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类别 Category:flavor and fragrance agents
美国 US/欧盟 EU/ fda / jecfa / fema / Flavis / 文献 Scholar /专利 Patent :
物理性质 Physical Properties:
| 出现 Appearance: | 白晶体（est） white crystals (est) |
| 化验 Assay: | 98.00至100.00 98.00 to 100.00
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| 食品化学品法典列表 Food Chemicals Codex Listed: | No |
| 比重 Specific Gravity: | 1.08800 to 1.11000 @ 25.00 °C.
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| 磅每加仑-（est）。 Pounds per Gallon - (est).: | 9.053 to 9.236
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| 折光率 Refractive Index: | 1.44000 to 1.46000 @ 20.00 °C.
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| 熔点 Melting Point: | 18.00 to 20.00 °C. @ 760.00 mm 汞 Hg
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| 沸点 Boiling Point: | 55.00 to 56.00 °C. @ 12.00 mm 汞 Hg
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| 沸点 Boiling Point: | 167.00 to 170.00 °C. @ 760.00 mm 汞 Hg
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| 蒸汽压力 Vapor Pressure: | 0.023000 毫米汞柱 mm汞 Hg @ 25.00 °C. (est) |
| 闪点 Flash Point: | 155.00 °F. tcc TCC ( 68.33 °C. )
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| logp（o / w） logP (o/w): | 0.236（est） 0.236 (est) |
| 保质期 Shelf Life: | 如果正确存放，则为12.00个月或更长时间。 12.00 month(s) or longer if stored properly. |
| 存储 Storage: | 存放在阴凉处 store in cool, 干燥处，密封容器中 dry place in tightly sealed containers, 免受热和光照。 protected from heat and light. |
| 溶于 Soluble in: |
| | alcohol | | | 水 water, 5.00e + 04 mg / l @ 15摄氏度（经验值 exp） |
| 不溶于 Insoluble in: |
| | 水 water |
| 类似物品 Similar Items:note |
| β-当归内酯 beta-angelica lactone |
感官特性 Organoleptic Properties:
| 气味类型 Odor Type: coconut |
气味强度 Odor Strength:介质 medium ,
建议在10.00％或更少的溶液中闻到 recommend smelling in a 10.00 % solution or less |
| 实体性 Substantivity: ＆gt; 356 于100.00％ > 356 hour(s) at 100.00 % |
| sweet solvent nutty tonka coumarinic tobacco |
气味描述 Odor Description:at 10.00 % in 二丙烯 dipropylene glycol. sweet solvent nutty tonka coumarin tobacco
Luebke, 威廉 William RBC , (1996) |
| 来自的气味样本 Odor sample from: Sigma-Aldrich |
| sweet solvent oily coconut nutty coumarinic tobacco |
气味描述 Odor Description:甜 Sweet, 类溶剂 solvent-like, oily, coconut, 香豆素与坚果 nutty with coumarin, tobacco nuances
Mosciano, 杰拉德·普夫15 Gerard P&F 15, 2 No. 2, 69, (1990) |
| 风味类型 Flavor Type: creamy |
| sweet creamy coconut vanilla hay coumarinic |
口味描述 Taste Description: at 100.00 百万分之几 ppm. 甜 Sweet, creamy, coconut, vanilla hay and 香豆素样 coumarin-like nuances
Mosciano, 杰拉德·普夫15 Gerard P&F 15, 2 No. 2, 69, (1990) |
| 来自其他 的气味和/或风味描述（如果找到）。 Odor and/or flavor descriptions from others (if found). |
| 高砂 Takasago |
| 当归内酯α≥98％ Angelica Lactone Alpha ≥98% |
气味描述 Odor Description:甜 Sweet-herbaceous
用于口腔护理配方，使薄荷香气和咖啡风味更完美。 Used in oral care formulations to round out mint notes and in coffee flavors. |
化妆品信息 Cosmetic Information:
供应商 Suppliers:
安全信息 Safety Information:
| 首选SDS Preferred SDS: 视图 View |
| 欧洲信息 European information : |
| 最重要的危害 Most important hazard(s): | | 无-找不到。 None - None found. |
S 02 - 保持 Keep out of the 达到 reach of 孩子们 children.
S 24/25 - 避免 Avoid contact with skin 皮 and 眼睛 eyes.
