类别 Category:flavoring agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
出现 Appearance: | 无色至黄澄清液体(est) colorless to yellow clear liquid (est) |
化验 Assay: | 98.00至100.00 98.00 to 100.00
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食品化学品法典列表 Food Chemicals Codex Listed: | No |
比重 Specific Gravity: | 1.19800 to 1.20200 @ 25.00 °C.
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磅每加仑-(est)。 Pounds per Gallon - (est).: | 9.969至10.002 9.969 to 10.002
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折光率 Refractive Index: | 1.53100 to 1.54100 @ 20.00 °C.
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沸点 Boiling Point: | 115.00 to 118.00 °C. @ 760.00 mm 汞 Hg
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蒸汽压力 Vapor Pressure: | 21.613001 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
闪点 Flash Point: | 72.00 °F. tcc TCC ( 22.22 °C. )
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logp(o / w) logP (o/w): | 0.440 |
溶于 Soluble in: |
| alcohol | | 水 water, 5.378e + 004 mg / l @ 25°c(est) 5.378e+004 mg/L @ 25 °C (est) |
感官特性 Organoleptic Properties:
气味类型 Odor Type: fishy |
气味强度 Odor Strength:高 high , 建议在0.10%或更少的溶液中闻到 recommend smelling in a 0.10 % solution or less |
fishy nutty meaty |
气味描述 Odor Description:at 0.10 % in propylene glycol. pyridine nutty meaty |
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
首选SDS Preferred SDS: 视图 View |
欧洲信息 European information : |
最重要的危害 Most important hazard(s): | xn-有害。 Xn - Harmful. |
R 10 - 易燃的 Flammable. R 22 - 有害 Harmful if 吞下 sw允许 al低 lowed. R 37/38 - 烦 的 Irritating to 呼吸的 respiratory 系统 system and skin 皮. R 41 - 风险 Risk of 严重 serious 损伤 damage to 眼睛 眼睛 eyes. S 02 - 保持 Keep out of the 达到 reach of 孩子们 children. S 16 - 保持 Keep 远 away from 资料来源 sources of 点火 ignition - No 抽烟 Smoking. S 20/21 - 什么时候 When 使用 using do not eat, 喝 drink or 抽烟 smoke. S 24/25 - 避免 Avoid contact with skin 皮 and 眼睛 眼睛 eyes. S 26 - In 案件 case of contact with 眼睛 眼睛 eyes, 冲洗 rinse 立即 immediately with 充裕 plenty of 水 water and 寻求 seek 医疗 medical advice. S 37/39 - 穿 Wear 适当 suitable 手套 gloves and 眼睛 eye/face 保护 protection.
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危害识别 Hazards identification |
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物质或混合物的分类 Classification of the substance or mixture |
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
没有找到。 None found. |
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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象形图 Pictogram | |
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危险说明 Hazard statement(s) |
没有找到。 None found. |
防范说明 Precautionary statement(s) |
没有找到。 None found. |
口服/肠胃外毒性 Oral/Parenteral Toxicity: |
老鼠 口服 oral-mouse LD50 983 mg/kg Drug and Chemical 毒理学 Toxicology. 卷 Vol. 3, pg。 249 Pg. 249, 1980.
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皮肤毒性 Dermal Toxicity: |
未定 Not determined
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吸入毒性 Inhalation Toxicity: |
未定 Not determined
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使用安全信息 Safety in Use Information:
类别 Category: | flavoring agents |
噻唑用量建议 Recommendation for thiazole usage levels up to: | | 不用于香水。 not for fragrance use.
