| Name: | 4,5-二甲基-2-（苯甲基）-1 5-dimethyl-2-(phenylmethyl)-1,3-dioxolane |
| CAS号 CAS Number: | 5468-06-4 |  3D/INCHI
|
| nikkaji网站 Nikkaji Web: | J1.536.383E |
| 代号 CoE Number: | 669 |
| XlogP3-AA: | 2.70（估 est） |
| 分子量 Molecular Weight: | 192.25792000 |
| 式 Formula: | c12 h16 o2 C12 H16 O2 |
| 生物活性总结 BioActivity Summary: | 清单 listing |
| 核磁共振预测器 NMR Predictor: | 预测（适用于Chrome或Firefox） Predict (works with chrome or firefox) |
| efsa / jecfa评论 EFSA/JECFA Comments: |
| 根据jecfa According to the JECFA: 分 Min. assay value is "93 %" and 次要的 secondary components "丁烷2 butane-2,3-diol".
消旋剂。次要成分 Racemate. Secondary component: 丁烷2 butane-2,3-二醇（2-3％）（有效成分 3-diol (2-3 %) (EFFA, 2010a）。 2010a). |
类别 Category:flavor and fragrance agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 出现 Appearance: | 无色透明粘稠液体（估 est） |
| 化验 Assay: | 93.00至100.00 93.00 to 100.00
|
| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 比重 Specific Gravity: | 1.03000 to 1.04000 @ 25.00 °C.
|
| 磅每加仑-（估 est）。 : | 8.571 to 8.654
|
| 折光率 Refractive Index: | 1.49600 to 1.51200 @ 20.00 °C.
|
| 沸点 Boiling Point: | 263.00 to 264.00 °C. @ 760.00 mm 汞 Hg
|
| 蒸汽压力 Vapor Pressure: | 0.016000 毫米汞柱 mm汞 Hg @ 25.00 °C. (估 est) |
| 闪点 Flash Point: | 243.00 °F. tcc TCC ( 117.22 °C. )
|
| logp（o / w） logP (o/w): | 2.659（估 est） |
| 溶于 Soluble in: |
| | alcohol | | | 水 water, 259.6 mg / l @ 25°c（估 est） |
| 不溶于 Insoluble in: |
| | 水 water |
感官特性 Organoleptic Properties:
| 气味类型 Odor Type: floral |
| 气味强度 Odor Strength:介质 medium |
| floral sweet earthy |
| 气味描述 Odor Description:at 100.00 %. 花香甜土 floral sweet earthy |
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
| |
| 危害识别 Hazards identification |
| |
| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
|
未定 Not determined
|
| 皮肤毒性 Dermal Toxicity: |
|
未定 Not determined
|
| 吸入毒性 Inhalation Toxicity: |
|
未定 Not determined
|
使用安全信息 Safety in Use Information:
| 类别 Category: | flavor and fragrance agents |
| 推荐的苯乙醛2 Recommendation for phenyl acetaldehyde 2,3-丁二醇缩醛的使用量高达 3-butylene glycol acetal usage levels up to: | | | 香料浓缩物中的1.000％。 1.0000 % in the fragrance concentrate.
