已发布 PubMed:geranylgeranylacetone选择性结合幽门螺杆菌的hsp70,并改变其球状形态。 Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter pylori and alters its coccoid morphology. |
已发布 PubMed:阻塞性肾病中基于热休克蛋白70的细胞保护作用的介体和机制。 Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy. |
已发布 PubMed:geranylgeranylacetone通过增加热休克蛋白70的表达来减轻肝纤维化。 Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70. |
已发布 PubMed:雷贝拉唑对服用小剂量阿司匹林且有消化性溃疡病史的长期疗效和安全性 Long-term efficacy and safety of rabeprazole in patients taking low-dose aspirin with a history of peptic ulcers: 第2/3阶段 a phase 2/3, 随机的 a randomized, 平行组 parallel-group, 多中心 multicenter, 扩展临床试验。 extension clinical trial. |
已发布 PubMed:心房颤动疗法的未来 The future of atrial fibrillation therapy: 接下来的是对影响电病理的热休克蛋白的干预。 intervention on heat shock proteins influencing electropathology is the next in line. |
已发布 PubMed:hsp70通过与faf1竞争性结合来抑制应激诱导的心肌细胞凋亡。 HSP70 inhibits stress-induced cardiomyocyte apoptosis by competitively binding to FAF1. |
已发布 PubMed:香叶基香叶基丙酮对 橙花母细胞瘤细胞中过氧化氢诱导的氧化应激的保护作用。 Protective effect of geranylgeranylacetone against hydrogen peroxide-induced oxidative stress in human neuroblastoma cells. |
已发布 PubMed:香叶基香叶基丙酮可通过hsp70和硫氧还蛋白氧化还原系统改善肺缺血/再灌注损伤 Geranylgeranylacetone ameliorates lung ischemia/reperfusion injury by HSP70 and thioredoxin redox system: 涉及nf-kb途径。 NF-kB pathway involved. |
已发布 PubMed:香叶基香叶基丙酮可抑制结肠炎相关的小鼠结肠癌的发生。 Geranylgeranylacetone suppresses colitis‑related mouse colon carcinogenesis. |
已发布 PubMed:香叶基香叶基丙酮可预防风湿性疾病患者双氯芬酸引起的小肠损伤 Geranylgeranylacetone protects against small-intestinal injuries induced by diclofenac in patients with rheumatic diseases: 前瞻性随机研究。 a prospective randomized study. |
已发布 PubMed:瑞派肽对阿司匹林加氯吡格雷在酸分泌刺激下引起的胃出血和胃溃疡反应的影响 Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats. |
已发布 PubMed:小剂量阿司匹林对替普瑞酮和法莫替丁抗胃十二指肠粘膜损害的Comparison of teprenone and famotidine against gastroduodenal mucosal damage in patients taking low-dose aspirin. |
已发布 PubMed:香叶基香叶基丙酮可预防脑缺血和再灌注损伤 Geranylgeranylacetone protects against cerebral ischemia and reperfusion injury: hsp90和enos磷酸化参与。 HSP90 and eNOS phosphorylation involved. |
已发布 PubMed:热休克蛋白72通过增加凋亡相关蛋白在肾脏缺血/再灌注损伤中的稳定性而抑制凋亡。 Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury. |
已发布 PubMed:ppi与替普利酮预防小剂量阿司匹林期间溃疡复发。 PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin. |
已发布 PubMed:ppi PPI vs. teprenone in 预防 避免 preventing 复发 recurrence of 溃疡 溃疡 ulcers 中 during 低剂量 low-剂量 dose 阿司匹林 aspirin - 作家 authors' 回复 reply. |
已发布 PubMed:涉及微管马达kif12的抗氧化剂信号传导是β细胞营养过剩的细胞内靶标。 Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells. |
已发布 PubMed:诱导肌肉热休克蛋白70可改善老年小鼠的胰岛素敏感性和肌肉性能。 Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice. |
已发布 PubMed:随机临床试验 Randomised clinical trial: 雷贝拉唑预防低剂量阿司匹林患者预防消化性溃疡的复发。 prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin. |
已发布 PubMed:内质网相关的niemann-pick c1降解 Endoplasmic reticulum-associated degradation of Niemann-Pick C1: 热激蛋白作用的证据以及接受泛素的赖氨酸残基的鉴定。 evidence for the role of heat shock proteins and identification of lysine residues that accept ubiquitin. |
已发布 PubMed:geranylgeranyl化合物对 类嗜碱性粒细胞脱粒的调节作用。 Modulation of human basophil degranulation by geranylgeranyl compounds. |
已发布 PubMed:香叶基香叶基丙酮可阻断阿霉素诱导的心脏毒性,并通过抑制rho途径减少癌细胞的生长和侵袭。 Geranylgeranylacetone blocks doxorubicin-induced cardiac toxicity and reduces cancer cell growth and invasion through RHO pathway inhibition. |
已发布 PubMed:geranylgeranylacetone诱导热休克蛋白70表达在湿热胁迫下对小鼠心肌细胞具有细胞保护作用。 Induction of heat-shock protein 70 expression by geranylgeranylacetone shows cytoprotective effects in cardiomyocytes of mice under humid heat stress. |
已发布 PubMed:香叶基香叶基丙酮和挥发性麻醉药诱导的心脏保护协同作用取决于小窝和小窝蛋白3。 Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3. |
已发布 PubMed:通过增强心肌梗死后衰竭心脏线粒体中hspb1和hspb8的诱导来增强香叶基香叶基丙酮的保护作用。 Protective effect of geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats. |
已发布 PubMed:geranylgeranylacetone通过小窝和小窝蛋白3保护心脏。 Geranylgeranylacetone protects the heart via caveolae and caveolin-3. |
已发布 PubMed:通过共聚焦激光内镜在吲哚美辛诱发的肠病中,间隙密度的增加可预测体内上皮屏障的弱点。 Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy. |
已发布 PubMed:Geranylgeranylacetone, 胃粘膜保护药 a gastromucoprotective drug, 防止因食道诱发的食道 protects against NSAID-induced esophageal, 健康受试者的十二指肠和小肠粘膜损伤 gastroduodenal and small intestinal mucosal injury in healthy subjects: 一项与法莫替丁比较的前瞻性随机研究。 A prospective randomized study involving a comparison with famotidine. |
已发布 PubMed:伏隔核中伴侣蛋白热激蛋白70 Chaperone heat shock protein 70 in nucleus accumbens core: 是大鼠吗啡行为敏化的新型生物学靶标。 a novel biological target of behavioural sensitization to morphine in rats. |
已发布 PubMed:抑制 Suppression of Alzheimer's 疾病相关 疾病 disease-re晚了 lated 表型 phenotypes by by geranylgeranylacetone in 老鼠 mice. |
已发布 PubMed:geranylgeranylacetone对甲基苯丙胺诱导的大鼠嗜铬细胞瘤细胞橙花毒性的保护作用。 Protective effect of geranylgeranylacetone against methamphetamine-induced neurotoxicity in rat pheochromocytoma cells. |
已发布 PubMed:香叶基香叶基丙酮对实验性颅脑损伤的橙花保护作用。 Neuroprotective effects of geranylgeranylacetone in experimental traumatic brain injury. |
已发布 PubMed:功能性消化不良患者根除幽门螺杆菌和药物治疗的评价 Evaluation of Helicobacter pylori eradication and drug therapy in patients with functional dyspepsia. |
已发布 PubMed:热休克蛋白70诱导的肾保护作用部分由cd4 + cd25 + foxp3 +调节性t细胞在缺血/再灌注诱导的急性肾损伤中介导。 The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4+ CD25+ Foxp3 + regulatory T cells in ischemia/reperfusion-induced acute kidney injury. |
已发布 PubMed:热休克蛋白诱导剂可改变心律失常的底物并抑制衰竭心脏的房颤。 Heat shock protein inducer modifies arrhythmogenic substrate and inhibits atrial fibrillation in the failing heart. |
已发布 PubMed:立即诱导热休克蛋白不能保护正常 成纤维细胞中的冷冻保存。 Immediate induction of heat shock proteins is not protective against cryopreservation in normal human fibroblasts. |
