羟丙基甲基纤维素邻苯二甲酸酯 hydroxypropyl methylcellulose phthalate
邻苯二甲酸纤维素羟丙基甲基醚 cellulose phthalate hydroxypropyl methyl ether

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CAS号 CAS Number: 9050-31-1 其他 Other: 168395-88-8 FDA UNII: G4U024CQK6 MDL : mfcd00147216 MFCD00147216 类别 Category:oral care agents   美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent : 谷歌学术 Google Scholar: 搜索 Search 谷歌书 Google Books: 搜索 Search 谷歌学术 Google Scholar: with word "volatile" 搜索 Search 谷歌学术 Google Scholar: with word "flavor" 搜索 Search 谷歌学术 Google Scholar: with word "odor" 搜索 Search 谷歌专利 Google Patents: 搜索 Search 美国专利 US Patents: 搜索 Search 欧盟专利 EU Patents: 搜索 Search 已发布 PubMed: 搜索 Search NCBI: 搜索 Search   物理性质 Physical Properties: 化验 Assay: 95.00至100.00 95.00 to 100.00 食品化学品法典列表 Food Chemicals Codex Listed: No   感官特性 Organoleptic Properties: 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found).   化妆品信息 Cosmetic Information: CosIng: 化妆品数据 cosmetic data 化妆品用途 Cosmetic Uses: oral care agents   供应商 Suppliers: 西格玛·奥尔德里奇 Sigma-Aldrich 仅供实验/研究使用。 For experimental / research use only. 羟丙甲纤维素 Hypromellose phthalate 欧洲药典（ep）参考标准 European Pharmacopoeia (EP) Reference Standard   安全信息 Safety Information:   危害识别 Hazards identification   物质或混合物的分类 Classification of the substance or mixture 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) 没有找到。 None found. ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements   象形图 Pictogram   危险说明 Hazard statement(s) 没有找到。 None found. 防范说明 Precautionary statement(s) 没有找到。 None found. 口服/肠胃外毒性 Oral/Parenteral Toxicity: 口鼠 oral-rat ld LD > 15000 毫克 mg/kg 行为的 BEHAVIORAL: 共济失调 ATAXIA 行为的 BEHAVIORAL: 嗜睡 SOMNOLENCE (一般 GENERAL 郁闷 DEPRESSED 活动 ACTIvi VITY) oyo Oyo 矢久里 Yakuri. 药理学 Pharmacometrics. 卷 Vol. 4, pg. 1017 Pg. 1017, 1970. 皮肤毒性 Dermal Toxicity: 未定 Not determined 吸入毒性 Inhalation Toxicity: 未定 Not determined   使用安全信息 Safety in Use Information: 类别 Category: oral care agents 羟丙基甲基纤维素邻苯二甲酸酯用量建议 Recommendation for hydroxypropyl methylcellulose phthalate usage levels up to:   不用于香水。 not for fragrance use.   羟丙基甲基纤维素邻苯二甲酸酯风味剂用量建议 Recommendation for hydroxypropyl methylcellulose phthalate flavor usage levels up to:   不用于调味料。 not for flavor use.   安全参考 Safety references: EPA物质注册服务（tsca TSCA） :9050-31-1 EPA ACToR:毒理学资料 Toxicology Data EPA物质注册服务（srs sr Srs RS） :注册表 Registry 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data 德国wgk WGK Germany:1 chemidplus Chemidplus:0009050311   参考资料 References: pubchem（sid） Pubchem (sid): 135029952   其他资料 Other Information: hmdb（人类代谢组数据库） HMDB (The Human Metabolome Database): 搜索 Search   潜在搅拌机 Potential Blenders and 核心组件 core components note 没找到 None Found   潜在用途 Potential Uses: 没找到 None Found   存在（自然 Occurrence (nature, 餐饮 food, 其他） other):note   自然界中找不到 not found in nature   同义词 Synonyms:   邻苯二甲酸纤维素羟丙基甲基醚 cellulose phthalate hydroxypropyl methyl ether   HP 55   HP 55 F   hydroxypropyl methyl cellulose phthalate 2- hydroxypropyl methyl cellulose phthalate   羟丙基甲基纤维素 hydroxypropylmethylcellulose phthalate   文章 Articles: 已发布 PubMed:肠溶胶囊，内含β-半乳糖苷酶的聚乳酸纳米胶囊 Enteric-coated capsule containing β-galactosidase-loaded polylactic acid nanocapsules: 模拟胃肠道条件下的酶稳定性和牛奶乳糖水解。 