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最大化源自调查的每日摄入量(msdi-eu) Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012(微克/ 均/天) 0.012 (μg/capita/day) |
最大化源自调查的每日摄入量(msdi-usa) Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.07(微克/ 均/天) 0.07 (μg/capita/day) |
结构类 Structure Class: | II |
采用 Use 等级 levels for FEMA GRAS flavoring 物质 物质 substances on 哪一个 which the FEMA 专家 Expert 面板 Panel 基于 based its 判断 judgments that the 物质 物质 substances are 通常 generally 公认的 recognized as safe (GRAS). |
The 专家 Expert 面板 Panel 也 also 发表 publishes 分离 separate 广泛 extensive 评论 reviews of scientific information on all FEMA GRAS flavoring 物质 物质 substances and can be 发现 found at FEMA 味道 Flavor Ingredient 图书馆 Library |
出版编号 publication number: 12 |
单击此处查看出版物12 Click here to view publication 12 |
| 平均 average 通常 usual 百万分之几 ppm | 平均 average 最大 maximum 百万分之几 ppm |
焙烤食品 baked goods: | - | - |
饮料(不含醇) beverages(nonalcoholic): | - | - |
醇饮料 beverages(alcoholic): | - | - |
早餐麦片 breakfast cereal: | - | - |
起司 cheese: | - | - |
口香糖 chewing gum: | - | 10.00000 |
调味品/调味品 condiments / relishes: | - | - |
糖果烧烤 confectionery froastings: | - | - |
蛋制品 egg products: | - | - |
脂肪/油 fats / oils: | - | - |
鱼产品 fish products: | - | - |
冷冻乳制品 frozen dairy: | - | - |
水果冰 fruit ices: | - | - |
明胶/布丁 gelatins / puddings: | - | - |
砂糖 granulated sugar: | - | - |
肉汁 gravies: | - | - |
硬糖 hard candy: | - | - |
仿乳制品 imitation dairy: | - | 5.00000 |
速溶咖啡/茶 instant coffee / tea: | - | - |
果酱/果冻 jams / jellies: | - | - |
肉制品 meat products: | - | 5.00000 |
奶制品 milk products: | - | - |
坚果产品 nut products: | - | 5.00000 |
其他谷物 other grains: | - | - |
家禽 poultry: | - | - |
加工水果 processed fruits: | - | - |
加工蔬菜 processed vegetables: | - | - |
重构蔬菜 reconstituted vegetables: | - | 10.00000 |
调味料 seasonings / flavors: | - | 5.00000 |
休闲食品 snack foods: | - | - |
软糖 soft candy: | - | - |
汤类 soups: | - | - |
糖替代品 sugar substitutes: | - | - |
甜酱 sweet sauces: | - | - |
安全参考 Safety references:
欧洲食品安全法规(efsa) European Food Safety Athority(efsa):风味使用水平;亚急性 Flavor usage levels; Subacute, 亚慢性 Subchronic, 慢性和致癌性研究;发育/ 毒性研究;遗传毒性研究... Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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欧洲食品安全局(efsa EFSA)参考 :
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调味组评估76 Flavouring Group Evaluation 76, (fge.76)[1]-考虑通过与结构上相关的噻唑的jecfa(第五十九次会议)评估的含硫杂环化合物 (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, 来自化学组29的噻唑啉和噻吩衍生物 thiazoline and thienyl derivatives from chemical group 29, efsa EFSA在fge.21中评估了化学30组的其他杂物-食品添加剂专家组的科学观点 , 调味料 seasonings / flavors, 处理中 Processing 艾滋病 Aids and 材料 Materials in 联系 Contact with Food 视图 View page or 视图 View pdf
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调味品组评价的科学见解76 Scientific Opinion on Flavouring Group Evaluation 76, 版本1(fge.76rev1) Revision 1 (FGE.76Rev1): jecfa(第五十九次会议)评估的与噻唑结构相关的含硫杂环化合物的考虑 Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, 来自化学组29的噻唑啉和噻吩衍生物 thiazoline and thienyl derivatives from chemical group 29 and 杂 mis细胞 cellaneous 物质 物质 substances from chemical group 30 已评估 evaluated by by efsa EFSA in ge FGE.21Rev3 视图 View page or 视图 View pdf
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Epi系统 EPI System: 视图 View |