已发布 PubMed:geranylgeranylacetone通过mel-ab细胞中的erk激活抑制黑素的合成。 Geranylgeranylacetone inhibits melanin synthesis via ERK activation in Mel-Ab cells. |
已发布 PubMed:阿司匹林和氯吡格雷双重抗血小板治疗引起的胃出血动物模型-抗溃疡药物的预防作用。 Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs. |
已发布 PubMed:geranylgeranylacetone诱导的热休克蛋白70在四氯化碳暴露的成年大鼠睾丸中的作用。 The role of heat shock protein 70 induced by geranylgeranylacetone in carbon tetrachloride-exposed adult rat testes. |
已发布 PubMed:诱导热休克蛋白70可改善小鼠紫外线诱发的光性角膜炎。 Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. |
已发布 PubMed:geranylgeranylacetone对 诱导的对 类角质形成细胞的延迟作用的保护作用。 Protective effect of geranylgeranylacetone against radiation-induced delayed effects on human keratinocytes. |
已发布 PubMed:香叶基香叶基丙酮可预防吗啡引起的肝和肾损伤。 Geranylgeranylacetone protects against morphine-induced hepatic and renal damage in mice. |
已发布 PubMed:geranylgeranylacetone在慢性轻度抑郁症抑郁模型中的抗抑郁作用及其可能的机制。 Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism. |
已发布 PubMed:双膦酸酯诱导的胃肠道粘膜损伤是由线粒体超氧化物的产生和脂质过氧化作用介导的。 Bisphosphonate-induced gastrointestinal mucosal injury is mediated by mitochondrial superoxide production and lipid peroxidation. |
已发布 PubMed:热休克蛋白诱导化合物作为恢复房颤蛋白变性的治疗剂。 Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation. |
已发布 PubMed:对联合用药预防阿司匹林引起的胃肠道损伤的认识较差。 Poor awareness of preventing aspirin-induced gastrointestinal injury with combined protective medications. |
已发布 PubMed:鉴定现有药物作用的分子机制及其在药物开发中的应用 [Identification of a molecular mechanism for actions of existing medicines and its application for drug development]. |
已发布 PubMed:香叶基香叶基丙酮对大鼠乙醇诱发的胃炎的预防作用。 Preventive effects of geranylgeranylacetone on rat ethanol-induced gastritis. |
已发布 PubMed:奥美拉唑的疗效 Efficacy of omeprazole, 法莫替丁 famotidine, 莫沙必利和替普利酮治疗上消化道症状的患者 mosapride and teprenone in patients with upper gastrointestinal symptoms: 奥美拉唑对照的随机研究(j-focus)。 an omeprazole-controlled randomized study (J-FOCUS). |
已发布 PubMed:geranylgeranylacetone通过抑制细胞内p53含量的升高来减弱顺铂诱导的细胞活力降低,而无需热激蛋白诱导。 Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein induction. |
已发布 PubMed:阿司匹林加氯吡格雷在酸分泌刺激下诱发大鼠胃出血的新模型。抗溃疡药的预防作用。 A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs. |
已发布 PubMed:失去蛋白调节性控制作为房颤的基质 Loss of proteostatic control as a substrate for atrial fibrillation: 通过热激蛋白进行上游治疗的新靶标。 a novel target for upstream therapy by heat shock proteins. |
已发布 PubMed:常规压力性溃疡对进行心脏手术的患者有益处吗? Is routine stress ulcer prophylaxis of benefit for patients undergoing cardiac surgery? |
已发布 PubMed:gi保留nsaids处理nsaid /阿司匹林引起的小肠损伤 Management of NSAID/aspirin-induced small intestinal damage by GI-sparing NSAIDs, 抗溃疡药和食品成分。 anti-ulcer drugs and food constituents. |
已发布 PubMed:香叶基香叶基丙酮可保护小鼠免受吗啡引起的运动过度 Geranylgeranylacetone protects mice against morphine-induced hyperlocomotion, 有益的作用 rewarding effect, 和戒断综合症。 and withdrawal syndrome. |
已发布 PubMed:T细胞白血病易位相关基因蛋白在 类肿瘤发生和破骨细胞形成中的作用 The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis. |
已发布 PubMed:[改良的聚乙二醇干扰素治疗慢性丙型肝炎的 学应答 [Improved virologic response in chronic hepatitis C treated with peginterferon, 利巴韦林和附加药物]。 ribavirin and add-on drug]. |
已发布 PubMed:吉非替尼抑制热休克蛋白70的表达及其对肺纤维化的作用。 Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. |
已发布 PubMed: geranylgeranylacetone通过抑制大鼠中的高迁移率的group 框 box 1蛋白来预防心肌缺血和再灌注损伤。 |
已发布 PubMed:geranylgeranylacetone通过激活 类肝癌细胞中的mtor具有抗丙型肝炎 活性。 Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells. |
已发布 PubMed:莫沙必利或替普利酮治疗功能性消化不良的大规模随机临床研究 Large-scale randomized clinical study on functional dyspepsia treatment with mosapride or teprenone: 日本莫沙必利 mosapride大型研究(jmms)。 |
已发布 PubMed:热休克蛋白72增强自噬作为脂多糖诱导的大鼠腹膜炎的一种保护机制。 Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats. |
已发布 PubMed:Geranylgeranylacetone, 热休克蛋白90 / amp激活蛋白激酶/内皮型一氧化氮合酶/一氧化氮途径 heat shock protein 90/AMP-activated protein kinase/endothelial nitric oxide synthase/nitric oxide pathway, 和 类的内皮功能 and endothelial function in humans. |
已发布 PubMed:geranylgeranylacetone抑制过氧化氢诱导的骨节螺藻软骨细胞凋亡。 Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes. |
已发布 PubMed:geranylgeranylacetone抑制耳蜗中噪声诱导的促炎细胞因子的表达。 Geranylgeranylacetone suppresses noise-induced expression of proinflammatory cytokines in the cochlea. |
已发布 PubMed:hspb小成员对果蝇房颤果蝇模型的收缩功能障碍和结构变化的影响。 Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation. |
已发布 PubMed:热休克蛋白70刺激胃溃疡愈合 Stimulation of gastric ulcer healing by heat shock protein 70. |
已发布 PubMed:肺癌细胞中hsp90的上调与对顺铂耐药的相关性 [The correlation between the up-regulation of Hsp90 and drug resistance to cisplatin in lung cancer cell line]. |
已发布 PubMed:抗溃疡剂替普瑞酮抑制丙型肝炎 复制 Anti-ulcer agent teprenone inhibits hepatitis C virus replication: 丙型肝炎的潜在治疗方法。 potential treatment for hepatitis C. |
已发布 PubMed:热休克蛋白70(hsp70)对于视网膜脱离后通过调节抗凋亡akt激酶的感光器应激反应至关重要。 Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. |
已发布 PubMed:恢复hsp70缺乏症可改善糖尿病猴的葡萄糖耐量。 Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys. |
已发布 PubMed:诱导热休克蛋白70抑制缺血性肾损伤。 Induction of heat shock protein 70 inhibits ischemic renal injury. |
已发布 PubMed:热激因子(hsf)-1对锚定蛋白sap97的转录激活可稳定hl-1细胞中的k(v)1.5通道。 Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells. |
已发布 PubMed:geranylgeranylacetone对洛索洛芬钠致大鼠小肠损伤的保护作用。 Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats. |
已发布 PubMed:异戊二烯类香叶基香叶基丙酮通过诱导凋亡和细胞周期停滞来抑制 结肠癌细胞。 Isoprenoid geranylgeranylacetone inhibits human colon cancer cells through induction of apoptosis and cell cycle arrest. |
已发布 PubMed:香叶基香叶基丙酮预处理可减轻大鼠的热诱导炎症和多器官功能障碍。 Geranylgeranylacetone preconditioning may attenuate heat-induced inflammation and multiorgan dysfunction in rats. |
已发布 PubMed:酰基聚异戊二烯衍生物 An acylic polyisoprenoid derivative, geranylgeranylacetone可以防止高脂喂养小鼠的内脏肥胖和胰岛素抵抗。 geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice. |
