀菌素分析标准 Germacrone analytical standard
|
安全信息 Safety Information:
| |
| 危害识别 Hazards identification |
| |
| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
|
未定 Not determined
|
| 皮肤毒性 Dermal Toxicity: |
|
未定 Not determined
|
| 吸入毒性 Inhalation Toxicity: |
|
未定 Not determined
|
使用安全信息 Safety in Use Information:
| 类别 Category: | natural substances and extractives |
| 推荐使用杀菌菌素水平最高为 Recommendation for germacrone usage levels up to: | | | 不用于香水。 not for fragrance use.
|
| |
| 器酮风味使用水平的推荐值 Recommendation for germacrone flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
|
安全参考 Safety references:
参考资料 References:
| | (3e (3E,7e）-3 7E)-3,7-二甲基-10-丙烷-2-亚烷基环癸3 7-dimethyl-10-propan-2-ylidenecyclodeca-3,7点1个 7-dien-1-one |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| pubchem（cid） Pubchem (cid): | 6436348 |
| pubchem（sid） Pubchem (sid): | 135036792 |
| 信息基 Pherobase: | 视图 View |
其他资料 Other Information:
潜在 有力的 Potential 搅拌机 Blenders and 核心组件 core components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, food, 其他） other): note
同义词 Synonyms:
| 3,7- | cyclodecadien-1-one, 3,7-二甲基-10-（1-甲基亚乙基）- 7-dimethyl-10-(1-methylethylidene)-, (3e (3E,7E)- | | 3,7- | cyclodecadien-1-one, 3,7-二甲基-10-（1-甲基亚乙基）- 7-dimethyl-10-(1-methylethylidene)-, (7E)- | | 3,7- | cyclodecadien-1-one, 3,7-二甲基-10-（1-甲基亚乙基）- 7-dimethyl-10-(1-methylethylidene)-, (e (E,E)- | | (e (E,e）-3 E)-3,7- | dimethyl-10-(1-methyl 亚ethylidene)-3,7-环癸二烯-1-一 7-cyclodecadien-1-one | | (3e (3E,7e）-3 7E)-3,7- | dimethyl-10-(propan-2-ylidene)cyclodeca-3,7点1个 7-dien-1-one | | （7e）-3 (7E)-3,7- | dimethyl-10-(propan-2-ylidene)cyclodeca-3,7点1个 7-dien-1-one | | (3e (3E,7e）-3 7E)-3,7- | dimethyl-10-(propan-2-ylidene)cyclodeca-3,7-dienone | | (3e (3E,7e）-3 7E)-3,7- | dimethyl-10-propan-2-ylidenecyclodeca-3,7点1个 7-dien-1-one | | (e (E,E)- | germacra-3,7(11),9-trien-6-one | | (3e (3E,7E)-10-iso | propylidene-3,7-二甲基-3 7-dimethyl-3,7-环癸二烯-1-一 7-cyclodecadien-1-one | | (7E)-10-iso | propylidene-3,7-二甲基-3 7-dimethyl-3,7-环癸二烯-1-一 7-cyclodecadien-1-one | | (3e (3E,7E)-10-iso | propylidene-3,7-二甲基环癸3 7-dimethylcyclodeca-3,7点1个 7-dien-1-one |
文章 Articles:
| 已发布 PubMed:胚芽酮抑制流感 感染的早期阶段。 Germacrone inhibits early stages of influenza virus infection. |
| 已发布 PubMed: 器酮通过诱导g2 / m细胞周期停滞和促进细胞凋亡对 肝癌细胞系的抗肿瘤作用。 Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. |
| 已发布 PubMed:胚芽酮通过抑制jak2 / stat3信号通路诱导 肝癌hepg2细胞凋亡。 Germacrone induces apoptosis in human hepatoma HepG2 cells through inhibition of the JAK2/STAT3 signalling pathway. |
| 已发布 PubMed:倍半萜烯酮和胚芽酮与 细胞色素p450系统的相互作用。 Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. |
| 已发布 PubMed:天然胚芽酮和环氧衍生物跨环环化的结构多样性 Structural diversity from the transannular cyclizations of natural germacrone and epoxy derivatives: 理论实验研究。 a theoretical-experimental study. |
| 已发布 PubMed:固定剂量的混合杀菌素的影响 Impact of fixed-dose combination of germacrone, 姜黄酮 curdione, 和呋喃二烯对乳腺癌细胞的增殖作用。 and furanodiene on breast cancer cell proliferation. |
| 已发布 PubMed:胚芽酮可通过诱导细胞周期停滞并促进细胞凋亡来抑制乳腺癌细胞系的增殖。 Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis. |