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| 危害识别 Hazards identification |
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| 物质或混合物的分类 Classification of the substance or mixture |
| 根据29 cfr 1910（osha hcs）进行ghs分类 GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| 没有找到。 None found. |
| ghs标签元素 GHS Label elements, 包括预防性声明 including precautionary statements |
| |
| 象形图 Pictogram | |
| |
| 危险说明 Hazard statement(s) |
| 没有找到。 None found. |
| 防范说明 Precautionary statement(s) |
| 没有找到。 None found. |
| 口服/肠胃外毒性 Oral/Parenteral Toxicity: |
口鼠 口服 oral-rat LD50 3900 mg/kg kg
BEHAVIORAL: 嗜睡（一般抑郁活动） SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
感官和特殊感官 SENSE ORGANS AND SPECIAL SENSES: 下垂 PTOSIS: 眼睛 EYE
肺 LUNGS, 胸部 THORAX, 或呼吸 OR RESPIRATION: DYSPNEA
国民 National 技术 Technical Information 服务 Service. 卷 Vol. OTS0571138
管鼠 gavage-老鼠 mouse LD50 [性别 sex: M,F] 2800 mg/kg kg
(莫兰 Moran et al., 1980)
腹腔内小鼠 intraperitoneal-老鼠 mouse LD50 3000 mg/kg kg
Acta 药理学 Pharmacologica et 毒理学 Toxicologica. 卷 Vol. 2, pg。 109 Pg. 109, 1946.
老鼠 口服 oral-老鼠 mouse LD50 2800 mg/kg kg
Drug and Chemical 毒理学 Toxicology. 卷 Vol. 3, pg。 249 Pg. 249, 1980.
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| 皮肤毒性 Dermal Toxicity: |
|
未定 Not determined
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| 吸入毒性 Inhalation Toxicity: |
|
未定 Not determined
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使用安全信息 Safety in Use Information:
| 类别 Category: | | flavor and fragrance agents |
| IFRA IFRA 码 Code of 实践 Practice 通知 not Notification of the 49th 修正案 Amendment to the IFRA IFRA 码 Code of 实践 Practice |
| 建议使用当归内酯的水平 Recommendation for alpha-angelica lactone usage levels up to: | | | 0.50香料浓缩物中的00％。 0.5000 % in the fragrance concentrate.
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| 最大化源自调查的每日摄入量（msdi-eu） Maximised Survey-derived Daily Intakes (MSDI-EU): | 300.00（微克/ 均/天） 300.00 (μg/capita/day) |
| 采用 Use 等级 levels for FEMA GRAS flavoring 物质 substances on 哪一个 which the FEMA 专家 Expert 面板 Panel 基于 based its its 判断 judgments that the 物质 substances are 通常 基因 generally 公认的 recognized as safe (GRAS). |
| The 专家 Expert 面板 Panel 也 also 发表 publishes 分离 sepa率 rate 广泛 extensive 评论 reviews of scientific information on all FEMA GRAS flavoring 物质 substances and can be 发现 found at FEMA 味道 Flavor Ingredient 图书馆 Library |
| 出版编号 publication number: 5 |
| 点击这里查看出版物5 Click here to view publication 5 |
| | 平均 average 通常 usual 百万分之几 ppm | 平均 average 最大 maximum 百万分之几 ppm |
| 焙烤食品 baked goods: | - | 4.00000 |
| 饮料（不含醇） beverages(nonalcoholic): | - | - |
| 醇饮料 beverages(alcoholic): | - | - |
| 早餐麦片 breakfast cereal: | - | 2.00000 |
| 起司 cheese: | - | - |
| 口香糖 chewing gum: | - | - |
| 调味品/调味品 condiments / relishes: | - | - |
| 糖果烧烤 confectionery froastings: | - | - |
| 蛋制品 egg products: | - | - |
| 脂肪/油 fats / oils: | - | - |
| 鱼产品 fish products: | - | - |
| 冷冻乳制品 frozen dairy: | - | 0.20000 |