已发布 PubMed:热休克蛋白70保护博莱霉素诱导的小鼠肺纤维化。 Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice. |
已发布 PubMed:香叶基香叶基丙酮可减轻3-硝基丙酸引起的急性耳蜗损伤。 Geranylgeranylacetone ameliorates acute cochlear damage caused by 3-nitropropionic acid. |
已发布 PubMed:磷脂酰肌醇3激酶/ akt途径介导香叶基香叶基丙酮诱导的大鼠脑梗死橙花保护作用。 The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats. |
已发布 PubMed:依赖hsp的胃肠道疾病防护。 HSP-dependent protection against gastrointestinal diseases. |
已发布 PubMed:hsp72抑制smad3激活和核上皮向间充质过渡中的核易位。 HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition. |
已发布 PubMed:香叶基香叶基丙酮对慢性高眼压大鼠视网膜中hsp70表达的影响 Influence of geranylgeranylacetone on the expression of HSP70 in retina of rats with chronic IOP elevation. |
已发布 PubMed:橙花退行性疾病中的热休克蛋白 Heat shock proteins in neurodegenerative diseases: 致病作用和治疗意义。 pathogenic roles and therapeutic implications. |
已发布 PubMed:(热激)蛋白在胃肠道中的表达和功能 Expression and function of stress (heat shock) proteins in gastrointestinal tract. |
已发布 PubMed:随机的 a randomized, 双盲 double-blind, 小剂量香叶基香叶基丙酮和安慰剂在服用低剂量肠溶阿司匹林的患者中的初步研究。小剂量阿司匹林引起的小肠损害。 pilot study of geranylgeranylacetone versus placebo in patients taking low-dose enteric-coated aspirin. Low-dose aspirin-induced small bowel damage. |
已发布 PubMed:hsp70伴侣的药理靶向。 Pharmacological targeting of the Hsp70 chaperone. |
已发布 PubMed:香叶基香叶基丙酮可保护双氯芬酸对健康受试者的胃和小肠粘膜损伤 Geranylgeranylacetone protects against diclofenac-induced gastric and small intestinal mucosal injuries in healthy subjects: 前瞻性随机安慰剂对照双盲交叉研究。 a prospective randomized placebo-controlled double-blind cross-over study. |
已发布 PubMed:溶血磷脂酸和入侵。 Lysophosphatidic acid and invasion. |
已发布 PubMed:香叶基香叶基丙酮的保护作用 Protective effect of geranylgeranylacetone, 热休克蛋白70的诱导剂 an inducer of heat shock protein 70, 在动物模型中抗药性肺损伤/纤维化。 against drug-induced lung injury/fibrosis in an animal model. |
已发布 PubMed:geranylgeranylacetone通过诱导hsp70保护大鼠和纹状体橙花元免受热损伤。 Geranylgeranylacetone protects rat and striatum neurons against heat injury via induction of Hsp70. |
已发布 PubMed:诱导热休克蛋白可防止心律失常的心房颤动。 Induction of heat shock proteins prevents the arrhythmogenic substrate for atrial fibrillation. |
已发布 PubMed:香叶香叶基丙酮对实验性自身免疫性脑脊髓炎的视橙花炎的保护作用。 Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis. |
已发布 PubMed:[非甾体类抗炎药对胃粘膜的副作用和替普利酮的预防作用]。 [Side effects of non-steroidal anti-inflammatory drugs on gastric mucosa and preventive effects of teprenone]. |
已发布 PubMed:Geranylgeranylacetone, 热休克蛋白的无毒诱导剂 a non-toxic inducer of heat shock protein, 诱导类风湿节螺藻患者的成纤维样滑膜细胞死亡。 induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis. |
已发布 PubMed:hsp70赋予针对吲哚美辛诱导的小肠损伤的保护作用。 HSP70 confers protection against indomethacin-induced lesions of the small intestine. |
已发布 PubMed:hsp70在预防消炎痛诱导的胃部损伤中的作用。 A role for HSP70 in protecting against indomethacin-induced gastric lesions. |
已发布 PubMed:生物疗法对类风湿节螺藻患者全身性骨质疏松的影响 [Effects of biologic therapies on systemic osteoporosis in patients with rheumatoid arthritis]. |
已发布 PubMed:增强香精基香叶基丙酮对结蛋白相关性心肌病的保护作用。 Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy. |
已发布 PubMed:热休克蛋白90表达增加会导致门脉高压大鼠胃粘膜的适应性细胞保护受损。 Increased heat-shock protein 90 expression contributes to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rats. |
已发布 PubMed:Piceatannol-3-o-β-d-吡喃葡萄糖苷对精氨酸酶的抑制作用可通过激活高胆固醇饮食的无载脂蛋白的小鼠体内的内皮一氧化氮合酶的活化来改善内皮功能障碍。 Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice. |
已发布 PubMed:肝切除术后肝再生的机制与门静脉栓塞(结扎)有何不同? Mechanism of liver regeneration after liver resection and portal vein embolization (ligation) is different? |
已发布 PubMed:hsp70的预诱导促进缺氧耐受性并促进小鼠脑中急性低压缺氧的适应。 Preinduction of HSP70 promotes hypoxic tolerance and facilitates acclimatization to acute hypobaric hypoxia in mouse brain. |
已发布 PubMed:香叶基香叶基丙酮对顺铂耳毒性的保护作用。 Protective effect of geranylgeranylacetone on cisplatin ototoxicity. |
已发布 PubMed:hplc-apci-ms用于测定 血浆中的维生素k(1) HPLC-APCI-MS for the determination of vitamin K(1) in human plasma: 方法和临床应用。 method and clinical application. |
已发布 PubMed:低剂量七氟醚吸入可增强抗溃疡药Geranylgeranylacetone的后期心脏保护作用。 Low-dose sevoflurane inhalation enhances late cardioprotection from the anti-ulcer drug geranylgeranylacetone. |
已发布 PubMed:geranylgeranylacetone通过抑制cxc趋化因子gro1和诱导热休克蛋白来预防大鼠大面积肝切除术后的急性肝损伤。 Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GRO1 and induction of heat shock proteins. |
已发布 PubMed:莫沙必利治疗胃肠道疾病。 Mosapride in gastrointestinal disorders. |
已发布 PubMed:热休克蛋白诱导剂减轻与年龄有关的听力损失模型中的进行性听力损失 Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, 香叶基香叶基丙酮。 geranylgeranylacetone. |
已发布 PubMed:hsp72可减轻阻塞性肾病中肾小管细胞凋亡和间质纤维化。 HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy. |
已发布 PubMed: [强的松龙对强的松龙摄入后胃中热休克蛋白70和c-fos c-fos表达的影响 : 大鼠实验]。 experiment with rats]. |
已发布 PubMed:热激蛋白诱导剂对急性心房缺血引起的心房颤动基质的影响。 Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia. |
已发布 PubMed:香叶基香叶基丙酮可减轻鼠巨噬细胞对脂多糖(lps)的炎症反应 Geranylgeranylacetone ameliorates inflammatory response to lipopolysaccharide (LPS) in murine macrophages: 抑制lps结合到细胞表面。 inhibition of LPS binding to the cell surface. |
已发布 PubMed:[胃粘膜保护剂的副作用]。 [Side effects of gastric muco-protective agents]. |
已发布 PubMed:geranylgeranylacetone诱导热休克蛋白72降低乙醇对大鼠门脉高压性胃黏膜损伤的作用。 Reduction of ethanol-induced injury in portal hypertensive gastric mucosa of rats by induction of heat shock protein 72 by geranylgeranylacetone. |
已发布 PubMed:香叶基香叶基丙酮和西咪替丁在消化不良症状和胃部病变的胃炎中的疗效Comparison of the effectiveness of geranylgeranylacetone with cimetidine in gastritis patients with dyspeptic symptoms and gastric lesions: 随机的 a randomized, 日本的双盲审判。 double-blind trial in Japan. |
已发布 PubMed:geranylgeranylacetone钝化nf-kappab和依赖nf-kappab的基因表达 Blunted activation of NF-kappaB and NF-kappaB-dependent gene expression by geranylgeranylacetone: 参与展开的蛋白质反应。 involvement of unfolded protein response. |
