类别 Category:flavoring agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
出现 Appearance: | 淡黄透明液体(est) pale yellow clear liquid (est) |
化验 Assay: | 95.00至100.00 95.00 to 100.00
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食品化学品法典列表 Food Chemicals Codex Listed: | No |
比重 Specific Gravity: | 1.06200 to 1.06800 @ 25.00 °C.
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磅每加仑-(est)。 Pounds per Gallon - (est).: | 8.837 to 8.887
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折光率 Refractive Index: | 1.52500 to 1.53100 @ 20.00 °C.
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熔点 Melting Point: | -38.00 to -36.00 °C. @ 760.00 mm 汞 Hg
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沸点 Boiling Point: | 84.00 °C. @ 760.00 mm 汞 Hg
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蒸汽压力 Vapor Pressure: | 81.697998 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
蒸气密度 Vapor Density: | 2.9 ( 空气 Air = 1 ) |
闪点 Flash Point: | 30.00 °F. tcc TCC ( -1.11 °C. )
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logp(o / w) logP (o/w): | 1.810 |
溶于 Soluble in: |
| alcohol | | 水 water, 3654 mg/L @ 25 &deg °C (est) | | 水 water, 3010 mg / l @ 25°C(实验) 3010 mg/L @ 25 °C (exp) |
不溶于 Insoluble in: |
| 水 water |
感官特性 Organoleptic Properties:
气味类型 Odor Type: sulfurous |
气味强度 Odor Strength:高 high , 建议在0.10%或更少的溶液中闻到 recommend smelling in a 0.10 % solution or less |
alliaceous garlic |
气味描述 Odor Description:at 0.10 % in propylene glycol. 蒜香蒜 alliaceous garlic |
来自其他 的气味和/或风味描述(如果找到)。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
首选SDS Preferred SDS: 视图 View |
欧洲信息 European information : |
最重要的危害 Most important hazard(s): | xn-有害。 Xn - Harmful. |
R 11 - 高度 Highly 易燃的 flammable. R 22 - 有害 Harmful if 吞下 swallowed. R 37/38 - 烦 的 Irritating to 呼吸的 respiratory 系统 system and skin 皮. R 41 - 风险 Risk of 严重 serious 损伤 damage to 眼睛 眼睛 eyes. S 02 - 保持 Keep out of the 达到 reach of 孩子们 children. S 16 - 保持 Keep 远 away from 资料来源 sources of 点火 ignition - No 抽烟 Smoking. S 20/21 - 什么时候 When 使用 using do not eat, 喝 drink or 抽烟 smoke. S 24/25 - 避免 Avoid contact with skin 皮 and 眼睛 眼睛 eyes. S 26 - In 案件 case of contact with 眼睛 眼睛 eyes, 冲洗 rinse 立即 immediately with 充裕 plenty of 水 water and 寻求 seek 医疗 medical 忠告 advice. S 37/39 - 穿 Wear 适当 suitable 手套 gloves and 眼睛 eye/face 保护 protection.
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危害识别 Hazards identification |
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物质或混合物的分类 Classification of the substance or mixture |
根据29 cfr 1910(osha hcs)进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
没有找到。 None found. |
ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
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象形图 Pictogram | |
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危险说明 Hazard statement(s) |
没有找到。 None found. |
防范说明 Precautionary statement(s) |
没有找到。 None found. |
口服/肠胃外毒性 Oral/Parenteral Toxicity: |
老鼠 oral-mouse LD50 [性别 sex: M] 1902 mg/kg kg (o&rsquo O’Donoghue Donoghue, 1979)
老鼠 oral-mouse LD50 [性别 sex: F] > 500 mg/kg kg (eli Eli 礼来公司 Lilly & Co., 1992)
口鼠 oral-rat LD50 [性别 sex: M] 1131 mg/kg kg (o&rsquo O’Donoghue Donoghue, 1979)
灌胃鼠 gavage-rat LD50 [性别 sex: M,F] 3120 mg/kg kg (更年轻 Younger, 1964)
腹腔内小鼠 intraperitoneal-mouse LD50 100 mg/kg kg 国民 National 技术 Technical 信息 Information 服务 Service. 卷 Vol. AD277-689
老鼠 oral-mouse LD50 420 mg/kg kg Gigiena 特鲁达 Truda i Professional'奈 nye Zabolevaniya Zabolevaniya. 劳工 Labor 卫生 Hygiene and 职业的 Occupational 疾病 Diseases. 卷 Vol. 10(2), pg。 57 Pg. 57, 1966.
