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类别 Category:natural substances and extractives
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 出现 Appearance: | 黄至棕色粉末（est） yellow to brown powder (est) |
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 沸点 Boiling Point: | 374.00 to 375.00 °C. @ 760.00 mm 汞 Hg
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| 蒸汽压力 Vapor Pressure: | 0.000001 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
| 闪点 Flash Point: | 525.00 °F. tcc TCC ( 273.89 °C. )
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| logp（o / w） logP (o/w): | 5.188（est） 5.188 (est) |
| 保质期 Shelf Life: | 如果正确存放，则为12.00个月或更长时间。 12.00 month(s) or longer if stored properly. |
| 存储 Storage: | 在密封容器中冷藏。 refrigerate in tightly sealed containers. |
| 溶于 Soluble in: |
| | alcohol | | | 水 water, 略 slightly | | | 水 water, 25°C（3.24 mg / l）（est） 3.284 mg/L @ 25 °C (est) |
| 不溶于 Insoluble in: |
| | 水 water |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
| 首选sds SDS : 视图 View |
| 欧洲信息 European information : |
| 最重要的危害 Most important hazard(s): | | 无-找不到。 None - None found. |
S 02 - 保持 Keep out of the 达到 reach of 孩子们 children.
S 22 - do Do not 呼吸 breath dust.
S 24/25 - 避免 Avoid contact with skin 皮 and 眼睛 eyes.
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| 危害识别 Hazards identification |
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| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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| 象形图 Pictogram | |
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| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
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未定 Not determined
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| 皮肤毒性 Dermal Toxicity: |
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未定 Not determined
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| 吸入毒性 Inhalation Toxicity: |
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未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | natural substances and extractives |
| 戊烯酸用量建议 Recommendation for valerenic acid usage levels up to: | | | 不用于香水。 not for fragrance use.
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| 戊酸酸使用量的推荐水平 Recommendation for valerenic acid flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
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安全参考 Safety references:
参考资料 References:
| | （e）-3-[（4s (E)-3-[(4S,7r 7R,7ar）-3 7aR)-3,7-二甲基-2 7-dimethyl-2,4,5,6,7,7a-六氢-1h-茚满-4-基] -2-甲基丙-2-烯酸 7a-hexahydro-1H-inden-4-yl]-2-methylprop-2-enoic acid |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| pubchem（cid） Pubchem (cid): | 6440940 |
| pubchem（sid） Pubchem (sid): | 135115560 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, food, 其他） other): note
同义词 Synonyms:
| （2e）-3-[（4s (2E)-3-[(4S,7r 7R,7ar）-3 7aR)-3,7- | dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylacrylic acid | | （2e）-3-[（4s (2E)-3-[(4S,7r 7R,7ar）-3 7aR)-3,7- | dimethyl-2,4,5,6,7,7a-六氢-1h-茚满-4-基] -2-甲基丙-2-烯酸 7a-hexahydro-1H-inden-4-yl]-2-methylprop-2-enoic acid | | （e）-3-[（4s (E)-3-[(4S,7r 7R,7ar）-3 7aR)-3,7- | dimethyl-2,4,5,6,7,7a-六氢-1h-茚满-4-基] -2-甲基丙-2-烯酸 7a-hexahydro-1H-inden-4-yl]-2-methylprop-2-enoic acid | | （2e）-3-[（4s (2E)-3-[(4S,7r 7R,7ar）-2 7aR)-2,4,5,6,7,7a- | hexadydro-3,7-二甲基-1h-茚满-4-基] -2-甲基- 7-dimethyl-1H-inden-4-yl]-2-methyl-2-丙酸 2-propenoic acid | | (4S-(4alpha(E),7测试版 7beta,7aalpha））-3-（2 7aalpha))-3-(2,4,5,6,7,7a- | hexahydro-3,7-dimethyl-1H-inden-4-yl)-2-methyl-2-丙酸 2-propenoic acid | | 2- | propenoic acid, 3-[（4s 3-[(4S,7r 7R,7ar）-2 7aR)-2,4,5,6,7,7a-六氢-3 7a-hexahydro-3,7-二甲基-1h-茚满-4-基] -2-甲基- 7-dimethyl-1H-inden-4-yl]-2-methyl-, （2e）- (2E)- | | | valerenicacid | | | 缬草酸 valerinic acid |
