gastrodin
4-（羟甲基）苯基-β-d-吡喃葡萄糖苷 4-(hydroxymethyl)phenyl-beta-D-glucopyranoside

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  g0468天麻素> 98.0％（hplc） G0468 Gastrodin >98.0%(HPLC)

CAS号 CAS Number: 62499-27-8 3D/INCHI FDA UNII: 5YS9U2W3RQ nikkaji网站 Nikkaji Web: J39.391F MDL : mfcd00272169 MFCD00272169 XlogP3: -0.80（est） -0.80 (est) 分子量 Molecular Weight: 286.28086000 式 Formula: c13 h18 o7 C13 H18 O7 生物活性总结 BioActivity Summary: 清单 listing 核磁共振预测器 NMR Predictor: 预测（适用于Chrome或Firefox） Predict (works with chrome or firefox) 类别 Category:cosmetic agents   美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent : 谷歌学术 Google Scholar: 搜索 Search 谷歌书 Google Books: 搜索 Search 谷歌学术 Google Scholar: with word "volatile" 搜索 Search 谷歌学术 Google Scholar: with word "flavor" 搜索 Search 谷歌学术 Google Scholar: with word "odor" 搜索 Search 谷歌专利 Google Patents: 搜索 Search 美国专利 US Patents: 搜索 Search 欧盟专利 EU Patents: 搜索 Search pubchem专利 Pubchem Patents: 搜索 Search 已发布 PubMed: 搜索 Search NCBI: 搜索 Search   物理性质 Physical Properties: 化验 Assay: 95.00至100.00 95.00 to 100.00 食品化学品法典列表 Food Chemicals Codex Listed: No 沸点 Boiling Point: 563.20 °C. @ 760.00 mm 汞 Hg (est) 闪点 Flash Point: 562.00 °F. tcc TCC ( 294.40 °C. ) (est) logp（o / w） logP (o/w): -1.939（est） -1.939 (est) 溶于 Soluble in:   水 water, 25°C（2.38e + 005 mg / l）（est） 2.38e+005 mg/L @ 25 °C (est)   感官特性 Organoleptic Properties: 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found).   化妆品信息 Cosmetic Information: CosIng: 化妆品数据 cosmetic data 化妆品用途 Cosmetic Uses: 皮肤调理 skin conditioning   供应商 Suppliers: BOC Sciences 仅供实验/研究使用。 For experimental / research use only. Gastrodin 碳合蛋白 Carbosynth 仅供实验/研究使用。 For experimental / research use only. Gastrodin 长沙有机药草 Changsha Organic Herb 天麻天麻块茎提取物 Gastrodin Gastrodia Tuber Extract 库姆波 Coompo 仅供实验/研究使用。 For experimental / research use only. Gastrodin from 植物 Plants ≥98% 气味 Odor: characteristic 采用 Use: 酚苷天麻素（气体） Phenolic glucoside gastrodin (Gas), 这是从中药天麻中提取的主要成分 which is a main component extracted from the Chinese herbs Gastrodia elata Bl, 从中间果胶的茎皮中分离出来。山楂酸是衍生自干燥的橄榄果渣油（橄榄皮蜡）的化合物，该油是橄榄油提取的副产物。它是三萜类化合物中的一种，被称为油精。山楂酸是五环三萜 is a well-known natural calcium antagonist with antioxidant and anti-inflammatory functions. It has long been used clinically for treatment of cardiovascular and cerebrovascular diseases. Previous studies have shown that gastrodin possesses comprehensive pharmacological functions. However, 2-（2-乙氧基乙氧基）-乙氧基二甘醇乙氧基二甘醇2-（2-乙氧基乙氧基）乙醇2-（2-乙氧基乙氧基）-乙醇2-（2-乙氧基乙氧基）乙烷-1-醇2-（2-乙氧基乙氧基）乙醇2-（2-乙氧基乙氧基）乙醇99％乙基卡必醇乙基二甘醇乙基二甘醇乙基二甘醇二甘醇单乙醚乙二醇二甘醇乙二醇二甘醇单乙醚乙二醇醚de1-hydroxy-3 very little is known about whether gastrodin has protective role on cardiac hypertrophy. The aim of this study was to determine whether gastrodin attenuates pressure overload-induced cardiac hypertrophy in mice and to clarify the underlying molecular mechanisms. Our data demonstrated that gastrodin prevented cardiac hypertrophy induced by aortic banding (AB), 通过心脏重量/体重和肺部重量/体重比评估 as assessed by heart weight/body weight and lung weight/body weight ratios, 超声心动图参数 echocardiographic parameters, 而且还可以通过减少去 小鼠的破骨细胞数量来抑制骨丢失。橙皮苷抑制骨吸收的分子机制尚不清楚。橙皮苷被认为在植物防御中起作用。根据体外研究，它可作为抗氧化剂。 