已发布 PubMed:[热休克蛋白在胃粘膜保护中的作用]。 [Role of heat shock protein in gastric mucosal protection]. |
已发布 PubMed:香叶基香叶基丙酮对缺血性视网膜损伤的橙花保护作用。 Neuroprotective effect of geranylgeranylacetone against ischemia-induced retinal injury. |
已发布 PubMed:Geranylgeranylacetone, 70 kda热激蛋白(hsp70)的诱导剂 an inducer of the 70-kDa heat shock protein (HSP70), 引起展开的蛋白质反应并独立于hsp70协调细胞命运。 elicits unfolded protein response and coordinates cellular fate independently of HSP70. |
已发布 PubMed:geranylgeranylacetone通过诱导热休克蛋白70保护 胃粘膜免受双氯芬酸诱导的损伤。 Geranylgeranylacetone protects the human gastric mucosa from diclofenac-induced injury via induction of heat shock protein 70. |
已发布 PubMed:geranylgeranylacetone诱导的热休克蛋白70在萎缩性胃炎中的保护作用。 Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats. |
已发布 PubMed:线粒体是香叶基香叶基丙酮诱导的大鼠心脏缺血再灌注的心脏保护作用的靶标。 Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart. |
已发布 PubMed:热疗改善2 Hyperthermia ameliorates 2,4,6-三硝基苯磺酸诱发的大鼠结肠炎 6-trinitrobenzene sulphonic acid-induced colitis in rats: 热激蛋白的作用。 the role of heat shock proteins. |
已发布 PubMed:热疗减弱了 动脉内皮细胞中tnf-alpha诱导的内皮细胞粘附分子的上调。 Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells. |
已发布 PubMed:geranylgeranylaceton诱导骨骼肌细胞中的热休克蛋白72。 Geranylgeranylaceton induces heat shock protein 72 in skeletal muscle cells. |
已发布 PubMed:hplc-apci-ms测定 血浆中的替普利酮 HPLC-APCI-MS for the determination of teprenone in human plasma: 方法和临床应用。 method and clinical application. |
已发布 PubMed:geranylgeranylacetone通过nf-kappab诱导培养的大鼠胃上皮细胞中环氧合酶2的表达。 Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB. |
已发布 PubMed:geranylgeranylacetone在体外和体内均能抑制 癌的进展。 Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo. |
已发布 PubMed:黏膜保护对胃溃疡愈合质量的影响 [Effect of mucosal protective on the quality of gastric ulcer healing]. |
已发布 PubMed:热休克蛋白70诱导与小鼠实验性自身免疫性葡萄膜视网膜炎的改善的相关性。 Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice. |
已发布 PubMed:热休克蛋白的药理诱导在实验性脑出血中发挥橙花保护作用。 Pharmacological induction of heat shock protein exerts neuroprotective effects in experimental intracerebral hemorrhage. |
已发布 PubMed:非甾体类抗炎药引起的胃病及替普利酮对大鼠胃病的预防作用 [Non-steroidal anti-inflammatory drug induced gastropathy and preventive effects of teprenone on the gastropathy in rats]. |
已发布 PubMed:遗传证据证明热休克因子1对刺激性胃病具有保护作用。 Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions. |
已发布 PubMed: geranylgeranylacetone(hsp-诱导剂 诱导 inducer)在胃粘膜中诱导分子伴侣hsp70的机制。 |
已发布 PubMed:诱发热休克反应可保护心脏免于心房颤动。 Induction of heat shock response protects the heart against atrial fibrillation. |
已发布 PubMed:回顾性和前瞻性随机研究揭示了组胺h2受体阻断对慢性心力衰竭的影响。 Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies. |
已发布 PubMed:geranylgeranylacetone对庆大霉素耳蜗培养中耳毒性的影响。 Effect of geranylgeranylacetone on gentamycin ototoxicity in rat cochlea culture. |
已发布 PubMed:热休克蛋白上调可防止hl-1心房肌细胞和 心房颤动中起搏引起的肌溶解。 Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation. |
已发布 PubMed:激酶c在香叶基香叶基丙酮的橙花保护作用中的作用 Role of protein kinase C in neuroprotective effect of geranylgeranylacetone, 热休克蛋白的非侵入性诱导剂 a noninvasive inducing agent of heat shock protein, 对短暂性脑缺血所致的橙花元延迟死亡的影响。 on delayed neuronal death caused by transient ischemia in rats. |
已发布 PubMed:戊烯酮对幽门螺杆菌诱发的小鼠胃黏膜损伤的预防作用 [Preventive effects of teprenone on gastric mucosal lesions induced by Helicobacter pylori in mice]. |
已发布 PubMed:缺血再灌注的脂肪肝中的热休克蛋白和促分裂原活化蛋白激酶 Heat shock proteins and mitogen-activated protein kinases in steatotic livers undergoing ischemia-reperfusion: 一些答案。 some answers. |
已发布 PubMed:Geranylgeranylacetone, 热休克蛋白70的诱导物 an inducer of HSP 70, 减弱睡眠剥夺后的雷姆 REM睡眠反弹。 |
已发布 PubMed:香叶基香叶基丙酮诱导的热休克蛋白70对大鼠肠上皮细胞氧化损伤的保护作用。 Protective effects of heat shock protein 70 induced by geranylgeranylacetone on oxidative injury in rat intestinal epithelial cells. |
已发布 PubMed:Geranylgeranylacetone, 非侵入性热休克蛋白诱导剂 a noninvasive heat shock protein inducer, 诱导蛋白激酶c并导致对大鼠脑梗死的橙花保护。 induces protein kinase C and leads to neuroprotection against cerebral infarction in rats. |
已发布 PubMed:香叶基香叶基丙酮对三硝基苯磺酸所致小鼠结肠炎的保护作用。 Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice. |
已发布 PubMed:geranylgeranylacetone通过诱导热激蛋白70来保护对乙酰氨基酚引起的肝毒性。 Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70. |
已发布 PubMed:geranylgeranylacetone抑制 破骨细胞的形成和功能,并防止尾部悬浮大鼠和去 大鼠的骨质流失。 Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats. |
已发布 PubMed:胃粘膜对类固醇酮类固醇激素所致损伤的保护作用 [Protection of gastric mucosa against steroids-induced damage by teprenone]. |
已发布 PubMed:Geranylgeranylacetone, 热激蛋白诱导剂 a heat shock protein inducer, 防止豚鼠的听觉损伤。 prevents acoustic injury in the guinea pig. |
已发布 PubMed:热激蛋白的药理学诱导减轻了聚谷氨酰胺介导的运动橙花元疾病。 Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. |
已发布 PubMed:口服香叶基香叶基丙酮提高大鼠内毒素休克模型的存活率 Oral administration of geranylgeranylacetone improves survival rate in a rat endotoxin shock model: 给药时机和热休克蛋白70的诱导。 administration timing and heat shock protein 70 induction. |
已发布 PubMed:香叶基香叶基丙酮通过增强muc5ac和muc6来保护胃粘膜。 Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone. |
已发布 PubMed:口服香叶基香叶基丙酮加上局部体温刺激 Oral administration of geranylgeranylacetone plus local somatothermal stimulation: 一个简单的 a simple, 有效 effective, 安全和可操作的预处理组合可赋予大鼠肝脏对缺血-再灌注损伤的耐受性。 safe and operable preconditioning combination for conferring tolerance against ischemia-reperfusion injury in rat livers. |
已发布 PubMed:geranylgeranylacetone保护小鼠免受硫酸葡聚糖钠诱导的结肠炎的侵害。 Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis. |
已发布 PubMed:抗溃疡药 an anti-ulcer agent, geranylgeranylacetone, 抑制培养的血管平滑肌细胞中的诱导型一氧化氮合酶。 suppresses inducible nitric oxide synthase in cultured vascular smooth muscle cells. |
已发布 PubMed:芬太尼对化合物48/80治疗大鼠急性胃黏膜病变进展的影响 Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, 肥大细胞脱粒机 a mast cell degranulator, 与替普利酮相比。 in comparison with that of teprenone. |
