matrine
Matridin-15-一 matridin-15-one

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    519-02-8苦参碱> 98% 519-02-8 Matrine >98%
    苦参碱((+)-苦参碱)是一种生物碱,存在于槐属植物中 Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, 具有多种药理作用 which has a variety of pharmacological effects, 包括抗癌作用 including anti-cancer effects, 和作为κ 受体激动剂的作用。 and action as a kappa opioid receptor agonist.
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    gp0925苦参碱 GP0925 Matrine
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    m2120苦参碱> 98.0%(gc)(t) M2120 Matrine >98.0%(GC)(T)
CAS号 CAS Number: 519-02-8Picture of molecule3D/INCHI
FDA UNII:N390W430AC
贝尔斯坦数 Beilstein Number:0085851
MDL :mfcd00210527 MFCD00210527
XlogP3-AA:1.60(est) 1.60 (est)
分子量 Molecular Weight:248.36948000
式 Formula:c15 h24 n2 o C15 H24 N2 O
生物活性总结 BioActivity Summary:清单 listing
核磁共振预测器 NMR Predictor:预测(适用于Chrome或Firefox) Predict (works with chrome or firefox)
类别 Category:antioxidants
 
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
谷歌学术 Google Scholar:搜索 Search
谷歌书 Google Books:搜索 Search
谷歌学术 Google Scholar: with word "volatile"搜索 Search
谷歌学术 Google Scholar: with word "flavor"搜索 Search
谷歌学术 Google Scholar: with word "odor"搜索 Search
谷歌专利 Google Patents:搜索 Search
美国专利 US Patents:搜索 Search
欧盟专利 EU Patents:搜索 Search
pubchem专利 Pubchem Patents:搜索 Search
已发布 PubMed:搜索 Search
NCBI:搜索 Search
 
物理性质 Physical Properties:
化验 Assay: 95.00至100.00 95.00 to 100.00
食品化学品法典列表 Food Chemicals Codex Listed: No
熔点 Melting Point: 76.00 °C. @ 760.00 mm 汞 Hg
沸点 Boiling Point: 396.00 to 397.00 °C. @ 760.00 mm 汞 Hg (est)
闪点 Flash Point: 343.00 °F. tcc TCC ( 172.70 °C. ) (est)
logp(o / w) logP (o/w): 1.440(est) 1.440 (est)
溶于 Soluble in:
 水 water, 251.5°C(估计值)831.5 mg / l 831.5 mg/L @ 25 °C (est)
 
感官特性 Organoleptic Properties:
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found).
 
化妆品信息 Cosmetic Information:
CosIng:化妆品数据 cosmetic data
化妆品用途 Cosmetic Uses: antioxidants
皮肤调理 skin conditioning
 
供应商 Suppliers:
AuNutra® 行业 Industries
苦参碱 Matrine P.E.
BOC Sciences
仅供实验/研究使用。 For experimental / research use only.
苦参碱> 98% Matrine >98%
气味 Odor: characteristic
采用 Use: 苦参碱((+)-苦参碱)是一种生物碱,存在于槐属植物中 Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, 具有多种药理作用 which has a variety of pharmacological effects, 包括抗癌作用 including anti-cancer effects, 和作为κ 受体激动剂的作用。 and action as a kappa opioid receptor agonist.
库姆波 Coompo
仅供实验/研究使用。 For experimental / research use only.
Matrine from 植物 Plants ≥95%
气味 Odor: characteristic
采用 Use: 苦参碱具有多种药理作用 Matrine has a variety of pharmacological effects, 包括抗癌作用 including anti-cancer effects, 作为κ 受体和受体激动剂起作用。 and action as a kappa opioid receptor and �-receptor agonist. 苦参碱在体内外均具有很强的抗肿瘤活性。抑制细胞增殖和诱导细胞凋亡是苦参碱抗肿瘤活性的可能机制。 Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities. 主要临床应用是治疗癌症患者 The main clinical applications are treatment of people with cancer, 性肝炎 viral hepatitis, 心脏病(如 性心肌炎) cardiac diseases (such as viral myocarditis), 和皮肤疾病(如牛皮癣和湿疹)。 and skin diseases (such as psoriasis and eczema).
Glentham Life Sciences
Matrine
圣克鲁斯生物技术 Santa Cruz Biotechnology
仅供实验/研究使用。 For experimental / research use only.
苦参碱≥98% Matrine ≥98%
陕西浩康生物科技 Shaanxi Haokang Bio-technology
苦参提取物(2.5%苦参碱) Sophorae Flavescentis Extract (2.5% Matrine)
西格玛·奥尔德里奇 Sigma-Aldrich: 西格玛 Sigma
仅供实验/研究使用。 For experimental / research use only.
Matrine
TCI AMERICA
仅供实验/研究使用。 For experimental / research use only.
苦参碱> 98.0%(gc)(t) Matrine >98.0%(GC)(T)
 
安全信息 Safety Information:
首选SDS Preferred SDS: 视图 View
 
危害识别 Hazards identification
 
物质或混合物的分类 Classification of the substance or mixture
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
没有找到。 None found.
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements
 
象形图 Pictogram
 
危险说明 Hazard statement(s)
没有找到。 None found.
防范说明 Precautionary statement(s)
没有找到。 None found.
口服/肠胃外毒性 Oral/Parenteral Toxicity:
腹膜内大鼠 intraperitoneal-rat LD50 125 mg/kg
Chemical and 制药业 Pharmaceutical 通报 Bulletin. 卷 Vol. 18, pg. 2555 Pg. 2555, 1970.