and gene expression of hypertrophic markers. The inhibitory effect of gastrodin on cardiac hypertrophy is mediated by ERK1/2 signaling and GATA-4 activation. Further studies showed that gastrodin attenuated fibrosis and collagen synthesis through abrogating ERK1/2 signaling pathway. Therefore, 这些发现表明天麻素 these findings indicated that gastrodin, 这是一种潜在的安全廉价的临床疗法 which is a potentially safe and inexpensive therapy for clinical use, 通过抑制erk1 / 2信号传导在靶向心肌肥大和纤维化方面具有保护潜力。 has protective potential in targeting cardiac hypertrophy and fibrosis through suppression of ERK1/2 signaling. 天麻素通过抑制lps刺激的小胶质细胞中的nf-Δb信号通路和Mapks磷酸化，从而显着降低橙花毒性促炎介质和促炎细胞因子的水平。由上述产生 Gastrodin significantly attenuate levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-?B signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. Arising from the above, 我们建议天麻素在橙花退行性疾病中作为抗炎药的潜力。 we suggest that gastrodin has a potential as an anti-inflammatory drug candidate in neurodegenerative diseases. 天麻素是预防使用cpb进行二尖瓣置换手术的患者橙花认知功能下降的有效且安全的药物。 Gastrodin is an effective and a safe drug for the prevention of neurocognitive decline in patients undergoing mitral valve replacement surgery with CPB. 道尔顿制药服务 Dalton Pharma Services 仅供实验/研究使用。 For experimental / research use only. 天麻素> 95％ Gastrodin >95% 西格玛·奥尔德里奇 Sigma-Aldrich: 西格玛 Sigma 仅供实验/研究使用。 For experimental / research use only. 天麻素≥98％（hplc） Gastrodin ≥98% (HPLC) sds sds TCI AMERICA 仅供实验/研究使用。 For experimental / research use only. 天麻> 98.0％（hplc） Gastrodin >98.0%(HPLC)   安全信息 Safety Information: 首选SDS Preferred SDS: 视图 View   危害识别 Hazards identification   物质或混合物的分类 Classification of the substance or mixture 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) 没有找到。 None found. ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements   象形图 Pictogram   危险说明 Hazard statement(s) 没有找到。 None found. 防范说明 Precautionary statement(s) 没有找到。 None found. 口服/肠胃外毒性 Oral/Parenteral Toxicity: 未定 Not determined 皮肤毒性 Dermal Toxicity: 未定 Not determined 吸入毒性 Inhalation Toxicity: 未定 Not determined   使用安全信息 Safety in Use Information: 类别 Category: cosmetic agents 推荐的天麻素使用水平 Recommendation for gastrodin usage levels up to:   不用于香水。 not for fragrance use.   关于天麻素风味使用水平的建议 Recommendation for gastrodin flavor usage levels up to:   不用于调味料。 not for flavor use.   安全参考 Safety references: Epi系统 EPI System: 视图 View 毒理学引文 Toxicology Citations:搜索 Search EPA ACToR:毒理学资料 Toxicology Data EPA物质注册服务（SRS） :注册表 Registry 实验室化学安全摘要 Laboratory Chemical Safety Summary :115067 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data 德国wgk WGK Germany:3 (2R,3s 3S,4s 4S,5r 5R,6s）-2-（羟甲基）-6- [4-（羟甲基）苯氧基]恶烷-3 6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-三醇 5-triol chemidplus Chemidplus:0062499278 技术 RTECS:CAS＃62499-27-8的lz5776885 LZ5776885 for cas# 62499-27-8   参考资料 References:   (2R,3s 3S,4s 4S,5r 5R,6s）-2-（羟甲基）-6- [4-（羟甲基）苯氧基]恶烷-3 6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-三醇 5-triol NIST化学网络书籍 NIST Chemistry WebBook: 搜索INCHI pubchem（cid） Pubchem (cid): 115067 pubchem（sid） Pubchem (sid): 135072124   其他资料 Other Information: （iupac） (IUPAC): 元素的原子量2009 Atomic Weights of the Elements 2009 （iupac） (IUPAC): 