已发布 PubMed:香叶基香叶基丙酮可限制继发性损伤 Geranylgeranylacetone limits secondary injury, 橙花元死亡 neuronal death, 脊髓损伤后进行性坏死和空化。 and progressive necrosis and cavitation after spinal cord injury. |
已发布 PubMed:香叶基香叶基丙酮可保护膜免受非甾体类抗炎药的侵害。 Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs. |
已发布 PubMed:[有望减轻二恶英毒性的化合物的可能候选物]。 [Possible candidates for the compound which is expected to attenuate dioxin toxicity]. |
已发布 PubMed:热激蛋白 Heat shock proteins: 开发细胞保护疗法的新钥匙。 new keys to the development of cytoprotective therapies. |
已发布 PubMed:香叶基香叶基丙酮对hsp的上调保护了耳蜗侧壁免受内毒素诱导的炎症的影响。 Upregulation of HSP by geranylgeranylacetone protects the cochlear lateral wall from endotoxin-induced inflammation. |
已发布 PubMed:胰岛素抵抗对高脂饮食大鼠香叶基香叶基丙酮诱导的热休克蛋白72表达和心脏保护的影响。 Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats. |
已发布 PubMed:口服香叶基香叶基丙酮丙酮可钝化大鼠心脏缺血和再灌注引起的内皮功能障碍。 Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart. |
已发布 PubMed:香叶基香叶基丙酮可通过诱导hsp70改善缺血性急性肾衰竭。 Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70. |
已发布 PubMed:香叶基香叶醇的两相作用 Biphasic effects of geranylgeraniol, teprenone, 和植物醇对金黄熊果的生长。 and phytol on the growth of Staphylococcus aureus. |
已发布 PubMed:热休克蛋白70延迟了庆大霉素诱导的前庭毛细胞死亡。 Heat shock protein 70 delays gentamicin-induced vestibular hair cell death. |
已发布 PubMed:香叶基香叶基丙酮对视网膜光氧化损伤的细胞保护作用。 Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage. |
已发布 PubMed:香叶基香叶基丙酮可抑制溶血磷脂酸诱导的 癌侵袭体外癌细胞。 Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro. |
已发布 PubMed:心脏手术后最佳预防性治疗上消化道并发症的前瞻性随机试验。 Prospective randomized trial for optimal prophylactic treatment of the upper gastrointestinal complications after open heart surgery. |
已发布 PubMed:热休克蛋白诱导剂的橙花保护作用 Neuroprotective effect of a heat shock protein inducer, 香叶基香叶基丙酮在永久性局灶性脑缺血中的作用。 geranylgeranylacetone in permanent focal cerebral ischemia. |
已发布 PubMed:香叶基香叶基丙酮的橙花保护作用 Neuroprotective effect of geranylgeranylacetone, 非侵入性热休克蛋白诱导剂 a noninvasive heat shock protein inducer, 对大鼠脑梗塞 on cerebral infarction in rats. |
已发布 PubMed:热激蛋白72拮抗大鼠蛛网膜下腔出血后脑血管痉挛的潜在作用。 Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage. |
已发布 PubMed:恢复热休克蛋白70抑制幽门螺杆菌诱导的胃粘膜诱导型一氧化氮合酶表达。 Restoration of heat shock protein70 suppresses gastric mucosal inducible nitric oxide synthase expression induced by Helicobacter pylori. |
已发布 PubMed:香叶菊乙丙酮减弱幽门螺杆菌提取物对 脐静脉上皮细胞生长的抑制作用。 Geranylgeranylacetone attenuates suppression by Helicobacter pylori extract of human umbilical vein epithelial cell growth. |
已发布 PubMed:单次口服香叶基香叶基丙酮丙酮可以减轻海藻酸诱导的癫痫发作和橙花元细胞死亡。 A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus. |
已发布 PubMed:减少2的毒性 Reduction of the toxicity of 2,3,7,使用抗溃疡药在小鼠体内生成8-四氯二苯并-对-二恶英 8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, 香叶基香叶基丙酮。 geranylgeranylacetone. |
已发布 PubMed:单次口服剂量的香叶基香叶基丙酮可预防短暂性脑缺血引起的橙花元延迟死亡。 Single oral dose of geranylgeranylacetone for protection against delayed neuronal death induced by transient ischemia. |
已发布 PubMed:[抗癌发展的基础研究 [Basic studies for the development of anticancer, 抗痴呆 antidementia, 和味觉改善药物]。 and taste modifier drugs]. |
已发布 PubMed:戊烯酮 Teprenone, 但不是H2受体阻滞剂或硫糖铝 but not H2-receptor blocker or sucralfate, 抑制 的幽门螺杆菌幽门螺杆菌定植和胃炎 suppresses corpus Helicobacter pylori colonization and gastritis in humans: 替普利酮抑制h。幽门螺杆菌诱导的mkn28胃上皮细胞系中的明串球菌介素8。 teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines. |
已发布 PubMed:[香叶基香叶基丙酮 [Geranylgeranylacetone, 抗溃疡药 an anti-ulcer agent, 有效抑制 破骨细胞的形成和功能以及去 大鼠的骨丢失 potently inhibits formation and function of human osteoclasts in vitro and bone loss in ovariectomized rats]. |
已发布 PubMed:戊酸睾酮对化合物48/80治疗的大鼠急性胃粘膜病变进展的预防作用。 Preventive effect of teprenone on acute gastric mucosal lesion progression in compound 48/80-treated rats. |
已发布 PubMed:香叶基香叶基丙酮保护视网膜橙花节细胞 Retinal ganglion cell protection with geranylgeranylacetone, 热激蛋白诱导剂 a heat shock protein inducer, 在大鼠青光眼模型中。 in a rat glaucoma model. |
已发布 PubMed:[由于抗结核药物包括异烟肼(inh)和利福平(rfp)引起的粒细胞缺乏症-4例病例报告并复习文献]。 [Agranulocytosis due to anti-tuberculosis drugs including isoniazid (INH) and rifampicin (RFP)--a report of four cases and review of the literature]. |
已发布 PubMed:替普利酮对化合物48/80诱导的急性胃粘膜损伤的保护作用 Protective effect of teprenone against acute gastric mucosal lesions induced by compound 48/80, 肥大细胞脱粒机 a mast cell degranulator, 在大鼠中。 in rats. |
已发布 PubMed:对日本使用的抗溃疡药物对(13)c-尿素呼气试验对幽门螺杆菌感染诊断的影响 Influence of anti-ulcer drugs used in Japan on the result of (13)C-urea breath test for the diagnosis of Helicobacter pylori infection. |
已发布 PubMed:提出了由香叶基香叶基丙酮催化ras蛋白的异戊烯基化作用诱导热休克蛋白70的机理。 Proposed mechanism for induction of heat shock protein 70 by geranylgeranyl acetone by prenylation of Ras proteins. |
已发布 PubMed: 香叶基香叶基丙酮通过诱导热休克蛋白70减轻败血症性光圈 diaphragm肌功能障碍。 |
已发布 PubMed:单次口服香叶基香叶基丙酮之后,星形胶质细胞活化伴随大鼠脑中的热休克蛋白上调。 Astroglial activation accompanies heat shock protein upregulation in rat brain following single oral dose of geranylgeranylacetone. |
已发布 PubMed:胆固醇基葡萄糖苷诱导的胃溃疡保护作用。 Cholesteryl glucoside-induced protection against gastric ulcer. |
已发布 PubMed:香叶基香叶基丙酮的抗 作用 Antiviral effects of geranylgeranylacetone: 在流感 感染过程中增强mxa表达和pkr磷酸化。 enhancement of MxA expression and phosphorylation of PKR during influenza virus infection. |
已发布 PubMed:激酶c在香叶基香叶基丙酮诱导的大鼠心脏热休克蛋白72表达和心脏保护中的作用 Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. |
已发布 PubMed:香叶基香叶基丙酮保护视网膜橙花节细胞 Retinal ganglion cell protection with geranylgeranylacetone, 热激蛋白诱导剂 a heat shock protein inducer, 在大鼠青光眼模型中。 in a rat glaucoma model. |
已发布 PubMed:分子伴侣在医学和疾病中的诱导作用 [Molecular chaperone inducers in medicine and diseases]. |
已发布 PubMed:抗溃疡药物抑制幽门螺杆菌诱导的胃癌细胞系中IL-8的产生 Suppression of Helicobacter pylori-induced interleukin-8 production in gastric cancer cell lines by an anti-ulcer drug, 香叶基香叶基丙酮。 geranylgeranylacetone. |