| 水果冰 fruit ices: | - | 0.20000 |
| 明胶/布丁 gelatins / puddings: | - | 2.00000 |
| 砂糖 granulated sugar: | - | - |
| 肉汁 gravies: | - | 2.00000 |
| 硬糖 hard candy: | - | 2.00000 |
| 仿乳制品 imitation dairy: | - | - |
| 速溶咖啡/茶 instant coffee / tea: | - | - |
| 果酱/果冻 jams / jellies: | - | - |
| 肉制品 meat products: | - | 2.00000 |
| 奶制品 milk products: | - | 0.20000 |
| 坚果产品 nut products: | - | - |
| 其他谷物 other grains: | - | - |
| 家禽 poultry: | - | - |
| 加工水果 processed fruits: | - | - |
| 加工蔬菜 processed vegetables: | - | - |
| 重构蔬菜 reconstituted vegetables: | - | - |
| 调味料 seasonings / flavors: | - | - |
| 休闲食品 snack foods: | - | - |
| 软糖 soft candy: | - | - |
| 汤类 soups: | - | 2.00000 |
| 糖替代品 sugar substitutes: | - | - |
| 甜酱 sweet sauces: | - | - |
安全参考 Safety references:
欧洲食品安全法规（efsa） European Food Safety Athority(efsa):风味使用水平；亚急性 Flavor usage levels; Subacute, 亚慢性 Subchronic, 慢性和致癌性研究；发育/ 毒性研究；遗传毒性研究... Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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欧洲食品安全局（efsa EFSA）参考 :
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食品添加剂科学小组的意见 Opinion of the Scientific Panel on Food Additives, 调味料 seasonings / flavors, 与调味料评估委员会有关的要求，与食品（AFC）接触的加工助剂和材料10 Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: 脂族伯和仲饱和和不饱和醇 Aliphatic primary and secondary saturated and unsaturated alcohols, 醛类 aldehydes, acetals, 含有额外的氧化官能团的羧酸和酯以及化学基团的内酯9 carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (佣金 Commission 规 Regulation (ec EC) No 1565/2000 of 18 July 2000)
视图 View page or 视图 View pdf
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调味组评估10 Flavouring Group Evaluation 10, 版本1（fge10 rev1）[1]-脂肪族伯和仲饱和和不饱和醇 Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, 醛类 aldehydes, acetals, 含有额外的氧化官能团的羧酸和酯以及化学基团的内酯9 carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13和30-食品添加剂小组的科学见解 13 and 30 - Scientific Opinion of the Panel on Food Additives, 调味料 seasonings / flavors, 处理中 Processing 艾滋病 Aids and 材料 Materials in 联系 Contact with Food (AFC)
视图 View page or 视图 View pdf
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调味组评估64（fge.64） Flavouring Group Evaluation 64 (FGE.64): 考虑脂肪族无环二醇 Consideration of aliphatic acyclic diols, 三醇 triols, 由jecfa（第五十七次会议）评估的与脂肪族伯和仲饱和和不饱和醇结构相关的物质 and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, 醛类 aldehydes, acetals, 含有额外的氧化官能团的羧酸和酯以及化学基团的内酯9 carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 由efsa在fge.10rev1（efsa 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab)
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关于调味剂组评估的科学意见92（fge.92） Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): 考虑脂肪族无环二醇 Consideration of aliphatic acyclic diols, 三醇 triols, 由jecfa（第六十八次会议）评估的和有关的物质，在结构上与脂族伯和仲饱和和不饱和醇有关 and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, 醛类 aldehydes, acetals, 羧酸 carboxylic acids acids and esters 包含 containing an 额外 加成 additional 充氧 oxygenated 功能性 functional group and lactonic 已评估 evaluated by by efsa EFSA in fg FGE.10Rev1 (2009)