enzyme stability and milk lactose hydrolysis under simulated gastrointestinal conditions. 已发布 PubMed:ph响应硫醇化壳聚糖纳米颗粒用于口服低分子量肝素 pH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: 体外和体内评估。 in vitro and in vivo evaluation. 已发布 PubMed:奥美拉唑的瞬时肠溶纳米胶囊 Instantaneous enteric nano-encapsulation of omeprazole: 药学和药理学评估。 pharmaceutical and pharmacological evaluation. 已发布 PubMed:磁吸泡沫的稳定性和粘弹性。 Stability and viscoelasticity of magneto-Pickering foams. 已发布 PubMed:制备 Preparation, 表征 characterization, 口服胰岛素的ins-sio 2 -hp55（载有胰岛素的二氧化硅涂层hp55）的体内评价和评价。 and evaluation in vivo of Ins-SiO₂-HP55 (insulin-loaded silica coating HP55) for oral delivery of insulin. 已发布 PubMed:用于无定形固体分散体配方开发的高效微型化共沉淀筛选（micos）。 Highly efficient miniaturized coprecipitation screening (MiCoS) for amorphous solid dispersion formulation development. 已发布 PubMed:包含兰索拉唑的新型每日一次微粒剂型，在胃食管反流疾病中可防止夜酸突破 A novel once daily microparticulate dosage form comprising lansoprazole to prevent nocturnal acid breakthrough in the case of gastro-esophageal reflux disease: 制备 Preparation, 药代动力学和药效动力学评估。 pharmacokinetic and pharmacodynamic evaluation. 已发布 PubMed:一种预测无定形固体分散体物理稳定性的实用方法。 A practical method to predict physical stability of amorphous solid dispersions. 已发布 PubMed:溶剂介导的微结构和胰岛素从ph敏感纳米颗粒的释放行为。 Solvent mediated microstructures and release behavior of insulin from pH-sensitive nanoparticles. 已发布 PubMed:hp55包衣的胶囊，内含plga / rs纳米颗粒，用于口服胰岛素。 HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. 已发布 PubMed:木瓜肠溶性亚微米颗粒制剂的研制 Development of enteric submicron particle formulation of papain for oral delivery. 已发布 PubMed:鼠李糖乳杆菌凝聚层缓释微粒递送系统的制备和表征。 Preparation and characterization of a coacervate extended-release microparticulate delivery system for Lactobacillus rhamnosus. 已发布 PubMed:口服递送的α-淀粉酶肠溶性亚微米颗粒制剂的开发。 Development of enteric submicron particles formulation of α-amylase for oral delivery. 已发布 PubMed:磁感应泡棉。 Magnetically responsive pickering foams. 已发布 PubMed:格列美脲和聚（酯酰胺）超支化聚合物的固体分散体的片剂的制备和表征 Preparation and characterization of tablet formulation based on solid dispersion of glimepiride and poly(ester amide) hyperbranched polymer. 已发布 PubMed:hpmc基聚合物作为载体使用熔体挤出机制造固体分散体的性能比较。 Comparison of HPMC based polymers performance as carriers for manufacture of solid dispersions using the melt extruder. 已发布 PubMed:木瓜蛋白酶的肠溶微球制剂，用于口服给药。 Enteric microsphere formulations of papain for oral delivery. 已发布 PubMed:hpmc和hpmcp的无定形固体分散体中尼群地平对映异构体结晶速率的差异。 Differences in crystallization rate of nitrendipine enantiomers in amorphous solid dispersions with HPMC and HPMCP. 已发布 PubMed:设计和评估用于口服胰岛素递送的新型ph敏感壳聚糖纳米颗粒。 Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. 已发布 PubMed:基于多糖衍生物的凝胶中sr（ii）离子的吸附和解吸 Adsorption and desorption of Sr(II) ions in the gels based on polysaccharide derivates. 