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类别 Category:stabilising agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 化验 Assay: | 95.00至100.00 95.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 沸点 Boiling Point: | 609.45 °C. @ 760.00 mm 汞 Hg (est)
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| 蒸汽压力 Vapor Pressure: | 1.170000 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
| 闪点 Flash Point: | 638.00 °F. tcc TCC ( 336.40 °C. ) (est)
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| logp（o / w） logP (o/w): | 5.748（est） 5.748 (est) |
| 溶于 Soluble in: |
| | 水 water, 0.05987 mg / l @ 25°C（est） 0.05987 mg/L @ 25 °C (est) |
感官特性 Organoleptic Properties:
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
| 首选SDS Preferred SDS: 视图 View |
| |
| 危害识别 Hazards identification |
| |
| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
|
未定 Not determined
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| 皮肤毒性 Dermal Toxicity: |
|
未定 Not determined
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| 吸入毒性 Inhalation Toxicity: |
|
未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | stabilising agents |
| 推荐的最高使用量为亚洲酸 Recommendation for asiatic acid usage levels up to: | | | 不用于香水。 not for fragrance use.
|
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| 推荐的亚硝酸风味剂使用水平最高为 Recommendation for asiatic acid flavor usage levels up to: |
| | 不用于调味料。 not for flavor use.
|
安全参考 Safety references:
| Epi系统 EPI System: 视图 View |
| nlm NLM有害物质数据库 :搜索 Search |
| 癌症引文 Cancer Citations:搜索 Search |
| 毒理学引文 Toxicology Citations:搜索 Search |
| EPA ACToR:毒理学资料 Toxicology Data |
| EPA物质注册服务（SRS） :注册表 Registry |
| 实验室化学安全摘要 Laboratory Chemical Safety Summary :119034 |
| 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data |
| 德国wgk WGK Germany:3 |
| (1s (1S,2R,4as 4aS, 6a 6ar , 6a 6as , 6b 6br , 8a 8ar ,9r 9R,10r 10R,11r 11R,12ar 12aR,14bs）-10 14bS)-10,11-二羟基-9-（羟甲基）-1 11-dihydroxy-9-(hydroxymethyl)-1,2,6a 6a,6b 6b,9,12a-六甲基-2 12a-hexamethyl-2,3,4,5,6,6a 6a,7,8,8a 8a,10,11,12,13,14b-十四氢-1h-picene-4a-羧酸 14b-tetradecahydro-1H-picene-4a-carboxylic acid |
| chemidplus Chemidplus:0000464926 |
参考资料 References:
| | (1s (1S,2R,4as 4aS, 6a 6ar , 6a 6as , 6b 6br , 8a 8ar ,9r 9R,10r 10R,11r 11R,12ar 12aR,14bs）-10 14bS)-10,11-二羟基-9-（羟甲基）-1 11-dihydroxy-9-(hydroxymethyl)-1,2,6a 6a,6b 6b,9,12a-六甲基-2 12a-hexamethyl-2,3,4,5,6,6a 6a,7,8,8a 8a,10,11,12,13,14b-十四氢-1h-picene-4a-羧酸 14b-tetradecahydro-1H-picene-4a-carboxylic acid |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| pubchem（cid） Pubchem (cid): | 119034 |
| pubchem（sid） Pubchem (sid): | 135075428 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, food, 其他） other): note
同义词 Synonyms:
| | 积雪草酸 asiaticacid | | (1s (1S,2R,4as 4aS, 6a 6ar , 6a 6as , 6b 6br , 8a 8ar ,9r 9R,10r 10R,11r 11R,12ar 12aR,14bs）-10 14bS)-10,11- | dihydroxy-9-(hydroxymethyl)-1,2,6a 6a,6b 6b,9,12a-六甲基-2 12a-hexamethyl-2,3,4,5,6,6a 6a,7,8,8a 8a,10,11,12,13,14b-十四氢-1h-picene-4a-羧酸 14b-tetradecahydro-1H-picene-4a-carboxylic acid | | (2a (2a, 3b 3b）-2 ,3,23- | trihydroxyurs-12-en-28-oic acid | | | urs-12-en-28-oic acid, 2,3,23-三羟基 23-trihydroxy-, (2a (2a,3b 3b,4a)- | | | urs-12-en-28-oic acid, 2,3,23-三羟基 23-trihydroxy-, (2a (2a, 3b 3b）- |
文章 Articles:
| 已发布 PubMed:[从铁线莲的子叶的空中部分的三萜类。猕猴桃]。 [Triterpenes from aerial parts of Clematoclethra scandens subsp. actinidioides]. |