| 已发布 PubMed:跨环环化（4s Transannular cyclization of (4S,5s）-germacrone-4 5S)-germacrone-4,5-环氧化物分为愈创木酚型和癸二愈创木酚型倍半萜烯。 5-epoxide into guaiane and secoguaiane-type sesquiterpenes. |
| 已发布 PubMed:从可持续的 器有效合成抗癌β-榄香烯和其他生物活性榄香素。 Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone. |
| 已发布 PubMed:[对苯二酚含量的比较 [Comparison of content of curdione, 姜黄醇 curcumol, 醋支持的姜黄不同品种中的杀菌素和β-榄香烯] germacrone and beta-elemene in different varieties of vinegar backed Rhizoma Curcuma]. |
| 已发布 PubMed: 环的环过环化的新途径[germacra-1（10） New pathways in transannular cyclization of germacrone [germacra-1(10),4,7（11）-trien-8-one] 7(11)-trien-8-one]: 有关协调机制的证据。 evidence regarding a concerted mechanism. |
| 已发布 PubMed:高效液相色谱法分析家兔血浆中的马鞭草酮及其在应用姜黄酮姜黄油后对马鞭草酮的药代动力学研究中。 A HPLC method for the analysis of germacrone in rabbit plasma and its application to a pharmacokinetic study of germacrone after administration of zedoary turmeric oil. |
| 已发布 PubMed:交替变种从 器隆生物转化的两种新倍半萜的结构测定。 Structural determination of two new sesquiterpenes biotransformed from germacrone by Mucor alternata. |
| 已发布 PubMed:用一个参考标准同时测定姜黄温郁金中草药和相关产品中的多种倍半萜。 Simultaneous determination of multiple sesquiterpenes in Curcuma wenyujin herbal medicines and related products with one single reference standard. |
| 已发布 PubMed:贯叶连翘对复方姜黄油复方抗 制剂药代动力学的影响研究 [Study on effect of Hypericum perforatum on pharmacokinetics of zedoary turmeric oil in compound antiviral preparation]. |
| 已发布 PubMed:快速测定姜黄素 Fast determination of curcumol, 气相色谱质谱法中使用离子液体固定相测定苯并噻唑和苯并三唑应用于废水的表征。 curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry. |
| 已发布 PubMed:高速逆流色谱法从姜黄郁郁素根茎精油中分离纯化提克酮和姜黄酮 Preparative isolation and purification of germacrone and curdione from the essential oil of the rhizomes of Curcuma wenyujin by high-speed counter-current chromatography. |
| 已发布 PubMed:进一步抗菌天竺葵大出血l。代谢物和环氧ger草酮的合成。 Further antibacterial Geranium macrorrhizum L. metabolites and synthesis of epoxygermacrones. |
| 已发布 PubMed:姜黄素姜黄根茎提取倍半萜的抗雄激素作用 Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb. |
| 已发布 PubMed:姜黄根茎的抑菌活性及活性化合物的部分纯化。 Antibacterial Activity of Rhizome of Curcuma aromatica and Partial Purification of Active Compounds. |
| 已发布 PubMed:不含姜黄素的姜黄具有抗炎和抗癌活性 Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: 鉴定姜黄的新成分。 Identification of novel components of turmeric. |
| 已发布 PubMed:[莪术四叶挥发油 [The volatile oil of zedoaria IV: 薄层色谱光度法测定温郁金和姜黄中香精油中的杀菌力。广新]。 TLC densitometric determination of germacrone in the essential oils from Curcuma wenyujin and C. kwangsinensis]. |
| 已发布 PubMed:气相色谱-质谱联用法和高效液相色谱法定量分析姜黄素蒸熟和未蒸熟根茎的含量 Quantitative Analysis and Discrimination of Steamed and Non-Steamed Rhizomes of Curcuma wenyujin by GC-MS and HPLC. |
| 已发布 PubMed:胚芽酮可保护雪地兔免于浏览拉布拉多茶。 Germacrone defends labrador tea from browsing by snowshoe hares. |
| 已发布 PubMed:天竺葵大出血（香菊科）精油 Geranium macrorrhizum L. (Geraniaceae) essential oil: 抗枯草芽孢杆菌的有效药物。 a potent agent against Bacillus subtilis. |
| 已发布 PubMed:姜黄中萜类化合物的抗癌特性-综述 Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae--a review. |
| 已发布 PubMed:uplc / qtof / ms对姜黄中姜黄酮的成分分析和药代动力学研究 Analysis and pharmacokinetic study of curdione in Rhizoma Curcumae by UPLC/QTOF/MS. |