已发布 PubMed:设计质量 Quality by design: draper-lin复合设计优化液体填充的ph响应大颗粒。 optimization of a liquid filled pH-responsive macroparticles using Draper-Lin composite design. 已发布 PubMed:开发含有益生菌的片剂 Development of tablets containing probiotics: 配方和加工参数对细菌生存力的影响。 Effects of formulation and processing parameters on bacterial viability. 已发布 PubMed:pan托拉唑微球的研制和体外评价。 Development and in vitro evaluation of pantoprazole-loaded microspheres. 已发布 PubMed:基于壳聚糖和肠溶性聚合物的醋氯芬酸每日一次缓释片 Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: 体外和体内研究。 in vitro and in vivo studies. 已发布 PubMed:制备包含伊曲康唑固体分散体的快速崩解片剂。 Preparation of rapidly disintegrating tablets containing itraconazole solid dispersions. 已发布 PubMed: 水溶性添加剂和hpmcp对含有坦洛新盐酸盐的su释放 release包衣小丸中药物释放的影响。 已发布 PubMed:eudragit e共混物中相行为的力学研究。 Mechanistic investigations of phase behavior in Eudragit E blends. 已发布 PubMed:hpmcp和hpmc混合物包衣的坦洛新盐酸盐控释药丸的统计学优化。 Statistical optimization of tamsulosin hydrochloride controlled release pellets coated with the blend of HPMCP and HPMC. 已发布 PubMed:响应面方法开发和优化新型盐酸坦洛新口服控释系统。 Development and optimization of a novel oral controlled delivery system for tamsulosin hydrochloride using response surface methodology. 已发布 PubMed:坦索罗辛盐酸盐缓释微丸的缓释和中和hpmcp包衣的优化。 Optimization of tamsulosin hydrochloride controlled release pellets coated with Surelease and neutralized HPMCP. 已发布 PubMed:设计自缔合阳离子聚合物以增强相容性 Designing a self-associated cationic polymer for enhanced compatibility, 适口性 palatability, 和 呋辛酯的胃释放。 and gastric release of cefuroxime axetil. 已发布 PubMed:反向肠溶性聚合物与肠溶性和pH无关的聚合物的共混物 Blends of reverse enteric polymer with Enteric and pH-independent polymers: 量身定制药物释放机制的研究。 mechanistic investigations for tailoring drug release. 已发布 PubMed:伊曲康唑和肠溶聚合物的固体分散体，通过快速冷冻制成。 Solid dispersions of itraconazole and enteric polymers made by ultra-rapid freezing. 已发布 PubMed:采用四流体喷嘴喷雾干燥技术的三组分系统缓释颗粒设计。 Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique. 已发布 PubMed:胰岛素的plga-hp55纳米颗粒的口服制备。 Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. 已发布 PubMed:结肠给药 Colonic drug delivery: 交联剂对果胶微珠性能的影响以及壳胶囊类型的作用。 influence of cross-linking agent on pectin beads properties and role of the shell capsule type. 已发布 PubMed:针对慢性问题的新解决方案；水性肠溶衣。 A new solution for a chronic problem; aqueous enteric coating. 已发布 PubMed:两种新型比卡鲁胺制剂在健康男性志愿者中的药代动力学。 Pharmacokinetics of two novel bicalutamide formulations in healthy male volunteers. 已发布 PubMed:双螺杆挤出机制备和评价硝苯地平-卡波姆和硝苯地平-hpmcp系统的固体分散体。 Preparation and evaluation of solid dispersion for nitrendipine-carbopol and nitrendipine-HPMCP systems using a twin screw extruder. 已发布 PubMed:球形结晶法盐析法制备齐墩果酸双半邻苯二甲酸钠肠溶微球 Preparation of enteric microsphere of oleanolic acid dihemiphthalate sodium by salting-out action using spherical crystallization technique. 已发布 PubMed:[使用去卷积法评估三种自行设计的缓释尼群地平制剂的体内外相关性]。 [Evaluation of in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method]. 已发布 PubMed:依赖于ph的tcm缓释微丸的制备和评价。 