类别 Category:flavoring agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
出现 Appearance: | 白固体(est) white solid (est) |
化验 Assay: | 异构体总和为99.00至100.00 99.00 to 100.00 sum of isomers
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食品化学品法典列表 Food Chemicals Codex Listed: | No |
熔点 Melting Point: | 72.00 °C. @ 760.00 mm 汞 Hg
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沸点 Boiling Point: | 185.00 °C. @ 760.00 mm 汞 Hg
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沸点 Boiling Point: | 66.00 to 67.00 °C. @ 10.00 mm 汞 Hg
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蒸汽压力 Vapor Pressure: | 0.505000 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
蒸气密度 Vapor Density: | 2.9 ( 空气 Air = 1 ) |
闪点 Flash Point: | 186.00 °F. tcc TCC ( 85.56 °C. )
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logp(o / w) logP (o/w): | 0.720 |
溶于 Soluble in: |
| alcohol | | 水 water, 在25°C(实验)下为8.60e + 04 mg / l 8.60E+04 mg/L @ 25 °C (exp) |
不溶于 Insoluble in: |
| 水 water |
感官特性 Organoleptic Properties:
气味类型 Odor Type: milky |
气味强度 Odor Strength:高 high , 建议在0.10%或更少的溶液中闻到 recommend smelling in a 0.10 % solution or less |
roasted burnt |
气味描述 Odor Description:at 0.10 % in propylene glycol. 烤烧 roasted burnt |
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found). |
弗鲁塔罗姆 Frutarom |
2-丁烯酸(巴豆酸) 2-BUTENOIC ACID (CROTONIC ACID) |
气味描述 Odor Description:烤 Roast, 烧了 Burnt 建议用途 Suggested Uses: 面包 FLbread, 咖啡 FLcoffee, 热带水果 Tropical Fruits |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
欧洲信息 European information : |
最重要的危害 Most important hazard(s): | xn-有害。 Xn - Harmful. |
r 20/21/22-吸入有害 R 20/21/22 - Harmful by inhalation, in contact with skin and if 吞下 sw允许的 allowed. R 34 - 原因 Causes 烧伤 burns. S 02 - 保持 Keep out of the 达到 r每 each of 孩子们 children. S 26 - In 案件 case of contact with 眼睛 眼睛 eyes, 冲洗 rinse 立即 immediately with 充裕 plenty of 水 water and 寻求 seek 医疗 medical 忠告 advice. S 27 - 采取 Take off 立即 immediately all 污染 contaminated 服装 clothing. S 28 - 后 After contact with skin, 洗 wash 立即 immediately with 充裕 plenty of 水 water. S 36/37/39 - 穿 我们 Wear 适当 suitable 服装 clothing, 手套和眼睛/面部防护。 gloves and eye/face protection.
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危害识别 Hazards identification |
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物质或混合物的分类 Classification of the substance or mixture |
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
没有找到。 None found. |
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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象形图 Pictogram | |
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危险说明 Hazard statement(s) |
没有找到。 None found. |
防范说明 Precautionary statement(s) |
没有找到。 None found. |
口服/肠胃外毒性 Oral/Parenteral Toxicity: |
口鼠 口服 oral-rat LD50 1000 mg/kg kg 日志 Journal of 产业 Industrial 卫生 Hygiene and 毒理学 有毒的 Toxicology. 卷 Vol. 26, pg。 269 Pg. 269, 1944.
老鼠 口服 oral-老鼠 mouse LD50 4800 mg/kg kg Biochemical 日志 Journal. 卷 Vol. 34, pg. 1196 Pg. 1196, 1940.
腹腔内小鼠 intraperitoneal-老鼠 mouse LD50 25 mg/kg kg "Patty's 产业 Industrial 卫生 Hygiene and 毒理学 有毒的 Toxicology," 第三版ed。 3rd rev. ed., 克莱顿 Clayton, g.d. G.D., 和f.e.克莱顿 and F.E. Clayton, eds。 eds., 纽约 New York, 约翰·威利&儿子 John Wiley & Sons, 公司 Inc., 1978-82年。卷3原来的酒吧。 1979年;酒馆作为2n转。 ed。 1985年2c 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, pg. 4953 Pg. 4953, 1982.