静脉老鼠 intravenous-mouse LD50 64.85 mg/kg
Zhongguo 药学 Yaoxue 杂志 Zazhi. 中文 Chinese 药学的 Pharmacuetical 日志 Journal. 卷 Vol. 27, pg。 201 Pg. 201, 1992.

腹腔内小鼠 intraperitoneal-mouse LD50 150 mg/kg
Zhongcaoyao. 中文 Chinese 传统的 Traditional and 草药 Herbal 药物 Medicine. 卷 Vol. 18, pg。 214 Pg. 214, 1987.

肌内小鼠 intramuscular-mouse LD50 74150 ug ug/kg
Zhongguo 药学 Yaoxue 杂志 Zazhi. 中文 Chinese 药学的 Pharmacuetical 日志 Journal. 卷 Vol. 27, pg。 201 Pg. 201, 1992.

静脉老鼠 intravenous-mouse LD50 64850 ug ug/kg
Zhongguo 药学 Yaoxue 杂志 Zazhi. 中文 Chinese 药学的 Pharmacuetical 日志 Journal. 卷 Vol. 27, pg。 201 Pg. 201, 1992.

皮肤毒性 Dermal Toxicity:
未定 Not determined
吸入毒性 Inhalation Toxicity:
未定 Not determined
 
使用安全信息 Safety in Use Information:
类别 Category: antioxidants
苦参使用水平的建议 Recommendation for matrine usage levels up to:
 不用于香水。 not for fragrance use.
 
苦参风味使用水平的推荐值 Recommendation for matrine flavor usage levels up to:
 不用于调味料。 not for flavor use.
 
安全参考 Safety references:
Epi系统 EPI System: 视图 View
辅助引文 AIDS Citations:搜索 Search
癌症引文 Cancer Citations:搜索 Search
毒理学引文 Toxicology Citations:搜索 Search
EPA ACToR:毒理学资料 Toxicology Data
EPA物质注册服务(SRS) :注册表 Registry
实验室化学安全摘要 Laboratory Chemical Safety Summary :638232
国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data
德国wgk WGK Germany:3
chemidplus Chemidplus:0000519028
技术 RTECS:适用于CAS#519-02-8的oq1754000 OQ1754000 for cas# 519-02-8
 
参考资料 References:
NIST化学网络书籍 NIST Chemistry WebBook: 搜索INCHI
pubchem(cid) Pubchem (cid):638232
pubchem(sid) Pubchem (sid):135048634
 
其他资料 Other Information:
(iupac) (IUPAC):元素的原子量2009 Atomic Weights of the Elements 2009
(iupac) (IUPAC):元素的原子量2009(pdf) Atomic Weights of the Elements 2009 (pdf)
影片 Videos:元素周期表 The Periodic Table of Videos
RBC :本网站使用的原子量 Atomic Weights use for this web site
(iupac) (IUPAC):元素周期表 Periodic Table of the Elements
hmdb(人类代谢组数据库) HMDB (The Human Metabolome Database):搜索 Search
出口关税代码 Export Tariff Code:2933.99.9700
vcf在线 VCF-Online:食品中的挥发性有机化合物 VCF Volatile Compounds in Food
化学蜘蛛 ChemSpider:视图 View
维基百科 Wikipedia:视图 View
rsc学习化学 RSC Learn Chemistry:视图 View
 
潜在搅拌机 Potential Blenders and 核心组件 core components note
没找到 None Found
 
潜在用途 Potential Uses:
没找到 None Found
 
存在(自然 Occurrence (nature, 餐饮 food, 其他) other):note
 苦参 sophora flavescens
搜索 Search Trop Picture
 
同义词 Synonyms:
 Matridin-15-一 matridin-15-one
 

文章 Articles:

已发布 PubMed:天然植物药中治疗肥胖的有效成分。 Active ingredients from natural botanicals in the treatment of obesity.
已发布 PubMed:水果中苦参碱和小ber碱同时测定 Simultaneous determination of matrine and berberine in fruits, 蔬菜 vegetables, 高效液相色谱/串联质谱法测定土壤和土壤。 and soil using ultra-performance liquid chromatography/tandem mass spectrometry.
已发布 PubMed:通过基于液相色谱-串联质谱检测的稳定同位素稀释测定法对游离香豆素的定量分析及其从糖基化前体中的释放 Protective effects of matrine against progression of high-fructose diet-induced steatohepatitis by enhancing antioxidant and anti-inflammatory defences involving Nrf2 translocation.
已发布 PubMed:用非接触电导检测微流控芯片测定苦参碱注射液中的苦参碱。 [Determination of matrine in matrine injection by microfluidic chip with contactless conductivity detection].
已发布 PubMed:槐果碱和苦参碱抑制小鼠巨噬细胞中tnf-α和il-6的产生,并预防结肠26腺癌在小鼠中诱发的恶病质相关症状。 Sophocarpine and matrine inhibit the production of TNF-alpha and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice.
已发布 PubMed:HPLC法测定苦参碱脂质体中苦参碱含量。 [HPCE determination of matrine in matrine liposome].
已发布 PubMed:[疾病技术 [Techniques of diseases, 害虫和杂草的防治及其在生物合理大米生产中的功效] insect pests and weeds control and their efficacy in bio-rational rice production].
 
笔记 Notes:
苦参的生物碱具有驱虫活性。 alkaloid from sophora flavescens with anthelmintic activity.
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