Preparation and evaluation of pH-dependent gradient-release pellets for TCM. 已发布 PubMed:尼群地平ii的新型ph依赖性梯度释放系统。研究影响系统释放行为的因素。 A novel pH-dependent gradient-release delivery system for nitrendipine II. Investigations of the factors affecting the release behaviors of the system. 已发布 PubMed:环孢素α-羟丙基甲基纤维素邻苯二甲酸酯纳米粒在大鼠体内的相对生物利用度 [Relative bioavailability of cyclosporine A-loaded hydroxypropyl methylcellulose phthalate nanoparticles for oral administration in rats]. 已发布 PubMed:尼群地平的一种新的依赖ph的梯度释放系统 A novel pH-dependent gradient-release delivery system for nitrendipine: 一世。制造业 I. Manufacturing, 评估健康犬的体外和生物利用度。 evaluation in vitro and bioavailability in healthy dogs. 已发布 PubMed:口服环孢素a负载的ph敏感纳米颗粒的生物利用度和药代动力学。 Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration. 已发布 PubMed:悬浮剂对大鼠口服环孢素A载脂蛋白纳米粒相对生物利用度的影响 [Influence of suspending agents on relative bioavailability of cyclosporine A-loaded HPMCP nanoparticles for oral administration to rats]. 已发布 PubMed:通过向大鼠施用肠溶微球和硫酸氢钠可增强胃肠道对胰岛素的吸收。 Gastrointestinal absorption enhancement of insulin by administration of enteric microspheres and SNAC to rats. 已发布 PubMed:使用具有多角度激光散射检测器的尺寸排阻色谱法测定羟丙甲纤维素邻苯二甲酸酯（hpmcp）的分子量。 Molecular weight determination of hypromellose phthalate (HPMCP) using size exclusion chromatography with a multi-angle laser light scattering detector. 已发布 PubMed:羟丙基甲基纤维素邻苯二甲酸酯（hpmcp）纳米颗粒包衣的片剂的溶胀和药物释放行为。 Swelling and drug release behavior of tablets coated with aqueous hydroxypropyl methylcellulose phthalate (HPMCP) nanoparticles. 已发布 PubMed:物理稳定性和药物-羟丙基甲基纤维素邻苯二甲酸酯的焓变松弛共沉淀物。 Physical stability and enthalpy relaxation of drug-hydroxypropyl methylcellulose phthalate solvent change co-precipitates. 已发布 PubMed:溶剂变化共沉淀过程中影响药物与hpmcp掺入固溶体的因素 Factors affecting incorporation of drug into solid solution with HPMCP during solvent change co-precipitation. 已发布 PubMed:与羟丙基共溶剂变化共沉淀邻苯二甲酸甲基纤维素酯可改善水溶性差的药物的溶出特性。 Solvent change co-precipitation with hydroxypropyl methylcellulose phthalate to improve dissolution characteristics of a poorly water-soluble drug. 已发布 PubMed:捏合桨的作用以及螺杆转速和水含量对双螺杆挤出机制备固体分散体的影响。 The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder. 已发布 PubMed:大鼠小肠中肠粘膜粘附膜的保留和转运。 Retention and transit of intestinal mucoadhesive films in rat small intestine. 已发布 PubMed:浸渍法制备的肠道压力控制结肠递送胶囊的评价。 Evaluation of an intestinal pressure-controlled colon delivery capsules prepared by a dipping method. 已发布 PubMed:药物粒径对液滴挤出/沉淀法生产的肠溶珠的影响。 Drug particle size influence on enteric beads produced by a droplet extrusion/precipitation method. 已发布 PubMed:设计 Design, 多潘立酮共蒸发的优化和评估。 optimization and evaluation of domperidone coevaporates. 已发布 PubMed:[评价羟丙基甲基纤维素邻苯二甲酸酯（hp 55）假胶乳的成膜性能]。 [Evaluation of film forming properties of a hydroxypropylmethylcellulose phthalate (HP 55) pseudolatex]. 已发布 PubMed:设计 Design of a "杀菌剂 microbicide" for 预防 避免 prevention of 性爱 sexually 已传送 transmitted 疾病 疾病 diseases 使用 using "不活跃 inactive" 制药业 pharmaceutical 辅料 excipients. 已发布 PubMed:水性包衣对肠溶衣丸剂和片剂稳定性的影响。 