| 已发布 PubMed:积雪酸微生物转化。 Microbial transformation of asiatic acid. |
| 已发布 PubMed:谷胱甘肽偶联的积雪草酸负载牛血清白蛋白纳米颗粒的开发，用于脑靶向药物递送。 Development of glutathione-conjugated asiatic acid-loaded bovine serum albumin nanoparticles for brain-targeted drug delivery. |
| 已发布 PubMed:积雪草酸抗菌作用和作用方式。 Antibacterial effects and action modes of asiatic acid. |
| 已发布 PubMed:通过灵敏而强大的hplc-ms方法确定的积雪草中积雪草酸生物制药和药代动力学特征。 Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC-MS method. |
| 已发布 PubMed:积雪草酸可减轻l型诱发的高血压大鼠的心血管重塑。 Asiatic acid alleviates cardiovascular remodelling in rats with L-NAME-induced hypertension. |
| 已发布 PubMed:积雪草酸通过抑制线粒体介导的nlrp3炎性体活化来改善硫酸葡聚糖钠诱导的鼠实验性结肠炎。 Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation. |
| 已发布 PubMed:酸对成年大鼠海马空间工作记忆和细胞增殖的影响 Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus. |
| 已发布 PubMed:点地梅伊萨贝利娜异常微生物内酯化和积雪草酸羟基化。 Unusual microbial lactonization and hydroxylation of asiatic acid by Umbelopsis isabellina. |
| 已发布 PubMed:积雪草酸通过减弱 类肝癌hepg2细胞中p21（waf1 / cip1）的ndr1 / 2依赖性磷酸化来促进p21（waf1 / cip1）蛋白质的稳定性。 Asiatic acid promotes p21(WAF1/CIP1) protein stability through attenuation of NDR1/2 dependent phosphorylation of p21(WAF1/ CIP1) in HepG2 human hepatoma cells. |
| 已发布 PubMed:积雪草酸通过恢复enos / inos表达减轻血液动力学和代谢改变 Asiatic acid alleviates hemodynamic and metabolic alterations via restoring eNOS/iNOS expression, 氧化应激 oxidative stress, 和饮食诱发的代谢综合征大鼠的炎症反应。 and inflammation in diet-induced metabolic syndrome rats. |
| 已发布 PubMed:积雪酸抗焦虑和抗抑郁作用的评估 Evaluation of the anxiolytic and antidepressant effects of asiatic acid, 来自葛头可乐或积雪草的化合物 a compound from Gotu kola or Centella asiatica, 在雄性鼠疫dawley大鼠中。 in the male Sprague Dawley rat. |
| 已发布 PubMed:苯胺衍生的亚洲酸衍生物作为潜在抗癌药的合成及生物学评价。 Synthesis and biological evaluation of novel aniline-derived asiatic acid derivatives as potential anticancer agents. |
| 已发布 PubMed:积雪草酸在体外和体内均可诱导多形性胶质母细胞瘤细胞内质网应激和凋亡死亡。 Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo. |
| 已发布 PubMed:积雪草酸和柚皮素的平衡使tgf-β/ smad信号平衡来治疗肾纤维化。 Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin. |
| 已发布 PubMed:积雪草酸可降低血压可以通过调节enos和p47phox的表达增强一氧化氮致高血压大鼠的一氧化氮生物利用度。 Asiatic acid reduces blood pressure by enhancing nitric oxide bioavailability with modulation of eNOS and p47phox expression in L-NAME-induced hypertensive rats. |
| 已发布 PubMed:积雪草酸可减轻五味崎大鼠的高血糖症并减少胰岛纤维化 Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, 自发的2型糖尿病动物模型。 a spontaneous type 2 diabetic animal model. |
| 已发布 PubMed:糖尿病大鼠中积雪草酸通过pi3k / akt信号转导途径中glut4的易位和激活引起的葡萄糖摄取。 Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats. |
| 已发布 PubMed:积雪草酸抗氧化和抗炎活性 Antioxidative and antiinflammatory activities of asiatic acid, 甘草酸 glycyrrhizic acid, 和支气管上皮细胞中齐墩果酸含量 and oleanolic acid in human bronchial epithelial cells. |
| 已发布 PubMed:积雪草酸衍生物作为抗纤维化剂的合成与评价 Synthesis and evaluation of asiatic acid derivatives as anti-fibrotic agents: 结构/活性研究。 structure/activity studies. |
| 已发布 PubMed:积雪草酸对糖尿病大鼠的抗糖尿病和降血脂活性 Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, hmg HMG COA的作用 : 体内和计算机方法。 in vivo and in silico approaches. |
| 已发布 PubMed:去甲半乳糖处理的小鼠大脑中积雪草酸抗凋亡和抗糖基化作用。 Anti-apoptotic and anti-glycative effects of asiatic acid in the brain of D-galactose treated mice. |
| 已发布 PubMed:揭示了积雪草酸与 血清白蛋白的结合机理及其生物学意义。 Unraveling the binding mechanism of asiatic acid with human serum albumin and its biological implications. |
| 已发布 PubMed:牛cha子籽油牛蒡子亚种。从牛ju种子中提取的马朱斯籽油牛蒡子精油种子牛ma子牛至马朱斯籽油牛d子油固定油 Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway. |