元素的原子量2009（pdf） Atomic Weights of the Elements 2009 (pdf) 影片 Videos: 元素周期表 The Periodic Table of Videos RBC : 本网站使用的原子量 Atomic Weights use for this web site （iupac） (IUPAC): 元素周期表 Periodic Table of the Elements CHEBI: 视图 View CHEMBL: 视图 View KEGG (GenomeNet): C16964 hmdb（人类代谢组数据库） HMDB (The Human Metabolome Database): 搜索 Search 出口关税代码 Export Tariff Code: 2938.90.0000 vcf在线 VCF-Online: 食品中的挥发性有机化合物 VCF Volatile Compounds in Food 化学蜘蛛 ChemSpider: 视图 View 维基百科 Wikipedia: 视图 View rsc学习化学 RSC Learn Chemistry: 视图 View   潜在搅拌机 Potential Blenders and core components note 没找到 None Found   潜在用途 Potential Uses: 没找到 None Found   存在（自然 Occurrence (nature, 餐饮 food, 其他） other):note   天麻根 gastrodia elata root 搜索 Search Trop Picture   同义词 Synonyms:   天麻素 gastrodine beta beta-D- glucopyranoside, 4-(hydroxymethyl)phenyl 4-(beta beta-D- glucopyranosyloxy) benzyl alcohol (2R,3s 3S,4s 4S,5r 5R,6S)-2- hydroxymethyl-6-(4-hydroxymethyl-苯氧基 phenoxy)-tetrahydro-pyran-3,4,5-三醇 5-triol (2R,3s 3S,4s 4S,5r 5R,6S)-2-( hydroxymethyl)-6-(4-(hydroxymethyl)苯氧基 phenoxy)-tetrahydro-2H-pyran-3,4,5-三醇 5-triol (2R,3s 3S,4s 4S,5r 5R,6S)-2-( hydroxymethyl)-6-(4-(hydroxymethyl)苯氧基 phenoxy)tetrahydro-2H-pyran-3,4,5-三醇 5-triol (2R,3s 3S,4s 4S,5r 5R,6S)-2-( hydroxymethyl)-6-[4-(hydroxymethyl)苯氧基 phenoxy]oxane-3,4,5-三醇 5-triol 4-( hydroxymethyl)phenyl b-D-glucopyranoside 4-( hydroxymethyl)苯基-β-d-吡喃葡萄糖苷 phenyl-beta beta-D-glucopyranoside   文章 Articles: 已发布 PubMed:天麻的两种新的橙花保护性酚类化合物。 Two new neuroprotective phenolic compounds from Gastrodia elata. 已发布 PubMed:天麻水提物的化学成分 [Chemical constituents from aqueous extract of Gastrodia elata]. 已发布 PubMed:大川雄坊天麻活性成分的体内转移 [In vivo transmigration of active ingredients from Gastrodia elata in dachuanxiong fang]. 已发布 PubMed:一种新型中药配方及其相容性的药代动力学比较研究。 Pharmacokinetics comparative study of a novel Chinese traditional herbal formula and its compatibility. 已发布 PubMed: [运动会conopsea conopsea的组成部分]。 已发布 PubMed:Gastrodin 防止 prevents 发动机 motor 赤字 deficits and 氧化 oxidative 强调 stress in the mptp MPTP 老鼠 mouse 模型 model of Parkinson's 疾病 disease: erk1 / 2-nrf2信号通路的参与。 Involvement of ERK1/2-Nrf2 signaling pathway. 已发布 PubMed:基于核磁共振的代谢组学揭示了天麻素干预大鼠的性别特异性代谢变化。 H nuclear magnetic resonance-based metabolomics reveals sex-specific metabolic changes of gastrodin intervention in rats. 已发布 PubMed:超快速液相色谱-串联质谱法对狗中天麻素和对羟基苯甲醇的分析和药代动力学研究。 Analysis and pharmacokinetics studies of gastrodin and p-hydroxybenzyl alcohol in dogs using ultra fast liquid chromatography-tandem mass spectrometry method. 已发布 PubMed:台湾高血压中草药处方模式 Prescription pattern of Chinese herbal products for hypertension in Taiwan: 基于 口的研究。 A population-based study. 已发布 PubMed:超快速液相色谱电喷雾电离串联质谱法鉴定和分析天麻素及其五种代谢物，以研究多剂量和食品的影响。 Identification and analysis of gastrodin and its five metabolites using ultra fast liquid chromatography electrospray ionization tandem mass spectrometry to investigate influence of multiple-dose and food. 已发布 PubMed:[唐古柳叶菜（iii）全株的化学成分]。 [Chemical constituents from whole plants of Aconitum tanguticum (III)]. 已发布 PubMed:天麻素通过上调 多巴胺能细胞中的p38 mapk / nrf2途径上调血红素加氧酶1的表达，从而防止mpp（+）诱导的氧化应激。 Gastrodin protects against MPP(+)-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells. 