Influence of aqueous coatings on the stability of enteric coated pellets and tablets. 已发布 PubMed:通过固体分散技术改善了阿苯达唑在兔中的口服生物利用度。 Improving the oral bioavailability of albendazole in rabbits by the solid dispersion technique. 已发布 PubMed:甲酸香茅酯Extra FCC甲酸香茅酯FCC柠檬酸香茅酯天然柠檬酸香茅酯纯柠檬酸香茅酯甲酸FCC柠檬酸香茅酯甲酸香茅酯（1）-3 Characterization of impurities formed by interaction of duloxetine HCl with enteric polymers hydroxypropyl methylcellulose acetate succinate and hydroxypropyl methylcellulose phthalate. 已发布 PubMed:羟丙基甲基纤维素邻苯二甲酸酯处理的鸡卵黄抗体在小牛胃肠道中的传播。 Passage of chicken egg yolk antibody treated with hydroxypropyl methylcellulose phthalate in the gastrointestinal tract of calves. 已发布 PubMed:新型HIV-1蛋白酶抑制剂口服剂型的生物利用度 The bioavailability of oral dosage forms of a new HIV-1 protease inhibitor, kni-272 KNI-272, 在比格犬。 in beagle dogs. 已发布 PubMed:使用固体分散技术改善难溶性药物的口服吸收。 Oral absorption improvement of poorly soluble drug using solid dispersion technique. 已发布 PubMed:制备 Preparation, ε-己内酯和羟丙基甲基纤维素邻苯二甲酸酯酮洛芬微球的表征和体外药物释放。 characterization and in vitro drug release of poly-epsilon-caprolactone and hydroxypropyl methylcellulose phthalate ketoprofen loaded microspheres. 已发布 PubMed:改善难溶性药物的肠溶性共沉淀物的口服吸收。 Improved oral absorption of enteric coprecipitates of a poorly soluble drug. 已发布 PubMed:物理老化对无聚合物薄膜机械性能的影响 Influence of physical aging on mechanical properties of polymer free films: 长期老化对聚合物薄膜衣片的透水性和溶出度的影响的预测。 the prediction of long-term aging effects on the water permeability and dissolution rate of polymer film-coated tablets. 已发布 PubMed:用于掩盖大环内酯类抗生素味道的聚合物载体系统。 A polymer carrier system for taste masking of macrolide antibiotics. 已发布 PubMed:ty21a 越橘的肠溶胶囊和液体制剂在随机对照试验中的比较。 Comparison of enteric-coated capsules and liquid formulation of Ty21a typhoid vaccine in randomised controlled field trial. 已发布 PubMed:物理老化对阴离子聚电解质溶解速率的影响。 The effect of physical aging on the dissolution rate of anionic polyelectrolytes. 已发布 PubMed:相对湿度对模型交互系统粘合特性的影响。 Influence of relative humidity on the adhesive properties of a model interactive system. 已发布 PubMed:[成膜剂和增塑剂对电阻稳定性和崩解行为的影响。 4.耐胃液商业制剂的药物技术和分析研究]。 [Effect of film formers and plasticizers on the stability of resistance and disintegration behavior. 4. Pharmaceutical-technological and analytical studies of gastric juice-resistant commercial preparations]. 已发布 PubMed:[乙酰水杨酸微粒的制备和涂层 [Fabrication and coating of microgranules of acetylsalicylic acid: 使用hp55]。 use of HP55]. 已发布 PubMed:hp55包覆的乙酰水杨酸微粒中痕量有机溶剂的分析 [Analysis of traces of organic solvents in microgranules of acetylsalicylic acid coated with HP55]. 已发布 PubMed:硝苯地平从颗粒中持续释放。 Sustained release of nifedipine from granules. 已发布 PubMed:用于评估肠溶衣的放射性遥测方法。 Radiotelemetric method for evaluating enteric coatings in vivo. 已发布 PubMed:改善左旋多巴vi生物利用度的剂型设计 Dosage form design for improvement of bioavailability of levodopa VI: 泡腾肠溶片的配方。 formulation of effervescent enteric-coated tablets.

笔记 Notes: 用于包覆微粒。 used to coat microgranules.

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