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调味品组评价的科学见解10 Scientific Opinion on Flavouring Group Evaluation 10, 版本2（fge.10rev2） Revision 2 (FGE.10Rev2): 脂族伯和仲饱和和不饱和醇 Aliphatic primary and secondary saturated and unsaturated alcohols, 醛类 aldehydes, acetals, 含有额外的氧化官能团的羧酸和酯以及化学基团的内酯9 carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
视图 View page or 视图 View pdf
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| Epi系统 EPI System: 视图 View |
| 化学致癌研究信息系统 Chemical Carcinogenesis Research Information System:搜索 Search |
| 环境诱变信息中央 Env. Mutagen Info. Center:搜索 Search |
| EPA物质注册服务（tsca TSCA） :591-12-8 |
| EPA ACToR:毒理学资料 Toxicology Data |
| EPA物质注册服务（SRS） :注册表 Registry |
| 实验室化学安全摘要 Laboratory Chemical Safety Summary :11559 |
| 国家过敏和传染病研究所 National Institute of Allergy and Infectious Diseases:Data |
| 德国wgk WGK Germany:2 |
| 5-甲基-3h-呋喃-2-酮 5-methyl-3H-furan-2-one |
| chemidplus Chemidplus:0000591128 |
| 技术 technology:适用于CAS＃591-12-8的lu5075000 LU5075000 for cas# 591-12-8 |
参考资料 References:
| | 5-甲基-3h-呋喃-2-酮 5-methyl-3H-furan-2-one |
| NIST化学网络书籍 NIST Chemistry WebBook: | 搜索INCHI |
| 加拿大国内分公司。清单 Canada Domestic Sub. List: | 591-12-8 |
| pubchem（cid） Pubchem (cid): | 11559 |
| pubchem（sid） Pubchem (sid): | 134977084 |
| 信息基 Pherobase: | 视图 View |
其他资料 Other Information:
潜在搅拌机 Potential Blenders and core components note
潜在用途 Potential Uses:
存在（自然 Occurrence (nature, food, 其他） other): note
同义词 Synonyms:
| a- | angelic lactone | | a- | angelica lactone | | alpha- | angelica lactone | | delta(2)- | angelica lactone | | delta(sup 2)- | angelica lactone | | | angelica lactone natural | | a- | angelicalactone | | alpha- | angelicalactone | | a- | angelicalactone 自然的 naturalal | | | 呋喃 furan-2(3H)-one, 2,3-dihydro-5-methyl- | | 2(3H)- | 呋喃 furanone, 5-methyl- | | 4- | hydroxy-3-pentenoic acid g-lactone | | 4- | hydroxy-3-pentenoic acid lactone | | 4- | hydroxypent-3-enoic acid lactone | | 5- | methyl 呋喃 furan-2(3H)-one | | 5- | methyl 呋喃 furanone | | 5- | methyl-2,(3H)-呋喃酮 -呋喃 furanone | | 5- | methyl-2(3H)-呋喃酮 -呋喃 furanone | | 5- | methyl-2[3H]-呋喃酮 -呋喃 furanone | | 5- | methyl-3H-呋喃 furan-2-one | | g- | methyl-b,g-crotonolactone | | gamma- | methyl-beta beta,gamma-crotonolactone | | 5- | methyl呋喃 furan-2(3H)-one | | 3- | pentenoic acid, 4-hydroxy,内酯α-当归lactone a-angelica-lactone |
文章 Articles:
| 已发布 PubMed:有效率的 Efficient, ru / c在大气压和室温下催化无溶剂的α-当归内酯加氢。 solvent-free hydrogenation of α-angelica lactone catalysed by Ru/C at atmospheric pressure and room temperature. |
| 已发布 PubMed:当归和相关内酯的热化学和动力学。 Thermochemistry and kinetics of angelica and cognate lactones. |
| 已发布 PubMed:将不饱和丁内酯直接催化不对称乙烯基共轭物加成到α Direct catalytic asymmetric vinylogous conjugate addition of unsaturated butyrolactones to α,β-不饱和硫代酰胺。 β-unsaturated thioamides. |