| 已发布 PubMed:积雪草酸和山梨酸通过糖尿病小鼠的抗糖化和抗凝活性保护心脏。 Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice. |
| 已发布 PubMed:积雪草酸通过在体内外阻断转化生长因子-β1介导的肥大信号来减轻心脏肥大。 Asiatic acid attenuates cardiac hypertrophy by blocking transforming growth factor-β1-mediated hypertrophic signaling in vitro and in vivo. |
| 已发布 PubMed:积雪草酸对 角质形成细胞的抗糖化作用 Anti-glycative effects of asiatic acid in human keratinocyte cells. |
| 已发布 PubMed:积雪草酸可改善食用高脂饮食的小鼠的肝脂质蓄积和胰岛素抵抗。 Asiatic acid ameliorates hepatic lipid accumulation and insulin resistance in mice consuming a high-fat diet. |
| 已发布 PubMed:合成 Synthesis, 积雪草酸氨基酸衍生物的抗肿瘤和抗血管生成活性评估。 anti-tumor and anti-angiogenic activity evaluations of asiatic Acid amino Acid derivatives. |
| 已发布 PubMed:积雪草酸诱导的con a激活的t淋巴细胞线粒体依赖性凋亡可预防鼠源性暴发性肝炎。 Mitochondria-dependent apoptosis of con A-activated T lymphocytes induced by asiatic acid for preventing murine fulminant hepatitis. |
| 已发布 PubMed:积雪草酸抑制骨髓基质细胞的成脂分化。 Asiatic acid inhibits adipogenic differentiation of bone marrow stromal cells. |
| 已发布 PubMed:使用lc / it-msn对斑马鱼中积雪草酸及其类似物的酪烷酸代谢物进行结构分析。 Structural analysis of metabolites of asiatic acid and its analogue madecassic acid in zebrafish using LC/IT-MSn. |
| 已发布 PubMed:积雪酸微生物转化。 Microbial transformation of asiatic acid. |
| 已发布 PubMed:积雪草酸对pc12细胞氧葡萄糖剥夺/复氧损伤的保护作用 [The protective effect of asiatic acid against oxygen-glucose deprivation/reoxygenation injury of PC12 cells]. |
| 已发布 PubMed:积雪草酸对局灶性栓塞性中风大鼠的橙花保护作用 Neuroprotective effect of asiatic acid in rat model of focal embolic stroke. |
| 已发布 PubMed:积雪草酸可保护初级橙花元免受c2-橙花酰胺诱导的细胞凋亡。 Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis. |
| 已发布 PubMed:积雪草酸 asiatic acid, 三萜 a triterpene, 通过调节多发性骨髓瘤细胞中粘着斑激酶的表达来抑制细胞增殖。 inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells. |
| 已发布 PubMed:从积雪草分离的积雪草酸通过ppar-γ激活抑制 瘢痕loid成纤维细胞中tgf-β1诱导的胶原蛋白表达。 Asiatic acid isolated from Centella asiatica inhibits TGF-β1-induced collagen expression in human keloid fibroblasts via PPAR-γ activation. |
| 已发布 PubMed:积雪草酸改善输尿管梗阻小鼠的肾小管间质纤维化。 Asiatic acid ameliorates tubulointerstitial fibrosis in mice with ureteral obstruction. |
| 已发布 PubMed:积雪草酸功效 Efficacy of asiatic acid, 五环三萜烯对链脲佐菌素诱导的糖尿病大鼠糖代谢关键酶活性的减弱。 a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats. |
| 已发布 PubMed:中国小菜籽中的积雪草酸通过抑制氧化应激和枯否细胞活化来减轻乙醇诱导的肝损伤。 Asiatic acid from Potentilla chinensis attenuate ethanol-induced hepatic injury via suppression of oxidative stress and Kupffer cell activation. |
| 已发布 PubMed:抗增殖 Antiproliferative, 新型积雪草酸衍生物对 非小细胞肺癌细胞的细胞周期失调作用。 cell-cycle dysregulation effects of novel asiatic acid derivatives on human non-small cell lung cancer cells. |
| 已发布 PubMed:液相色谱/电喷雾串联质谱法定量测定血浆中的积雪草酸 A liquid chromatography/electrospray ionization tandem mass spectrometric method for quantification of asiatic acid from plasma: 在大鼠药代动力学研究中的应用。 application to pharmacokinetic study in rats. |
| 已发布 PubMed:积雪草酸对乙酰胆碱酯酶的抑制作用 Inhibitory effect of asiatic acid on acetylcholinesterase, 兴奋性突触后电位和运动活动。 excitatory post synaptic potential and locomotor activity. |
| 已发布 PubMed:积雪草酸 asiatic acid, 积雪草中的五环三萜 a pentacyclic triterpene in Centella asiatica, 减轻谷氨酸诱导的小鼠认知功能障碍和sh-sy5y细胞凋亡。 attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells. |
| 已发布 PubMed:积雪草酸可减轻梗死体积 Asiatic acid attenuates infarct volume, 线粒体功能障碍 mitochondrial dysfunction, 脑缺血后基质金属蛋白酶9和基质金属蛋白酶的诱导 and matrix metalloproteinase-9 induction after focal cerebral ischemia. |
