气味 Odor: characteristic

采用 Use: 西西马汀是从微茶中提取的草药。西西马汀具有 Cirsimaritin is purified from the herbs of Microtea debilis. Cirsimaritin has

气味 Odor: characteristic

采用 Use: 西西马汀浓度依赖性地抑制了超氧阴离子（o（*-）（2））的生成和o（2）的消耗（ic（50）11.5 +/- 2.2 微 microm和17.0 +/- 3.9 微 microm , 中性粒细胞。西西马汀没有减少 respectively) of neutrophils. Cirsimaritin did not reduce, 3-苯基丙酸丁酯3-苯基-2-丙酸丁酯3-苯基丙-2-烯酸丁酯3-苯基丙酸丁酯β-苯基丙烯酸丁酯肉桂酸酯丁基丙烯酸丁酯肉桂酸丁酯肉桂酸正丁酯3-苯基2-丙烯酸丁酯 but slightly enhanced the O(*-)(2) generation in phorbol 12-myristate 13-acetate (PMA)-activated or arachidonic acid-stimulated NADPH oxidase preparation as well as during the autoxidation of dihydroxyfumaric acid. Cirsimaritin did not elevate cellular cAMP levels, 并且仅在存在或不存在细胞外ca（2+）的情况下部分抑制了fmlp诱导的[ca（2 +）]（i）变化。蛋白酪氨酸磷酸化 and only partially inhibited the fMLP-induced [Ca(2+)](i) changes in the presence or absence of extracellular Ca(2+). The phosphorylation of protein tyrosine, cirsimaritin以浓度依赖的方式减弱由fmlp引起的细胞外信号调节蛋白激酶和akt。相反 extracellular signal-regulated protein kinase and Akt caused by fMLP were attenuated by cirsimaritin in a concentration-dependent manner. In contrast, 西西马力汀对p38丝裂原活化蛋白激酶的磷酸化没有影响。西西马汀在磷脂酸和磷脂酰乙醇的形成中产生浓度依赖性的减少 cirsimaritin had no effect on the phosphorylation of p38 mitogen-activated protein kinase. Cirsimaritin produced a concentration-dependent reduction in the formation of phosphatidic acid and phosphatidylethanol, 在乙醇的存在下 in the presence of ethanol, 来自fmlp刺激的中性粒细胞（ic（50）15.1 +/- 6.5微米和15.6 +/- 3.4微米 from fMLP-stimulated neutrophils (IC(50) 15.1+/-6.5 micro M and 15.6+/-3.4 micro M, 分别） respectively), 但不影响对pma的磷脂酰乙醇的形成。在相似的浓度范围内 but did not affect the phosphatidylethanol formation in response to PMA. Under the similar concentration range, 西西马汀减弱了arf和rho a的膜移位。然而 cirsimaritin attenuated the membrane translocation of ARF and Rho A. However, 细胞裂解物中gtpgammas刺激的膜相关arf和rho不受西西马汀的影响。集体地 the GTPgammaS-stimulated membrane-associated ARF and Rho in cell lysate were unaffected by cirsimaritin. Collectively, 通过防止水分或水的逸出，可保持皮肤或化妆品的水分含量。丙二醇是使用最广泛的化妆品成分之一 these results indicate that the inhibition of fMLP-induced respiratory burst by cirsimaritin in rat neutrophils is likely mainly through the blockade of phospholipase D signaling pathway.