化学致癌研究信息系统 Chemical Carcinogenesis Research Information System:搜索 Search |
环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search |
橙花发育和 毒性 NLM Developmental and Reproductive Toxicity:搜索 Search |
EPA物质注册服务(tsca TSCA) :288-47-1 |
EPA ACToR:毒理学资料 Toxicology Data |
EPA物质注册服务(SRS) :注册表 Registry |
实验室化学安全摘要 Laboratory Chemical Safety Summary :9256 |
国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data |
明智的 WISER:1993年 UN 1993 |
德国wgk WGK Germany:3 |
1,3-thiazole |
chemidplus Chemidplus:0000288471 |
epa / noaa客串 EPA/NOAA CAMEO:有害物质 hazardous materials |
技术 technology:CAS#288-47-1的xj1290000 XJ1290000 for cas# 288-47-1 |
参考资料 References:
| 1,3-thiazole |
NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
加拿大国内分公司。清单 Canada Domestic Sub. List: | 288-47-1 |
pubchem(cid) Pubchem (cid): | 9256 |
pubchem(sid) Pubchem (sid): | 134974462 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core 组件 components note
潜在用途 Potential Uses:
存在(自然 Occurrence (nature, food, 其他) other): note
同义词 Synonyms:
文章 Articles:
已发布 PubMed:潜在 Potential of 芳基脲-苯并呋喃噻唑 aryl-urea-苯并 benzofuranylthiazoles hybrids as 多任务 multitaskin 皮g agents in Alzheimer's 疾病 disease. |
已发布 PubMed:链球菌溶血素的最小溶细胞单位的鉴定和毒素家族的扩展。 Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family. |
已发布 PubMed:关键中间体揭示了神秘大肠菌素途径中的新生物合成事件。 Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway. |
已发布 PubMed:噻唑-zn饲料处理对鼠瘟-道利大鼠的甲状腺滤泡性损伤为一年。 Thyroid follicular lesions induced by thiazole-Zn feed treatment for one year in Sprague-Dawley rats. |
已发布 PubMed:wnt /β-catenin的激活和抑制功能在肝细胞中的核受体诱导细胞色素p450中的作用。 Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells. |
已发布 PubMed:吡唑及其生物等排体的新型杂环 New heterocyclic hybrids of pyrazole and its bioisosteres: 设计 design, 合成和生物学评估作为双重作用的抗疟抗疟药。 synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. |
已发布 PubMed:隔离 Isolation, 鉴定 identification, 美拉德微黄颜料的合成及形成条件 and formation conditions of a novel Maillard yellowish pigment, 吡咯噻唑酸盐。 pyrrolothiazolate. |
已发布 PubMed:3dqsar 3D-QSAR, 一系列rorγt抑制剂的分子对接和分子动力学研究。 molecular docking and molecular dynamics studies of a series of RORγt inhibitors. |
已发布 PubMed:玉米器官中硫胺素生物合成途径中的分工。 Divisions of labor in the thiamin biosynthetic pathway among organs of maize. |
已发布 PubMed:鞘氨醇激酶抑制剂ski-ii对转录因子nrf2信号的激活是由keap1二聚体的形成介导的。 Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. |
已发布 PubMed: 通过联合微粉/芬顿工艺以微克 μg/ l的规模处理模拟的农业食品工业废水来处理噻菌灵的命运。 |
已发布 PubMed:肽核酸(pnas)用于通过溶液和表面方法进行基因分型的用途。 Use of peptide nucleic acids (PNAs) for genotyping by solution and surface methods. |
已发布 PubMed:2的合成与抗蚊性能 Synthesis and antimosquito properties of 2,6-取代的苯并[d]噻唑和2 6-substituted benzo[d]thiazole and 2,抗阿拉伯按蚊的4-取代苯并[d]噻唑类似物。 4-substituted benzo[d]thiazole analogues against Anopheles arabiensis. |
已发布 PubMed:萨嫩山羊和萨福克羊羔肉的挥发性和水溶性和脂溶性前体。 Volatiles and water- and fat-soluble precursors of Saanen goat and cross Suffolk lamb flavour. |
已发布 PubMed:暴露于噻唑-zn对雌性大鼠甲状腺功能和发育的影响 Effects of pubertal exposure to thiazole-Zn on thyroid function and development in female rats. |
已发布 PubMed:使用虚拟筛选选择的经fda批准的药物与g-四链体dna特异性结合。 FDA-approved drugs selected using virtual screening bind specifically to G-quadruplex DNA. |
已发布 PubMed:4-取代甲氧基苯甲酰基-芳基-噻唑和2-芳基-4-苯甲酰基-咪唑的药代动力学优化,可提高口服生物利用度。 Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability. |