| 已发布 PubMed:积雪草酸可保护链脲佐菌素诱导的糖尿病大鼠的β细胞量并减轻高血糖症。 Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats. |
| 已发布 PubMed:新积雪草酸衍生物的合成及抗肿瘤活性评价 Synthesis and antitumor activity evaluation of new asiatic acid derivatives. |
| 已发布 PubMed: 真菌镰刀菌（镰刀菌 Fusarium 燕麦 avenaceum）对积雪草酸进行生物转化获得的两种新的氧化产物为3.4594。 |
| 已发布 PubMed: 积雪草酸通过在体内和体外阻断tgf-beta beta / smad信号传导来抑制肝纤维化。 |
| 已发布 PubMed:microrna-1290通过降低a549非小细胞肺癌细胞中bcl2蛋白的水平来促进积雪草酸诱导的细胞凋亡。 MicroRNA-1290 promotes asiatic acid‑induced apoptosis by decreasing BCL2 protein level in A549 non‑small cell lung carcinoma cells. |
| 已发布 PubMed: 积雪酸对雄性sp生的 rawque-dawley大鼠被动和主动回避任务的影响 |
| 已发布 PubMed:积雪草酸可抑制内皮细胞培养模型中的vegf和 类橙花胶质瘤的促血管生成作用。 Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. |
| 已发布 PubMed:链格孢菌对亚洲酸微生物转化。 Microbial transformation of asiatic acid by Alternaria longipes. |
| 已发布 PubMed:积雪草酸 asiatic acid, 积雪草的五环三萜 a pentacyclic triterpene from Centella asiatica, 在局灶性脑缺血的小鼠模型中具有橙花保护作用。 is neuroprotective in a mouse model of focal cerebral ischemia. |
| 已发布 PubMed:积雪草酸通过线粒体死亡级联反应诱导结肠癌细胞生长抑制和凋亡。 Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade. |
| 已发布 PubMed:小鼠体内抗伤害性活性和积雪草酸抗炎机制。 Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. |
| 已发布 PubMed:茄苷A和积雪草酸调节与淀粉样β前体蛋白加工和淀粉样β蛋白清除相关的多个靶标。 Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance. |
| 已发布 PubMed:糖原磷酸化酶抑制剂的积雪草酸衍生物的合成和生物学评估。 Synthesis and biological evaluation of asiatic acid derivatives as inhibitors of glycogen phosphorylases. |
| 已发布 PubMed:通过氧化还原调节白三烯c4合酶表达途径，积雪草酸对d-半乳糖胺/脂多糖诱导的肝细胞和枯否细胞共培养系统的肝毒性的保护作用。 Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. |
| 已发布 PubMed:nf-κb灭活在未加工的264.7巨噬细胞中抑制积雪酸对lps诱导的no和pge2产生的抑制作用 Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: ikk和mapk途径可能参与其中。 possible involvement of the IKK and MAPK pathways. |
| 已发布 PubMed:积雪草酸和cpt-11对ht-29细胞生长的抑制作用。 Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells. |
| 已发布 PubMed:积雪草酸 asiatic acid, 三萜 a triterpene, 温带地区五种具有生态反差的树种在阳光和阴凉处诱导光合作用的过程以及限制的重要性。 induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. |
| 已发布 PubMed:积雪草酸对7的抑制作用 Inhibitory effects of asiatic acid on 7,12-二甲基苯并[a]蒽和12-o-十四烷酰佛波醇13-乙酸酯诱导的小鼠肿瘤生长。 12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. |
| 已发布 PubMed:积雪草酸衍生物可保护培养的皮质橙花元免受谷氨酸诱导的兴奋性毒性作用。 Asiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxicity. |
| 已发布 PubMed:抑制 角质形成细胞中积雪草酸和熊果酸对紫外线α调节的信号通路的抑制。 Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes. |
| 已发布 PubMed:柱前衍生化rp-hplc口服给予积雪草提取物后测定比格犬血浆中的积雪草酸。 Determination of asiatic acid in beagle dog plasma after oral administration of Centella asiatica extract by precolumn derivatization RP-HPLC. |
| 已发布 PubMed:从浓脂树胶树脂中分离出有效的杀微生物杀胚芽剂。 Search for a potent microbicidal spermicide from the isolates of Shorea robusta resin. |
| 已发布 PubMed:对健康志愿者单次或多次给药后，积雪草的总三萜成分的药代动力学。一种测定积雪草酸新方法。 Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid. |
| 已发布 PubMed:积雪草酸对鱼藤酮或过氧化氢诱导的sh-sy5y细胞损伤的保护作用。 Protective effects of asiatic acid on rotenone- or H2O2-induced injury in SH-SY5Y cells. |
| 已发布 PubMed:积雪草酸和熊果酸可增强铜绿假单胞菌生物膜对妥布霉素的敏感性。 Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. |
| 已发布 PubMed:积雪草酸衍生物部分通过改善乙酰胆碱合成来增强认知能力。 Asiatic acid derivatives enhance cognitive performance partly by improving acetylcholine synthesis. |
| 已发布 PubMed:积雪草酸影响 Influence of asiatic acid, 酪酸 madecassic acid, 和积雪草苷对 胶原i的合成。 and asiaticoside on human collagen I synthesis. |