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皮肤毒性 Dermal Toxicity: |
皮肤兔子 skin-rabbit LD50 600 mg/kg kg "Prehled 恶作剧 Prumyslove 毒物学 Toxikologie; 有机酮 有机 Organicke 懒汉 Latky," 马尔霍尔德 Marhold, j. J., 布拉格 Prague, 捷克斯洛伐克 Czechoslovakia, 香橙 Avicenum, 1986卷-- 1986Vol. -, pg。 309 Pg. 309, 1986.
皮下老鼠 subcutaneous-老鼠 mouse LD50 3590 mg/kg kg 日志 Journal of 药店 Pharmacy and 药理 Pharmacology. 卷 Vol. 21, pg。 85 Pg. 85, 1969.
几内亚皮肤病 skin-guinea 猪 pig LD50 200 mg/kg kg "Patty's 产业 Industrial 卫生 Hygiene and 毒理学 有毒的 Toxicology," 第三版ed。 3rd rev. ed., 克莱顿 Clayton, g.d. G.D., 和f.e.克莱顿 and F.E. Clayton, eds。 eds., 纽约 New York, 约翰·威利&儿子 John Wiley & Sons, 公司 Inc., 1978-82年。卷3原来的酒吧。 1979年;酒馆作为2n转。 ed。 1985年2c 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, pg. 4953 Pg. 4953, 1982.
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吸入毒性 Inhalation Toxicity: |
未定 Not determined
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使用安全信息 Safety in Use Information:
类别 Category: | flavoring agents |
推荐的2-丁烯酸使用量最高为 Recommendation for 2-butenoic acid usage levels up to: | | 不用于香水。 not for fragrance use.
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最大化源自调查的每日摄入量(msdi-eu) Maximised Survey-derived Daily Intakes (MSDI-EU): | 4.00(微克/ 均/天) 4.00 (μg/capita/day) |
关注点 Threshold of Concern: | 1800(微克/ /天) 1800 (μg/person/day) |
结构类 Structure Class: | I |
采用 Use 等级 水平 levels for FEMA GRAS flavoring 物质 substances on 哪一个 which the FEMA 专家 Expert 面板 Panel 基于 based its its 判断 judgments that the 物质 substances are 通常 generally 公认的 recognized as safe (GRAS). |
The 专家 Expert 面板 Panel 也 also 发表 publishes 分离 separate 广泛 extensive 评论 转速 reviews of 科学的 scientific information on all FEMA GRAS flavoring 物质 substances and can be 发现 found at FEMA 味道 Flavor Ingredient 图书馆 Library |
出版编号 publication number: 19 |
单击此处查看出版物19 Click here to view publication 19 |
| 平均 average 通常 usual 百万分之几 ppm | 平均 average 最大 maximum 百万分之几 ppm |
焙烤食品 baked goods: | 5.00000 | 7.00000 |
饮料(不含醇) beverages(nonalcoholic): | 2.00000 | 5.00000 |
醇饮料 beverages(alcoholic): | - | - |
早餐麦片 breakfast cereal: | - | - |
cheese: | - | - |
口香糖 chewing gum: | - | - |
调味品/调味品 condiments / relishes: | - | - |
糖果烧烤 confectionery froastings: | - | - |
蛋制品 egg products: | - | - |
脂肪/油 fats / oils: | 0.20000 | 0.50000 |
鱼产品 fish products: | - | - |
冷冻乳制品 frozen dairy: | 5.00000 | 7.00000 |
水果冰 fruit ices: | - | - |
明胶/布丁 gelatins / puddings: | 5.00000 | 7.00000 |
砂糖 granulated sugar: | - | - |
肉汁 gravies: | - | - |
硬糖 hard candy: | - | - |
仿乳制品 imitation dairy: | - | - |
速溶咖啡/茶 instant coffee / tea: | - | - |
果酱/果冻 jams / jellies: | - | - |
肉制品 meat products: | - | - |
奶制品 milk products: | - | - |
坚果产品 nut products: | - | - |
其他谷物 other grains: | - | - |
家禽 poultry: | - | - |
加工水果 processed fruits: | - | - |
加工蔬菜 processed vegetables: | - | - |