已发布 PubMed:[硫胺素及其衍生物在细胞代谢中的调控]。 [Thiamine and its derivatives in the regulation of cell metabolism]. |
已发布 PubMed:番茄风味增强剂的风味释放 Flavor release of the tomato flavor enhancer, 2-异丁基噻唑 2-isobutylthiazole, 来自乳清蛋白稳定的模型敷料。 from whey protein stabilized model dressings. |
已发布 PubMed:充电状态为1 Charged states of 1,3,5-三嗪分子作为星形分子结构的模型 5-triazine molecules as models for star-shaped molecular architecture: dft和光谱电化学研究。 a DFT and spectroelectrochemical study. |
已发布 PubMed:化学的可尼丁和相关化合物。 Chemistry of clothianidin and related compounds. |
已发布 PubMed:设计和合成具有抗肥胖和抗糖尿病活性的新型丙二酰-coa脱羧酶抑制剂。 Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. |
已发布 PubMed:用于荧光的基于dna /配体/离子的集成打开了具有可调动态范围的半胱氨酸和组氨酸检测功能 DNA/ligand/ion-based ensemble for fluorescence turn on detection of cysteine and histidine with tunable dynamic range. |
已发布 PubMed:[Mu3-cis-n- -n- N-(2-aminoethyl)-N'-(2-carboxylatophenyl)草酰胺 oxamidato(3-)]bis(2,2'-diamino-4,4'-bi-1,3-噻唑)四铜(ii)双(2 3-thiazole)tetracopper(II) bis(2,4,6-三硝基苯酚盐)。 6-trinitrophenolate). |
已发布 PubMed:活力染色与流式细胞仪结合使用可快速评估鼠李糖乳杆菌gg在复合物蛋白质基质中的活力。 Use of viability staining in combination with flow cytometry for rapid viability assessment of Lactobacillus rhamnosus GG in complex protein matrices. |
已发布 PubMed:1的合成与生物活性评价 Synthesis and biological activity evaluation of 1,2,3-噻二唑衍生物作为潜在引发剂具有高度系统性获得性抵抗力。 3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance. |
已发布 PubMed:取代(1)的合成及其杀虫活性 Synthesis and insecticidal activity of N-substituted (1,3-噻唑)烷基亚磺酰亚胺衍生物。 3-thiazole)alkyl sulfoximine derivatives. |
已发布 PubMed:合成 Synthesis, 除草活性 herbicidal activities, 和含有芳族甲胺部分的2-氰基丙烯酸酯的3d-qsar。 and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties. |
已发布 PubMed:网状血小板干扰流式细胞仪网织红细胞计数。 Reticulated platelets interfere with flow cytometric reticulocyte counts. |
已发布 PubMed:硝基噻唑和溴噻唑并诱导被原生动物新 感染的细胞中的速殖子流出 Induction of tachyzoite egress from cells infected with the protozoan Neospora caninum by nitro- and bromo-thiazolides, 一类广谱抗寄生虫药。 a class of broad-spectrum anti-parasitic drugs. |
已发布 PubMed:水(2 Aqua(2,2'-diamino-4,4'-bi-1,3-噻唑-kappa2n 3-thiazole-kappa2N,N')(oxydiacetato-kappa3O,O',O'')钴 cobalt(II) 三水合物 trihydrate. |
已发布 PubMed:无菌包装豆浆中热诱导的香气的仪器和感官表征。 Instrumental and sensory characterization of heat-induced odorants in aseptically packaged soy milk. |
已发布 PubMed:硝基和溴代噻唑基-水杨酰胺化合物(噻唑类内酯)对贝罗氏菌在贝罗韦氏菌感染中的体外功效。 In vitro efficacy of nitro- and bromo-thiazolyl-salicylamide compounds (thiazolides) against Besnoitia besnoiti infection in Vero cells. |
已发布 PubMed:气相色谱-嗅觉法和气相色谱-硫检测法比较三种荔枝品种的气味特征 Comparison of three lychee cultivar odor profiles using gas chromatography-olfactometry and gas chromatography-sulfur detection. |
已发布 PubMed: 噻唑化物系列对细胞内api复合物 complexan api复合物 complexan原生动物新 的体外功效与构效关系的研究。 |
已发布 PubMed: 紫外线对脱氧核糖核酸 DNA的损伤对噻唑橙嵌入的影响 : 一个方便的记者,对dna的损害。 a convenient reporter for DNA damage. |
已发布 PubMed:diaqua(2 Diaqua(2,2'-diamino-4,4'-bi-1,3-噻唑)氧代硫酸根合钒(iv)四水合物。 3-thiazole)oxosulfatovanadium(IV) tetrahydrate. |
已发布 PubMed:金属蛋白酶在醇和热氧化葵花籽油诱导的毒性中的表达模式 Expression pattern of matrix metalloproteinases in alcohol- and thermally oxidized sunflower oil-induced toxicity: 氨基噻唑衍生物的保护作用。 protective role of an aminothiazole derivative. |
已发布 PubMed:ki值的鱼类鲜度控制质量评价传感器的研制。 Development of quality evaluation sensor for fish freshness control based on KI value. |