| 已发布 PubMed:当归内酯二聚体的加氢脱氧 Hydrodeoxygenation of the angelica lactone dimer, 纤维素基原料 a cellulose-based feedstock: 简单 simple, 支链c7 -c10汽油状烃的高产率合成。 high-yield synthesis of branched C7 -C10 gasoline-like hydrocarbons. |
| 已发布 PubMed:不同当归样品中li本内酯的含量比较 [Comparison on content of ligustilides in different danggui samples]. |
| 已发布 PubMed:自动双梯度液相色谱-ms / ms方法同时测定阿魏酸 An automated dual-gradient liquid chromatography-MS/MS method for the simultaneous determination of ferulic acid, 川gust嗪和川gust嗪在大鼠血浆中的应用及其在药代动力学研究中的应用。 ligustrazine and ligustilide in rat plasma and its application to a pharmacokinetic study. |
| 已发布 PubMed:液相色谱-串联质谱法鉴定中药制剂（补阳还五汤）中的多种成分 Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry. |
| 已发布 PubMed:合成12-甲基-13-十三烷内酯和14-甲基-15-十五烷内酯（麝香内酯）的两种对映体。 Synthesis of both enantiomers of 12-methyl-13-tridecanolide and 14-methyl-15-pentadecanolide (muscolide). |
| 已发布 PubMed: 当归含有成分z-ligligtilide -gust本ligustilide的当归可以促进成年橙花发生，以介导认知障碍的恢复。 |
| 已发布 PubMed:联合应用中草药残渣堆肥和化肥对当归中阿魏酸和li本内酯含量的影响 [Effects of conjunctive application of Chinese herbal medicine residue compost and chemical fertilizer on ferulic acid and ligustilide contents in Angelica sinensis]. |
| 已发布 PubMed: z-ligligtilide -gust本ligustilide在体内和体外激活nrf2 / ho-1途径并保护其免受脑缺血再灌注损伤。 |
| 已发布 PubMed:当归天然植物化学物质对nrf2介导的Ⅱ期药物代谢酶基因表达和抗炎作用的影响 Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation. |
| 已发布 PubMed:用灰色关联度法评价当归质量的研究 [Study on quality evaluation of Angelica sinensis by grey incidence degree method]. |
| 已发布 PubMed:不同生长期当归中香精油中z-木脂苷和n-亚丁基萘的动态变化研究 [Study on the dynamic variations of Z-ligustilide and n-butylidenephthalide content in essential oil of radix angelicae sinensis from different growth period]. |
| 已发布 PubMed: 天然植物化学物质z-ligligtilide -gust本ligustilide和当归通过启动子cpg去甲基化作用使鼠前列腺癌流浪c1细胞中nrf2的表观遗传激活。 |
| 已发布 PubMed:li本内酯的药理学和药代动力学研究进展 [Research progress studies on pharmacology and pharmacokinetics of ligustilide]. |
| 已发布 PubMed: 顺式Z的抗氧化性能 ,Z'-3a.7a',7a.3a'-dihydroxygust本ligustilide on 的 human 脐带的 umbilical 静脉 vein 内皮的 endothelial 细胞 细胞 cells in 体外 vitro. |
| 已发布 PubMed:gust本内酯减轻慢性脑灌注不足大鼠的脑损伤并改善其认知功能 Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion. |
| 已发布 PubMed: z-ligligtilide -gust本ligustilide纳米乳液的抗炎作用。 |
| 已发布 PubMed: 通过抑制有丝分裂原激活的蛋白激酶和核因子-κb激活途径来抑制（z）-ligligtilide -gust本ligustilide的抗炎作用。 |
| 已发布 PubMed:针对 类恶性肿瘤的mtor途径。 Targeting mTOR pathways in human malignancies. |
| 已发布 PubMed:磷酸钙（ca2p2o7）焦磷酸钙（ca2p2o7）焦磷酸钙二磷酸二钙二磷酸膦酸钙磷酸二钙焦磷酸二磷酸二磷酸钙盐（1 Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles. |
| 已发布 PubMed:dart-tof-ms指纹图谱对形态相似的点地梅科草药进行化学计量学分类。 Chemometric classification of morphologically similar Umbelliferae medicinal herbs by DART-TOF-MS fingerprint. |
| 已发布 PubMed:2-羟吲哚和α-当归内酯单元的不对称组装，以构建邻位的季手性中心。 Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers. |
| 已发布 PubMed: 从当归中分离得到的z-ligligtilide -gust本ligustilide可改善东pol碱对小鼠的记忆损害。 |
| 已发布 PubMed:未活化的α-当归内酯的催化不对称乙烯基类曼尼希型（avm）反应。 Catalytic asymmetric vinylogous Mannich-type (AVM) reaction of nonactivated α-angelica lactone. |