已发布 PubMed:美伐他汀 Mevastatin, hmg-coa还原酶抑制剂 an inhibitor of HMG-CoA reductase, 诱导细胞凋亡 induces apoptosis, 分化和rap1表达hl-60细胞。 differentiation and Rap1 expression in HL-60 cells. |
已发布 PubMed:抗溃疡剂对d-半乳糖胺诱发的肝炎大鼠乙醇诱导的胃粘膜损伤的影响。 Effects of anti-ulcer agents on ethanol-induced gastric mucosal lesions in D-galactosamine-induced hepatitis rats. |
已发布 PubMed:香叶基香叶基丙酮可保护豚鼠胃粘膜细胞免受胃应激物诱导的细胞凋亡。 Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced apoptosis. |
已发布 PubMed:香叶基香叶基丙酮对培养的脊髓橙花元中蛋白酶体抑制所致细胞损伤的影响。 Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons. |
已发布 PubMed:硫氧还蛋白超家族和硫氧还蛋白诱导剂。 Thioredoxin superfamily and thioredoxin-inducing agents. |
已发布 PubMed:香叶基香叶基丙酮可抑制大鼠大面积肝切除术后的炎症反应并提高其存活率。 Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats. |
已发布 PubMed:[使用粘膜保护剂治疗消化性溃疡的新方法]。 [New therapeutic approaches to peptic ulcer using mucosal protective agents]. |
已发布 PubMed:硫氧还蛋白抑制大鼠pc12细胞中1-甲基-4-苯基吡啶鎓诱导的橙花毒性。 Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells. |
已发布 PubMed:香叶基香叶基丙酮促进胃粘膜细胞和外周血淋巴细胞中硫氧还蛋白的诱导和分泌。 Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes. |
已发布 PubMed:geranylgeranylacetone可以独立于hsp70表达而保护 类单核细胞免于线粒体膜去极化。 Geranylgeranylacetone protects human monocytes from mitochondrial membrane depolarization independently of Hsp70 expression. |
已发布 PubMed:单次口服剂量的香叶基香叶基丙酮可诱导热休克蛋白72并防止大鼠心脏缺血/再灌注损伤。 Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/reperfusion injury in rat heart. |
已发布 PubMed:geranylgeranylacetone通过诱导热休克蛋白保护豚鼠胃粘膜细胞免受胃应激源诱导的坏死。 Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced necrosis by induction of heat-shock proteins. |
已发布 PubMed:无毒的热激蛋白70诱导剂 A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, 抑制过氧化氢和乙醇引起的培养大鼠肝细胞凋亡。 suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol. |
已发布 PubMed:Geranylgeranylacetone, 热激蛋白诱导剂 a heat shock protein inducer, 防止大鼠肝移植中原发性移植物失效。 prevents primary graft nonfunction in rat liver transplantation. |
已发布 PubMed: 高剂量的香叶基香叶基丙酮在大鼠肝脏中积累hsp72 姆纳 mRNA。 |
已发布 PubMed:戊酸酮对幽门螺杆菌诱发的大鼠胃黏膜损伤的保护作用 Effect of teprenone on gastric mucosal injury induced by Helicobacter pylori in rats. |
已发布 PubMed:替普利酮通过抑制溃疡性胃组织中的中性粒细胞浸润和脂质过氧化作用,促进乙酸诱导的大鼠慢性胃溃疡的愈合。 Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues. |
已发布 PubMed:香叶基香叶基丙酮在 肝癌细胞中诱导抗 基因表达。 Geranylgeranylacetone induces antiviral gene expression in human hepatoma cells. |
已发布 PubMed:动脉内施用香叶基香叶基丙酮可诱导热休克蛋白70(hsp-70)。 Induction of heat shock protein-70 (hsp-70) by intraarterial administration of geranylgeranylacetone. |
已发布 PubMed:geranylgeranylacetone预防大鼠肝移植中的热缺血性损伤。 Prevention of warm ischemic injury in rat liver transplantation by geranylgeranylacetone. |
已发布 PubMed:口服香叶基香叶基丙酮刺激hsp72在大鼠肝脏中的功效。 Efficacy of HSP72 induction in rat liver by orally administered geranylgeranylacetone. |
已发布 PubMed:geranylgeranylacetone通过诱导橙花元一氧化氮合酶刺激培养的豚鼠胃腔细胞黏蛋白的合成。 Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase. |
已发布 PubMed:geranylgeranylacetone保护培养的豚鼠胃粘膜细胞免受吲哚美辛的侵害。 Geranylgeranylacetone protects cultured guinea pig gastric mucosal cells from indomethacin. |
已发布 PubMed:geranylgeranylacetone增强硫氧还蛋白的表达,并抑制乙醇诱导的培养肝细胞的细胞毒性。 Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes. |
已发布 PubMed:无毒的热激蛋白70诱导剂 A non-toxic heat shock protein 70 inducer, 香叶基香叶基丙酮 geranyl-geranyl-acetone, 恢复蛋白质营养不良大鼠胃粘膜的热休克反应。 restores the heat shock response in gastric mucosa of protein-malnourished rats. |
已发布 PubMed:热休克预处理前施用香叶基香叶基-香叶基丙酮对大鼠肝脏缺血再灌注损伤的耐受性 Effects of geranyl-geranyl-acetone administration before heat shock preconditioning for conferring tolerance against ischemia-reperfusion injury in rat livers. |
已发布 PubMed:热休克蛋白在胃粘膜保护中的作用 Role of heat shock proteins in gastric mucosal protection. |
已发布 PubMed:血管内皮生长因子在门脉高压性胃病中的作用 Role of vascular endothelial growth factor in portal hypertensive gastropathy. |
已发布 PubMed:口服香叶基香叶基丙酮可保护大鼠肝脏免于热缺血性损伤。 Oral administration of geranylgeranylacetone protects rat livers from warm ischemic injury. |
已发布 PubMed:geranylgeranylacetone抑制培养的豚鼠胃凹细胞中的自发凋亡dna片段。 Geranylgeranylacetone suppresses spontaneous apoptotic DNA fragmentation in cultured guinea pig gastric pit cells. |
已发布 PubMed:香叶基香叶基丙酮可诱导hl-60细胞凋亡。 Geranylgeranylacetone induces apoptosis in HL-60 cells. |
已发布 PubMed:w / wv小鼠因胃运动受阻而引起的 反流是自发性胃溃疡的原因。 Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. |
已发布 PubMed:氨溶液对肝硬化大鼠胃黏膜的影响及香叶基香叶基丙酮的治疗作用。 Effects of ammonia solution on the gastric mucosa in cirrhotic rats and therapeutic effects of geranylgeranylacetone. |
已发布 PubMed:瑞巴派特对束缚应激下吲哚美辛诱导的大鼠胃出血的影响 Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress. |
已发布 PubMed:避免戊酸酮对应激性胃黏膜损伤的保护作用及其与胃黏膜组成型一氧化氮合酶活性的关系 Preventive effect of teprenone on stress-induced gastric mucosal lesions and its relation to gastric mucosal constitutive nitric oxide synthase activity. |
已发布 PubMed:替普利酮和草酸氢氟酸对牛磺胆酸盐/盐酸诱导的大鼠急性胃黏膜损伤的保护作用 [Protective effects of teprenone and gefarnate against taurocholate/hydrochloric acid-induced acute gastric mucosal lesions in rats]. |
已发布 PubMed:geranylgeranylacetone在大鼠小肠中诱导热休克蛋白73。 Geranylgeranylacetone induces heat shock protein-73 in rat small intestine. |
已发布 PubMed: 抑制香叶基香叶基丙酮中的培养豚鼠胃黏膜细胞乙醇诱导的凋亡脱氧核糖核酸 DNA片段化。 |
已发布 PubMed:戊烯酮 Teprenone, 抗溃疡药 an anti-ulcer agent, 通过一氧化氮增加大鼠胃粘膜黏液的水平。 increases gastric mucosal mucus level via nitric oxide in rats. |
已发布 PubMed:瑞巴派特联合兰索拉唑和阿莫西林对幽门螺杆菌感染的胃溃疡患者的作用。 Effects of rebamipide in combination with lansoprazole and amoxicillin on Helicobacter pylori-infected gastric ulcer patients. |
已发布 PubMed:Geranylgeranylacetone, 抗溃疡药 an anti-ulcer agent, 通过结合特定的胞质蛋白刺激大鼠胃粘膜细胞系中己糖胺的产生。 stimulates hexosamine production in a rat gastric mucosal cell line through binding to a specific cytosolic protein. |