|
| |
| 最大化源自调查的每日摄入量（msdi-eu） Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.12（微克/ 均/天） 0.12 (μg/capita/day) |
| 最大化源自调查的每日摄入量（msdi-usa） Maximised Survey-derived Daily Intakes (MSDI-USA): | 1.00（微克/ 均/天） 1.00 (μg/capita/day) |
| 结构类 Structure Class: | I |
| 采用 Use 等级 levels for FEMA GRAS flavoring 物质 substances on 哪一个 which the FEMA 专家 Expert 面板 Panel 基于 based its its 判断 judgments that the 物质 substances are 通常 generally 公认的 recognized as safe (GRAS). |
| The 专家 Expert 面板 Panel also 发表 publishes 分离 separate 广泛 extensive 评论 reviews of scientific information on all FEMA GRAS flavoring 物质 substances and can be 发现 found at FEMA 味道 Flavor Ingredient 图书馆 Library |
| 出版编号 publication number: 3 |
| 单击此处查看出版物3 Click here to view publication 3 |
| | 平均 average 通常 usual 百万分之几 ppm | 平均 average 最大 maximum 百万分之几 ppm |
| 焙烤食品 baked goods: | - | - |
| 饮料（不含醇） beverages(nonalcoholic): | - | - |
| 醇饮料 beverages(alcoholic): | - | - |
| 早餐麦片 breakfast cereal: | - | - |
| 起司 cheese: | - | - |
| 口香糖 chewing gum: | - | - |
| 调味品/调味品 condiments / relishes: | - | - |
| 糖果烧烤 confectionery froastings: | - | - |
| 蛋制品 egg products: | - | - |
| 脂肪/油 fats / oils: | - | - |
| 鱼产品 fish products: | - | - |
| 冷冻乳制品 frozen dairy: | - | - |
| 水果冰 fruit ices: | - | - |
| 明胶/布丁 gelatins / puddings: | - | - |
| 砂糖 granulated sugar: | - | - |
| 肉汁 gravies: | - | - |
| 硬糖 hard candy: | - | 4.00000 |
| 仿乳制品 imitation dairy: | - | - |
| 速溶咖啡/茶 instant coffee / tea: | - | - |
| 果酱/果冻 jams / jellies: | - | - |
| 肉制品 meat products: | - | - |
| 奶制品 milk products: | - | - |
| 坚果产品 nut products: | - | - |
| 其他谷物 other grains: | - | - |
| 家禽 poultry: | - | - |
| 加工水果 processed fruits: | - | - |
| 加工蔬菜 processed vegetables: | - | - |
| 重构蔬菜 reconstituted vegetables: | - | - |
| 调味料 seasonings / flavors: | - | - |
| 休闲食品 snack foods: | - | - |
| 软糖 soft candy: | - | - |
| 汤类 soups: | - | - |
| 糖替代品 sugar substitutes: | - | - |
| 甜酱 sweet sauces: | - | - |
安全参考 Safety references:
欧洲食品安全法规（efsa） European Food Safety Athority(efsa):风味使用水平；亚急性 Flavor usage levels; Subacute, 亚慢性 Subchronic, 慢性和致癌性研究；发育/ 毒性研究；遗传毒性研究... Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
|
欧洲食品安全局（efsa EFSA）参考 :
|
食品添加剂科学小组的意见 Opinion of the Scientific Panel on food additives, 调味料 seasonings / flavors, 与食品有关的加工助剂和材料（afc AFC） : 调味组评估14（fge.14） Flavouring Group Evaluation 14 (FGE.14): 苯乙醇 Phenethyl alcohol, aldehyde, esters, and 有关 related 苯乙酸 phenylacetic acid esters from chemical group 15 (佣金 Commission 规 Regulation (e (EC) No 1565/2000 of 18 July 2000)
视图 View page or 视图 View pdf
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调味组评估53（fge.53） Flavouring Group Evaluation 53 (FGE.53): 考虑苯乙醇 Consideration of phenethyl alcohol, aldehyde, jecfa（第五十九次会议）评估与苯乙醇结构相关的酸和相关缩醛和酯 acid and related acetals and esters evaluated by JECFA (59th meeting) structurally related to phenethyl alcohol, aldehyde, efsa在fge.14（2005）中评估了其酯和相关的苯乙酸酯，并在fge.23（2006）中评估了一种苯氧基乙基酯（委员会法规（ec）2000年7月18日第1565/2000号）-科学小组关于食品添加剂 esters and related phenylacetic acid esters evaluated by EFSA in FGE.14 (2005) and one phenoxyethyl ester evaluated in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, 调味料 seasonings / flavors, 处理中 Processing 艾滋病 Aids and 材料 Materials in contact with Food (afc AFC)
视图 View page or 视图 View pdf
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调味组评估14 Flavouring Group Evaluation 14, 版本1（fge.14rev1） Revision 1 (FGE.14Rev1): 苯乙醇 Phenethyl alcohol, aldehyde, acetals, 第15和22类化学物质中的羧酸和相关酯[1]-食品添加剂科学小组的意见 carboxylic acid and related esters from chemical group 15 and 22 [1] - Opinion of the Scientific Panel on Food Additives, 调味料 seasonings / flavors, 处理中 Processing 艾滋病 Aids and 材料 Materials in 联系 Contact with Food
视图 View page or 视图 View pdf
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调味组评估53 Flavouring Group Evaluation 53, 修订版1（fge.53rev1） Revision 1 (FGE.53Rev1): 考虑苯乙醇 Consideration of phenethyl alcohol, aldehyde, acid and 有关 related acetals and esters 已评估 evaluated by by Jec ECFA (59th 会议 meeting) ge FGE.23Rev1 (2008)
视图 View page or 视图 View pdf
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关于调味剂组评估的科学意见96（fge.96） Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): 核酸酶p1富集和32p后标记分析后，检测经n-羟基-4-氨基联苯处理的 尿道上皮细胞dna中的脱氧腺苷-4-氨基联苯加合物。 Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.