已发布 PubMed:天麻素可改善3的记忆障碍 Gastrodin ameliorates memory deficits in 3,3'-iminodipropionitrile诱发 -诱发的 induced 老鼠 rats: 多巴胺能系统的可能参与。 possible involvement of dopaminergic system. 已发布 PubMed:具有新型功能性单体的分子印迹聚合物，可从天麻的水提物中选择性固相萃取天麻素。 Molecularly imprinted polymers with novel functional monomer for selective solid-phase extraction of gastrodin from the aqueous extract of Gastrodia elata. 已发布 PubMed:Gastrodin 减轻 alle通过 viates 记忆 memory 赤字 deficits and 减少 reduces 橙花病理学 neuropathology in a 老鼠 mouse 模型 model of Alzheimer's 疾病 disease. 已发布 PubMed:天麻素抑制大鼠初级感觉橙花元中酸敏感离子通道的活性。 Gastrodin inhibits the activity of acid-sensing ion channels in rat primary sensory neurons. 已发布 PubMed:天麻素通过抑制camkii / ask-1 / p38 mapk / p53信号级联反应来抑制谷氨酸诱导的pc12细胞凋亡。 Gastrodin inhibits glutamate-induced apoptosis of PC12 cells via inhibition of CaMKII/ASK-1/p38 MAPK/p53 signaling cascade. 已发布 PubMed:天麻素改善大鼠抑郁样行为并上调海马源性橙花干细胞的增殖 Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: 参与其抗炎作用。 involvement of its anti-inflammatory action. 已发布 PubMed:天麻素改善大鼠的抑郁样行为，并上调大鼠海马和海马来源星形胶质细胞中bdnf的表达。 Gastrodin ameliorates depressive-like behaviors and up-regulates the expression of BDNF in the hippocampus and hippocampal-derived astrocyte of rats. 已发布 PubMed: 天麻素改善了创伤后应激障碍大鼠模型的焦虑样行为，并抑制了海马的il-1beta beta水平和p38 mapk磷酸化。 已发布 PubMed:针刺配合天麻素穴位治疗眩晕八十七例 [Eighty-seven cases of vertigo treated by acupuncture and acupoint injection of gastrodin]. 已发布 PubMed:菲 Phenanthrenes, 9,10-二氢菲 10-dihydrophenanthrenes, 联苄及其衍生物 bibenzyls with their derivatives, 和苹果油或酒石酸苄酯葡萄糖苷的块茎。 and malate or tartrate benzyl ester glucosides from tubers of Cremastra appendiculata. 已发布 PubMed:洗脱-逆流色谱法从叶块茎的块茎中分离出两种新的苄基酯葡糖苷和三种其他高极性化合物。 Elution-extrusion counter-current chromatography separation of two new benzyl ester glucosides and three other high-polarity compounds from the tubers of Pleione bulbocodioides. 已发布 PubMed:Gastrodin 改善 ameliorates Parkinson's 疾病 disease by by 下调 downregulating 连接蛋白 connexin 43. 已发布 PubMed:天麻的两种新的橙花保护性酚类化合物。 Two new neuroprotective phenolic compounds from Gastrodia elata. 已发布 PubMed:[来自百叶香球藻的化学成分]。 [Chemical constituents from Pleione bulbocodioides]. 已发布 PubMed:天麻中天麻素含量的提取与检测方法研究 [Research the extraction and detection method of gastrodin content in Gastrodia elata]. 已发布 PubMed:磁性纳米颗粒涂层构建的具有串联/混合固定相的开管毛细管电色谱柱的特性 The characteristics of open-tubular capillary electrochromatography columns with series/mixed stationary phases constructed with magnetic nanoparticle coating. 已发布 PubMed:天麻素刺激抗癌免疫反应并抑制移植的h22肝腹水肿瘤细胞的生长 Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: nf-κb信号激活参与cd4 + t细胞。 Involvement of NF-κB signaling activation in CD4+ T cells. 已发布 PubMed:Gastrodin 保护 保护 protects 凋亡的 apoptotic 多巴胺能 多巴胺 dopaminergic 橙花元 neurons in a 毒素诱导 toxin诱发 -诱发的 induced Parkinson's 疾病 disease 模型 model. 已发布 PubMed:类天麻素衍生物的合成和抗流感 活性 Synthesis and anti-influenza virus activities of a novel class of gastrodin derivatives. 已发布 PubMed:通过对付曲霉和青霉环孢菌的培养细胞进行生物转化，由对-2-羟基苄醇生产天麻素。 Gastrodin production from p-2-hydroxybenzyl alcohol through biotransformation by cultured cells of Aspergillus foetidus and Penicillium cyclopium. 