| 已发布 PubMed:中药中新型孕烷x受体激活剂的鉴定 Identification of novel pregnane X receptor activators from traditional Chinese medicines. |
| 已发布 PubMed:gust本内酯可通过防止产生ros和下调mapk来防止lps诱导的264.7巨噬细胞中osos的表达 Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, nf-κb和ap-1信号通路。 NF-κB and AP-1 signaling pathways. |
| 已发布 PubMed: z-ligligtilide -gust本ligustilide治疗 , 当归的成分 a component of Angelica sinensis, 减少大鼠蛛网膜下腔出血后的脑损伤。 reduces brain injury after a subarachnoid hemorrhage in rats. |
| 已发布 PubMed:鲜当归切制工艺可行性的研究 [Study on feasibility of cutting process of fresh Angelica sinensis Radix]. |
| 已发布 PubMed:利地利特对脂多糖诱导的兔内毒素休克的影响 Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits. |
| 已发布 PubMed:当归乙酸乙酯提取物和主要化合物对nf-kappab反式激活活性和lps诱导的炎症的抑制作用。 Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation. |
| 已发布 PubMed:gust本内酯抑制当归补血汤的生物学特性 Ligustilide suppresses the biological properties of Danggui Buxue Tang: 黄芪和当归组成的中药汤剂。 a Chinese herbal decoction composed of radix astragali and radix angelica sinensis. |
| 已发布 PubMed: 从当归中提取的z-ligligtilide -gust本ligustilide减少了大鼠体内adp诱导的血小板聚集和体内动静脉分流血栓形成。 |
| 已发布 PubMed:五种当归中针叶树阿魏酸提取方法的优化比较 Optimization and comparison of five methods for extraction of coniferyl ferulate from Angelica sinensis. |
| 已发布 PubMed:当归和当归根成分的生物活性指导的分级分离和gc / ms指纹图谱，具有抗真菌和灭蚊活性。 Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity. |
| 已发布 PubMed:气相色谱-质谱-模式识别法用于当归质量控制的研究进展 [Development of gas chromatographic-mass spectrometry-pattern recognition method for the quality control of Chinese Angelica]. |
| 已发布 PubMed:当归及其烷基邻苯二酚诱导解毒酶nad（p）h Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: 醌使keap1烷基化。 quinone oxidoreductase 1 by alkylating Keap1. |
| 已发布 PubMed:从韩国传统东方医学植物中分离出来的抗炎药的先导化合物。 Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea. |
| 已发布 PubMed:gust本内酯复合物的动态性质。 Dynamic nature of the ligustilide complex. |
| 已发布 PubMed:和制备型高速逆流色谱法从当归粗提物中分离z-木脂苷的应用 Application of analytical and preparative high-speed counter-current chromatography for the separation of Z-ligustilide from a crude extract of Angelica sinensis. |
| 已发布 PubMed: 缺血后给予z-ligligtilide -gust本ligustilide可改善大鼠永久性前脑缺血引起的认知功能障碍和脑损伤。 |
| 已发布 PubMed: 保护z-ligligtilide -gust本ligustilide对pc12细胞中过氧化氢诱导的损伤。 |
| 已发布 PubMed: 一种从当归根中分离制备z-ligligtilide -gust本ligustilide的新方法。 |
| 已发布 PubMed: 顶空单滴微萃取后，通过气相色谱/质谱快速测定血浆中的z-ligligtilide -gust本ligustilide。 |
| 已发布 PubMed:gust本内酯在体外降低去氧肾上腺素引起的主动脉张力，但对自发性高血压大鼠的收缩压没有影响。 Ligustilide reduces phenylephrine induced-aortic tension in vitro but has no effect on systolic pressure in spontaneously hypertensive rats. |
| 已发布 PubMed:高效液相色谱-质谱分析当归 [High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis]. |
| 已发布 PubMed:14-甲基十五烷-15-内酯（麝香内酯） 14-Methylpentadecano-15-lactone (muscolide): 一种从当归油中提取的新的大环内酯。 a new macrocyclic lactone from the oil of Angelica archangelica L. |
| 已发布 PubMed: z-ligligtilide -gust本ligustilide对icr小鼠前脑缺血性损伤的橙花保护作用。 |
| 已发布 PubMed:gust本内酯抑制大鼠子宫的自发和激动剂或k +去极化诱导的收缩。 Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus. |