视图 View page or 视图 View pdf
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| Epi系统 EPI System: 视图 View |
| EPA ACToR:毒理学资料 Toxicology Data |
| EPA物质注册服务（SRS） :注册表 Registry |
| 实验室化学安全摘要 Laboratory Chemical Safety Summary :230525 |
| 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:数据 Data |
| 4,5-二甲基-2-（苯甲基）-1 5-dimethyl-2-(phenylmethyl)-1,3-dioxolane |
| chemidplus Chemidplus:0005468064 |
参考资料 References:
| | 4,5-二甲基-2-（苯甲基）-1 5-dimethyl-2-(phenylmethyl)-1,3-dioxolane |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| 加拿大国内分公司。清单 Canada Domestic Sub. List: | 5468-06-4 |
| pubchem（cid） Pubchem (cid): | 230525 |
| pubchem（sid） Pubchem (sid): | 135263461 |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core components note
| 气味 For Odor |
| 醛 aldehydic |
nonanal diethyl acetal
FL/FR |
| 香醋 balsamic |
短叶蛙 brachyleana 哈钦西 hutchinsii 木 wood oil
FR |
| 焦糖色 caramellic |
propyl pyruvate
FL/FR |
| 柑橘类 citrus |
2- heptanol
FL/FR |
| earthy |
1- octen-3-ol
FL/FR |
| 空灵的 ethereal |
ethyl formate
FL/FR |
| 脂肪的 fatty |
十一醛 undecanal propylene glycol acetal
FL/FR |
| floral |
异 iso amyl undecylenate
FL/FR |
benzyl alcohol
FL/FR |
butyl benzyl ether
FL/FR |
citronellal
FL/FR |
citronellyl acetate
FL/FR |
citronellyl propionate
FL/FR |
gamma- damascone
FR |
(Z)-alpha- damascone
FL/FR |
(Z)-4- decen-1-yl acetate
FL/FR |
dihydrocarvyl acetate
FL/FR |
dimethyl benzyl carbinol
FL/FR |
法呢基 farnesyl acetate
FL/FR |
floral pyran
FR |
香叶基 geranyl acetate
FL/FR |
香叶基 geranyl formate
FL/FR |
(E)- 香叶基 geranyl linalool
FL/FR |
山楂 hawthorn ethanol
FR |
巯基 heliotropyl diethyl acetal
FR |
蜜糖 honeysuckle fragrance
FR |
蜜糖 honeysuckle specialty
FR |
紫丁香 lilac specialty
FR |
linalool oxide
FL/FR |
2- methyl octanal
FL/FR |
2- methyl-4-phenyl butanal
FL/FR |
穆格 muguet carbinol
FL/FR |
麝香 musk acetate
FR |
水仙 narcissus acetate
FL/FR |
neryl acetate
FL/FR |
neryl isovalerate
FL/FR |
nonanol
FL/FR |
苦 bitter 橙花 orangeflower 浸膏 concrete morocco
FR |
苯乙基 phenethyl acetate
FL/FR |
苯乙基 phenethyl anthranilate
FL/FR |
苯乙基 phenethyl formate
FL/FR |
苯乙基 phenethyl lactate
FL/FR |
苯乙基 phenethyl phenyl acetate
FL/FR |
苯乙基 phenethyl salicylate
FL/FR |
phenyl acetaldehyde 二香叶基 di香叶基 geranyl acetal
FR |
phenyl propyl phenyl acetate
FR |
(E)-2- phenyl-1(2)-propene-1-yl acetate
FR |
(Z)- 玫瑰 rose oxide
FL/FR |