已发布 PubMed:转运蛋白在天麻素肠吸收中的作用 Role of glucose transporters in the intestinal absorption of gastrodin, 具有良好口服生物利用度的高度水溶性药物。 a highly water-soluble drug with good oral bioavailability. 已发布 PubMed:天麻根茎提取物主要成分及其在整个发酵过程中的相互转化的实验分析。 Experimental analysis on the main contents of Rhizoma gastrodiae extract and inter-transformation throughout the fermentation process of Grifola frondosa. 已发布 PubMed:天麻素减弱h9c2心肌细胞的炎症反应涉及通过磷脂酰肌醇3-激酶信号转导抑制nf-κb和mapks激活。 Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phosphatidylinositol 3-kinase signaling. 已发布 PubMed:高效液相色谱法同时测定大鼠血浆中天麻素和葛根素及其在药代动力学中的相互作用 Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. 已发布 PubMed:天麻水提物的化学成分 [Chemical constituents from aqueous extract of Gastrodia elata]. 已发布 PubMed:天麻通过erk1 / 2-nrf2途径保护原代培养的大鼠海马橙花元免受淀粉样β肽诱导的橙花毒性。 Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway. 已发布 PubMed:天麻素抑制血管平滑肌细胞中的细胞增殖并减弱体内新内膜的形成。 Gastrodin inhibits cell proliferation in vascular smooth muscle cells and attenuates neointima formation in vivo. 已发布 PubMed:天麻素可改善自发性高血压大鼠的压力反射敏感性并增加大脑中γ-氨基丁酸含量，而不会降低血压。 Gastrodin improved baroreflex sensitivity and increased gamma-amino butyric acid content in brains without decreasing blood pressure in spontaneously hypertensive rats. 已发布 PubMed:天麻素通过降低伤害性初级感觉橙花元的兴奋性来抑制糖尿病性橙花病大鼠的异常性疼痛和痛觉过敏。 Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing excitability of nociceptive primary sensory neurons. 已发布 PubMed:天麻素对大鼠三叉橙花节降钙素基因相关肽的药理作用 [The pharmacological mechanism of gastrodin on calcitonin gene-related peptide of cultured rat trigeminal ganglion]. 已发布 PubMed:天麻软糖及其纯化合物保护bv-2小胶质细胞衍生的细胞系抵抗β-淀粉样蛋白 Gastrodia elata Blume and its pure compounds protect BV-2 microglial-derived cell lines against β-amyloid: grp78和印章的参与。 the involvement of GRP78 and CHOP. 已发布 PubMed:三种新型多酚化合物的鉴定 Identification of three novel polyphenolic compounds, 牛至a-c origanine A-C, 牛至的独特骨架。使用连字的lc-dad-spe-nmr / ms方法。 with unique skeleton from Origanum vulgare L. using the hyphenated LC-DAD-SPE-NMR/MS methods. 已发布 PubMed:天麻素鼻内给药的原位胶凝系统的配方和评价。 Formulation and evaluation of in situ gelling systems for intranasal administration of gastrodin. 已发布 PubMed:大川雄坊天麻活性成分的体内转移 [In vivo transmigration of active ingredients from Gastrodia elata in dachuanxiong fang]. 已发布 PubMed:天麻素可防止心脏肥大和纤维化。 Gastrodin protects against cardiac hypertrophy and fibrosis. 已发布 PubMed:天麻素抑制诱导型无合酶的表达 Gastrodin inhibits expression of inducible NO synthase, 培养的lps刺激的小胶质细胞通过mapk途径产生环氧合酶2和促炎细胞因子。 cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. 已发布 PubMed:一种新型中药配方及其相容性的药代动力学比较研究。 Pharmacokinetics comparative study of a novel Chinese traditional herbal formula and its compatibility. 已发布 PubMed:复方天麻颗粒中天麻素的大鼠药代动力学 [Pharmacokinetics of gastrodin from compound Tianma granule in rats]. 已发布 PubMed:小胶质橙花毒性抑制剂 Inhibitors of microglial neurotoxicity: 专注于天然产品。 focus on natural products. 已发布 PubMed:胃泌素在caco-2细胞中的转运以及bcap37和bcap37 / mdr1细胞的摄取。 The transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37/MDR1 cells. 已发布 PubMed: [运动会conopsea conopsea的组成部分]。 已发布 PubMed:通过微生物转化和纯化天麻素生物合成酶进行天麻素的酶促合成。 Enzymic synthesis of gastrodin through microbial transformation and purification of gastrodin biosynthesis enzyme. 