| 已发布 PubMed:五环三萜与环丙沙星的结合有助于根除大肠杆菌在体外形成的生物膜。 Pentacyclic triterpenes combined with ciprofloxacin help to eradicate the biofilm formed in vitro by Escherichia coli. |
| 已发布 PubMed:积雪草酸衍生物通过细胞抗氧化剂系统保护大鼠肝细胞的原代培养物免受四氯化碳诱导的损伤。 Asiatic acid derivatives protect primary cultures of rat hepatocytes against carbon tetrachloride-induced injury via the cellular antioxidant system. |
| 已发布 PubMed:铁青树柴提取物的抗伤害性和抗炎活性。 Antinociceptive and anti-inflammatory activities of Schefflera octophylla extracts. |
| 已发布 PubMed:酸衍生物对β淀粉样蛋白（β）诱导的橙花毒性的构效关系研究。 Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity. |
| 已发布 PubMed:积雪草的多种活性成分和提取物对三种主要 类细胞色素p450酶的体外调节作用。 In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. |
| 已发布 PubMed:内质网的破坏和细胞质钙的增加是天然三萜类积雪草酸诱导的细胞死亡的早期事件。 Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid. |
| 已发布 PubMed:线粒体保护积雪草酸抗小鼠肝毒性的机理。 Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice. |
| 已发布 PubMed:积雪草酸衍生物在大鼠肝星状细胞系中的结构相关细胞毒性和抗肝纤维化作用 Structure-related cytotoxicity and anti-hepatofibric effect of asiatic acid derivatives in rat hepatic stellate cell-line, hsc-t6。 HSC-T6. |
| 已发布 PubMed:三萜类积雪草酸和甲基尸烷酸在水溶液中自组装的分子动力学模拟和热力学建模。 Molecular dynamics simulation and thermodynamic modeling of the self-assembly of the triterpenoids asiatic acid and madecassic acid in aqueous solution. |
| 已发布 PubMed:c2官能团对积雪草酸修饰和对肝保护作用的评估。 Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects. |
| 已发布 PubMed:结构作用亚硫酸衍生物作为新型伤口愈合剂的关系研究。 Structure-activity relationship study of asiatic acid derivatives for new wound healing agent. |
| 已发布 PubMed:积雪草酸诱导的胶质母细胞瘤细胞死亡。 Glioblastoma cell death induced by asiatic acid. |
| 已发布 PubMed:积雪草酸诱导sk-mel-2 黑素瘤细胞凋亡。 Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. |
| 已发布 PubMed:积雪草酸 asiatic acid, 三萜 a triterpene, 在hepg2 肝癌细胞中通过细胞内ca2 +释放和p53增强表达诱导凋亡。 induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells. |
| 已发布 PubMed:茉莉酸甲酯诱导的药用草本积雪草（l。）城市中三萜类化合物产生的代谢组学分析。 Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban. |
| 已发布 PubMed:皮肤科亚洲积雪 Centella asiatica in dermatology: 概述。 an overview. |
| 已发布 PubMed:新的亚洲酸衍生物的测定 Determination of a new asiatic acid derivative, 在大鼠血浆和尿液中为2-006a 6a , 高效液相色谱法测定 血浆。 and human plasma by high-performance liquid chromatography. |
| 已发布 PubMed:[同时测定马角asso苷 [Simultaneous determination of madecassoside, rp-hplc RP-hplc HPlc LC法测定积雪草（l。）城市提取物中的积雪草苷及其苷元。 |
| 已发布 PubMed:三个五环三萜保护h9c2心肌母细胞免受高糖诱导的伤害。 Three pentacyclic triterpenes protect H9c2 cardiomyoblast cells against high-glucose-induced injury. |
| 已发布 PubMed:[通过粉末玻璃上的薄层色谱法分离积雪草酸。洗脱液中甲草酸测定]。 [Separation of asiatic acid by thin-layer chromatography on powdered glass. Determination of asiatic acid on an eluate]. |
| 已发布 PubMed:[积雪草苷，尤其是积雪草酸化学组成。 vi。 α-淀粉胺系列中包含积雪草酸]。 [Chemical constitution of asiaticoside and especially of asiatic acid. VI. Inclusion of asiatic acid in the alpha-amyrine series]. |
| 已发布 PubMed:五环三萜及其新型合成衍生物抑制 肠道 71复制。 Inhibition of human enterovirus 71 replication by pentacyclic triterpenes and their novel synthetic derivatives. |
| 已发布 PubMed:十二指肠肿瘤的化学成分及其对ht-29细胞中IL-8产生的抑制作用。 Chemical constituents from Melastoma dodecandrum and their inhibitory activity on interleukin-8 production in HT-29 cells. |
| 已发布 PubMed:[来自冬青根的化学成分]。 [Chemical constituents from the roots of Ilex pubescens]. |
| 已发布 PubMed:积雪酸代谢 The metabolism of asiatic acid,酸和积雪草苷在大鼠体内。 -madecassic acid and asiaticoside in the rat. |