重构蔬菜 reconstituted vegetables: | - | - |
调味料 seasonings / flavors: | - | - |
休闲食品 snack foods: | - | - |
软糖 soft candy: | 5.00000 | 7.00000 |
汤类 soups: | - | - |
糖替代品 sugar substitutes: | - | - |
甜酱 sweet sauces: | - | - |
安全参考 Safety references:
欧洲食品安全法规(efsa) European Food Safety Athority(efsa):风味使用水平;亚急性 Flavor usage levels; Subacute, 亚慢性 Subchronic, 慢性和致癌性研究;发育/ 毒性研究;遗传毒性研究... Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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欧洲食品安全局(efsa EFSA)参考 :
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调味组评估5 Flavouring Group Evaluation 5, 版本1(fge.05转速 rev1) :支链和直链脂族饱和伯醇与一种仲醇的酯 Esters of branched- and straight-chain aliphatic saturated primary alcohols and of one secondary alcohol, 化学族1的支链和直链不饱和羧酸 and branched- and straight-chain unsaturated carboxylic acids from chemical groups 1, 2, 和5(委员会法规(ec)1565 / 2000,2000年7月18日)[1]-食品添加剂科学小组的意见 and 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) [1] - Opinion of the Scientific Panel on Food Additives, 调味料 seasonings / flavors, 处理中 Processing 艾滋病 Aids and 材料 Materials in contact with Food (afc AFC) 视图 View page or 视图 View pdf
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调味组评估14 Flavouring Group Evaluation 14, 版本1(fge.14转速 rev1) : 苯乙醇 Phenethyl alcohol, aldehyde, acetals, 第15和22类化学物质中的羧酸和相关酯[1]-食品添加剂科学小组的意见 carboxylic acid and related esters from chemical group 15 and 22 [1] - Opinion of the Scientific Panel on Food Additives, 调味料 seasonings / flavors, 处理中 Processing 艾滋病 Aids and 材料 Materials in 联系 Contact with Food 视图 View page or 视图 View pdf
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调味组评估20 Flavouring Group Evaluation 20, 版本1(fge.20转速 rev1) : 苄醇 Benzyl alcohols, benzaldehydes, 相关的乙a related acetal, benzoic acids and 有关 related esters from chemical group 23 视图 View page or 视图 View pdf
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调味品组评价的科学意见71 Scientific Opinion on Flavouring Group Evaluation 71: 考虑脂肪族 Consideration of aliphatic, linear, α alpha,β-不饱和 beta-不饱和 un饱和的 saturated 羧酸 carboxylic acids and 有关 related esters 视图 View page or 视图 View pdf
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调味组评估的科学见解13转速 rev1 : 糠基 Furfuryl and 呋喃 furan 衍生品 derivatives with and 没有 without 额外 additional 侧链 side-链 chain 取代基 substituents and 杂原子 heteroatoms from chemical group 14 视图 View page or 视图 View pdf
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调味品组评价的科学见解20 Scientific Opinion on Flavouring Group Evaluation 20, 版本2(fge.20转速 rev2) : 苄醇 Benzyl alcohols, benzaldehydes, 相关的乙a related acetal, benzoic acids, and 有关 related esters from chemical 团体 groups 23 and 30 视图 View page or 视图 View pdf