已发布 PubMed:厚朴酚和厚朴酚的橙花保护作用 Neuroprotective effect of honokiol and magnolol, 木兰的化合物 compounds from Magnolia officinalis, 对β-淀粉样蛋白诱导的pc12细胞毒性的影响。 on beta-amyloid-induced toxicity in PC12 cells. 已发布 PubMed:hplc结合光电二极管阵列检测器测定 血浆中天麻素的含量和药代动力学。 Determination and pharmacokinetics of gastrodin in human plasma by HPLC coupled with photodiode array detector. 已发布 PubMed:天麻碱对乙醇诱导的肝细胞株102损伤的影响 [The effect of gastrodine on hepatitic cell line L02 injury induced by ethanol]. 已发布 PubMed:反相高效液相色谱法同时测定天麻中的四种成分 [Simultaneous determination of four components in Gastrodia elata by RP-HPLC]. 已发布 PubMed:效果 影响 Effects of gastrodin on the 多巴胺 dopamine 系统 system of Tourette's 综合症 syndrome rat 楷模 模型 models. 已发布 PubMed:通过流化床包衣制备天麻中含有活性成分的缓释微丸的研究。 [Study on the preparation of sustained-release pellets containing active components from Gastrodia elata by fluid-bed coating]. 已发布 PubMed:波米野生和栽培天麻中三种有效成分的测定 [The determination of three effective constituents in wild and cultivated Gastrodia elata from Bomi]. 已发布 PubMed: [天麻碱抑制il-1 beta beta的表达 , 高血糖诱导的Gil il-6在IL-6细胞中的表达 IL-6 induced by hyperglycemia in gitter cells]. 已发布 PubMed:天麻素对铅诱导的大鼠海马突触可塑性缺陷的保护作用。 Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus. 已发布 PubMed:基因组成之间的关系 Relationships among genetic makeup, 有效成分含量 active ingredient content, 和药用天麻块茎的产地。 and place of origin of the medicinal plant Gastrodia tuber. 已发布 PubMed:天麻素及其代谢产物对羟基苯甲醇在大鼠血液中的药代动力学 Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, 通过微透析将大脑和 与lc-ms / ms耦合。 brain and bile by microdialysis coupled to LC-MS/MS. 已发布 PubMed: 天麻碱对培养的大鼠大脑皮层橙花元缺氧损伤的表达nda受体nr1 姆纳 mRNA的表达 已发布 PubMed:[天麻素注射液对老年顽固性高血压患者血压和血管活性物质的影响 [Effects of gastrodin injection on blood pressure and vasoactive substances in treatment of old patients with refractory hypertension: 一项随机对照试验]。 a randomized controlled trial]. 已发布 PubMed:天麻素激活的鼻腔原位凝胶体外释药研究 [Study on drug release of gastrodin ion-activated nasal in situ gel in vitro]. 已发布 PubMed:天麻素鼻原位凝胶的脑靶向研究 [Brain targeting of gastrodin nasal in situ gel]. 已发布 PubMed: cremastra Cremastra阑尾的块茎的化学成分 已发布 PubMed:天麻口服后天麻素和对羟基苄醇的含量测定及药代动力学高效液相色谱-电喷雾电离质谱法测定大鼠中的提取物。 Determination and pharmacokinetics of gastrodin and p-hydroxybenzylalcohol after oral administration of Gastrodia elata Bl. extract in rats by high-performance liquid chromatography-electrospray ionization mass spectrometric method. 已发布 PubMed:冰片对小鼠口服天麻素对大脑中分布的影响 Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration. 已发布 PubMed:热水萃取和微波辅助萃取技术评价天麻中热不稳定生物活性化合物的提取效率 Evaluation of the extraction efficiency of thermally labile bioactive compounds in Gastrodia elata Blume by pressurized hot water extraction and microwave-assisted extraction. 已发布 PubMed:天麻素在大鼠脑中的分布和代谢 Distribution and metabolism of gastrodin in rat brain. 已发布 PubMed:来自天麻的两种新的苯并呋喃及其对dna的拓扑异构酶i和ii的抑制活性。 Two new benzofurans from Gastrodia elata and their DNA topoisomerases I and II inhibitory activities. 已发布 PubMed:大喘雄方治疗偏头痛的有效部位提取纯化研究 [Study on extraction and purification of active parts from Da Chuan Xiong Fang for treatment of migraine]. 已发布 PubMed:[天麻质量评价bl。 hplc-dad / ms]。 [Evaluation of the quality of Gastrodia elata Bl. by HPLC-DAD/MS]. 已发布 PubMed:加压液体萃取在室温下测定天麻中天麻素和香兰醇的含量。 