| 已发布 PubMed:淀粉样蛋白系列的三萜烯（山梨酸苷）对植物芽和生长的影响 [Effects of a triterpene (asiatic acid glycoside) of the amyrine series on plant germination and growth]. |
| 已发布 PubMed:离体灌流大鼠肝脏对 分泌的研究ii。另外两个五环三萜的作用 Studies on bile secretion with the aid of the isolated perfused rat liver. II. The effect of two further pentacyclic triterpenes, 积雪草酸和22β-angelyloxy齐墩果酸 oleanolic酸。 |
| 已发布 PubMed:[荷尔蒙 Hormonal action of the "皮质类固醇 corticosteroid type" of 2 三萜 三萜 tri萜烯 terpenes: 阿尿酸和积雪草酸]。 arjunolic acid and asiatic acid]. |
| 已发布 PubMed:和熊果酸对形态的影响 Effect of asiatic and ursolic acids on morphology, 疏水性 hydrophobicity, 和上皮细胞对尿道上皮细胞的粘附。 and adhesion of UPECs to uroepithelial cells. |
| 已发布 PubMed:生物活性植物天然产物诱导p-糖蛋白外排转运蛋白的表达和功能活性。 Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products. |
| 已发布 PubMed:三萜皂苷对环磷酰胺诱导的免疫和肝系统功能障碍的保护作用 Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: 其可能的作用机制。 its possible mechanisms of action. |
| 已发布 PubMed:澳大利亚积雪草中三萜和酚类化合物的季节性变化。 Seasonal Variation of Triterpenes and Phenolic Compounds in Australian Centella asiatica (L.) Urb. |
| 已发布 PubMed:影响积雪草原料中五环三萜含量的因素 Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials. |
| 已发布 PubMed:积雪草苷对大鼠皮质橙花元缺血缺氧的橙花保护作用。 Nerve Protective Effect of Asiaticoside against Ischemia-Hypoxia in Cultured Rat Cortex Neurons. |
| 已发布 PubMed:马德卡索活性成分的比较稳态生物利用度。 The comparative steady-state bioavailability of the active ingredients of Madecassol. |
| 已发布 PubMed:龙胆茎中酚和三萜皂苷的测定 [Determination of phenols and triterpenoid saponins in stems of Sargentodoxa cuneata]. |
| 已发布 PubMed:确定负责积雪草草药烧伤伤口愈合的主要活性成分。 Identification of Major Active Ingredients Responsible for Burn Wound Healing of Centella asiatica Herbs. |
| 已发布 PubMed:五环三萜类化合物抑制ikkβ介导的nf-κb途径的激活 Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: 计算机和体外证据。 In Silico and In Vitro Evidences. |
| 已发布 PubMed:忍冬忍冬根的化学成分研究 [Study on Chemical Constituents from Roots of Lonicera macranthoides]. |
| 已发布 PubMed: psiloxylon 毛里求斯 mauritianum（bouton ex hook.f.）baillon（桃金娘科） : 来自玛斯卡林群岛的有前途的传统药用植物。 A promising traditional medicinal plant from the Mascarene Islands. |
| 已发布 PubMed:重要草药活性成分的体外作用对 细胞色素p450 1a2（cyp1a2）活性的影响。 In vitro effect of important herbal active constituents on human cytochrome P450 1A2 (CYP1A2) activity. |
| 已发布 PubMed:积雪草苷 Asiaticoside, 积雪草的组成部分 a component of Centella asiatica, 抑制b16f10小鼠黑素瘤中的黑素生成。 inhibits melanogenesis in B16F10 mouse melanoma. |
| 已发布 PubMed:形态的 Morphological, 恒河印度平原商业化种植的积雪草种质的化学和分子特征。 chemical and molecular characterization of Centella asiatica germplasms for commercial cultivation in the Indo-Gangetic plains. |
| 已发布 PubMed:榄仁的果实中的新乌桑三萜。 New ursane triterpene from the fruits of Terminalia arjuna. |
| 已发布 PubMed:积雪草不同提取物在切口和烧伤创面中的伤口愈合活性 Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: 实验动物研究。 an experimental animal study. |
| 已发布 PubMed:积雪草减弱橙花行为 Centella asiatica attenuates the neurobehavioral, 短暂性局灶性大脑中动脉闭塞大鼠的橙花化学和组织学变化。 neurochemical and histological changes in transient focal middle cerebral artery occlusion rats. |
| 已发布 PubMed:[从铁线莲的子叶的空中部分的三萜类。猕猴桃]。 [Triterpenes from aerial parts of Clematoclethra scandens subsp. actinidioides]. |
| 已发布 PubMed:枯草杆菌可能抑制 癌Hela细胞的生长并诱导其凋亡。 Growth inhibition and induction of apoptosis in human cancerous HeLa cells by Maytenus procumbens. |
| 已发布 PubMed:滴定的积雪草提取物通过改变 类皮肤成纤维细胞中的microrna表达谱，提供uvb保护作用。 Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts. |