口鼠 oral-rat LD50 1400 mg/kg kg Gigiena 特鲁达 Truda i Professional'奈 nye Zabolevaniya Zabolevaniya. 劳工 Labor 卫生 Hygiene and 职业的 Occupational 疾病 Diseases. 卷 Vol. 10(2), pg。 57 Pg. 57, 1966.
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皮肤毒性 Dermal Toxicity: |
几内亚皮肤病 skin 皮-guinea 猪 pig LD50 > 20 ml/kg kg Gigiena 特鲁达 Truda i Professional'奈 nye Zabolevaniya Zabolevaniya. 劳工 Labor 卫生 Hygiene and 职业的 Occupational 疾病 Diseases. 卷 Vol. 10(2), pg。 57 Pg. 57, 1966.
皮下兔子 subcutaneous-rabbit LD50 830 mg/kg kg Gigiena 特鲁达 Truda i Professional'奈 nye Zabolevaniya Zabolevaniya. 劳工 Labor 卫生 Hygiene and 职业的 Occupational 疾病 Diseases. 卷 Vol. 10(2), pg。 57 Pg. 57, 1966.
几内亚皮肤病 skin 皮-guinea 猪 pig LD50 > 20 毫升 mL/kg kg 国民 National 技术 Technical 信息 Information 服务 Service. 卷 Vol. OTS0555960
皮下兔子 subcutaneous-rabbit LD50 830 mg/kg kg "Prehled 恶作剧 Prumyslove 毒物学 Toxikologie; 有机酮 Organicke 懒汉 Latky," 马尔霍尔德 Marhold, j. J., 布拉格 Prague, 捷克斯洛伐克 Czechoslovakia, 香橙 Avicenum, 1986卷-- 1986Vol. -, pg. 1089 Pg. 1089, 1986.
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吸入毒性 Inhalation Toxicity: |
吸入小鼠 inhalation-mouse LC50 9500 mg/m3/2H Gigiena 特鲁达 Truda i Professional'奈 nye Zabolevaniya Zabolevaniya. 劳工 Labor 卫生 Hygiene and 职业的 Occupational 疾病 Diseases. 卷 Vol. 10(2), pg。 57 Pg. 57, 1966.
吸入大鼠 inhalation-rat 克洛 LCLo 2000 百万分之几 ppm/6H Toxicologist. 卷 Vol. 8, pg。 141 Pg. 141, 1988.
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使用安全信息 Safety in Use Information:
类别 Category: | flavoring agents |
噻吩使用水平的建议 Recommendation for thiophene usage levels up to: | | 不用于香水。 not for fragrance use.
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最大化源自调查的每日摄入量(msdi-eu) Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.12(微克/ 均/天) 0.12 (μg/capita/day) |
修改后的理论增加的最大每日摄入量(mtamdi) Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 78(微克/ /天) 78 (μg/person/day) |
关注点 Threshold of Concern: | 90(微克/ /天) 90 (μg/person/day) |
结构类 Structure Class: | iii III |
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根据委员会法规EC号的食品类别。 1565/2000(ec Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000)在fge.06(efsa 2000) in FGE.06 (EFSA, 2002a). 根据 According to the Industry the "正常 normal" use is 定义的 defined as the 平均 average of 已报告 reported 用法 用法 usages and "最大 maximum use" is 定义的 defined as the 95th 百分位 percentile of 已报告 reported 用法 用法 usages (efsa EFSA, 2002i)。 2002i). |
注意 Note: 毫克/千克= 0.001 / 1000 = 0.000001 = 1/1000000 = 百万分之几 ppm |
| 平均 average 用法 usage mg/kg kg | 最大 maximum 用法 usage mg/kg kg |
乳制品 Dairy products, 不包括02.0(01.0)类产品 excluding products of category 02.0 (01.0): | 0.20000 | 1.00000 |
脂肪和油脂 Fats and oils, 和脂肪乳液(油包水型)(02.0) and fat emulsions (type water-in-oil) (02.0): | 0.10000 | 0.50000 |
食用冰 Edible ices, 包括果子露和果汁冰糕(03.0) including sherbet and sorbet (03.0): | 0.20000 | 1.00000 |
加工水果(04.1) Processed fruit (04.1): | 0.20000 | 1.00000 |
加工蔬菜(包括蘑菇和真菌) Processed vegetables (incl. mushrooms & fungi, 根与根块茎 roots & tubers, 豆类和豆类) pulses and legumes), 和坚果种子(04.2) and nuts & seeds (04.2): | - | - |
糖果(05.0) Confectionery (05.0): | 0.20000 | 1.00000 |