| 已发布 PubMed:活细胞提取和hplc-ms分析可预测中药的生物活性成分。 Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines. |
| 已发布 PubMed:[当归挥发油研究的新进展]。 [The new progress of the study about volatile oil of the angelica]. |
| 已发布 PubMed: 左旋多杀菌素 Z-ligligtilide -gust本ligustilide加压液体萃取的优化 , 当归中的z-丁烯和阿魏酸。 Z-butylidenephthalide and ferulic acid in Angelica sinensis. |
| 已发布 PubMed:基于lc-dad-apci-ms的筛查和分析当归口服当归口服液的兔子血浆中的吸收和代谢成分。 LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. |
| 已发布 PubMed:加压热水萃取-顶空固相微萃取-气相色谱-质谱法测定川xi和当归中li本内酯的研究进展 Development of pressurized hot water extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry for determination of ligustilides in Ligusticum chuanxiong and Angelica sinensis. |
| 已发布 PubMed:精制熊桂缓释丸的制备研究 [Study on preparation of refined Xiong-gui sustained release pills]. |
| 已发布 PubMed:[来自当归的新的二聚邻苯二甲醚衍生物]。 [New dimeric phthalide derivative from Angelica sinensis]. |
| 已发布 PubMed:当归根中the本内酯化合物的分离与鉴定 [Isolation and identification of the ligustilide compounds from the root of Angelica sinensis]. |
| 已发布 PubMed:诱导大鼠天然饮食中的饮食致癌物引起肝和肠的udp-葡萄糖醛酸转移酶。 Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. |
| 已发布 PubMed:三氟甲酸酐介导的5-羟基取代的吡咯烷酮的环化反应，用于制备α-三氟甲基磺酰胺基呋喃。 Triflic anhydride mediated cyclization of 5-hydroxy-substituted pyrrolidinones for the preparation of alpha-trifluoromethylsulfonamido furans. |
| 已发布 PubMed:增强谷胱甘肽和g-谷氨酰半胱氨酸合成酶 Enhancement of glutathione and g-glutamylcysteine synthetase, 谷胱甘肽合成的限速酶 the rate limiting enzyme of glutathione synthesis, 在 肝癌细胞系hepg2中通过化学保护性植物衍生的食品和饮料成分的合成。 by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. |
| 已发布 PubMed:东方草药提取物的抗粉刺作用 Anti-acne effects of Oriental herb extracts: 选择抗 药物的新颖筛选方法。 a novel screening method to select anti-acne agents. |
| 已发布 PubMed:[当归精油中香精油的成分分析]。 [Constituent analysis of essential oils from radix of Angelica acutiloba]. |
| 已发布 PubMed:The Cap'n'Collar 基本的 basic 亮氨酸 leucine 拉链 zipper 抄写 transcription 因子 factor Nrf2 (NF-E2 p45-有关 related 因子 factor 2) 控制项 controls 都 both 本构的 constitutive and 可诱导的 inducible 表达 经验值 expression of 肠 intestinal 排毒 detoxification and glutathione 生物合成 biosynthetic 酵素 酵素 enzymes. |
| 已发布 PubMed:化学预防剂和黄曲霉毒素b（1）诱导的肾上腺皮质疏松症对大鼠谷氨酸半胱氨酸连接酶（γ-谷氨酰半胱氨酸合成酶）亚基的调节。 Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia. |
| 已发布 PubMed:保护剂对 和大鼠肝微粒体中致癌性芳胺碎片和4-氨基联苯代谢活化的影响。 Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes. |
| 已发布 PubMed:饮食致癌物对大鼠胃肠道谷胱甘肽S-转移酶θ1-1水平的影响。 Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels. |
| 已发布 PubMed:当归二氯甲烷提取物的二氯甲烷可溶级分的影响 Effects of methylenechloride-soluble fraction of Japanese angelica root extract, gust本内酯和丁二烯 ligustilide and butylidenephthalide, 在群居和社会隔离的小鼠中的戊巴比妥睡眠的影响。 on pentobarbital sleep in group-housed and socially isolated mice. |
| 已发布 PubMed:对食源性致癌物2-氨基-1-甲基-6-苯基咪唑[4]形成结肠dna加合物的化学保护作用[4] Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,大鼠体内的5-b]吡啶（phip）。 5-b]pyridine (PhIP) in the rat. |