laevo- 玫瑰 rose oxide
FL/FR |
玫瑰 rose pyran
FR |
styralyl propionate
FL/FR |
晚香玉 tube玫瑰 rose 精华/精粹/精萃 absolute (from 浸膏 concrete)
FL/FR |
晚香玉 tube玫瑰 rose 精华/精粹/精萃 absolute (from Pommade pommade)
FL/FR |
2- undecen-1-ol
FL/FR |
(E)-2- undecen-1-ol
FL/FR |
| 果味的 fruity |
异 iso butyl anthranilate
FL/FR |
butyl propionate
FL/FR |
cyclohexyl crotonate
FR |
(E)-alpha- damascone
FL/FR |
草莓 strawberry 缩水橙花酯 glycidate 2
FL/FR |
热带 tropical trithiane
FL/FR |
| 真菌的 fungal |
hydroxymethyl hexyl ethyl ketone
FL/FR |
| 绿 green |
异 iso decanal
FL/FR |
earthy acetal
FL/FR |
geranium 精华/精粹/精萃 absolute
FL/FR |
(Z)-3- hexen-1-yl phenyl acetate
FL/FR |
己氧基乙醛 hexoxyacetaldehyde dimethyl acetal
FR |
methyl 环柠檬酮 cyclocitrone (IFF)
FR |
octyl oxyacetaldehyde
FR |
苯乙基 phenethyl isopropyl ether
FR |
苯乙基 phenethyl oxyacetaldehyde
FR |
苯乙基 phenethyl tiglate
FL/FR |
phenyl acetaldehyde
FL/FR |
1- phenyl-2-pentanol
FL/FR |
3,5,5- trimethyl hexanol
FL/FR |
| herbal |
6- hydroxydihydrotheaspirane (混合物 mixture of 异构体 isomers)
FL/FR |
| 蜜糖 honey |
phenyl acetic acid
FL/FR |
| 皮革的 leathery |
皮革 leather cyclohexanol
FR |
| 麝香 musk |
麝香 musk gx gx 100%
FR |
麝香 musk gx gx 50% in BB
FR |
麝香 musk gx gx 50% in DEP
FR |
麝香 musk gx gx 50% in IPM
FR |
| naphthyl |
ortho- methyl anisole
FL/FR |
| 辣的 spicy |
气泡 bubble gum fragrance
FR |
(E)-para- methoxycinnamaldehyde
FL/FR |
| 萜烯 terpenic |
(e (E,e）-2 E)-2,6-allo ocimene
FL/FR |
| 木本 woody |
(E)- ethyl geranate
FR |
4,6,11- trimethyl-5-oxatricyclo(6.2.2.0*4,9*)dodec-6-ene
FR |
| 用于调味 For Flavor |
| 找不到适合这些的口味组 No flavor group found for these |
异 iso amyl undecylenate
FL/FR |
benzyl disulfide
FL |
butyl benzyl ether
FL/FR |
(Z)-alpha- damascone
FL/FR |
异 iso decanal
FL/FR |
(Z)-4- decen-1-yl acetate
FL/FR |
earthy acetal
FL/FR |
(E)- 香叶基 geranyl linalool
FL/FR |
hydroxymethyl hexyl ethyl ketone
FL/FR |
(E)-para- methoxycinnamaldehyde
FL/FR |
2- methyl octanal
FL/FR |
2- methyl-4-phenyl butanal
FL/FR |
nonanal diethyl acetal
FL/FR |
(e (E,e）-2 E)-2,6-allo ocimene
FL/FR |
苯乙基 phenethyl lactate
FL/FR |
propyl pyruvate
FL/FR |
十一醛 undecanal propylene glycol acetal
FL/FR |
(E)-2- undecen-1-ol
FL/FR |
2- undecen-1-ol
FL/FR |
| 樟脑的 camphoreous |
| 樟脑的 camphoreous |
6- hydroxydihydrotheaspirane (混合物 mixture of 异构体 isomers)
FL/FR |
ortho- methyl anisole
FL/FR |
| 柑橘类 citrus |
styralyl propionate