谷物和谷物产品 Cereals and cereal products, 含税面粉根和淀粉块茎 incl. flours & starches from roots & tubers, 脉冲和豆类 pulses & legumes, 不包括面包店(06.0) excluding bakery (06.0): | 0.10000 | 0.50000 |
烘焙用具(07.0) Bakery wares (07.0): | 0.20000 | 1.00000 |
肉和肉制品 Meat and meat products, 包括家禽和野味(08.0) including poultry and game (08.0): | 0.10000 | 0.20000 |
鱼和鱼制品 Fish and fish products, 包括软体动物 including molluscs, 甲壳类和棘皮类动物(麦克 MCE)(09.0) : | 0.10000 | 0.20000 |
鸡蛋和蛋制品(10.0) Eggs and egg products (10.0): | - | - |
甜味剂 Sweeteners, 包括蜂蜜(11.0) including honey (11.0): | - | - |
盐 Salts, 香料 spices, 汤类 soups, 酱料 sauces, 色拉 salads, 蛋白产品 protein products, 等(12.0) etc. (12.0): | 0.10000 | 0.50000 |
用于特定营养用途的食品(13.0) Foodstuffs intended for particular nutritional uses (13.0): | 0.20000 | 1.00000 |
不含醇 Non-alcoholic ("柔软的 soft") 饮料 beverages, 不包括乳制品(14.1) excl. dairy products (14.1): | 0.10000 | 0.50000 |
含醇的饮料 Alcoholic beverages, 含税无醇和低醇的对口(14.2) incl. alcohol-free and low-alcoholic counterparts (14.2): | 0.20000 | 1.00000 |
即食美味(15.0) Ready-to-eat savouries (15.0): | 0.40000 | 2.00000 |
复合食品(例如砂锅菜) Composite foods (e.g. casseroles, 肉馅饼 meat pies, 百果馅)-无法放在01.0-15.0(16.0)类别中的食物 mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 0.10000 | 0.50000 |
安全参考 Safety references:
欧洲食品安全法规(efsa) European Food Safety Athority(efsa):风味使用水平;亚急性 Flavor usage levels; Subacute, 亚慢性 Subchronic, 慢性和致癌性研究;发育/ 毒性研究;遗传毒性研究... Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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欧洲食品安全局(efsa EFSA)参考 :
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调味组评估21 Flavouring Group Evaluation 21: 噻唑类 Thiazoles, thiophene, 来自化学组29的噻唑啉和噻吩衍生物;来自化学组30的 物质(委员会法规(ec)2000年7月18日第1565/2000号)-食品添加剂科学小组的意见 thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, 调味料 Flavourings, 处理中 Processing 艾滋病 Aids and 材料 Materials in contact with Food (afc AFC) 视图 View page or 视图 View pdf
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调味组评估76 Flavouring Group Evaluation 76, (fge.76)[1]-考虑通过与结构上相关的噻唑的jecfa(第五十九次会议)评估的含硫杂环化合物 (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, 来自化学组29的噻唑啉和噻吩衍生物 thiazoline and thienyl derivatives from chemical group 29, efsa EFSA在fge.21中评估了化学30组的其他杂物-食品添加剂专家组的科学观点 , 调味料 Flavourings, 处理中 Processing 艾滋病 Aids and 材料 Materials in 联系 Contact with Food 视图 View page or 视图 View pdf
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调味组评估21 Flavouring Group Evaluation 21, 修订版1(fge.21rev1) Revision 1 (FGE.21Rev1): 噻唑类 Thiazoles, thiophene, 来自化学组29的噻唑啉和噻吩衍生物 thiazoline and thienyl derivatives from chemical group 29 杂 Miscellaneous 物质 物质 substances from chemical group 30 视图 View page or 视图 View pdf
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调味组评估93(fge.93) Flavouring Group Evaluation 93 (FGE.93): jecfa(第六十八次会议)评估的与噻唑结构相关的硫杂环的考虑 Consideration of sulphur heterocyclic evaluated by JECFA (68th meeting) structurally related to thiazoles, thiophene, 噻唑啉 thiazoline and 噻吩基 thienyl 已评估 evaluated by by efsa EFSA in ge FGE.21Rev1 (2009) 视图 View page or 视图 View pdf