已发布 PubMed:戊酸肾上腺素对大鼠胃黏膜损伤的保护和预防作用。 Protective and preventive effects of teprenone on gastric mucosal lesions in rats. |
已发布 PubMed:戊酸酮对家兔培养细胞模型胃上皮修复的影响 Effects of teprenone on gastric epithelial restoration in a rabbit cultured cell model. |
已发布 PubMed:四丙烯基丙酮预防胃溃疡复发。 Prevention of gastric ulcer recurrence with tetraprenylacetone. |
已发布 PubMed:[胃淋巴瘤-一例报告]。 [Gastric lymphoma--a case report]. |
已发布 PubMed: gefarnate gefarnate在体外刺激角膜上皮分泌粘蛋白样糖蛋白,并在体内保护角膜上皮免于干燥。 |
已发布 PubMed: geranylgeranylacetone和 曲酯 cetraxate hydrochloride可增加大鼠胃黏膜的udp-半乳糖基转移酶活性。 |
已发布 PubMed:吲哚美辛通过渗透泵延缓大鼠乙酸性溃疡愈合的新模型 [A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump]. |
已发布 PubMed:抑制性的 Suppressive 影响 effect of 四异戊基丙酮 tetraprenylacetone on 胃的 gastric 萎缩 atrophy 诱发的 诱导 induced by by 短期 short-term 管理 administration of N-methyl-N'-nitro-N-nitrosoguanidine 在大鼠中。 in rats. |
已发布 PubMed:戊四烯酮对活动性胃溃疡治疗中溃疡愈合率和愈合质量的影响 [The effects of teprenone on the ulcer healing rate and the quality of healing in the treatment of active gastric ulcers]. |
已发布 PubMed:替普利酮可增加肝组织血流量。 Increase in hepatic tissue blood flow by teprenone. |
已发布 PubMed:热休克和替普瑞酮对乙醇诱导的兔胃黏膜细胞损伤的影响 Effects of heat shock and teprenone on ethanol-induced damage to cultured rabbit gastric mucosal cells. |
已发布 PubMed:1的抗胃酸分泌机理 Anti-gastric acid secretory mechanism of 1,6-二氢-2- [2-(2-(甲基丙氧基)苯胺基] -6-氧代-5-嘧啶羧酸。对粘膜肥大细胞的影响。 6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid. Effect on mucosal mast cell. |
已发布 PubMed:肝硬化门静脉高压症患者胃黏液的产生。四异戊二烯丙酮的作用。 Gastric mucus generation in cirrhotic patients with portal hypertension. Effects of tetraprenylacetone. |
已发布 PubMed:geranylgeranylacetone在培养的豚鼠胃粘膜细胞和大鼠胃粘膜中诱导热激蛋白。 Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. |
已发布 PubMed:普仑诺醇的体外和体内抗菌活性 In-vitro and in-vivo antibacterial activity of plaunotol, 细胞保护性抗溃疡药 a cytoprotective antiulcer agent, 对抗幽门螺杆菌。 against Helicobacter pylori. |
已发布 PubMed:肾上腺素对出血和再输血后大鼠胃黏膜血流量和组织学病变发生率的保护作用 Protective effect of teprenone on blood flow and incidence of histologic lesions in rat gastric mucosa after hemorrhage and retransfusion. |
已发布 PubMed:根除幽门螺杆菌对十二指肠溃疡愈合和溃疡复发的影响 Effect of the eradication of Helicobacter pylori on duodenal ulcer healing and ulcer relapse: 日本的随机对照研究。 randomized controlled study in Japan. |
已发布 PubMed:[甲泼尼龙治疗慢性浅表性胃炎 [Teprenone in the treatment of chronic superficial gastritis, 多中心研究]。 a multicentre study]. |
已发布 PubMed:普利酮对门脉高压性胃粘膜的影响。 Effect of teprenone on portal hypertensive gastric mucosa. |
已发布 PubMed:胃黏膜糖蛋白分泌的药理调节。 Pharmacological regulation of gastric mucous glycoprotein secretion. |
已发布 PubMed:替普利酮的临床评价 Clinical evaluation of teprenone, 粘膜保护剂 a mucosal protective agent, 在胃溃疡患者的治疗中 in the treatment of patients with gastric ulcers: 全国 a nationwide, 多中心临床研究。 multicenter clinical study. |
已发布 PubMed:黏液在局部缺血/再灌注引起的胃粘膜损伤中的作用 Role of mucus in gastric mucosal injury induced by local ischemia/reperfusion. |
已发布 PubMed:异戊二烯酮对大鼠两个实验模型中胰腺外分泌和急性胰腺炎的影响 Effects of tetraprenylacetone on pancreatic exocrine secretion and acute pancreatitis in two experimental models in rats. |
已发布 PubMed:扫描电镜观察大鼠胃黏液分泌 Scanning electron microscopic observations on gastric mucus secretion in rats, 和四异戊基丙酮的作用。 and the effects of tetraprenylacetone. |
已发布 PubMed:特罗西肽对大鼠缺血/再灌注加氨水致急性胃黏膜病变(agml)的新模型的预防作用 [Preventive effects of troxipide on a newly developed model of acute gastric mucosal lesion (AGML) induced by ischemia/reperfusion plus ammonia in the rat]. |
已发布 PubMed:kb-5492的结合特性 Binding properties of KB-5492, 新型抗溃疡药 a novel anti-ulcer agent, 在猪胃底粘膜中的σ受体 at sigma receptors in porcine gastric fundic mucosa. |
已发布 PubMed:kb-5492的受体结合谱 Receptor binding profiles of KB-5492, 新型抗溃疡药 a novel anti-ulcer agent, 豚鼠大脑中的sigma受体。 at sigma receptors in guinea-pig brain. |
已发布 PubMed:轻油霉素诱发的急性胰腺炎大鼠胃亚细胞器脆性和胃能量水平受损 Gastric subcellular organelle fragility and impaired gastric energy charge levels in rats with caerulein-induced acute pancreatitis: 抗溃疡药的保护作用 protective effect of anti-ulcer agent, 戊烯酮。 teprenone. |
已发布 PubMed:拉伤大鼠的胃部损害和体重减轻 Gastric damage and body weight loss in LHA-lesioned rats: 保护性香叶基香叶基丙酮的作用。 effects of cytoprotective geranylgeranylacetone. |
已发布 PubMed:kb-5492的效果 Effects of KB-5492, 对sigma受体具有选择性亲和力的新型抗溃疡药 a new anti-ulcer agent with a selective affinity for the sigma-receptor, 阿司匹林诱导的大鼠胃粘膜屏障破坏。 on aspirin-induced disruption of the rat gastric mucosal barrier. |
已发布 PubMed:替普瑞酮的抗菌活性 Antibacterial activity of teprenone, 非水溶性抗溃疡药 a non water-soluble antiulcer agent, 对抗幽门螺杆菌。 against Helicobacter pylori. |
已发布 PubMed:粘液糖蛋白在保护培养的大鼠胃粘膜细胞免受有毒氧代谢产物中的作用 Role for mucous glycoprotein in protecting cultured rat gastric mucosal cells against toxic oxygen metabolites. |
已发布 PubMed:用作抗溃疡剂的香叶基香叶基丙酮是强力诱导各种 类髓样白血病细胞系分化的诱导剂。 Geranylgeranylacetone used as an antiulcer agent is a potent inducer of differentiation of various human myeloid leukemia cell lines. |
已发布 PubMed:效果 影响 Effects of the new 组胺 histamine H2-receptor 对抗者 antagonist N-ethyl-N'-[3-[3-(哌啶子基甲基 piperidinomethyl)苯氧基 phenoxy]propyl] 尿素 urea with 有力的 potent 胃的 gastric 黏膜的 黏mucosal 保护性 保护 protective 活动 activity on 急性 acute 胃的 gastric 病灶 病灶 lesions and duodenal 溃疡 溃疡 ulcers 在大鼠中。 in rats. |
已发布 PubMed:药物对豚鼠胃腺磷脂酰胆碱合成的影响 Effects of antiulcer drugs on phosphatidylcholine synthesis in isolated guinea pig gastric glands. |
已发布 PubMed:胃粘膜保护剂对肝硬化大鼠的保护作用 Effects of a gastric mucosal protecting agent in rats with liver cirrhosis. |
已发布 PubMed:普瑞酮对冷约束应激诱导的急性胃粘膜损伤的作用 Effect of teprenone on acute gastric mucosal lesions induced by cold-restraint stress. |
已发布 PubMed:新型抗溃疡药kb-5492对实验性胃黏膜病变和胃黏膜防御因子的影响 Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, 与替普瑞酮和西咪替丁相比。 as compared to those of teprenone and cimetidine. |