| 已发布 PubMed:生物利用度 Bioavailability, 分配 Distribution, 和选定的三萜对小鼠的抗氧化作用。 and antioxidative effects of selected triterpenes in mice. |
| 已发布 PubMed:一种改进的hplc-uv方法，用于同时量化积雪草（l。）urb（apiaceae）叶片中的三萜糖苷和糖苷配基。 An improved HPLC-UV method for the simultaneous quantification of triterpenic glycosides and aglycones in leaves of Centella asiatica (L.) Urb (APIACEAE). |
| 已发布 PubMed:靶向抑制肿瘤增殖 Targeted inhibition of tumor proliferation, 生存 survival, 五环三萜类化合物的转移和转移 and metastasis by pentacyclic triterpenoids: 在预防和治疗癌症中的潜在作用。 potential role in prevention and therapy of cancer. |
| 已发布 PubMed:积雪草提取物 Centella asiatica Extract 改善 Improves 行为的 Behavi口服 oral 赤字 Deficits in a 老鼠 Mouse 模型 Model of Alzheimer's 疾病 Disease: 调查可能的作用机制。 Investigation of a Possible Mechanism of Action. |
| 已发布 PubMed:青霉菌的化学成分和抑菌活性 Chemical constituents and antibacterial activity of Melastoma malabathricum L. |
| 已发布 PubMed:榄仁木的保肝活性叶和它的两个三萜。 Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. |
| 已发布 PubMed:顶草和榄仁提取物对免疫抑制大鼠皮肤伤口愈合的体内抗真菌作用。 In vivo antifungal effect of Combretum and Terminalia species extracts on cutaneous wound healing in immunosuppressed rats. |
| 已发布 PubMed:影响皮肤更新 Effecting skin renewal: 多方面的方法。 a multifaceted approach. |
| 已发布 PubMed:一种来自积雪草叶的新的熊s型三萜糖苷可调节活化的原始264.7细胞中一氧化氮的产生和tnf-α的分泌。 A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells. |
| 已发布 PubMed:桔梗中的三萜皂苷。 Triterpenoid saponins from Symplocos lancifolia. |
| 已发布 PubMed:[hplc对亚洲积雪草指纹的研究]。 [Studies on fingerprints of Centella asiatica by HPLC]. |
| 已发布 PubMed:三种五环三萜类化合物对小鼠钙诱导的肝线粒体通透性转变的抑制作用 [Inhibition of three pentacyclic triterpenoids on calcium-induced liver mitochondrial permeability transition in mice]. |
| 已发布 PubMed:三萜的组成和生物活性。 Triterpene composition and bioactivities of Centella asiatica. |
| 已发布 PubMed:积雪草的三萜类化合物刺激大鼠实验伤口中细胞外基质的积累。 Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. |
| 已发布 PubMed:从积雪草中提取的三萜对成纤维细胞培养物中胶原合成的刺激作用。 Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. |
| 已发布 PubMed:[冬青叶的三萜类化合物]。 [Triterpenoids from leaves of Ilex cornuta]. |
| 已发布 PubMed:积雪草中的两个新的三萜糖苷。 Two new triterpene glycosides from Centella asiatica. |
| 已发布 PubMed: 康柏（菊科 Combretaceae）叶片中分离的两种相关三萜的生物活性。 |
| 已发布 PubMed:糖苷配基三萜的缔合（胶束化）和分配。 Association (micellization) and partitioning of aglycon triterpenoids. |
| 已发布 PubMed:天然存在的五环三萜作为糖原磷酸化酶的抑制剂 Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: 合成 Synthesis, 构效关系 structure-activity relationships, 和X射线晶体学研究。 and X-ray crystallographic studies. |
| 已发布 PubMed:猕猴桃根系化学成分的研究 [Studies on chemical constituents from root of Actinidia macrosperma]. |
| 已发布 PubMed:三萜类化合物对d-半乳糖胺和四氯化碳损伤的原代培养大鼠肝细胞的保护作用 [Protective effects of triterpenoids on primarily cultured rat hepatocytes injured by D-galactosamine and carbon tetrachloride]. |
| 已发布 PubMed:口服积雪草可促进橙花再生，并含有多个活性成分，可增加橙花突的体外延伸。 Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro. |
| 已发布 PubMed:积雪草三萜诱导的 类成纤维细胞中的基因表达变化。 Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. |
| 已发布 PubMed: 积雪草（印度薄荷草 pennywort） , 有效的治疗剂，但弱敏剂。 an effective therapeutic but a weak sensitizer. |
| 已发布 PubMed:积雪草植物细胞培养物将α-amyrin转化为糖苷。 Conversion of alpha-amyrin into centellosides by plant cell cultures of Centella asiatica. |
| 已发布 PubMed:由于积雪草引起的接触性皮炎。 Contact dermatitis due to Centella asiatica. |
| 已发布 PubMed: 一种来自三叶草（阿克比亚 Akebia 三叶草 trifoliata var）茎的新三萜皂苷。澳洲 |
| 已发布 PubMed: 几内亚（糖浆 Syzygium guineense）的抗菌三萜。 |