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调味品组评价的科学见解21 Scientific Opinion on Flavouring Group Evaluation 21, 版本2(fge.21rev2) Revision 2 (FGE.21Rev2): 噻唑类 Thiazoles, thiophene, 来自化学组29的噻唑啉和噻吩衍生物 thiazoline and thienyl derivatives from chemical group 29. 杂 Miscellaneous 物质 物质 substances from chemical group 30. 视图 View page or 视图 View pdf
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调味品组评价的科学见解21 Scientific Opinion on Flavouring Group Evaluation 21, 版本3(fge.21rev3) Revision 3 (FGE.21Rev3): 噻唑类 Thiazoles, thiophenes, 噻唑啉 thiazoline and 噻吩基 thienyl 衍生品 derivatives from chemical 团体 groups 29 and 30 视图 View page or 视图 View pdf
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调味品组评价的科学见解21 Scientific Opinion on Flavouring Group Evaluation 21, 修订版4(fge.21rev4) Revision 4 (FGE.21Rev4): 噻唑类 Thiazoles, thiophenes, 噻唑啉 thiazoline and 噻吩基 thienyl 衍生品 derivatives from chemical 团体 groups 29 and 30 视图 View page or 视图 View pdf
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调味品组评价的科学见解21 Scientific Opinion on Flavouring Group Evaluation 21, 版本5(fge.21rev5) Revision 5 (FGE.21Rev5): 噻唑类 Thiazoles, thiophenes, 噻唑啉 thiazoline and 噻吩基 thienyl 衍生品 derivatives from chemical 团体 groups 29 and 30 视图 View page or 视图 View pdf
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Epi系统 EPI System: 视图 View |
尼什国际化学品安全卡 NIOSH International Chemical Safety Cards:search |
nlm NLM有害物质数据库 :搜索 Search |
化学致癌研究信息系统 Chemical Carcinogenesis Research Information System:搜索 Search |
环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search |
EPA物质注册服务(tsca TSCA) :110-02-1 |
EPA ACToR:毒理学资料 Toxicology Data |
EPA物质注册服务(SRS) :注册表 Registry |
实验室化学安全摘要 Laboratory Chemical Safety Summary :8030 |
国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data |
明智的 WISER:联合国2414 UN 2414 |
德国wgk WGK Germany:3 |
thiophene |
chemidplus Chemidplus:0000110021 |
epa / noaa客串 EPA/NOAA CAMEO:有害物质 hazardous materials |
技术 RTECS:110-02-1 |
参考资料 References:
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core 组件 components note
潜在用途 Potential Uses:
存在(自然 Occurrence (nature, food, 其他) other): note
同义词 Synonyms:
| 二乙烯硫 divinylene sulfide | | furan, thio- | | 硫呋喃 thiofuran | | thiofurfuran | | 硫醇 thiole | | thiophene [UN2414] [易燃的 Flammable 液体 liquid] |
文章 Articles:
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美拉德产品 Maillard product
在室温下 At room temperature, 噻吩是一种无色液体,具有令 愉快的气味,让 联想到苯 thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene, 与噻吩有一些相似之处。噻吩对磺化反应的高反应性是噻吩与苯分离的基础 with which thiophene shares some similarities. The high reactivity of thiophene toward sulfonation is the basis for the separation of thiophene from benzene, 由于沸点相似(在常压下相差4 oC),很难通过蒸馏分离。像苯 which are difficult to separate by distillation due to their similar boiling points (4 �C difference at ambient pressure). Like benzene, 噻吩与水形成共沸物。噻吩不仅对亲电试剂具有反应性 thiophene forms an azeotrope with water.; Not only is thiophene reactive toward electrophiles, 也可以很容易地用丁基锂锂化,得到2-lithiothiophene it is also readily lithiated with butyl lithium to give 2-lithiothiophene, 这是各种衍生物的前身 which is a precursor to a variety of derivatives, 包括二噻吩基。 including dithienyl.
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