| 已发布 PubMed:口服姜黄素油和姜黄素-β-环糊精包合物的药代动力学研究。 Pharmacokinetic study of rhizoma Curcumae oil and rhizoma Curcumae oil-β-cyclodextrin inclusion complex in pigs after oral administration. |
| 已发布 PubMed:姜黄温郁金中三种香精油的化学成分和抑菌活性 Chemical composition and antimicrobial activity of three essential oils from Curcuma wenyujin. |
| 已发布 PubMed:乳化电动色谱法分析姜黄根茎中的挥发性成分 Analysis of volatile components in Curcuma rhizome by microemulsion electrokinetic chromatography. |
| 已发布 PubMed: Zedoary Zedoary zedoary油（ezhu you）抑制ags细胞的增殖。 |
| 已发布 PubMed:使用1h nmr光谱和多变量分析在不同地区生长的姜黄种类的代谢产物图谱。 Metabolite profiling of Curcuma species grown in different regions using 1H NMR spectroscopy and multivariate analysis. |
| 已发布 PubMed:温郁金姜黄根茎精油的杀虫成分的研究 Identification of insecticidal constituents of the essential oil of Curcuma wenyujin rhizomes active against Liposcelis bostrychophila Badonnel. |
| 已发布 PubMed:气相色谱-质谱法分析芳香姜黄精油成分 [Analysis of compositions of the essential oil from Curcuma aromatica by gas chromatography-mass spectrometry]. |
| 已发布 PubMed:姜黄的倍半萜。 Sesquiterpenes from Curcuma comosa. |
| 已发布 PubMed:sm草精油的抗真菌活性和化学成分（apiaceae）来自意大利和葡萄牙。 Antifungal activity and chemical composition of essential oils from Smyrnium olusatrum L. (Apiaceae) from Italy and Portugal. |
| 已发布 PubMed:三种姜黄不同部位挥发性成分的比较 [Comparisons of volatile components in different parts of three species of Rhizoma Curcumae]. |
| 已发布 PubMed:姜黄素精油抑制变形链球菌生物膜的形成。 Essential oil of Curcuma longa inhibits Streptococcus mutans biofilm formation. |
| 已发布 PubMed:用高效离心分配色谱法从姜黄郁金精油中分离纯化六种挥发性化合物。 Preparative isolation and purification of six volatile compounds from essential oil of Curcuma wenyujin using high-performance centrifugal partition chromatography. |
| 已发布 PubMed:姜黄提取物对乳腺癌细胞的抗肿瘤潜力。 Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. |
| 已发布 PubMed:气相色谱-质谱联用对三种姜黄种类进行质量控制和鉴别的代谢组学研究。 Metabolomics study on quality control and discrimination of three curcuma species based on gas chromatograph-mass spectrometry. |
| 已发布 PubMed:从姜黄中提取的化合物。抑制 类p450酶。 Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes. |
| 已发布 PubMed:[rp-hplc的姜黄温榆金指纹图谱]。 [Fingerprints of Curcuma wenyujin by RP-HPLC]. |
| 已发布 PubMed:希腊sm的不同部分的挥发性成分。 Volatile constituents of different parts of Smyrnium olusatrum from Greece. |
| 已发布 PubMed:载纳米结构脂质载体的制备与表征 Preparation and characterization of nanostructured lipid carriers loaded traditional Chinese medicine, Zedoary Zedoary zedoary姜黄油。 |
| 已发布 PubMed: 用原位单次灌流模型在大鼠肠道中吸收Zedoary Zedoary zedoary油。 |
| 已发布 PubMed:高效液相色谱法测定姜黄油及其相关注射剂中的六种成分 [HPLC determination of six components in zedoary turmeric oil and its related injections]. |
| 已发布 PubMed: 口服Zedoary Zedoary精油的自纳米乳化药物递送系统（snedds） : 配方和生物利用度研究。 formulation and bioavailability studies. |
| 已发布 PubMed:中国姜黄的分子遗传和化学评估。 Molecular genetic and chemical assessment of Rhizoma Curcumae in China. |
| 已发布 PubMed:加压液相萃取和气相色谱-质谱联用技术鉴定和定量分析三种姜黄根茎中的11种倍半萜。 Identification and quantitation of eleven sesquiterpenes in three species of Curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry. |
| 已发布 PubMed:[姜黄温榆金茎叶中的倍半萜]。 [Sesquiterpenes from stems and leaves of Curcuma wenyujin]. |