Determination of gastrodin and vanillyl alcohol in Gastrodia elata Blume by pressurized liquid extraction at room temperature. 已发布 PubMed:hplc-uv-ms鉴定天麻中的酚类和核苷衍生物。 Identification of phenolics and nucleoside derivatives in Gastrodia elata by HPLC-UV-MS. 已发布 PubMed:来自天麻根茎的酚类化合物。 Phenolic compounds from the rhizomes of Gastrodia elata. 已发布 PubMed:天麻素对缺氧诱导的大鼠皮层橙花元原代培养物毒性的保护作用。 Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons. 已发布 PubMed:在检测窗口上具有薄的pmd膜的混合微型设备，用于uv吸光度检测。 A hybrid microdevice with a thin PDMS membrane on the detection window for UV absorbance detection. 已发布 PubMed:天麻后天麻素在大鼠血浆和脑脊液中的药代动力学和i.v. Pharmacokinetics of Gastrodin in rat plasma and CSF after i.n. and i.v. 已发布 PubMed:营养补充剂的大脑分布和 排泄的分析 Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, 在老鼠 in rat. 已发布 PubMed:天麻素对缺血/再灌注大鼠脑海马橙花化学变化影响的微透析研究。 A microdialysis study of effects of gastrodin on neurochemical changes in the ischemic/reperfused rat cerebral hippocampus. 已发布 PubMed:天麻素对大鼠脑纹状体缺血再灌注损伤后氨基酸影响 Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. 已发布 PubMed:天麻根茎中的酚类成分。 Phenolic constituents from the rhizomes of Gastrodia elata. 已发布 PubMed:[通过微生物转化合成天麻素]。 [Synthesis of gastrodin by microbial transformation]. 已发布 PubMed:天麻素分散片的制备及稳定性研究。 [Preparation and stability investigation of gastrodin dispersible tablets]. 已发布 PubMed:曼陀罗细胞悬浮培养通过对羟基苯甲醛的生物转化生产天麻素。 [The production of gastrodin through biotransformation of p-hydroxybenzaldehyde by cell suspension culture of Datura stramonium]. 已发布 PubMed:体内和体外对酚苷天麻素在脑缺血中橙花保护作用的研究。 A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. 已发布 PubMed:曼陀罗细胞悬浮培养通过对羟基苯甲醛生物转化生产天麻素的研究 [Production of gastrodin through biotransformation of p-hydroxybenzaldehyde by cell suspension cultures of Datura tatula L]. 已发布 PubMed:天麻天花dna序列的克隆及其在鉴定天麻中的应用 [Cloning of distinguishing DNA sequences of Gastrodia elata Blume and application of them in identifying gastrodia tuber]. 已发布 PubMed:天麻素与 纤维蛋白原的相互作用 Gastrodin interaction with human fibrinogen: 抗凝作用和结合研究。 anticoagulant effects and binding studies. 已发布 PubMed:梯度高效液相色谱法同时测定狗血浆中天麻素和盐酸川gust嗪。 Simultaneous determination of Gastrodin and Ligustrazine hydrochloride in dog plasma by gradient high-performance liquid chromatography. 已发布 PubMed:[保护性 Protective 效果 影响 effects of gastrodin on the 蜂窝状的 细胞 cellular 模型 model of Alzheimer's 疾病 disease 诱发的 induced by by Abeta beta25-35]. 已发布 PubMed:高速逆流色谱法从中药天麻中制备纯化天麻素。 Preparative isolation and purification of gastrodin from the Chinese medicinal plant Gastrodia elata by high-speed counter-current chromatography. 已发布 PubMed: 罗马草变种变种的根茎的化学成分。 c头。 Chemical constituents of the rhizomes of Coeloglossum viride var. bracteatum. 已发布 PubMed:[关于藏药旺腊的化学成分的研究]。 [Studies on chemical constituents from Tibetan medicine wangla(rhizome of Coeloglossum viride var. bracteatum)]. 已发布 PubMed: [关于西洋古罗马草（l。）hartm的化学成分的研究。变种bracteatum bracteatum（willd。）richter]。 已发布 PubMed:各种营养液对天麻品质的影响 [Effect of various nutrient solutions on quality of Gastrodia elata]. 已发布 PubMed:天麻素降低癫痫发作敏感沙鼠海马中γ-氨基丁酸分流酶的免疫反应性。 Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils. 已发布 PubMed:［分析天麻中各种天麻的含量］。 [Analysis gastrodin in various types of Gastrodia elata Bl]. 