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调味组评估72(fge.72) Flavouring Group Evaluation 72 (FGE.72): 考虑脂肪族 Consideration of aliphatic, 支链饱和和不饱和醇 branched-chain saturated and unsaturated alcohols, 醛类 aldehydes, acids, and 有关 related esters 已评估 evaluated by by the JECFA (61st 会议 meeting) 结构上 结构的 structurally 有关 related to 分支的 branched- and 直链 straight-链 chain 不饱和 un饱和的 saturated 羧酸 carboxylic acids. 酯类 Esters of 这些 these and 直链 straight-链 chain 脂族的 aliphatic 饱和的 saturated alcohols 已评估 evaluated by by efsa EFSA in ge FGE.05Rev2 (2010) 视图 View page or 视图 View pdf
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调味组评估5 Flavouring Group Evaluation 5, 版本2(fge.05转速 rev2) : 支链和直链不饱和羧酸及其与化学组1的脂族饱和醇的酯 Branched- and straight-chain unsaturated carboxylic acids and esters of these with aliphatic saturated alcohols from chemical groups 1, 2, 3 and 5 视图 View page or 视图 View pdf
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调味品组评价的科学见解20 Scientific Opinion on Flavouring Group Evaluation 20, 版本3(fge.20转速 rev3) : 苄醇 Benzyl alcohols, benzaldehydes, 相关的乙a related acetal, benzoic acids, and 有关 related esters from chemical 团体 groups 23 and 30 视图 View page or 视图 View pdf
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Epi系统 EPI System: 视图 View |
尼什国际化学品安全卡 NIOSH International Chemical Safety Cards:search |
nlm NLM有害物质数据库 :搜索 Search |
环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search |
EPA物质注册服务(tsca TSCA) :3724-65-0 |
EPA ACToR:毒理学资料 Toxicology Data |
EPA物质注册服务(SRS) :注册表 Registry |
实验室化学安全摘要 Laboratory Chemical Safety Summary :19499 |
国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:数据 Data |
明智的 WISER:联合国2823 UN 2823 |
德国wgk WGK Germany:1 |
丁-2-烯酸 but-2-enoic acid |
chemidplus Chemidplus:0003724650 |
epa / noaa客串 EPA/NOAA CAMEO:有害物质 hazardous materials |
技术 RTECS:3724-65-0 |
参考资料 References:
| 丁-2-烯酸 but-2-enoic acid |
NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
加拿大国内分公司。清单 Canada Domestic Sub. List: | 3724-65-0 |
pubchem(cid) Pubchem (cid): | 19499 |
pubchem(sid) Pubchem (sid): | 134985492 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and 核心 core components note
潜在用途 Potential Uses:
存在(自然 Occurrence (nature, food, 其他) other): note
同义词 Synonyms:
| 丁-2-烯酸 but-2-enoic acid | 2- | butenic acid | 2- | butenoic acid | a- | butenoic acid | α alpha- | butenoic acid | 2- | butenoic acid (巴豆酸 crotonic acid) | | 巴豆酸 crotonic acid | a- | 巴豆酸 crotonic acid | α alpha- | 巴豆酸 crotonic acid | b- | meth丙烯酸 acrylic acid | beta- | meth丙烯酸 acrylic acid | 3- | methyl 丙烯酸 acrylic acid | beta- | methyl 丙烯酸 acrylic acid | 3- | methyl丙烯酸 acrylic acid | b- | methyl丙烯酸 acrylic acid | beta- | methyl丙烯酸 acrylic acid |
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已发布 PubMed:氨基葡萄糖基衍生物的新型二丁基锡羧酸盐的合成及抗肿瘤活性。 Synthesis and antitumor activity of novel dibutyltin carboxylates of aminoglucosyl derivatives. |
已发布 PubMed:枸杞的香气活性成分。 Aroma-active components of Lycii fructus (kukija). |