文章 Articles:
| 已发布 PubMed:戊烯酸酯作为潜在的前药。 Esters of valerenic acid as potential prodrugs. |
| 已发布 PubMed: 修订的纳达尔 nardal和纳丁 nardin结构 : 与戊戊醛和戊烯酸同一性。 identity with valerenal and valerenic acid. |
| 已发布 PubMed:缬草提取物及其主要成分 Valeriana officinalis extract and its main component, valerenic acid, 减轻d-半乳糖引起的记忆力减退 ameliorate D-galactose-induced reductions in memory, 细胞增殖 cell proliferation, 通过降低皮质酮水平和脂质过氧化作用来分化成橙花细胞。 and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation. |
| 已发布 PubMed:缬草和西洋樱的抗氧化作用及生物活性成分的研究。 Antioxidant effect and study of bioactive components of Valeriana sisymbriifolia and Nardostachys jatamansii in comparison to Valeriana officinalis. |
| 已发布 PubMed:valerena-1的功能鉴定 Functional identification of valerena-1,10-二烯合酶 10-diene synthase, 萜合酶催化缬草中生物活性倍半萜的生物合成中的独特化学级联反应。 a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis. |
| 已发布 PubMed:以高戊烯酸和低乙酰氧基戊酸含量为特征的缬草提取物具有抗焦虑活性。 Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity. |
| 已发布 PubMed:缬草在斑马鱼中的抗焦虑特性 Anxiolytic properties of Valeriana officinalis in the zebrafish: 代谢型谷氨酸受体的可能作用。 a possible role for metabotropic glutamate receptors. |
| 已发布 PubMed:酶法合成缬草4 Enzymatic synthesis of valerena-4,7（11）-二烯由缬草植物（缬草）的独特倍半萜合酶合成。 7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). |
| 已发布 PubMed:静脉和口服给药后戊戊酸在大鼠体内的药代动力学。 Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations. |
| 已发布 PubMed:高效，可扩展的一锅合成2 Efficient and scalable one-pot synthesis of 2,环烯酮的4-二烯醇 4-dienols from cycloalkenones: 优化了戊烯酸总合成。 optimized total synthesis of valerenic acid. |
| 已发布 PubMed:三相中空纤维lpme与hplc-uv结合进行萃取 Three phases hollow fiber LPME combined with HPLC-UV for extraction, 缬草中戊烯酸富集和测定。 preconcentration and determination of valerenic acid in Valeriana officinalis. |
| 已发布 PubMed:缬草提取物和缬草酸与[h]谷氨酸结合至大鼠突触膜的选择性相互作用。 Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes. |
| 已发布 PubMed:遥测作为一种工具来测量缬草根提取物及其单一成分在小鼠中的镇静作用。 Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice. |
| 已发布 PubMed:老年妇女单次或多次服用缬草后戊酸药代动力学。 Pharmacokinetics of valerenic acid after single and multiple doses of valerian in older women. |
| 已发布 PubMed:valerena-4的简要合成 Concise synthesis of Valerena-4,7(11)-diene, 高活性镇静剂 a highly active sedative, 戊酸。 from valerenic acid. |
| 已发布 PubMed:戊酸衍生物作为新型亚基选择性gabaa受体配体-体外和体内表征。 Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization. |
| 已发布 PubMed:戊烯酸衍生物对gaba（a）受体的高效调节。 Highly potent modulation of GABA(A) receptors by valerenic acid derivatives. |
| 已发布 PubMed:缬草根提取物对实验大鼠具有有效的抗焦虑作用。 Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. |
| 已发布 PubMed:共生的丛枝菌根真菌对根的定殖增加了缬草中倍半萜酸浓度。 Root colonization by symbiotic arbuscular mycorrhizal fungi increases sesquiterpenic acid concentrations in Valeriana officinalis L. |
| 已发布 PubMed:缬草提取物对孤立的 非怀孕子宫肌的松弛作用。 Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle. |
| 已发布 PubMed:戊烯酸全合成 Total synthesis of valerenic acid, 有力的gabaa受体调节剂。 a potent GABAA receptor modulator. |
| 已发布 PubMed:离体灌流大鼠肝脏中戊酸肝代谢和 排泄 Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: mrp2（abcc2）的角色。 role of Mrp2 (Abcc2). |
| 已发布 PubMed:缬草的Gabaa受体调节剂及其衍生物的转运。 s。 l。跨血脑屏障的体外细胞培养模型。 Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier. |
| 已发布 PubMed:gaba a受体作为缬草酸抗焦虑作用的体内底物 GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, 缬草根提取物的主要成分。 a major constituent of valerian root extracts. |
| 已发布 PubMed:基于hplc的活性分析方法，用于在非洲爪蟾卵母细胞上使用自动化的两个微电极电压钳测定法来发现gabaa受体配体。 HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes. |
| 已发布 PubMed:缬草化学成分研究 [Studies on chemical constituents of Valeriana officinalis]. |
| 已发布 PubMed:缬草的精油成分根植于伊朗。超临界二氧化碳萃取和加氢蒸馏的对比分析。 Essential oil composition of Valeriana officinalis L. roots cultivated in Iran. Comparative analysis between supercritical CO2 extraction and hydrodistillation. |