| 已发布 PubMed:杨梅果实精油和顶空固体微提取物的化学成分。和抗真菌活性。 Chemical composition of essential oil and headspace-solid microextracts from fruits of Myrica gale L. and antifungal activity. |
| 已发布 PubMed:来自日本和印度姜黄香根茎的精油成分。 Essential oil constituents from Japanese and Indian Curcuma aromatica rhizomes. |
| 已发布 PubMed:姜黄的挥发性成分分析x。 X。气相色谱-质谱法测定陈。 Analysis of volatile components of Curcuma sichuanensis X. X. Chen by gas chromatography-mass spectrometry. |
| 已发布 PubMed:紫菀的空中部分具有细胞毒性的萜烯氢过氧化物。 Cytotoxic terpene hydroperoxides from the aerial parts of Aster spathulifolius. |
| 已发布 PubMed:[ezhu的gc-ms指纹]。 [The fingerprint of Ezhu by GC-MS]. |
| 已发布 PubMed:姜黄的抗炎作用 Antiinflammatory effect of Curcuma xanthorrhiza Roxb, 及其积极原则。 and its active principles. |
| 已发布 PubMed:水不溶性油性药物的新配方设计 A novel formulation design about water-insoluble oily drug: 自乳化能力的Zedoary Zedoary zedoary姜黄油微球的制备及评价 |
| 已发布 PubMed:药用食品。 xxix。莪术中倍半萜和姜黄素对d-半乳糖胺/脂多糖或肿瘤坏死因子-α诱导的肝损伤的有效保护作用。 Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha. |
| 已发布 PubMed: 斯德氏菌石蕊香精油的化学成分。以及铁锈菌Raeseri boiss Boiss和Holdr。来自保加利亚和马其顿。 |
| 已发布 PubMed:哺乳动物对萜类化合物的生物转化 Biotransformation of terpenoids by mammals, 微生物 microorganisms, 和植物培养的细胞 and plant-cultured cells. |
| 已发布 PubMed:姜黄的抗炎倍半萜。 Anti-inflammatory sesquiterpenes from Curcuma zedoaria. |
| 已发布 PubMed:基于分析物的分辨率和稳定性优化gc-ms条件，以便同时测定三种姜黄根茎中的九种倍半萜。 Optimization of GC-MS conditions based on resolution and stability of analytes for simultaneous determination of nine sesquiterpenoids in three species of Curcuma rhizomes. |
| 已发布 PubMed: Zedoaria zedoariae根瘤和姜黄素抑制血小板衍生的生长因子诱导的 肝成纤维细胞增殖。 |
| 已发布 PubMed:莪术中倍半萜对d-半乳糖胺/脂多糖诱导的肝损伤的抑制作用及作用机理 Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae Rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury. |
| 已发布 PubMed:姜黄中具有抗炎活性的三种非酚类二芳基庚烷类化合物。 Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza. |
| 已发布 PubMed:姜黄根茎的类萜和姜黄素 [Terpenoids and curcuminoids of the rhizoma of Curcuma xanthorrhiza Roxb]. |
| 已发布 PubMed:led草精油的成分。 Composition of essential oil of Ledum palustre. |
| 已发布 PubMed:加压液相萃取和高效液相色谱法同时测定三种姜黄根茎中的11种特征成分。 Simultaneous determination of 11 characteristic components in three species of Curcuma rhizomes using pressurized liquid extraction and high-performance liquid chromatography. |
| 已发布 PubMed: 乳液-溶剂-扩散法制备含Zedoary Zedoary zedoary姜黄油的缓释微球的研究，并评价该油的自乳化和生物利用度。 |
| 已发布 PubMed:没药油（膝盖）的精油和超临界二氧化碳萃取物的化学成分。和a蒲l蒲属。 Chemical composition of the essential oil and supercritical CO2 extract of Commiphora myrrha (Nees) Engl. and of Acorus calamus L. |
| 已发布 PubMed:巴豆黄酮叶精油的精油分析和抗癌活性。来自瓜德罗普岛。 Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. |
| 已发布 PubMed: ［山竹 Kaempferia 边缘 marginata的化学成分研究］。 |
| 已发布 PubMed:g草属加勒比珊瑚中挥发性代谢物的化学变异性。 Chemical variability of the volatile metabolites from the Caribbean corals of the genus Gorgonia. |
| 已发布 PubMed:姜黄的化学成分研究 [Studies on the chemical constituents of Curcuma kwangsiensis]. |
| 已发布 PubMed:两种栽培百里香精油的实验研究 Experimental study of essential oils from two varieties of cultivated thyme, 倍半萜杀菌剂和双萜香紫苏醇具有胆碱和 的作用。 sesquiterpene Germacron and diterpene Sclareol for cholagogic and choleretic activity. |
|