| 已发布 PubMed:10种三萜类化合物对小鼠实验性肝损伤的影响。 The effects of 10 triterpenoid compounds on experimental liver injury in mice. |
| 已发布 PubMed:滨海罗氏a（油性树脂）与其季节性采集物的对比植物化学分析。 Comparative phytochemical analysis of Shorea robusta Gaertn (oleoresin) WSR to its seasonal collection. |
| 已发布 PubMed:从紫花苜蓿叶中分离出的三萜酸作为α-葡萄糖苷酶抑制剂。 Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors. |
| 已发布 PubMed:月见草抑制脂多糖诱导一氧化氮的产生。 Oenothera laciniata inhibits lipopolysaccharide induced production of nitric oxide, 前列腺素e2 prostaglandin E2, 和生的 raw264.7巨噬细胞中的促炎细胞因子。 |
| 已发布 PubMed:生物活性的五环三萜。 Bioactive pentacyclic triterpenes from the stems of Combretum laxum. |
| 已发布 PubMed:将三萜衍生物掺入o / w / o多重乳液中 Incorporation of triterpenic derivatives within an o/w/o multiple emulsion: 结构和释放研究。 structure and release studies. |
| 已发布 PubMed: 韦格拉 我们 Weigela ses subsessilis中的乌烷 ursane型三萜类化合物的抗补体活性。 |
| 已发布 PubMed:点地梅科植物的抗增殖成分vii。活性三萜和迷迭香中的迷迭香酸。 Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica. |
| 已发布 PubMed:积雪草的标准化和质量评估。 Standardisation and Quality Evaluation of Centella asiatica Linn. |
| 已发布 PubMed:疤痕管理方面的新创新。 New innovations in scar management. |
| 已发布 PubMed:粘菌bird的三萜。 Triterpenes from Mucuna birdwoodiana. |
| 已发布 PubMed:植物来源的微量营养元素通过调节其细胞外基质组成来抑制单核细胞粘附于培养的 主动脉内皮细胞层。 Plant-derived micronutrients suppress monocyte adhesion to cultured human aortic endothelial cell layer by modulating its extracellular matrix composition. |
| 已发布 PubMed:积雪草茧/愈合组织中三萜皂苷的含量及相关基因的表达水平 Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica. |
| 已发布 PubMed:从猕猴桃的根中分离出的新型胰腺脂肪酶抑制剂。 A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta. |
| 已发布 PubMed:[来自中国委陵菜的三萜]。 [Triterpenes from herb of Potentilla chinesis]. |
| 已发布 PubMed:月见草和月见草的三萜和黄酮醇葡糖醛酸苷。 Triterpenes and flavonol glucuronides from Oenothera cheiranthifolia. |
| 已发布 PubMed:桑ni叶片中2α-羟基五环三萜酸局部抗炎活性。 Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. |
| 已发布 PubMed: 对韦格拉 我们 Weigela ses subsessilis的叶和茎中成分在ht29细胞中的tnf-alpha诱导的il-8产生抑制作用。 |
| 已发布 PubMed:薄层色谱和质谱法鉴定积雪草的三萜类化合物。 Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry. |
| 已发布 PubMed:滴定c。提取物的水凝胶的先进配方和药理活性。 Asiatica。 Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. asiatica. |
| 已发布 PubMed:活性皂苷和三萜类苷元对 内皮素eta和血管紧张素at1受体的结合特性的评估。 Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors. |
| 已发布 PubMed:一种改进的hplc方法，用于定量测定积雪草提取物和商业产品中的六个三萜烯。 An improved HPLC method for quantitative determination of six triterpenes in Centella asiatica extracts and commercial products. |
| 已发布 PubMed:番石榴叶中的三萜。 Triterpenoids from the leaves of Psidium guajava. |
| 已发布 PubMed:乌头仓鼠乌头烷三萜类化合物的特征，对斜纹夜蛾具有生长抑制活性。 Characterization of an ursane triterpenoid from centella asiatica with growth inhibitory activity against spilarctia obliqua. |
| 已发布 PubMed:积雪草苷衍生物对β-淀粉样蛋白橙花毒性的保护作用。 Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity. |
| 已发布 PubMed:高效液相色谱法从抗蜂窝组织透皮给药系统中提取和分析化妆品活性成分。 Extraction and analysis of cosmetic active ingredients from an anti-cellulitis transdermal delivery system by high-performance liquid chromatography. |
| 已发布 PubMed:氢化物甾体环氧化物的区域选择性开环 Regioselective ring opening of steroidal epoxide with hydrides: c（2）-和c（3）-脱氧亚氨酸衍生物的形成。 formation of C(2)- and C(3)-deoxyasiatic acid derivatives. |
| 已发布 PubMed:铁青树eff皮中的三萜类化合物及其糖苷。 Triterpenoids and their glycosides from the bark of Schefflera octophylla. |
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3D/INCHI