| 已发布 PubMed:缬草提取物对Gabaa受体的调节与戊烯酸含量有关。 Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. |
| 已发布 PubMed: [gc GC-MS分析五种不同的中国沉香中的挥发性成分]。 |
| 已发布 PubMed:戊酸增强并抑制gaba（a）受体 Valerenic acid potentiates and inhibits GABA(A) receptors: 分子机制和亚基特异性。 molecular mechanism and subunit specificity. |
| 已发布 PubMed:缬草的作用 Effect of valerian, 缬草/蛇麻草提取物 valerian/hops extracts, 和缬草酸对体外葡萄糖醛酸化的影响。 and valerenic acid on glucuronidation in vitro. |
| 已发布 PubMed:缬草的nf-kappab调节剂。 NF-kappaB modulators from Valeriana officinalis. |
| 已发布 PubMed:[3h]氟硝西m和[3h] mk-801与大鼠突触膜结合的商业缬草相互作用。 Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes. |
| 已发布 PubMed:缬草种的化学指纹图谱 Chemical fingerprinting of valeriana species: 同时测定戊酸 simultaneous determination of valerenic acids, 类黄酮 flavonoids, 和苯丙烷类化合物，采用液相色谱-紫外检测。 and phenylpropanoids using liquid chromatography with ultraviolet detection. |
| 已发布 PubMed:在健康受试者中服用缬草后，缬草酸药代动力学。 Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects. |
| 已发布 PubMed:缬草提取物和缬草酸是5-ht5a受体在体外的部分激动剂。 Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. |
| 已发布 PubMed:从缬草根茎中提取缬草酸。 Extraction of valerenic acids from valerian (Valeriana officinalis L.) rhizomes. |
| 已发布 PubMed:缬草根提取物对 细胞色素p450 3a4的体外活性。 In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. |
| 已发布 PubMed:在健康志愿者中，夜间多次服用缬草（valeriana officinalis）对cyp3a4的活性影响最小，而对cyp2d6的活性则没有影响。 Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. |
| 已发布 PubMed:缬草地面物质和提取物的稳定性控制 Stability control of valerian ground material and extracts: 一种新的hplc方法，用于戊二烯酸和木脂素的常规定量。 a new HPLC-method for the routine quantification of valerenic acids and lignans. |
| 已发布 PubMed:缬草精油。商业有机栽培条件下，收获时间对其品种及其抗菌活性的影响。 Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. |
| 已发布 PubMed:藤黄素的镇静和增强睡眠特性 Sedative and sleep-enhancing properties of linarin, 从缬草中分离出的类黄酮。 a flavonoid-isolated from Valeriana officinalis. |
| 已发布 PubMed:缬草和戊烯酸对大鼠脑干橙花元活性的γ-氨基丁酸能作用。 The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. |
| 已发布 PubMed:从缬草片中体外释放缬草酸和羟基戊烯酸。 In vitro release of valerenic and hydroxyvalerenic acids from valerian tablets. |
| 已发布 PubMed:（-）-3 Beta (-)-3 beta,缬草中的4个β-环氧戊烯酸。 4 beta-epoxyvalerenic acid from Valeriana officinalis. |
| 已发布 PubMed:澳大利亚有商业化的缬草制剂中的戊酸和缬草酸。 Valepotriates and valerenic acids in commercial preparations of valerian available in Australia. |
| 已发布 PubMed:毛细管电泳法分析缬草中的倍半萜。 Analysis of sesquiterpenes in Valeriana officinalis by capillary electrophoresis. |
| 已发布 PubMed:多导睡眠图评估缬草标准化提取物对失眠患者的催眠作用。 Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia. |
| 已发布 PubMed:戊戊烯酸衍生物和戊三酸酯 Valerenic acid derivatives and valepotriates among individuals, 缬草的品种和种类。 varieties and species of Valeriana. |
| 已发布 PubMed:缬草活动的科学依据。 The scientific basis for the reputed activity of Valerian. |
| 已发布 PubMed:缬草成分和缬草tin的细胞毒性潜力。 Cytotoxic potential of valerian constituents and valerian tinctures. |
| 已发布 PubMed:精油的季节性变化 Seasonal variation of the essential oil, 戊酸及其衍生物 valerenic acid and derivatives, 缬草根和根茎中的叶和绒毛 and velopotriates in Valeriana officinalis roots and rhizomes, 以及选择适合植物药的植物。 and the selection of plants suitable for phytomedicines. |
| 已发布 PubMed:缬草相互作用的体外研究。提取物及其氨基酸对大鼠脑中gabaa受体的影响。 In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain. |
| 已发布 PubMed:戊酸在小鼠中枢橙花抑制活性。 Central nervous depressant activity of valerenic Acid in the mouse. |
| 已发布 PubMed:戊酸在小鼠中枢橙花抑制活性。 Central nervous depressant activity of valerenic Acid in the mouse. |
| 已发布 PubMed:戊烯酸衍生物对γ-氨基丁酸分解代谢的抑制作用 [Inhibition of gamma-aminobutyric acid catabolism by valerenic acid derivatives]. |
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3D/INCHI