已发布 PubMed:毛细管电泳-电化学检测法测定天麻中的有效成分 Determination of the active ingredients in Gastrodia rhizoma by capillary electrophoresis with electrochemical detection. 已发布 PubMed:天麻根茎中琥珀酸半醛脱氢酶抑制化合物的分离与鉴定。 Isolation and identification of succinic semialdehyde dehydrogenase inhibitory compound from the rhizome of Gastrodia elata Blume. 已发布 PubMed:天麻注射液对培养的血管平滑肌细胞增殖的影响 [The effect of Tianma injection on cultured vascular smooth muscle cells proliferation]. 已发布 PubMed:天麻和对羟基苄醇有助于记忆巩固和恢复 Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, 但不是收购 but not acquisition, 对大鼠的被动回避任务。 on the passive avoidance task in rats. 已发布 PubMed:天麻及其有效成分对东pol碱所致大鼠健忘症的影响。 Effects of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats. 已发布 PubMed:真诺宁胶囊中天麻素含量的定量测定方法 [Quantitative method for the determination of contents of gastrodin in zhennaonin capsules]. 已发布 PubMed:对羟基苄醇减轻抑制性回避任务中的学习缺陷 p-Hydroxybenzyl alcohol attenuates learning deficits in the inhibitory avoidance task: 涉及血清素能和多巴胺能系统。 involvement of serotonergic and dopaminergic systems. 已发布 PubMed:周围淋巴中的听力损失和微量元素fe2 +和zn2 +。 Hearing loss and trace elements Fe2+ and Zn2+ in the perilymph. 已发布 PubMed:篇名3h-胃泌二蛋白和3h-胃泌素在小鼠体内的生物分布和代谢 [Biodistribution and metabolism of 3H-gastrodigenin and 3H-gastrodin in mice]. 已发布 PubMed:[不同类型的药物治疗对胃液量和酸碱度的影响]。 [The effect of different types of premedication on gastric juice volume and pH]. 已发布 PubMed: [关于来自galeola Galeola faberi faberi rolfe的酚类衍生物的研究]。 已发布 PubMed:天麻素及其衍生物的机理研究。 [Study of the mechanism of gastrodin and derivatives of gastrodigenin]. 已发布 PubMed:[利用tdp（特定电磁波）培养天麻bl的试验]。 [A trial of utilizing TDP (specific electromagnetic wave) in cultivating Gastrodia elata Bl]. 已发布 PubMed:[注射型天麻的药理特性比较研究 [Comparison studies on pharmacological properties of injectio gastrodia elata, 无胃泌素的馏分和胃泌素]。 gastrodin-free fraction and gastrodin]. 已发布 PubMed:[3h-α-仲丁基-对羟基苄醇在小鼠中的分布]。 [The distribution of 3H-alpha-sec-butyl-p hydroxybenzyl alcohol in mice]. 已发布 PubMed:[关于天麻质量的研究。用各种真菌生长材料栽培]。 [Studies on the quality of Gastrodia elata Bl. cultivated with various kinds of fungus-growing materials]. 已发布 PubMed:氧化还原电势对好氧微生物生长的影响 [Effect of sapogenins from the leaves of Panax notoginseng on migraine]. 已发布 PubMed:[测定生物标本中天麻素和药代动力学]。 [Determination of gastrodin in biological specimens and in pharmacokinetics]. 已发布 PubMed:hplc同时测定天麻素及其代谢产物。 Simultaneous determination of gastrodin and its metabolite by HPLC. 已发布 PubMed:天麻素注射液稳定性的研究。 [Study on the stability of gastrodin injection]. 已发布 PubMed:合成天麻素对新生大鼠心脏细胞跳动和组织化学变化的影响 [Effect of synthetic gastrodin on the beating and histochemical changes of cultured heart cells of neonatal rats]. 已发布 PubMed:昼夜节律对大鼠天麻素药代动力学的影响。 [Circadian effect on gastrodin pharmacokinetics in rats]. 已发布 PubMed:[生产天麻的加工]。 [Processing of Gastrodia elata where it is produced]. 已发布 PubMed:天麻注射液和天麻素的一些药理作用研究。 [Studies on some pharmacological effects of gastrodia injection and gastrodin]. 已发布 PubMed:注射型合成天麻素对橙花衰弱的作用 [Effect of synthetic gastrodin in an injectable form on neurasthenia]. 已发布 PubMed:中国天麻的药理研究和临床应用的最新进展。 [Recent developments in pharmacological study and clinical application of Gastrodia elata in China].

笔记 Notes: 没找到 None Found