已发布 PubMed:吸收 Absorption, 组织分布 tissue distribution, excretion, 胺在大鼠体内的代谢和代谢 and metabolism of clothianidin in rats. |
已发布 PubMed:产生针对磺酰胺的基团特异性抗体。 Generation of group-specific antibodies against sulfonamides. |
已发布 PubMed:番茄基质对重要香气化合物挥发性的影响 Differential effects of tomato (Lycopersicon esculentum mill) matrix on the volatility of important aroma compounds. |
已发布 PubMed:流式细胞术方法的开发,以分析益生菌产品和乳制品发酵剂中细菌的亚群。 Development of a flow cytometric method to analyze subpopulations of bacteria in probiotic products and dairy starters. |
已发布 PubMed:流式细胞仪评估乳酸菌的生存能力。 Flow cytometric assessment of viability of lactic acid bacteria. |
已发布 PubMed:葡萄酒香气的方法 Approaches to wine aroma: 葡萄酒中半胱氨酸和羰基化合物之间的反应释放出香气化合物。 release of aroma compounds from reactions between cysteine and carbonyl compounds in wine. |
已发布 PubMed:氨基和脲取代的噻唑抑制光合作用电子转移。 Amino- and urea-substituted thiazoles inhibit photosynthetic electron transfer. |
已发布 PubMed:流式细胞仪检测血小板减少性马匹中噻唑橙阳性(网状)血小板。 Flow cytometric method for detecting thiazole orange-positive (reticulated) platelets in thrombocytopenic horses. |
已发布 PubMed:噻苯达唑和其他噻唑在小鼠体内形成有毒代谢产物。鉴定硫酰胺类作为环裂解产物。 Formation of toxic metabolites from thiabendazole and other thiazoles in mice. Identification of thioamides as ring cleavage products. |
已发布 PubMed:在谷胱甘肽缺乏的小鼠中,硫代甲酰胺在噻菌灵和相关噻唑的肾毒性中的作用 Possible role of thioformamide as a proximate toxicant in the nephrotoxicity of thiabendazole and related thiazoles in glutathione-depleted mice: 结构毒性和代谢研究。 structure-toxicity and metabolic studies. |
已发布 PubMed:通过用丁硫氨酸亚砜亚胺处理的小鼠,在摄入谷胱甘肽后,与噻菌灵在结构上相关的噻唑的肾毒性。 Nephrotoxicity of thiazoles structurally related to thiabendazole in mice depleted of glutathione by treatment with buthionine sulfoximine. |
已发布 PubMed:2-(恶二唑基)-和2-(噻唑基)咪唑[1 2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]嘧啶对苯二氮卓受体的激动剂和反向激动剂。 2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors. |
已发布 PubMed:啮齿动物饮食中n- [4-(5-硝基-2-呋喃基)-2-噻唑基]甲酰胺和2-氨基-4-(5-硝基-2-呋喃基)噻唑的定量分析 Quantitation of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and 2-amino-4-(5-nitro-2-furyl)thiazole in rodent diet. |
已发布 PubMed:清漆树脂通常更溶于高酸性油,另外,高酸性油通常为更好的油漆油。 adm的高级亚麻籽油是完全碱精制的 The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients. |
已发布 PubMed:组胺的作用 The effect of histamine, h1和h2激动剂 H1 and H2 agonists, 和h1和h2拮抗剂对犬餐后胰腺多肽的释放。 and H1 and H2 antagonists on postprandial pancreatic polypeptide release in dogs. |
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调味成分 Flavouring ingredient
噻唑部分是维生素b1(硫胺素)和埃博霉素的重要组成部分。其他重要的噻唑是苯并噻唑 The thiazole moiety is a crucial part of vitamin B1 (thiamine) and epothilone. Other important thiazoles are benzothiazoles, 例如 for example, 萤火虫化学萤光素。噻唑 the firefly chemical luciferin.; Thiazole, 或1 or 1,3-thiazole, 淡黄至淡黄可燃液体,带有吡啶样气味,分子式为c3h3ns。这是一个五元环 is a clear to pale yellow flammable liquid with a pyridine-like odor and the molecular formula C3H3NS. It is a 5-membered ring, 其中环的两个顶点是氮和硫 in which two of the vertices of the ring are nitrogen and sulfur, 其他三个是碳。噻唑是一类与具有共同噻唑官能团的唑有关的有机化合物。噻唑是芳香族的。 and the other three are carbons.; Thiazoles are a class of organic compounds related to azoles with a common thiazole functional group. Thiazoles are aromatic.
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