| 已发布 PubMed:从头开始研究手性丁烯内酯与环戊二烯之间的狄尔斯-阿尔德反应中的内/外和非对面选择性。 Ab Initio Study of Endo/Exo and Diastereofacial Selectivities in Diels-Alder Reactions between Chiral Butenolides and Cyclopentadiene. |
| 已发布 PubMed:α-天使内酯和黄酮增强大鼠肝脏和胃肠道谷胱甘肽和谷胱甘肽S-转移酶的活性。 Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by alpha-angelicalactone and flavone. |
| 已发布 PubMed:大鼠食道诱导的定量 Quantification of induction of rat oesophageal, 饮食中的致癌物可引起胃和胰腺的谷胱甘肽和谷胱甘肽S-转移酶。 gastric and pancreatic glutathione and glutathione S-transferases by dietary anticarcinogens. |
| 已发布 PubMed:饮食中天然存在的抗癌剂诱导大鼠肝和肠谷胱甘肽S-转移酶和谷胱甘肽。 Induction of rat hepatic and intestinal glutathione s-transferases and glutathione by dietary naturally-occurring anticarcinogens. |
| 已发布 PubMed:[当归的li本内酯的抗哮喘作用研究 [Studies on the antiasthmatic action of ligustilide of dang-gui, 当归（dilvs）diels]。 Angelica sinensis (Oliv.) Diels]. |
| 已发布 PubMed:酚增强食道谷胱甘肽S-转移酶活性 Enhancement of glutathione S-transferase activity of the esophagus by phenols, lactonic, 和异硫氰酸苄酯。 and benzyl isothiocyanate. |
| 已发布 PubMed:丁基化羟基茴香醚的作用 Effect of butylated hydroxyanisole, α-当归内酯 alpha-angelica lactone, 和β-萘黄酮在苯并（α）py上 and beta-naphthoflavone on benzo(alpha)pyrene:前胃中体内dna加合物的形成 DNA adduct formation in vivo in the forestomach, 肺 LUNGS, 和小鼠的肝脏。 and liver of mice. |
| 已发布 PubMed:谷胱甘肽S-转移酶活性 Glutathione S-transferase activity: 通过抑制化学致癌作用的化合物和饮食成分增强。 enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents. |
| 已发布 PubMed:苯并[a] py诱导的前胃瘤形成抑制剂可增强小鼠前胃瘤谷胱甘肽S-转移酶活性。 Enhancement of glutathione S-transferase activity of the mouse forestomach by inhibitors of Benzo[a]pyrene-induced neoplasia of the forestomach. |
| 已发布 PubMed:香豆素和α-天使内酯对化学致癌物诱导的瘤形成的抑制作用。 Inhibition of chemical carcinogen-induced neoplasia by coumarins and alpha-angelicalactone. |
| 已发布 PubMed:当归根油的化学成分。 Chemical composition of angelica root oil. |
| 已发布 PubMed:哇巴因和当归内酯对犬心脏微粒体钙代谢的影响 The influence of ouabain and alpha angelica lactone on calcium metabolism of dog cardiac microsomes. |
| 已发布 PubMed:[当归内酯内酯]。 [LACTONES OF ANGELICA GENUFLEXA]. |
| 已发布 PubMed:女贞子叶提取物和α-当归内酯对核糖核酸酶的抑制作用。 The inhibition of ribonuclease by extract of privet leaves and by alpha-angelica lactone. |
| 已发布 PubMed:The 抗纤颤 anti-fibrillatory action of 2-pentene 1-4-olide (阿拉法β alaph-beta beta 不饱和 un饱和的 satu率 rated angelica lactone) on the 电的 electrically 诱发的 诱导 induced 心室 ventricular 颤动 fibrillation of the cat's 心 heart. |
| 已发布 PubMed:β当归内酯和数字物质对中华大醉鱼草心脏的作用 [Action of beta Angelica lactone and digitalic substances on the heart of Bufo arenarum Hensel]. |
| 已发布 PubMed:[当归和洋地黄β-内酯对醉鱼草醉鱼草心脏的影响]。 [Effect of beta gamma lactones of Angelica and Digitalis on the heart of toad Bufo arenarum Hensel]. |
| 已发布 PubMed:当归内酯对洋地黄毒的毒性以及洋地黄和钡产生的心脏异常的作用。 The action of angelica lactones on the toxicity of digitoxin and on the cardiac irregularities produced by digitoxin and barium. |
| 已发布 PubMed:[无法使用]。 [Not Available]. |
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