已发布 PubMed:聚(丙烯酸)和聚(丙烯酸-共-甲基丙烯酸)水凝胶释放等温药物的比较动力学研究。 A comparative kinetics study of isothermal drug release from poly(acrylic acid) and poly(acrylic-co-methacrylic acid) hydrogels. |
已发布 PubMed:金属硫蛋白的基础表达在体外抑制肝匀浆中丁烯内酯诱导的氧化应激。 Basal expression of metallothionein suppresses butenolide-induced oxidative stress in liver homogenates in vitro. |
已发布 PubMed:一维聚合物,具有交替的cu2和ln2单位(ln = gd 1-D polymers with alternate Cu2 and Ln2 units (Ln = Gd, er Er, y)和羧酸酯键。 Y) and carboxylate linkages. |
已发布 PubMed:卵内暴露于镰刀菌霉菌毒素丁烯内酯引起的雏鸡心脏脂质过氧化和抗氧化防御功能受损。 Lipid peroxidation and antioxidant defense impairment in the hearts of chick embryos induced by in ovo exposure to Fusarium mycotoxin butenolide. |
已发布 PubMed:紫草干根中挥发油的环氧合酶-2抑制作用和组成。 Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon. |
已发布 PubMed:3-(4-乙氧基-苯胺基)丁-2-烯酸酯的(z)-甲基。 (Z)-Methyl 3-(4-ethoxy-anilino)but-2-enoate. |
已发布 PubMed:ace抑制剂苯那普利x hcl通过不对称的aza-michael反应进行正式合成。 Formal synthesis of the ACE inhibitor benazepril x HCl via an asymmetric aza-Michael reaction. |
已发布 PubMed:糖苷类幼激素 Glycosidic juvenogens: 带有α alpha的导数 ,β-不饱和酯官能团。 beta-unsaturated ester functionalities. |
已发布 PubMed:新型吲哚基哒嗪酮衍生物的有效合成和反应,具有预期的生物学活性。 An efficient synthesis and reactions of novel indolylpyridazinone derivatives with expected biological activity. |
已发布 PubMed:镰刀菌真菌毒素丁烯内酯对大鼠心肌和心肌细胞原代培养的毒性作用 Toxic effects of Fusarium mycotoxin butenolide on rat myocardium and primary culture of cardiac myocytes. |
已发布 PubMed:合成 Synthesis, 光谱学和结构解析的3-乙基氨基-2-(4-硝基-苯甲酰基)-丁-2-烯酸苯基酰胺。 spectroscopic and structural elucidation of 3-ethylamino-2-(4-nitro-benzoyl)-but-2-enoic acid phenylamide. |
已发布 PubMed:双重不可逆激酶抑制剂 Dual irreversible kinase inhibitors: 基于喹唑啉的抑制剂并入两个独立的反应中心,每个中心靶向egfr和vegfr-2激酶结构域中的不同半胱氨酸残基。 quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2. |
已发布 PubMed:有机磷杀虫剂(rpr-ii)对罗非鱼生化参数的亚致死作用 Sublethal effects of an organophosphorus insecticide (RPR-II) on biochemical parameters of tilapia, 莫桑比克罗非鱼。 Oreochromis mossambicus. |
已发布 PubMed:[碳化前后花粉 的脂肪成分的gc-ms分析]。 [GC-MS analysis of the fatty components of pollen Typhae before and after being carbonized]. |
已发布 PubMed:细胞内谷胱甘肽的耗竭介导丁烯内酯诱导的hepg2细胞的细胞毒性。 Depletion of intracellular glutathione mediates butenolide-induced cytotoxicity in HepG2 cells. |
已发布 PubMed:在雄性和雌性wistar大鼠中,由于亚慢性给药新的亚硫代磷酸酯(rpr-v)引起的血液学和临床化学变化。 Hematological and clinical chemistry changes induced by subchronic dosing of a novel phosphorothionate (RPR-V) in Wistar male and female rats. |
已发布 PubMed:巴豆酸作为胡萝卜种子中的生物活性因子(胡萝卜)。 Crotonic acid as a bioactive factor in carrot seeds (Daucus carota L.). |
已发布 PubMed:短小伞叶化学成分的分离与结构鉴定 [Isolation and structure identification of chemical constituents from Anabasis brevifolia]. |
已发布 PubMed:反复口服大剂量大鼠后,新型有机磷农药(rpr-v)对肝外解毒酶的影响 Effects of a novel organophosphorus pesticide (RPR-V) on extra hepatic detoxifying enzymes after repeated oral doses in rats. |
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