FL/FR |
| 空灵的 ethereal |
ethyl formate
FL/FR |
| floral |
citronellal
FL/FR |
citronellyl acetate
FL/FR |
citronellyl propionate
FL/FR |
dihydrocarvyl acetate
FL/FR |
法呢基 farnesyl acetate
FL/FR |
穆格 muguet carbinol
FL/FR |
neryl acetate
FL/FR |
苯乙基 phenethyl anthranilate
FL/FR |
phenyl acetic acid
FL/FR |
laevo- 玫瑰 rose oxide
FL/FR |
晚香玉 tube玫瑰 rose 精华/精粹/精萃 absolute (from 浸膏 concrete)
FL/FR |
晚香玉 tube玫瑰 rose 精华/精粹/精萃 absolute (from Pommade pommade)
FL/FR |
| 果味的 fruity |
benzyl alcohol
FL/FR |
异 iso butyl anthranilate
FL/FR |
butyl propionate
FL/FR |
(E)-alpha- damascone
FL/FR |
2- heptanol
FL/FR |
methyl 4-phenyl butyrate
FL |
neryl isovalerate
FL/FR |
1- phenyl-2-pentanol
FL/FR |
草莓 strawberry 缩水橙花酯 glycidate 2
FL/FR |
热带 tropical trithiane
FL/FR |
| 绿 green |
geranium 精华/精粹/精萃 absolute
FL/FR |
香叶基 geranyl acetate
FL/FR |
香叶基 geranyl formate
FL/FR |
(Z)-3- hexen-1-yl phenyl acetate
FL/FR |
linalool oxide
FL/FR |
水仙 narcissus acetate
FL/FR |
苯乙基 phenethyl formate
FL/FR |
苯乙基 phenethyl tiglate
FL/FR |
propylene glycol acetone ketal
FL |
(Z)- 玫瑰 rose oxide
FL/FR |
3,5,5- trimethyl hexanol
FL/FR |
| 蜜糖 honey |
苯乙基 phenethyl acetate
FL/FR |
苯乙基 phenethyl phenyl acetate
FL/FR |
phenyl acetaldehyde
FL/FR |
| 药用的 medicinal |
dimethyl benzyl carbinol
FL/FR |
苯乙基 phenethyl salicylate
FL/FR |
| 蘑菇 mushroom |
1- octen-3-ol
FL/FR |
| 蜡状的 waxy |
nonanol
FL/FR |
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, food, 其他） other): note
| | 自然界中找不到 not found in nature |
同义词 Synonyms:
| 2- | benzyl-4,5-二甲基-1 5-dimethyl-1,3-dioxolane | | 4,5- | dimethyl-2-(phenyl methyl)-1,3-dioxolane | | 4,5- | dimethyl-2-(苯甲基 phenylmethyl)-1,3-dioxolane | | 4,5- | dimethyl-2-benzyl-1,3-dioxolane | | 1,3- | dioxolane, 4,5-dimethyl-2-(苯甲基 phenylmethyl)- | | | 苯乙醛2 phenyl acetaldehyde 2,3-丁二醇缩醛 3-butylene glycol acetal | | | 苯乙醛2 phenyl acetaldehyde 2,3-丁二醇缩醛 3-butylene glycol acetal |
文章 Articles:
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烘焙食品调味料 Flavouring ingredient for baked goods, 布丁 puddings, 糖果和非醇饮料 candies and nonalcoholic beverages
噻洛芬酸是芳基丙酸（普罗芬 profen）类的非甾体类抗炎药 , 用来治疗疼痛 used to treat pain, 特别是节螺藻疼痛。成 的典型剂量是每天两次300mg。不建议儿童使用。 especially arthritic pain. The typical adult dose is 300mg twice daily. It is not recommended in children.
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