已发布 PubMed:MCI-727的作用 Effects of MCI-727, 一种新的抗溃疡药 a new anti-ulcer agent, 对大鼠和犬血浆胰泌素浓度及大鼠胰腺外分泌的影响 on plasma secretin concentration in rats and dogs and pancreatic exocrine secretion in rats. |
已发布 PubMed:胃粘膜中的六胺含量在各种肝病中。 Gastric mucosal hexosamine content in various liver diseases. |
已发布 PubMed:MCI-727的作用 Effects of MCI-727, 一种新的抗溃疡药 a new anti-ulcer agent, 在实验动物的各种胃和十二指肠病变中的作用。 on various gastric and duodenal lesions in experimental animals. |
已发布 PubMed:对分离的豚鼠胃腺中抗肿瘤药对磷脂酰胆碱合成的抑制作用以及其被香叶基香叶基丙酮逆转的作用。 The inhibitory effect of anti-tumor drugs on phosphatidylcholine synthesis and its reversal by geranylgeranylacetone in the isolated guinea pig gastric glands. |
已发布 PubMed:四戊烯基丙酮促进乙醇诱导的大鼠胃部损伤的愈合过程。 Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat. |
已发布 PubMed:促胰液素作为粘膜保护剂抗溃疡作用的潜在介质。 Secretin as a potential mediator of antiulcer actions of mucosal protective agents. |
已发布 PubMed:胃黏膜腺苷含量的变化 Changes in gastric mucosal content of adenosine, 黄嘌呤和次黄嘌呤受抑制的水浸应力诱导 xanthine and hypoxanthine induced by restrained water immersion stress: 四异戊基丙酮的抗溃疡作用。 antiulcer effects of tetraprenylacetone. |
已发布 PubMed:戊烯酮和h2-受体拮抗剂对豚鼠胃腺磷脂酰胆碱合成的影响 [Effect of teprenone and H2-receptor antagonists on phosphatidylcholine synthesis in the isolated guinea pig gastric glands]. |
已发布 PubMed:香叶基香叶基丙酮 geranyl-geranyl-acetone: 在狗中释放促胰液素的新型刺激剂。 a novel stimulant of secretin release in the dog. |
已发布 PubMed:四异戊烯基丙酮的作用 Effect of tetraprenylacetone, 新型抗溃疡药 a novel anti-ulcer agent, 对乙醇引起的大鼠胃损伤的愈合过程 on healing process of ethanol-induced gastric injury in rat. |
已发布 PubMed:剂对胃黏液理化性质的影响 Effect of antiulcer agents on the physicochemical properties of gastric mucus. |
已发布 PubMed:使用计算机图像处理系统测量胃粘液。 The measurement of gastric mucus using a computer image processing system. |
已发布 PubMed:对生姜成分的抗溃疡作用。 The anti-ulcer effect in rats of ginger constituents. |
已发布 PubMed:丹磺酰肼的荧光衍生高效液相色谱法测定 血浆中的四异戊基丙酮。 Determination of tetraprenylacetone in human plasma by high-performance liquid chromatography with fluorescence derivatization using dansylhydrazine. |
已发布 PubMed:四丙烯基丙酮对 的胃细胞保护作用。 Gastric cytoprotection by tetraprenylacetone in human subjects. |
已发布 PubMed:[抗溃疡药的给药方案,以防止消化性溃疡的复发;消化性溃疡保护因子协同药物的临床应用-根据临床症状和给药方法选择药物的标准] [Drug administration schedule of anti-ulcer agents to prevent recurrence of peptic ulcer; administration of synergistic drugs for protective factors in peptic ulcer--criteria of drug selection according to clinical symptoms and administration methods]. |
已发布 PubMed:香叶基香叶基丙酮对醇性胃粘膜损伤的保护作用 Protection against alcohol-induced gastric mucosal injury by geranylgeranylacetone: 消炎痛的作用。 effect of indomethacin. |
已发布 PubMed: 牛磺胆酸/ 盐酸 HCl单独或用香叶基香叶基丙酮预处理后对大鼠胃粘膜磷脂代谢的影响 |
已发布 PubMed:geranylgeranylacetone增强胃粘液的脂质含量和物理性质。 Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone. |
已发布 PubMed:香叶基香叶基丙酮的尿液和微粒体代谢产物的鉴定 Identification of urinary and microsomal metabolites of geranylgeranylacetone in rats. |
已发布 PubMed:向大鼠给药14c-香叶基香叶基丙酮后将放射性掺入氨基酸和脂肪酸中。 Incorporation of radioactivity into amino acids and fatty acids after administration of 14C-geranylgeranylacetone to rats. |
已发布 PubMed:消化性溃疡疾病药物治疗的新进展。 Advances in drug therapy for peptic ulcer disease. |
已发布 PubMed:戊酸酮对 胃分泌物中磷脂含量的影响 Effect of teprenone on the content of phospholipids in gastric secretion in man. |
已发布 PubMed:替普利酮的增强作用 Increasing action of teprenone, 一种新的抗溃疡药 a new anti-ulcer agent, 对乙酸诱导的大鼠溃疡愈合过程中胃粘液中高分子量糖蛋白的影响 on high-molecular-weight glycoprotein in gastric mucus during the healing process of acetic acid-induced ulcer in rats. |
已发布 PubMed:戊四烯基丙酮对乙醇诱导的大鼠胃粘膜损伤的保护作用 Protective action of tetraprenylacetone against ethanol-induced damage in rat gastric mucosa. |
已发布 PubMed:Geranylgeranylacetone, 新型抗溃疡药 a novel anti-ulcer agent, 甲氟喹对大鼠红细胞胆碱/ mg2 +反向转运的刺激作用。 stimulates mucus synthesis and secretion in rat gastric cultured cells. |
已发布 PubMed:替普利酮的促进愈合作用 Healing-promoting action of teprenone, 一种新的抗乙酸性溃疡大鼠抗溃疡药。 a new antiulcer agent on acetic acid ulcer in rats. |
已发布 PubMed:患者血清和胃组织中香叶基香叶基丙酮的含量。 Serum and stomach tissue levels of geranylgeranylacetone in patients. |
已发布 PubMed:香叶基香叶基丙酮对阿司匹林诱导的胃糖蛋白变化的影响 Effect of geranylgeranylacetone on aspirin-induced changes in gastric glycoproteins. |
已发布 PubMed:无环聚异戊二烯对大鼠冷约束应激性胃溃疡的保护作用 Effect of synthetic acyclic polyisoprenoids on the cold-restraint stress induced gastric ulcer in rats. |
已发布 PubMed:香叶基香叶基丙酮(gga)对局部阿司匹林加盐酸致胃损伤的作用 Effect of geranylgeranylacetone (GGA) on gastric lesions induced by topical aspirin plus HCl. |
已发布 PubMed:气相色谱-质谱法测定血清中抗溃疡药香叶基香叶基丙酮的含量 Determination of the anti-ulcer agent geranylgeranylacetone in serum by gas chromatography-mass spectrometry. |
已发布 PubMed:(平均摩尔比为10摩尔)油酸和三羟甲基丙烷的烷氧基化衍生物的三酯,平均含有120摩尔环氧乙烷和10摩尔环氧丙烷 [Study on the kinetics of mucus secreting cells in the gastrointestinal tract --effects of various drugs and hormones on the cell kinetics of the generative zone in mouse gastric mucosa]. |
已发布 PubMed:抗溃疡药香叶基香叶基丙酮对阿司匹林诱导的大鼠胃溃疡的治疗作用。 Effects of the antiulcer drug geranylgeranylacetone on aspirin-induced gastric ulcers in rats. |
已发布 PubMed:香叶基香叶基丙酮对大鼠胃肠道分泌的影响 Effects of geranylgeranylacetone on gastrointestinal secretion in rats. |
已发布 PubMed:环戊二烯异戊二烯对大鼠肝微粒体中甘露糖标记的糖脂生物合成的影响 Effect of acyclic polyisoprenoids on the biosynthesis of mannose-labeled glycolipids in rat liver microsomes. |
已发布 PubMed:[前列腺素e2的作用 [Effect of prostaglandin E2, 西咪替丁 cimetidine and 香叶基香叶基丙酮 geranyl-geranyl-acetone on rat 胃的 gastric 黏膜的 黏mucosal 损伤 damage (author's 翻译 transl)]. |
已发布 PubMed:香叶基香叶基丙酮的抗溃疡作用 Antiulcer effect of geranylgeranylacetone, 一种新的无环聚异戊二烯对实验性大鼠胃和十二指肠溃疡的作用。 a new acyclic polyisoprenoid on experimentally induced gastric and duodenal ulcers in rats. |